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Volumn 2, Issue 2, 2013, Pages 76-95

Circulating levels of soluble angiogenic factors in multiple myeloma: Correlation with parameters of disease activity and prognosis

Author keywords

Angiogenesis; Bone marrow; Chemokines; Cytokines; Microvascular density; Multiple myeloma; Prognosis

Indexed keywords

ANGIOGENIC FACTOR; ANGIOGENIN; B CELL ACTIVATING FACTOR; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; COLLAGEN; ENDOGLIN; FIBROBLAST GROWTH FACTOR 2; GELATINASE A; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; KI 67 ANTIGEN; OSTEOPONTIN; PLASMINOGEN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR AB; SCATTER FACTOR; SOMATOMEDIN C; STRUCTURAL PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

EID: 84952991720     PISSN: 22115528     EISSN: 22115536     Source Type: Journal    
DOI: 10.2174/22115528113026660012     Document Type: Article
Times cited : (4)

References (277)
  • 2
    • 84355162753 scopus 로고    scopus 로고
    • Biological aspects of angiogenesis in multiple myeloma
    • Otjacques E, Binsfeld M, Noel A, et al. Biological aspects of angiogenesis in multiple myeloma. Int J Hematol 2011; 94: 505-18.
    • (2011) Int J Hematol , vol.94 , pp. 505-518
    • Otjacques, E.1    Binsfeld, M.2    Noel, A.3
  • 4
    • 84876543606 scopus 로고    scopus 로고
    • Bone marrow angiogenesis and progression in multiple myeloma
    • Ria R, Reale A, De Luisi A, et al. Bone marrow angiogenesis and progression in multiple myeloma. Am J Blood Res 2011; 1: 76-89.
    • (2011) Am J Blood Res , vol.1 , pp. 76-89
    • Ria, R.1    Reale, A.2    de Luisi, A.3
  • 6
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 1997; 386: 671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 7
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 8
    • 33845537389 scopus 로고    scopus 로고
    • The history of the angiogenic switch concept
    • Ribatti D, Nico B, Crivellato E, et al. The history of the angiogenic switch concept. Leukemia 2007; 21: 44-52.
    • (2007) Leukemia , vol.21 , pp. 44-52
    • Ribatti, D.1    Nico, B.2    Crivellato, E.3
  • 9
    • 0028362802 scopus 로고
    • Bone marrow angiogenesis and progression in multiple myeloma
    • Vacca A, Ribatti D, Roncali L, et al. Bone marrow angiogenesis and progression in multiple myeloma. Br J Haematol 1994; 87: 503-508.
    • (1994) Br J Haematol , vol.87 , pp. 503-508
    • Vacca, A.1    Ribatti, D.2    Roncali, L.3
  • 10
    • 0035992360 scopus 로고    scopus 로고
    • Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis
    • Rajkumar SV, Mesa RA, Fonseca R, et al. Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis. Clin Cancer Res 2002; 8: 2210-6.
    • (2002) Clin Cancer Res , vol.8 , pp. 2210-2216
    • Rajkumar, S.V.1    Mesa, R.A.2    Fonseca, R.3
  • 11
    • 1542608411 scopus 로고    scopus 로고
    • Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma
    • Kumar S, Witzig TE, Dispenzieri A, et al. Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma. Leukemia 2004; 18: 624-7.
    • (2004) Leukemia , vol.18 , pp. 624-627
    • Kumar, S.1    Witzig, T.E.2    Dispenzieri, A.3
  • 12
    • 18744385489 scopus 로고    scopus 로고
    • Bone marrow angiogenesis in multiple myeloma: Effect of therapy
    • Kumar S, Fonseca R, Dispenzieri A, et al. Bone marrow angiogenesis in multiple myeloma: effect of therapy. Br J Haematol 2002; 119: 665-71.
    • (2002) Br J Haematol , vol.119 , pp. 665-671
    • Kumar, S.1    Fonseca, R.2    Dispenzieri, A.3
  • 13
    • 0035025130 scopus 로고    scopus 로고
    • Decrease of bone marrow angiogenesis in myeloma patients achieving a remission after chemotherapy
    • Sezer O, Niemöller K, Kaufmann O, et al. Decrease of bone marrow angiogenesis in myeloma patients achieving a remission after chemotherapy. Eur J Haematol 2001; 66: 238-44.
    • (2001) Eur J Haematol , vol.66 , pp. 238-244
    • Sezer, O.1    Niemöller, K.2    Kaufmann, O.3
  • 14
    • 84860526101 scopus 로고    scopus 로고
    • Clinical significance of sCD105 in angiogenesis and disease activity in multiple myeloma
    • Tsirakis G, Pappa CA, Spanoudakis M, et al. Clinical significance of sCD105 in angiogenesis and disease activity in multiple myeloma. Eur J Intern Med 2012; 23: 368-73.
    • (2012) Eur J Intern Med , vol.23 , pp. 368-373
    • Tsirakis, G.1    Pappa, C.A.2    Spanoudakis, M.3
  • 15
    • 4243166956 scopus 로고    scopus 로고
    • Cell proliferation of myeloma plasma cells: Comparison of the blood and marrow compartments
    • Kumar S, Rajkumar SV, Greipp PR, Witzig TE. Cell proliferation of myeloma plasma cells: comparison of the blood and marrow compartments. Am J Hematol 2004; 77: 7-11.
    • (2004) Am J Hematol , vol.77 , pp. 7-11
    • Kumar, S.1    Rajkumar, S.V.2    Greipp, P.R.3    Witzig, T.E.4
  • 16
    • 4043143471 scopus 로고    scopus 로고
    • The relation between bone marrow angiogenesis and the proliferation index Ki- 67 in multiple myeloma
    • Alexandrakis MG, Passam FH, Dambaki C, et al. The relation between bone marrow angiogenesis and the proliferation index Ki- 67 in multiple myeloma. J Clin Pathol 2004; 57: 856-60.
    • (2004) J Clin Pathol , vol.57 , pp. 856-860
    • Alexandrakis, M.G.1    Passam, F.H.2    Dambaki, C.3
  • 17
    • 84866279444 scopus 로고    scopus 로고
    • Role of platelet-derived growth factor-AB in tumour growth and angiogenesis in relation with other angiogenic cytokines in multiple myeloma
    • Tsirakis G, Pappa CA, Kanellou P, et al. Role of platelet-derived growth factor-AB in tumour growth and angiogenesis in relation with other angiogenic cytokines in multiple myeloma. Hematol Oncol 2012; 30: 131-6.
    • (2012) Hematol Oncol , vol.30 , pp. 131-136
    • Tsirakis, G.1    Pappa, C.A.2    Kanellou, P.3
  • 18
    • 77954590398 scopus 로고    scopus 로고
    • Diffuse MRI marrow pattern correlates with increased angiogenesis, advanced disease features and poor prognosis in newly diagnosed myeloma treated with novel agents
    • Moulopoulos LA, Dimopoulos MA, Christoulas D, et al. Diffuse MRI marrow pattern correlates with increased angiogenesis, advanced disease features and poor prognosis in newly diagnosed myeloma treated with novel agents. Leukemia 2010; 24: 1206-12.
    • (2010) Leukemia , vol.24 , pp. 1206-1212
    • Moulopoulos, L.A.1    Dimopoulos, M.A.2    Christoulas, D.3
  • 19
    • 0035172919 scopus 로고    scopus 로고
    • Relationship between bone marrow angiogenesis and plasma cell infiltration and serum beta2- microglobulin levels in patients with multiple myeloma
    • Sezer O, Niemöller K, Jakob C, et al. Relationship between bone marrow angiogenesis and plasma cell infiltration and serum beta2- microglobulin levels in patients with multiple myeloma. Ann Hematol 2001; 80: 598-601.
    • (2001) Ann Hematol , vol.80 , pp. 598-601
    • Sezer, O.1    Niemöller, K.2    Jakob, C.3
  • 20
    • 0036037427 scopus 로고    scopus 로고
    • Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients
    • Pruneri G, Ponzoni M, Ferreri AJ, et al. Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients. Br J Haematol 2002; 118: 817-20.
    • (2002) Br J Haematol , vol.118 , pp. 817-820
    • Pruneri, G.1    Ponzoni, M.2    Ferreri, A.J.3
  • 21
    • 8344244502 scopus 로고    scopus 로고
    • Bone marrow microvascular density and angiogenic growth factors in multiple myeloma
    • Alexandrakis MG, Passam FJ, Ganotakis E, et al. Bone marrow microvascular density and angiogenic growth factors in multiple myeloma. Clin Chem Lab Med 2004; 42: 1122-6.
    • (2004) Clin Chem Lab Med , vol.42 , pp. 1122-1126
    • Alexandrakis, M.G.1    Passam, F.J.2    Ganotakis, E.3
  • 22
    • 4344640371 scopus 로고    scopus 로고
    • Prognostic value of bone marrow angiogenesis in patients with multiple myeloma undergoing high-dose therapy
    • Kumar S, Gertz MA, Dispenzieri A, et al. Prognostic value of bone marrow angiogenesis in patients with multiple myeloma undergoing high-dose therapy. Bone Marrow Transplant 2004; 34: 235-9.
    • (2004) Bone Marrow Transplant , vol.34 , pp. 235-239
    • Kumar, S.1    Gertz, M.A.2    Dispenzieri, A.3
  • 23
    • 5444275347 scopus 로고    scopus 로고
    • Expression of proliferating cell nuclear antigen (PCNA) in multiple myeloma: Its relationship to bone marrow microvessel density and other factors of disease activity
    • Alexandrakis MG, Passam FH, Pappa CA, et al. Expression of proliferating cell nuclear antigen (PCNA) in multiple myeloma: its relationship to bone marrow microvessel density and other factors of disease activity. Int J Immunopathol Pharmacol 2004; 17: 49-56.
    • (2004) Int J Immunopathol Pharmacol , vol.17 , pp. 49-56
    • Alexandrakis, M.G.1    Passam, F.H.2    Pappa, C.A.3
  • 24
    • 33748108569 scopus 로고    scopus 로고
    • Prognostic value of bone marrow angiogenesis in multiple myeloma: Use of light microscopy as well as computerized image analyzer in the assessment of microvessel density and total vascular area in multiple myeloma and its correlation with various clinical, histological, and laboratory parameters
    • Bhatti SS, Kumar L, Dinda AK, Dawar R. Prognostic value of bone marrow angiogenesis in multiple myeloma: use of light microscopy as well as computerized image analyzer in the assessment of microvessel density and total vascular area in multiple myeloma and its correlation with various clinical, histological, and laboratory parameters. Am J Hematol 2006; 81: 649-56.
    • (2006) Am J Hematol , vol.81 , pp. 649-656
    • Bhatti, S.S.1    Kumar, L.2    Dinda, A.K.3    Dawar, R.4
  • 25
    • 33846880054 scopus 로고    scopus 로고
    • Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma
    • Hillengass J, Wasser K, Delorme S, et al. Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma. Clin Cancer Res 2007; 13: 475-81.
    • (2007) Clin Cancer Res , vol.13 , pp. 475-481
    • Hillengass, J.1    Wasser, K.2    Delorme, S.3
  • 26
    • 0035207952 scopus 로고    scopus 로고
    • Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis
    • Munshi NC, Wilson C. Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis. Semin Oncol 2001; 28: 565-9.
    • (2001) Semin Oncol , vol.28 , pp. 565-569
    • Munshi, N.C.1    Wilson, C.2
  • 27
    • 20644460600 scopus 로고    scopus 로고
    • International staging system for multiple myeloma
    • Greipp PR, San Miguel J, Durie BG, et al. International staging system for multiple myeloma. J Clin Oncol 2005; 23; 3412-20.
    • (2005) J Clin Oncol , vol.23 , pp. 3412-3420
    • Greipp, P.R.1    Miguel, J.S.2    Durie, B.G.3
  • 28
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1: 27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 29
    • 33747152779 scopus 로고    scopus 로고
    • Cytokines and chemokines as regulators of angiogenesis in health and disease
    • Benelli R, Lorusso G, Albini A, Noonan DM. Cytokines and chemokines as regulators of angiogenesis in health and disease. Curr Pharm Des 2006; 12: 3101-15.
    • (2006) Curr Pharm Des , vol.12 , pp. 3101-3115
    • Benelli, R.1    Lorusso, G.2    Albini, A.3    Noonan, D.M.4
  • 30
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 31
    • 80053483270 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment: Focus on angiogenesis
    • Fan F, Schimming A, Jaeger D, Podar K. Targeting the tumor microenvironment: focus on angiogenesis. J Oncol 2012; 2012: 281261.
    • (2012) J Oncol , pp. 281261
    • Fan, F.1    Schimming, A.2    Jaeger, D.3    Podar, K.4
  • 32
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249-57.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 33
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3: 401-10.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 36
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: Past, present and the near future
    • Kerbel RS. Tumor angiogenesis: past, present and the near future. Carcinogenesis 2000; 21: 505-15.
    • (2000) Carcinogenesis , vol.21 , pp. 505-515
    • Kerbel, R.S.1
  • 38
    • 84865422083 scopus 로고    scopus 로고
    • Interleukin-6 signaling pathway in targeted therapy for cancer
    • Guo Y, Xu F, Lu T, et al. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev 2012; 38: 904-10.
    • (2012) Cancer Treat Rev , vol.38 , pp. 904-910
    • Guo, Y.1    Xu, F.2    Lu, T.3
  • 39
    • 0038370952 scopus 로고    scopus 로고
    • A review of the cytokine network in multiple myeloma: Diagnostic, prognostic, and therapeutic implications
    • Lauta VM. A review of the cytokine network in multiple myeloma: diagnostic, prognostic, and therapeutic implications. Cancer. 2003; 97: 2440-52.
    • (2003) Cancer , vol.97 , pp. 2440-2452
    • Lauta, V.M.1
  • 40
    • 0028955069 scopus 로고
    • Diagnostic value of serum IL-6 level in monoclonal gammopathies
    • DuVillard L, Guiguet M, Casasnovas RO, et al. Diagnostic value of serum IL-6 level in monoclonal gammopathies. Br J Haematol 1995; 89: 243-9.
    • (1995) Br J Haematol , vol.89 , pp. 243-249
    • Duvillard, L.1    Guiguet, M.2    Casasnovas, R.O.3
  • 41
    • 0030807922 scopus 로고    scopus 로고
    • Circulating interleukin-6 type cytokines in patients with systemic lupus erythematosus
    • Robak E, Sysa-Jedrzejowska A, Stepień H, Robak T. Circulating interleukin-6 type cytokines in patients with systemic lupus erythematosus. Eur Cytokine Netw 1997; 8: 281-6.
    • (1997) Eur Cytokine Netw , vol.8 , pp. 281-286
    • Robak, E.1    Sysa-Jedrzejowska, A.2    Stepień, H.3    Robak, T.4
  • 42
    • 58249095935 scopus 로고    scopus 로고
    • Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells
    • Ara T, Song L, Shimada H, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res 2009; 69: 329-37.
    • (2009) Cancer Res , vol.69 , pp. 329-337
    • Ara, T.1    Song, L.2    Shimada, H.3
  • 43
    • 38049036969 scopus 로고    scopus 로고
    • Angiogenesis-related growth factors and cytokines in the serum of patients with B non- Hodgkin lymphoma; relation to clinical features and response to treatment
    • Passam FH, Sfiridaki A, Pappa C, et al. Angiogenesis-related growth factors and cytokines in the serum of patients with B non- Hodgkin lymphoma; relation to clinical features and response to treatment. Int J Lab Hematol 2008; 30: 17-25.
    • (2008) Int J Lab Hematol , vol.30 , pp. 17-25
    • Passam, F.H.1    Sfiridaki, A.2    Pappa, C.3
  • 44
    • 33646231503 scopus 로고    scopus 로고
    • Angiogenic molecules in Hodgkin's disease: Results from sequential serum analysis
    • Passam FH, Alexandrakis MG, Moschandrea J, et al. Angiogenic molecules in Hodgkin's disease: results from sequential serum analysis. Int J Immunopathol Pharmacol 2006; 19: 161-70.
    • (2006) Int J Immunopathol Pharmacol , vol.19 , pp. 161-170
    • Passam, F.H.1    Alexandrakis, M.G.2    Moschandrea, J.3
  • 45
    • 0036204784 scopus 로고    scopus 로고
    • Diagnostic value of interleukin-1alpha, interleukin-6, and tumor necrosis factor in pleural effusions
    • Xirouchaki N, Tzanakis N, Bouros D, et al. Diagnostic value of interleukin-1alpha, interleukin-6, and tumor necrosis factor in pleural effusions. Chest 2002; 121: 815-20.
    • (2002) Chest , vol.121 , pp. 815-820
    • Xirouchaki, N.1    Tzanakis, N.2    Bouros, D.3
  • 46
    • 0036695788 scopus 로고    scopus 로고
    • Serum proinflammatory cytokines and its relationship to clinical parameters in lung cancer patients with reactive thrombocytosis
    • Alexandrakis MG, Passam FH, Perisinakis K, et al. Serum proinflammatory cytokines and its relationship to clinical parameters in lung cancer patients with reactive thrombocytosis. Respir Med 2002; 96: 553-8.
    • (2002) Respir Med , vol.96 , pp. 553-558
    • Alexandrakis, M.G.1    Passam, F.H.2    Perisinakis, K.3
  • 48
    • 79956020086 scopus 로고    scopus 로고
    • Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation
    • Kim SY, Min HJ, Park HK, et al. Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation. Biol Blood Marrow Transplant 2011; 17: 810-20.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 810-820
    • Kim, S.Y.1    Min, H.J.2    Park, H.K.3
  • 49
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: Role in inflammation and cancer
    • Rose-John S, Scheller J, Elson G, Jones SA. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 2006; 80: 227-36.
    • (2006) J Leukoc Biol , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 51
    • 0038717067 scopus 로고    scopus 로고
    • Bone marrow stromalderived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms
    • Nefedova Y, Landowski TH, Dalton WS. Bone marrow stromalderived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms. Leukemia 2003; 17: 1175-82.
    • (2003) Leukemia , vol.17 , pp. 1175-1182
    • Nefedova, Y.1    Landowski, T.H.2    Dalton, W.S.3
  • 52
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005; 41: 2502-12.
    • (2005) Eur J Cancer , vol.41 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 53
    • 0025212688 scopus 로고
    • Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis
    • Motro B, Itin A, Sachs L, Keshet E. Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci USA 1990; 87: 3092-6.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3092-3096
    • Motro, B.1    Itin, A.2    Sachs, L.3    Keshet, E.4
  • 54
    • 0034655957 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma
    • Dankbar B, Padró T, Leo R, et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood 2000; 95: 2630-6.
    • (2000) Blood , vol.95 , pp. 2630-2636
    • Dankbar, B.1    Padró, T.2    Leo, R.3
  • 55
    • 28244475975 scopus 로고    scopus 로고
    • Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine
    • Nilsson MB, Langley RR, Fidler IJ. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res 2005; 65: 10794-800.
    • (2005) Cancer Res , vol.65 , pp. 10794-10800
    • Nilsson, M.B.1    Langley, R.R.2    Fidler, I.J.3
  • 56
    • 37549051776 scopus 로고    scopus 로고
    • Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro
    • Fan Y, Ye J, Shen F, et al. Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab 2008; 28: 90-8.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 90-98
    • Fan, Y.1    Ye, J.2    Shen, F.3
  • 57
    • 0038351087 scopus 로고    scopus 로고
    • Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma
    • Alexandrakis MG, Passam FH, Boula A, et al. Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma. Ann Hematol 2003; 82: 19-23.
    • (2003) Ann Hematol , vol.82 , pp. 19-23
    • Alexandrakis, M.G.1    Passam, F.H.2    Boula, A.3
  • 58
    • 3042784365 scopus 로고    scopus 로고
    • Angiogenesis and the role of bone marrow endothelial cells in haematological malignancies
    • De Raeve H, Van Marck E, Van Camp B, Vanderkerken K. Angiogenesis and the role of bone marrow endothelial cells in haematological malignancies. Histol Histopathol 2004; 19: 935-50.
    • (2004) Histol Histopathol , vol.19 , pp. 935-950
    • de Raeve, H.1    van Marck, E.2    van Camp, B.3    Vanderkerken, K.4
  • 59
    • 84862196382 scopus 로고    scopus 로고
    • Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase
    • Brown CO, Salem K, Wagner BA, et al. Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase. Biochem J 2012; 444: 515-27.
    • (2012) Biochem J , vol.444 , pp. 515-527
    • Brown, C.O.1    Salem, K.2    Wagner, B.A.3
  • 60
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • Hideshima T, Mitsiades C, Tonon G, et al. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007; 7: 585-98.
    • (2007) Nat Rev Cancer , vol.7 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3
  • 61
    • 0025853227 scopus 로고
    • Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: Correlation with disease activity and other prognostic parameters
    • Nachbaur DM, Herold M, Maneschg A, Huber H. Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters. Ann Hematol 1991; 62: 54-8.
    • (1991) Ann Hematol , vol.62 , pp. 54-58
    • Nachbaur, D.M.1    Herold, M.2    Maneschg, A.3    Huber, H.4
  • 62
    • 0031435327 scopus 로고    scopus 로고
    • Cytokines in the sera of patients with pemphigus vulgaris: Interleukin-6 and tumour necrosis factor-alpha levels are significantly increased as compared to healthy subjects and correlate with disease activity
    • D'Auria L, Bonifati C, Mussi A, et al. Cytokines in the sera of patients with pemphigus vulgaris: interleukin-6 and tumour necrosis factor-alpha levels are significantly increased as compared to healthy subjects and correlate with disease activity. Eur Cytokine Netw 1997; 8: 383-7.
    • (1997) Eur Cytokine Netw , vol.8 , pp. 383-387
    • D'Auria, L.1    Bonifati, C.2    Mussi, A.3
  • 63
    • 0031972658 scopus 로고    scopus 로고
    • Circulating interleukin- 6 levels are elevated in adult T-cell leukaemia/lymphoma patients and correlate with adverse clinical features and survival
    • Yamamura M, Yamada Y, Momita S, et al. Circulating interleukin- 6 levels are elevated in adult T-cell leukaemia/lymphoma patients and correlate with adverse clinical features and survival. Br J Haematol 1998; 100: 129-34.
    • (1998) Br J Haematol , vol.100 , pp. 129-134
    • Yamamura, M.1    Yamada, Y.2    Momita, S.3
  • 65
    • 0029782311 scopus 로고    scopus 로고
    • Endogenous interleukin 6 levels in patients with metastatic malignant melanoma: Correlation with tumor burden
    • Mouawad R, Benhammouda A, Rixe O, et al. Endogenous interleukin 6 levels in patients with metastatic malignant melanoma: correlation with tumor burden. Clin Cancer Res 1996; 2: 1405-9.
    • (1996) Clin Cancer Res , vol.2 , pp. 1405-1409
    • Mouawad, R.1    Benhammouda, A.2    Rixe, O.3
  • 66
    • 0028021853 scopus 로고
    • Elevation of circulating interleukin 6 after surgery: Factors influencing the serum level
    • Sakamoto K, Arakawa H, Mita S, et al. Elevation of circulating interleukin 6 after surgery: factors influencing the serum level. Cytokine 1994; 6: 181-6.
    • (1994) Cytokine , vol.6 , pp. 181-186
    • Sakamoto, K.1    Arakawa, H.2    Mita, S.3
  • 67
    • 0029130182 scopus 로고
    • Clinical significance of elevated soluble interleukin-6 receptor levels in the sera of patients with plasma cell dyscrasias
    • Ohtani K, Ninomiya H, Hasegawa Y, et al. Clinical significance of elevated soluble interleukin-6 receptor levels in the sera of patients with plasma cell dyscrasias. Br J Haematol 1995; 91: 116-20.
    • (1995) Br J Haematol , vol.91 , pp. 116-120
    • Ohtani, K.1    Ninomiya, H.2    Hasegawa, Y.3
  • 68
    • 0029914360 scopus 로고    scopus 로고
    • Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma
    • Kyrtsonis MC, Dedoussis G, Zervas C, et al. Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma. Br J Haematol 1996; 93: 398-400.
    • (1996) Br J Haematol , vol.93 , pp. 398-400
    • Kyrtsonis, M.C.1    Dedoussis, G.2    Zervas, C.3
  • 69
    • 0038446643 scopus 로고    scopus 로고
    • Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma
    • Bisping G, Leo R, Wenning D, et al. Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma. Blood 2003; 101: 2775-83.
    • (2003) Blood , vol.101 , pp. 2775-2783
    • Bisping, G.1    Leo, R.2    Wenning, D.3
  • 70
    • 0032525085 scopus 로고    scopus 로고
    • The prognostic value of soluble interleukin-6 receptor in patients with multiple myeloma
    • Stasi R, Brunetti M, Parma A, et al. The prognostic value of soluble interleukin-6 receptor in patients with multiple myeloma. Cancer 1998; 82: 1860-6.
    • (1998) Cancer , vol.82 , pp. 1860-1866
    • Stasi, R.1    Brunetti, M.2    Parma, A.3
  • 71
    • 84864913379 scopus 로고    scopus 로고
    • B cell-activating factor: Its clinical significance in multiple myeloma patients
    • Fragioudaki M, Boula A, Tsirakis G, et al. B cell-activating factor: its clinical significance in multiple myeloma patients. Ann Hematol 2012; 91: 1413-8.
    • (2012) Ann Hematol , vol.91 , pp. 1413-1418
    • Fragioudaki, M.1    Boula, A.2    Tsirakis, G.3
  • 72
    • 80052652545 scopus 로고    scopus 로고
    • Assessment of proliferating cell nuclear antigen and its relationship with proinflammatory cytokines and parameters of disease activity in multiple myeloma patients
    • Tsirakis G, Pappa CA, Kaparou M, et al. Assessment of proliferating cell nuclear antigen and its relationship with proinflammatory cytokines and parameters of disease activity in multiple myeloma patients. Eur J Histochem 2011; 55(3): e21.
    • (2011) Eur J Histochem , vol.55 , Issue.3
    • Tsirakis, G.1    Pappa, C.A.2    Kaparou, M.3
  • 73
    • 84879488668 scopus 로고    scopus 로고
    • Serum levels of angiopoietin- 2 are associated with the growth of multiple myeloma
    • Pappa CA, Tsirakis G, Samiotakis P, et al. Serum levels of angiopoietin- 2 are associated with the growth of multiple myeloma. Cancer Invest 2013; 31: 385-9.
    • (2013) Cancer Invest , vol.31 , pp. 385-389
    • Pappa, C.A.1    Tsirakis, G.2    Samiotakis, P.3
  • 74
    • 0028269888 scopus 로고
    • Interleukin-6 in multiple myeloma: Correlation with disease activity and Ki-67 proliferation index
    • Thaler J, Fechner F, Herold M, Huber H. Interleukin-6 in multiple myeloma: correlation with disease activity and Ki-67 proliferation index. Leuk Lymphoma 1994; 12: 265-71.
    • (1994) Leuk Lymphoma , vol.12 , pp. 265-271
    • Thaler, J.1    Fechner, F.2    Herold, M.3    Huber, H.4
  • 75
    • 0026708195 scopus 로고
    • C-reactive protein and beta-2 microglobulin produce a simple and powerful myeloma staging system
    • Bataille R, Boccadoro M, Klein B, et al. C-reactive protein and beta-2 microglobulin produce a simple and powerful myeloma staging system. Blood 1992; 80: 733-7.
    • (1992) Blood , vol.80 , pp. 733-737
    • Bataille, R.1    Boccadoro, M.2    Klein, B.3
  • 76
    • 0037325594 scopus 로고    scopus 로고
    • The clinical and prognostic significance of erythrocyte sedimentation rate (ESR), serum interleukin-6 (IL-6) and acute phase protein levels in multiple myeloma
    • Alexandrakis MG, Passam FH, Ganotakis ES, et al. The clinical and prognostic significance of erythrocyte sedimentation rate (ESR), serum interleukin-6 (IL-6) and acute phase protein levels in multiple myeloma. Clin Lab Haematol 2003; 25: 41-6.
    • (2003) Clin Lab Haematol , vol.25 , pp. 41-46
    • Alexandrakis, M.G.1    Passam, F.H.2    Ganotakis, E.S.3
  • 77
    • 34548208088 scopus 로고    scopus 로고
    • Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis
    • Yang J, Wezeman M, Zhang X, et al. Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis. Cancer Cell 2007; 12: 252-65.
    • (2007) Cancer Cell , vol.12 , pp. 252-265
    • Yang, J.1    Wezeman, M.2    Zhang, X.3
  • 78
    • 12744279346 scopus 로고    scopus 로고
    • Syndecan-1 and angiogenic cytokines in multiple myeloma: Correlation with bone marrow angiogenesis and survival
    • Andersen NF, Standal T, Nielsen JL, et al. Syndecan-1 and angiogenic cytokines in multiple myeloma: correlation with bone marrow angiogenesis and survival. Br J Haematol 2005; 128: 210-7.
    • (2005) Br J Haematol , vol.128 , pp. 210-217
    • Andersen, N.F.1    Standal, T.2    Nielsen, J.L.3
  • 79
    • 26844527660 scopus 로고    scopus 로고
    • Systemic levels of interleukin- 6 and matrix metalloproteinase-9 in patients with multiple myeloma may be useful as prognostic indexes of bone disease
    • Sfiridaki A, Miyakis S, Tsirakis G, et al. Systemic levels of interleukin- 6 and matrix metalloproteinase-9 in patients with multiple myeloma may be useful as prognostic indexes of bone disease. Clin Chem Lab Med 2005; 43: 934-8.
    • (2005) Clin Chem Lab Med , vol.43 , pp. 934-938
    • Sfiridaki, A.1    Miyakis, S.2    Tsirakis, G.3
  • 80
    • 0030057701 scopus 로고    scopus 로고
    • Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma
    • Pulkki K, Pelliniemi TT, Rajamäki A, et al. Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Br J Haematol 1996; 92: 370-4.
    • (1996) Br J Haematol , vol.92 , pp. 370-374
    • Pulkki, K.1    Pelliniemi, T.T.2    Rajamäki, A.3
  • 81
    • 25144517719 scopus 로고    scopus 로고
    • The combination of intermediate doses of thalidomide and dexamethasone reduces bone marrow micro-vessel density but not serum levels of angiogenic cytokines in patients with refractory/relapsed multiple myeloma
    • Hatjiharissi E, Terpos E, Papaioannou M, et al. The combination of intermediate doses of thalidomide and dexamethasone reduces bone marrow micro-vessel density but not serum levels of angiogenic cytokines in patients with refractory/relapsed multiple myeloma. Hematol Oncol. 2004; 22: 159-68.
    • (2004) Hematol Oncol , vol.22 , pp. 159-168
    • Hatjiharissi, E.1    Terpos, E.2    Papaioannou, M.3
  • 82
    • 17044393376 scopus 로고    scopus 로고
    • The influence of thalidomide therapy on cytokine secretion, immunophenotype, BCL-2 expression and microvessel density in patients with resistant or relapsed multiple myeloma
    • Dmoszynska A, Podhorecka M, Manko J, et al. The influence of thalidomide therapy on cytokine secretion, immunophenotype, BCL-2 expression and microvessel density in patients with resistant or relapsed multiple myeloma. Neoplasma. 2005; 52: 175-81.
    • (2005) Neoplasma , vol.52 , pp. 175-181
    • Dmoszynska, A.1    Podhorecka, M.2    Manko, J.3
  • 83
    • 84877102048 scopus 로고    scopus 로고
    • The relationship between soluble receptor of interleukin-6 with angiogenic cytokines andproliferation markers in multiple myeloma
    • Tsirakis G, Pappa CA, Kaparou M, et al. The relationship between soluble receptor of interleukin-6 with angiogenic cytokines andproliferation markers in multiple myeloma. Tumour Biol 2013; 34: 859-64.
    • (2013) Tumour Biol , vol.34 , pp. 859-864
    • Tsirakis, G.1    Pappa, C.A.2    Kaparou, M.3
  • 84
    • 0034353524 scopus 로고    scopus 로고
    • The interleukin-6 receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells
    • Rawstron AC, Fenton JA, Ashcroft J, et al. The interleukin-6 receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells. Blood 2000; 96: 3880-6.
    • (2000) Blood , vol.96 , pp. 3880-3886
    • Rawstron, A.C.1    Fenton, J.A.2    Ashcroft, J.3
  • 85
    • 58249084333 scopus 로고    scopus 로고
    • Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease
    • Perez-Andres M, Almeida J, Martin-Ayuso M, et al. Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease. Int J Cancer 2009; 124: 367-75.
    • (2009) Int J Cancer , vol.124 , pp. 367-375
    • Perez-Andres, M.1    Almeida, J.2    Martin-Ayuso, M.3
  • 86
    • 84862909316 scopus 로고    scopus 로고
    • An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: Levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification
    • Stephens OW, Zhang Q, Qu P, et al. An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification. Blood 2012; 119: 503-12.
    • (2012) Blood , vol.119 , pp. 503-512
    • Stephens, O.W.1    Zhang, Q.2    Qu, P.3
  • 87
    • 0026505773 scopus 로고
    • Molecular and biological properties of the vascular endothelial growth factor family of proteins
    • Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 1992; 13: 18-32.
    • (1992) Endocr Rev , vol.13 , pp. 18-32
    • Ferrara, N.1    Houck, K.2    Jakeman, L.3    Leung, D.W.4
  • 88
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 89
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653-60.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 90
    • 0028080215 scopus 로고
    • Cytokine networks in solid human tumors: Regulation of angiogenesis
    • Leek RD, Harris AL, Lewis CE. Cytokine networks in solid human tumors: regulation of angiogenesis. J Leukoc Biol 1994; 56: 423-35.
    • (1994) J Leukoc Biol , vol.56 , pp. 423-435
    • Leek, R.D.1    Harris, A.L.2    Lewis, C.E.3
  • 91
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362: 841-4.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 92
    • 0142151228 scopus 로고    scopus 로고
    • Expression of VEGF and its receptors by myeloma cells
    • Kumar S, Witzig TE, Timm M, et al. Expression of VEGF and its receptors by myeloma cells. Leukemia 2003; 17: 2025-31.
    • (2003) Leukemia , vol.17 , pp. 2025-2031
    • Kumar, S.1    Witzig, T.E.2    Timm, M.3
  • 93
    • 0142182270 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptors in multiple myeloma
    • Ria R, Roccaro AM, Merchionne F, et al. Vascular endothelial growth factor and its receptors in multiple myeloma. Leukemia 2003; 17: 1961-6.
    • (2003) Leukemia , vol.17 , pp. 1961-1966
    • Ria, R.1    Roccaro, A.M.2    Merchionne, F.3
  • 94
    • 0035195019 scopus 로고    scopus 로고
    • Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications
    • Gupta D, Treon SP, Shima Y, et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia 2001; 15: 1950-61.
    • (2001) Leukemia , vol.15 , pp. 1950-195061
    • Gupta, D.1    Treon, S.P.2    Shima, Y.3
  • 95
    • 33746257305 scopus 로고    scopus 로고
    • Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma
    • Ribatti D, Nico B, Vacca A. Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma. Oncogene 2006; 25: 4257-66.
    • (2006) Oncogene , vol.25 , pp. 4257-4266
    • Ribatti, D.1    Nico, B.2    Vacca, A.3
  • 96
    • 33947310737 scopus 로고    scopus 로고
    • Inhibition of VEGF signaling pathways in multiple myeloma and other malignancies
    • Podar K, Anderson KC. Inhibition of VEGF signaling pathways in multiple myeloma and other malignancies. Cell Cycle 2007; 6: 538-42.
    • (2007) Cell Cycle , vol.6 , pp. 538-542
    • Podar, K.1    Anderson, K.C.2
  • 97
    • 0037381271 scopus 로고    scopus 로고
    • Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma: Correlation with markers of disease activity
    • Alexandrakis MG, Passam FH, Sfiridaki A, et al. Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma: correlation with markers of disease activity. Am J Hematol 2003; 72: 229-33.
    • (2003) Am J Hematol , vol.72 , pp. 229-233
    • Alexandrakis, M.G.1    Passam, F.H.2    Sfiridaki, A.3
  • 98
    • 0033902037 scopus 로고    scopus 로고
    • Prognostic value of bone marrow angiogenesis in multiple myeloma
    • Rajkumar SV, Leong T, Roche PC, et al. Prognostic value of bone marrow angiogenesis in multiple myeloma. Clin Cancer Res 2000; 6: 3111-6.
    • (2000) Clin Cancer Res , vol.6 , pp. 3111-3116
    • Rajkumar, S.V.1    Leong, T.2    Roche, P.C.3
  • 99
    • 0034802758 scopus 로고    scopus 로고
    • High plasma basic fibroblast growth factor concentration is associated with response to thalidomide in progressive multiple myeloma
    • Neben K, Moehler T, Egerer G, et al. High plasma basic fibroblast growth factor concentration is associated with response to thalidomide in progressive multiple myeloma. Clin Cancer Res 2001; 7: 2675-81.
    • (2001) Clin Cancer Res , vol.7 , pp. 2675-2681
    • Neben, K.1    Moehler, T.2    Egerer, G.3
  • 100
    • 39949084691 scopus 로고    scopus 로고
    • Bone marrow angiogenesis and angiogenic factors in multiple myeloma treated with novel agents
    • Cibeira MT, Rozman M, Segarra M, et al. Bone marrow angiogenesis and angiogenic factors in multiple myeloma treated with novel agents. Cytokine 2008; 41: 244-53.
    • (2008) Cytokine , vol.41 , pp. 244-253
    • Cibeira, M.T.1    Rozman, M.2    Segarra, M.3
  • 101
    • 33749989367 scopus 로고    scopus 로고
    • Serum interleukin- 17 and its relationship to angiogenic factors in multiple myeloma
    • Alexandrakis MG, Pappa CA, Miyakis S, et al. Serum interleukin- 17 and its relationship to angiogenic factors in multiple myeloma. Eur J Intern Med 2006; 17: 412-6.
    • (2006) Eur J Intern Med , vol.17 , pp. 412-416
    • Alexandrakis, M.G.1    Pappa, C.A.2    Miyakis, S.3
  • 102
    • 81555229380 scopus 로고    scopus 로고
    • Angiogenesis-related cytokines, RANKL, and osteoprotegerin in multiple myeloma patients in relation to clinical features and response to treatment
    • Sfiridaki K, Pappa CA, Tsirakis G, et al. Angiogenesis-related cytokines, RANKL, and osteoprotegerin in multiple myeloma patients in relation to clinical features and response to treatment. Mediators Inflamm 2011; 2011: 867576.
    • (2011) Mediators Inflamm , pp. 867576
    • Sfiridaki, K.1    Pappa, C.A.2    Tsirakis, G.3
  • 103
    • 1942518925 scopus 로고    scopus 로고
    • Serum levels of leptin in multiple myeloma patients and its relation to angiogenic and inflammatory cytokines
    • Alexandrakis MG, Passam FH, Sfiridaki A, et al. Serum levels of leptin in multiple myeloma patients and its relation to angiogenic and inflammatory cytokines. Int J Biol Markers 2004; 19: 52-7.
    • (2004) Int J Biol Markers , vol.19 , pp. 52-57
    • Alexandrakis, M.G.1    Passam, F.H.2    Sfiridaki, A.3
  • 104
    • 18144450541 scopus 로고    scopus 로고
    • Response to thalidomide in multiple myeloma: Impact of angiogenic factors
    • Rosiñol L, Cibeira MT, Segarra M, et al. Response to thalidomide in multiple myeloma: impact of angiogenic factors. Cytokine 2004; 26: 145-8.
    • (2004) Cytokine , vol.26 , pp. 145-148
    • Rosiñol, L.1    Cibeira, M.T.2    Segarra, M.3
  • 105
    • 35748965314 scopus 로고    scopus 로고
    • Patients with multiple myeloma treated with thalidomide: Evaluation of clinical parameters, cytokines, angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome
    • Mileshkin L, Honemann D, Gambell P, et al. Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines, angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome. Haematologica 2007; 92: 1075-82.
    • (2007) Haematologica , vol.92 , pp. 1075-1082
    • Mileshkin, L.1    Honemann, D.2    Gambell, P.3
  • 106
    • 46149087993 scopus 로고    scopus 로고
    • R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways
    • Cao Y, Cao R, Hedlund EM. R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways. J Mol Med (Berl) 2008; 86: 785-9.
    • (2008) J Mol Med (Berl) , vol.86 , pp. 785-789
    • Cao, Y.1    Cao, R.2    Hedlund, E.M.3
  • 107
    • 0242573091 scopus 로고    scopus 로고
    • Regulation of vascular development by fibroblast growth factors
    • Auguste P, Javerzat S, Bikfalvi A. Regulation of vascular development by fibroblast growth factors. Cell Tissue Res 2003; 314: 157-66.
    • (2003) Cell Tissue Res , vol.314 , pp. 157-166
    • Auguste, P.1    Javerzat, S.2    Bikfalvi, A.3
  • 108
    • 18144364350 scopus 로고    scopus 로고
    • Fibroblast growth factor/ fibroblast growth factor receptor system in angiogenesis
    • Presta M, Dell'Era P, Mitola S, et al. Fibroblast growth factor/ fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev 2005; 16: 159-78.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 159-178
    • Presta, M.1    Dell'Era, P.2    Mitola, S.3
  • 109
    • 0141742631 scopus 로고    scopus 로고
    • Fibroblast growth factors and their receptors in the central nervous system
    • Reuss B, von Bohlen and Halbach O. Fibroblast growth factors and their receptors in the central nervous system. Cell Tissue Res 2003; 313: 139-57.
    • (2003) Cell Tissue Res , vol.313 , pp. 139-157
    • Reuss, B.1    Bohlen, V.2    Halbach, O.3
  • 110
    • 38449096256 scopus 로고    scopus 로고
    • FGF signaling: Its role in bone development and human skeleton diseases
    • Su N, Du X, Chen L. FGF signaling: its role in bone development and human skeleton diseases. Front Biosci 2008; 13: 2842-65.
    • (2008) Front Biosci , vol.13 , pp. 2842-2865
    • Su, N.1    Du, X.2    Chen, L.3
  • 111
    • 18144413583 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling in tumorigenesis
    • Grose R, Dickson C. Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev 2005; 16: 179-86.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 179-186
    • Grose, R.1    Dickson, C.2
  • 112
    • 0026736833 scopus 로고
    • The FGF family of growth factors and oncogenes
    • Basilico C, Moscatelli D. The FGF family of growth factors and oncogenes. Adv Cancer Res 1992; 59: 115-65
    • (1992) Adv Cancer Res , vol.59 , pp. 115-165
    • Basilico, C.1    Moscatelli, D.2
  • 113
    • 0027535914 scopus 로고
    • Biology and biochemistry of proteinases in tumor invasion
    • Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993; 73: 161-95.
    • (1993) Physiol Rev , vol.73 , pp. 161-195
    • Mignatti, P.1    Rifkin, D.B.2
  • 114
    • 0033490113 scopus 로고    scopus 로고
    • In vivo angiogenic activity of urokinase: Role of endogenous fibroblast growth factor-2
    • Ribatti D, Leali D, Vacca A, et al. In vivo angiogenic activity of urokinase: role of endogenous fibroblast growth factor-2. J Cell Sci 1999; 112: 4213-21.
    • (1999) J Cell Sci , vol.112 , pp. 4213-4221
    • Ribatti, D.1    Leali, D.2    Vacca, A.3
  • 115
    • 0033134764 scopus 로고    scopus 로고
    • Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase- 2 secretion parallel progression of human multiple myeloma
    • Vacca A, Ribatti D, Presta M, et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase- 2 secretion parallel progression of human multiple myeloma. Blood 1999; 93: 3064-73.
    • (1999) Blood , vol.93 , pp. 3064-3073
    • Vacca, A.1    Ribatti, D.2    Presta, M.3
  • 116
    • 85060992588 scopus 로고    scopus 로고
    • Do human myeloma cells directly produce basic FGF?
    • Colla S, Morandi F, Lazzaretti M, et al. Do human myeloma cells directly produce basic FGF? Blood 2003; 102: 3071-2.
    • (2003) Blood , vol.102 , pp. 3071-3072
    • Colla, S.1    Morandi, F.2    Lazzaretti, M.3
  • 117
    • 33746326785 scopus 로고    scopus 로고
    • The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: Interplay of growth factors, their receptors and stromal interactions
    • Mitsiades CS, Mitsiades NS, Munshi NC, et al. The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions. Eur J Cancer 2006; 42: 1564-73.
    • (2006) Eur J Cancer , vol.42 , pp. 1564-1573
    • Mitsiades, C.S.1    Mitsiades, N.S.2    Munshi, N.C.3
  • 118
    • 0030997316 scopus 로고    scopus 로고
    • Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients
    • Dirix LY, Vermeulen PB, Pawinski A, et al. Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. Br J Cancer 1997; 76: 238-43.
    • (1997) Br J Cancer , vol.76 , pp. 238-243
    • Dirix, L.Y.1    Vermeulen, P.B.2    Pawinski, A.3
  • 119
    • 0033835945 scopus 로고    scopus 로고
    • Angiogenic factors in multiple myeloma: Higher levels in bone marrow than in peripheral blood
    • Di Raimondo F, Azzaro MP, Palumbo G, et al. Angiogenic factors in multiple myeloma: higher levels in bone marrow than in peripheral blood. Haematologica 2000; 85: 800-5.
    • (2000) Haematologica , vol.85 , pp. 800-805
    • Di Raimondo, F.1    Azzaro, M.P.2    Palumbo, G.3
  • 120
    • 0030020056 scopus 로고    scopus 로고
    • Elevated intracellular level of basic fibroblast growth factor correlates with stage of chronic lymphocytic leukemia and is associated with resistance to fludarabine
    • Menzel T, Rahman Z, Calleja E, et al. Elevated intracellular level of basic fibroblast growth factor correlates with stage of chronic lymphocytic leukemia and is associated with resistance to fludarabine. Blood 1996; 87: 1056-63.
    • (1996) Blood , vol.87 , pp. 1056-1063
    • Menzel, T.1    Rahman, Z.2    Calleja, E.3
  • 121
    • 0033571339 scopus 로고    scopus 로고
    • A high pretreatment serum basic fibroblast growth factor concentration is an independent predictor of poor prognosis in non-Hodgkin's lymphoma
    • Salven P, Teerenhovi L, Joensuu H. A high pretreatment serum basic fibroblast growth factor concentration is an independent predictor of poor prognosis in non-Hodgkin's lymphoma. Blood 1999; 94: 3334-9.
    • (1999) Blood , vol.94 , pp. 3334-3339
    • Salven, P.1    Teerenhovi, L.2    Joensuu, H.3
  • 122
    • 20444446735 scopus 로고    scopus 로고
    • Serum evaluation of angiogenic cytokine basic fibroblast growth factor, hepatocyte growth factor and TNF-alpha in patients with myelodysplastic syndromes: Correlation with bone marrow microvascular density
    • Alexandrakis MG, Passam FH, Pappa CA, et al. Serum evaluation of angiogenic cytokine basic fibroblast growth factor, hepatocyte growth factor and TNF-alpha in patients with myelodysplastic syndromes: correlation with bone marrow microvascular density. Int J Immunopathol Pharmacol 2005; 18: 287-95.
    • (2005) Int J Immunopathol Pharmacol , vol.18 , pp. 287-295
    • Alexandrakis, M.G.1    Passam, F.H.2    Pappa, C.A.3
  • 123
    • 0035121440 scopus 로고    scopus 로고
    • Serum levels of the angiogenic cytokines basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in multiple myeloma
    • Sezer O, Jakob C, Eucker J, et al. Serum levels of the angiogenic cytokines basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in multiple myeloma. Eur J Haematol 2001; 66(2): 83-8.
    • (2001) Eur J Haematol , vol.66 , Issue.2 , pp. 83-88
    • Sezer, O.1    Jakob, C.2    Eucker, J.3
  • 124
    • 0034802758 scopus 로고    scopus 로고
    • High plasma basic fibroblast growth factor concentration is associated with response to thalidomide in progressive multiple myeloma
    • Neben K, Moehler T, Egerer G, et al. High plasma basic fibroblast growth factor concentration is associated with response to thalidomide in progressive multiple myeloma. Clin Cancer Res 2001; 7: 2675-81.
    • (2001) Clin Cancer Res , vol.7 , pp. 2675-2681
    • Neben, K.1    Moehler, T.2    Egerer, G.3
  • 125
    • 1642524472 scopus 로고    scopus 로고
    • Serum syndecan-1, basic fibroblast growth factor and osteoprotegerin in myeloma patients at diagnosis and during the course of the disease
    • Kyrtsonis MC, Vassilakopoulos TP, Siakantaris MP, et al. Serum syndecan-1, basic fibroblast growth factor and osteoprotegerin in myeloma patients at diagnosis and during the course of the disease. Eur J Haematol 2004; 72: 252-8.
    • (2004) Eur J Haematol , vol.72 , pp. 252-258
    • Kyrtsonis, M.C.1    Vassilakopoulos, T.P.2    Siakantaris, M.P.3
  • 126
    • 0025805633 scopus 로고
    • Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
    • Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991; 251: 802-4.
    • (1991) Science , vol.251 , pp. 802-804
    • Bottaro, D.P.1    Rubin, J.S.2    Faletto, D.L.3
  • 127
    • 0037399323 scopus 로고    scopus 로고
    • The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma
    • Derksen PW, de Gorter DJ, Meijer HP, et al. The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma. Leukemia 2003; 17: 764-74.
    • (2003) Leukemia , vol.17 , pp. 764-774
    • Derksen, P.W.1    de Gorter, D.J.2    Meijer, H.P.3
  • 128
    • 33644529120 scopus 로고    scopus 로고
    • Clinical significance of chemokine receptor (CCR1, CCR2 and CXCR4) expression in human myeloma cells: The association with disease activity and survival
    • Vande Broek I, Leleu X, Schots R, et al. Clinical significance of chemokine receptor (CCR1, CCR2 and CXCR4) expression in human myeloma cells: the association with disease activity and survival. Haematologica 2006; 91: 200-6.
    • (2006) Haematologica , vol.91 , pp. 200-206
    • Broek, I.V.1    Leleu, X.2    Schots, R.3
  • 129
    • 0033754009 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases
    • Harvey P, Clark IM, Jaurand MC, Warn RM, Edwards DR. Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases. Br J Cancer 2000; 83: 1147-53.
    • (2000) Br J Cancer , vol.83 , pp. 1147-1153
    • Harvey, P.1    Clark, I.M.2    Jaurand, M.C.3    Warn, R.M.4    Edwards, D.R.5
  • 130
    • 0026287917 scopus 로고
    • Structure and function of hepatocyte growth factor
    • Nakamura T. Structure and function of hepatocyte growth factor. Prog Growth Factor Res 1991; 3: 67-85.
    • (1991) Prog Growth Factor Res , vol.3 , pp. 67-85
    • Nakamura, T.1
  • 131
    • 19644395911 scopus 로고    scopus 로고
    • HGF/SF-Met signaling in tumor progression
    • Gao CF, Vande Woude GF. HGF/SF-Met signaling in tumor progression. Cell Res 2005; 15: 49-51.
    • (2005) Cell Res , vol.15 , pp. 49-51
    • Gao, C.F.1    Woude, G.F.V.2
  • 132
    • 38449103771 scopus 로고    scopus 로고
    • The biological role of HGF-MET axis in tumor growth and development of metastasis
    • Lesko E, Majka M. The biological role of HGF-MET axis in tumor growth and development of metastasis. Front Biosci 2008; 13: 1271-80.
    • (2008) Front Biosci , vol.13 , pp. 1271-1280
    • Lesko, E.1    Majka, M.2
  • 133
    • 33847688869 scopus 로고    scopus 로고
    • Relationship between serum levels of vascular endothelial growth factor, hepatocyte growth factor and matrix metalloproteinase-9 with biochemical markers of bone disease in multiple myeloma
    • Alexandrakis MG, Sfiridaki A, Miyakis S, et al. Relationship between serum levels of vascular endothelial growth factor, hepatocyte growth factor and matrix metalloproteinase-9 with biochemical markers of bone disease in multiple myeloma. Clin Chim Acta 2007; 379: 31-5.
    • (2007) Clin Chim Acta , vol.379 , pp. 31-35
    • Alexandrakis, M.G.1    Sfiridaki, A.2    Miyakis, S.3
  • 134
    • 81455141312 scopus 로고    scopus 로고
    • Monitoring serum levels ELR+ CXC chemokines and the relationship between microvessel density and angiogenic growth factors in multiple myeloma
    • Pappa CA, Tsirakis G, Kanellou P, et al. Monitoring serum levels ELR+ CXC chemokines and the relationship between microvessel density and angiogenic growth factors in multiple myeloma. Cytokine 2011; 56: 616-20.
    • (2011) Cytokine , vol.56 , pp. 616-620
    • Pappa, C.A.1    Tsirakis, G.2    Kanellou, P.3
  • 135
    • 84871390838 scopus 로고    scopus 로고
    • Lack of correlation between angiogenic cytokines and serum insulin-like growth factor-1 in patients with multiple myeloma
    • Pappa CA, Tsirakis G, Psarakis FE, et al. Lack of correlation between angiogenic cytokines and serum insulin-like growth factor-1 in patients with multiple myeloma. Med Oncol 2013; 30: 363.
    • (2013) Med Oncol , vol.30 , pp. 363
    • Pappa, C.A.1    Tsirakis, G.2    Psarakis, F.E.3
  • 136
    • 79955648124 scopus 로고    scopus 로고
    • Circulating osteopontin: A dual marker of bone destruction and angiogenesis in patients with multiple myeloma
    • Sfiridaki A, Miyakis S, Pappa C, et al. Circulating osteopontin: a dual marker of bone destruction and angiogenesis in patients with multiple myeloma. J Hematol Oncol 2011; 4: 22.
    • (2011) J Hematol Oncol , vol.4 , pp. 22
    • Sfiridaki, A.1    Miyakis, S.2    Pappa, C.3
  • 137
    • 0032006829 scopus 로고    scopus 로고
    • Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma
    • Seidel C, Børset M, Turesson I, Abildgaard N, Sundan A, Waage A. Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. Blood 1998; 91: 806-12.
    • (1998) Blood , vol.91 , pp. 806-812
    • Seidel, C.1    Børset, M.2    Turesson, I.3    Abildgaard, N.4    Sundan, A.5    Waage, A.6
  • 138
    • 0036122019 scopus 로고    scopus 로고
    • Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma
    • Iwasaki T, Hamano T, Ogata A, Hashimoto N, Kitano M, Kakishita E. Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma. Br J Haematol 2002; 116: 796-802.
    • (2002) Br J Haematol , vol.116 , pp. 796-802
    • Iwasaki, T.1    Hamano, T.2    Ogata, A.3    Hashimoto, N.4    Kitano, M.5    Kakishita, E.6
  • 139
    • 0037005993 scopus 로고    scopus 로고
    • Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis
    • Nemeth JA, Yousif R, Herzog M, et al. Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis. J Natl Cancer Inst 2002; 94: 17-25.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 17-25
    • Nemeth, J.A.1    Yousif, R.2    Herzog, M.3
  • 140
    • 27744528785 scopus 로고    scopus 로고
    • Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3Kdependent signaling pathway in a human vascular endothelial cell line
    • Ko HM, Kang JH, Choi JH, et al. Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3Kdependent signaling pathway in a human vascular endothelial cell line. FEBS Lett 2005; 579: 6451-8.
    • (2005) FEBS Lett , vol.579 , pp. 6451-6458
    • Ko, H.M.1    Kang, J.H.2    Choi, J.H.3
  • 141
    • 2342614186 scopus 로고    scopus 로고
    • Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: Evidence for a role of hepatocyte growth factor
    • Vande Broek I, Asosingh K, Allegaert V, et al. Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: evidence for a role of hepatocyte growth factor. Leukemia 2004; 18: 976-82.
    • (2004) Leukemia , vol.18 , pp. 976-982
    • Broek, I.V.1    Asosingh, K.2    Allegaert, V.3
  • 142
    • 0030293598 scopus 로고    scopus 로고
    • Matrix metalloproteinases and the development of cancer
    • Coussens LM, Werb Z. Matrix metalloproteinases and the development of cancer. Chem Biol 1996; 3: 895-904.
    • (1996) Chem Biol , vol.3 , pp. 895-904
    • Coussens, L.M.1    Werb, Z.2
  • 143
    • 36148994693 scopus 로고    scopus 로고
    • The other side of MMPs: Protective roles in tumor progression
    • Martin MD, Matrisian LM. The other side of MMPs: protective roles in tumor progression. Cancer Metastasis Rev 2007; 26: 717-24.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 717-724
    • Martin, M.D.1    Matrisian, L.M.2
  • 144
    • 0037145325 scopus 로고    scopus 로고
    • Upregulation of matrix metalloproteinase-9 in murine 5T33 multiple myeloma cells by interaction with bone marrow endothelial cells
    • Van Valckenborgh E, Bakkus M, Munaut C, et al. Upregulation of matrix metalloproteinase-9 in murine 5T33 multiple myeloma cells by interaction with bone marrow endothelial cells. Int J Cancer 2002; 101: 512-8.
    • (2002) Int J Cancer , vol.101 , pp. 512-518
    • van valckenborgh, E.1    Bakkus, M.2    Munaut, C.3
  • 145
    • 0038015276 scopus 로고    scopus 로고
    • Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions
    • Kumta SM, Huang L, Cheng YY, et al. Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions. Life Sci 2003; 73: 1427-36.
    • (2003) Life Sci , vol.73 , pp. 1427-1436
    • Kumta, S.M.1    Huang, L.2    Cheng, Y.Y.3
  • 146
    • 0000391746 scopus 로고    scopus 로고
    • Matrix metalloproteinase- 9 triggers the angiogenic switch during carcinogenesis
    • Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase- 9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000; 2: 737-44.
    • (2000) Nat Cell Biol , vol.2 , pp. 737-744
    • Bergers, G.1    Brekken, R.2    McMahon, G.3
  • 147
    • 1642300508 scopus 로고    scopus 로고
    • Stromal matrix metalloproteinase- 9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment
    • Chantrain CF, Shimada H, Jodele S, et al. Stromal matrix metalloproteinase- 9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res 2004; 64: 1675-86.
    • (2004) Cancer Res , vol.64 , pp. 1675-1686
    • Chantrain, C.F.1    Shimada, H.2    Jodele, S.3
  • 148
    • 10744223801 scopus 로고    scopus 로고
    • Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    • Hamano Y, Zeisberg M, Sugimoto H, et al. Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell 2003; 3: 589-601.
    • (2003) Cancer Cell , vol.3 , pp. 589-601
    • Hamano, Y.1    Zeisberg, M.2    Sugimoto, H.3
  • 149
    • 0030722012 scopus 로고    scopus 로고
    • Elevated levels of shed syndecan-1 correlate with tumour mass and decreased matrix metalloproteinase- 9 activity in the serum of patients with multiple myeloma
    • Dhodapkar MV, Kelly T, Theus A, et al. Elevated levels of shed syndecan-1 correlate with tumour mass and decreased matrix metalloproteinase- 9 activity in the serum of patients with multiple myeloma. Br J Haematol 1997; 99: 368-71.
    • (1997) Br J Haematol , vol.99 , pp. 368-371
    • Dhodapkar, M.V.1    Kelly, T.2    Theus, A.3
  • 150
    • 0028052841 scopus 로고
    • Specificity of urinary excretion of cross-linked N-telopeptides of type I collagen as a marker of bone turnover
    • Rosen HN, Dresner-Pollak R, Moses AC, et al. Specificity of urinary excretion of cross-linked N-telopeptides of type I collagen as a marker of bone turnover. Calcif Tissue Int 1994; 54: 26-9.
    • (1994) Calcif Tissue Int , vol.54 , pp. 26-29
    • Rosen, H.N.1    Dresner-Pollak, R.2    Moses, A.C.3
  • 151
    • 0034889427 scopus 로고    scopus 로고
    • Significance of angiogenin plasma concentrations in patients with acute myeloid leukaemia and advanced myelodysplastic syndrome
    • Verstovsek S, Kantarjian H, Aguayo A, et al. Significance of angiogenin plasma concentrations in patients with acute myeloid leukaemia and advanced myelodysplastic syndrome. Br J Haematol 2001; 114: 290-5.
    • (2001) Br J Haematol , vol.114 , pp. 290-295
    • Verstovsek, S.1    Kantarjian, H.2    Aguayo, A.3
  • 152
    • 0032925623 scopus 로고    scopus 로고
    • Increased serum angiogenin concentration in colorectal cancer is correlated with cancer progression
    • Shimoyama S, Yamasaki K, Kawahara M, Kaminishi M. Increased serum angiogenin concentration in colorectal cancer is correlated with cancer progression. Clin Cancer Res 1999; 5: 1125-30.
    • (1999) Clin Cancer Res , vol.5 , pp. 1125-1130
    • Shimoyama, S.1    Yamasaki, K.2    Kawahara, M.3    Kaminishi, M.4
  • 154
  • 155
    • 0027768660 scopus 로고
    • Angiogenin enhances actin acceleration of plasminogen activation
    • Hu GF, Riordan JF. Angiogenin enhances actin acceleration of plasminogen activation. Biochem Biophys Res Commun 1993; 197: 682-7.
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 682-687
    • Hu, G.F.1    Riordan, J.F.2
  • 156
  • 157
    • 0030896584 scopus 로고    scopus 로고
    • Serum levels of interleukins, growth factors and angiogenin in patients with endometrial cancer
    • Chopra V, Dinh TV, Hannigan EV. Serum levels of interleukins, growth factors and angiogenin in patients with endometrial cancer. J Cancer Res Clin Oncol 1997; 123: 167-72.
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 167-172
    • Chopra, V.1    Dinh, T.V.2    Hannigan, E.V.3
  • 158
    • 0033565399 scopus 로고    scopus 로고
    • Increased angiogenin expression in the tumor tissue and serum of urothelial carcinoma patients is related to disease progression and recurrence
    • Miyake H, Hara I, Yamanaka K, et al. Increased angiogenin expression in the tumor tissue and serum of urothelial carcinoma patients is related to disease progression and recurrence. Cancer 1999; 86: 316-24.
    • (1999) Cancer , vol.86 , pp. 316-324
    • Miyake, H.1    Hara, I.2    Yamanaka, K.3
  • 159
    • 8444223866 scopus 로고    scopus 로고
    • Relation between bone marrow angiogenesis and serum levels of angiogenin in patients with myelodysplastic syndromes
    • Alexandrakis MG, Passam FH, Pappa CA, et al. Relation between bone marrow angiogenesis and serum levels of angiogenin in patients with myelodysplastic syndromes. Leuk Res 2005; 29: 41-6.
    • (2005) Leuk Res , vol.29 , pp. 41-46
    • Alexandrakis, M.G.1    Passam, F.H.2    Pappa, C.A.3
  • 160
    • 34249325142 scopus 로고    scopus 로고
    • Serum concentrations of angiogenic cytokines in Waldenstrom macroglobulinaemia: The ration of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity
    • Anagnostopoulos A, Eleftherakis-Papaiakovou V, Kastritis E, et al. Serum concentrations of angiogenic cytokines in Waldenstrom macroglobulinaemia: the ration of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity. Br J Haematol 2007; 137: 560-8.
    • (2007) Br J Haematol , vol.137 , pp. 560-568
    • Anagnostopoulos, A.1    Eleftherakis-Papaiakovou, V.2    Kastritis, E.3
  • 161
    • 79953784016 scopus 로고    scopus 로고
    • Angiogenin as a molecular target for the treatment of prostate cancer
    • Li S, Ibaragi S, Hu GF. Angiogenin as a molecular target for the treatment of prostate cancer. Curr Cancer Ther Rev 2011; 7: 83-90.
    • (2011) Curr Cancer Ther Rev , vol.7 , pp. 83-90
    • Li, S.1    Ibaragi, S.2    Hu, G.F.3
  • 162
    • 84889102929 scopus 로고    scopus 로고
    • Emerging Roles of Endoglin/ CD105 and Angiogenic Cytokines For Disease Development and Progression In Multiple Myeloma Patients
    • doi: 10.1002/hon.2044
    • Pappa C, Alexandrakis M, Boula A, et al. Emerging roles of endoglin/ CD105 and angiogenic cytokines for disease development and progression in multiple myeloma patients. Hematol Oncol 2013. doi: 10.1002/hon.2044.
    • (2013) Hematol Oncol
    • Pappa, C.1    Alexandrakis, M.2    Boula, A.3
  • 163
    • 27544503538 scopus 로고    scopus 로고
    • Anti-angiogenic effect of bortezomib in patients with multiple myeloma
    • Politou M, Naresh K, Terpos E, et al. Anti-angiogenic effect of bortezomib in patients with multiple myeloma. Acta Haematol 2005; 114: 170-3.
    • (2005) Acta Haematol , vol.114 , pp. 170-173
    • Politou, M.1    Naresh, K.2    Terpos, E.3
  • 164
    • 0026093952 scopus 로고
    • Tumor necrosis factor induction of urokinase-type plasminogen activator in human endothelial cells
    • Niedbala MJ, Stein M. Tumor necrosis factor induction of urokinase-type plasminogen activator in human endothelial cells. Biomed Biochim Acta 1991; 50: 427-36.
    • (1991) Biomed Biochim Acta , vol.50 , pp. 427-436
    • Niedbala, M.J.1    Stein, M.2
  • 165
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • Cohen T, Nahari D, Cerem LW, et al. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 1996; 271: 736-41.
    • (1996) J Biol Chem , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3
  • 166
    • 0035121440 scopus 로고    scopus 로고
    • Serum levels of the angiogenic cytokines basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in multiple myeloma
    • Sezer O, Jakob C, Eucker J, et al. Serum levels of the angiogenic cytokines basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in multiple myeloma. Eur J Haematol 2001; 66: 83-8.
    • (2001) Eur J Haematol , vol.66 , pp. 83-88
    • Sezer, O.1    Jakob, C.2    Eucker, J.3
  • 167
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999; 18: 5356-62.
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 168
    • 0032985888 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
    • Oh H, Takagi H, Suzuma K, et al. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J Biol Chem 1999; 274: 15732-9.
    • (1999) J Biol Chem , vol.274 , pp. 15732-15739
    • Oh, H.1    Takagi, H.2    Suzuma, K.3
  • 169
    • 1342312142 scopus 로고    scopus 로고
    • Not just angiogenesis--wider roles for the angiopoietins
    • Jones PF. Not just angiogenesis--wider roles for the angiopoietins. J Pathol 2003; 201: 515-27.
    • (2003) J Pathol , vol.201 , pp. 515-527
    • Jones, P.F.1
  • 170
    • 24644439624 scopus 로고    scopus 로고
    • Angiopoietin-2 stimulates migration of endothelial progenitors and their interaction with endothelium
    • Gill KA, Brindle NP. Angiopoietin-2 stimulates migration of endothelial progenitors and their interaction with endothelium. Biochem Biophys Res Commun 2005; 336: 392-6.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 392-396
    • Gill, K.A.1    Brindle, N.P.2
  • 171
    • 20044371963 scopus 로고    scopus 로고
    • Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: Expression of angiopoietin-2 represents an independent prognostic factor for overall survival
    • Loges S, Heil G, Bruweleit M, et al. Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival. J Clin Oncol 2005; 23: 1109-17.
    • (2005) J Clin Oncol , vol.23 , pp. 1109-1117
    • Loges, S.1    Heil, G.2    Bruweleit, M.3
  • 172
    • 33750606029 scopus 로고    scopus 로고
    • Differential levels of soluble angiopoietin-2 and Tie-2 in patients with haematological malignancies
    • Quartarone E, Alonci A, Allegra A, et al. Differential levels of soluble angiopoietin-2 and Tie-2 in patients with haematological malignancies. Eur J Haematol 2006; 77: 480-5.
    • (2006) Eur J Haematol , vol.77 , pp. 480-485
    • Quartarone, E.1    Alonci, A.2    Allegra, A.3
  • 173
    • 23944495120 scopus 로고    scopus 로고
    • Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma
    • Vacca A, Scavelli C, Montefusco V, et al. Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma. J Clin Oncol 2005; 23: 5334-46.
    • (2005) J Clin Oncol , vol.23 , pp. 5334-5346
    • Vacca, A.1    Scavelli, C.2    Montefusco, V.3
  • 174
    • 0037480835 scopus 로고    scopus 로고
    • Proangiogenic properties of human myeloma cells: Production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis
    • Giuliani N, Colla S, Lazzaretti M, et al. Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis. Blood 2003; 102: 638-45.
    • (2003) Blood , vol.102 , pp. 638-645
    • Giuliani, N.1    Colla, S.2    Lazzaretti, M.3
  • 175
    • 79955858205 scopus 로고    scopus 로고
    • Angiopoietin-2: A potential novel diagnostic marker in multiple myeloma
    • Joshi S, Khan R, Sharma M, Kumar L, Sharma A. Angiopoietin-2: a potential novel diagnostic marker in multiple myeloma. Clin Biochem 2011; 44: 590-5.
    • (2011) Clin Biochem , vol.44 , pp. 590-595
    • Joshi, S.1    Khan, R.2    Sharma, M.3    Kumar, L.4    Sharma, A.5
  • 176
    • 84879396076 scopus 로고    scopus 로고
    • Angiopoietins as biomarker of disease activity and response to therapy in multiple myeloma
    • Bhaskar A, Gupta R, Vishnubhatla S, et al. Angiopoietins as biomarker of disease activity and response to therapy in multiple myeloma. Leuk Lymphoma 2013; 54: 1473-8.
    • (2013) Leuk Lymphoma , vol.54 , pp. 1473-1478
    • Bhaskar, A.1    Gupta, R.2    Vishnubhatla, S.3
  • 177
    • 82255191895 scopus 로고    scopus 로고
    • Circulating angiopoietin- 1 to angiopoietin-2 ratio is an independent prognostic factor for survival in newly diagnosed patients with multiple myeloma who received therapy with novel antimyeloma agents
    • Terpos E, Anargyrou K, Katodritou E, et al. Circulating angiopoietin- 1 to angiopoietin-2 ratio is an independent prognostic factor for survival in newly diagnosed patients with multiple myeloma who received therapy with novel antimyeloma agents. Int J Cancer 2012; 130: 735-42.
    • (2012) Int J Cancer , vol.130 , pp. 735-742
    • Terpos, E.1    Anargyrou, K.2    Katodritou, E.3
  • 178
    • 40849146069 scopus 로고    scopus 로고
    • Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib
    • Anargyrou K, Terpos E, Vassilakopoulos TP, et al. Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib. Haematologica 2008; 93: 451-4.
    • (2008) Haematologica , vol.93 , pp. 451-454
    • Anargyrou, K.1    Terpos, E.2    Vassilakopoulos, T.P.3
  • 179
    • 77955817597 scopus 로고    scopus 로고
    • High levels of serum angiogenic growth factors in patients with AL amyloidosis: Comparisons with normal individuals and multiple myeloma patients
    • Kastritis E, Roussou M, Michael M, et al. High levels of serum angiogenic growth factors in patients with AL amyloidosis: comparisons with normal individuals and multiple myeloma patients. Br J Haematol 2010; 150: 587-91.
    • (2010) Br J Haematol , vol.150 , pp. 587-591
    • Kastritis, E.1    Roussou, M.2    Michael, M.3
  • 180
    • 77955340890 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation
    • Wiens KM, Lee HL, Shimada H, et al. Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. PLoS One 2010; 5: e11324.
    • (2010) PLoS One , vol.5
    • Wiens, K.M.1    Lee, H.L.2    Shimada, H.3
  • 181
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22: 1276-312.
    • (2008) Genes Dev , vol.22 , pp. 1276-1331
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 182
    • 0036793520 scopus 로고    scopus 로고
    • Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors
    • Cao R, Bråkenhielm E, Li X, et al. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors. FASEB J 2002; 16: 1575-83.
    • (2002) FASEB J , vol.16 , pp. 1575-1583
    • Cao, R.1    Bråkenhielm, E.2    Li, X.3
  • 183
    • 34948905351 scopus 로고    scopus 로고
    • Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
    • Nissen LJ, Cao R, Hedlund EM, et al. Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest 2007; 117: 2766-77.
    • (2007) J Clin Invest , vol.117 , pp. 2766-2777
    • Nissen, L.J.1    Cao, R.2    Hedlund, E.M.3
  • 184
    • 34547662268 scopus 로고    scopus 로고
    • Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
    • McCarty MF, Somcio RJ, Stoeltzing O, et al. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest 2007; 117: 2114-22.
    • (2007) J Clin Invest , vol.117 , pp. 2114-2122
    • McCarty, M.F.1    Somcio, R.J.2    Stoeltzing, O.3
  • 185
    • 67649975270 scopus 로고    scopus 로고
    • Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer
    • Paulsson J, Sjöblom T, Micke P, et al. Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am J Pathol 2009; 175: 334-41.
    • (2009) Am J Pathol , vol.175 , pp. 334-341
    • Paulsson, J.1    Sjöblom, T.2    Micke, P.3
  • 186
    • 34247177839 scopus 로고    scopus 로고
    • Angiogenesis and antiangiogenic therapy in hematologic malignancies
    • Dong X, Han ZC, Yang R. Angiogenesis and antiangiogenic therapy in hematologic malignancies. Crit Rev Oncol Hematol 2007; 62: 105-18.
    • (2007) Crit Rev Oncol Hematol , vol.62 , pp. 105-118
    • Dong, X.1    Han, Z.C.2    Yang, R.3
  • 187
    • 58249114895 scopus 로고    scopus 로고
    • Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability
    • Zhang J, Cao R, Zhang Y, et al. Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability. FASEB J 2009; 23: 153-63.
    • (2009) FASEB J , vol.23 , pp. 153-163
    • Zhang, J.1    Cao, R.2    Zhang, Y.3
  • 188
    • 0029092781 scopus 로고
    • Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells
    • Kitami Y, Inui H, Uno S, Inagami T. Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells. J Clin Invest 1995; 96: 558-67.
    • (1995) J Clin Invest , vol.96 , pp. 558-567
    • Kitami, Y.1    Inui, H.2    Uno, S.3    Inagami, T.4
  • 189
    • 2942606661 scopus 로고    scopus 로고
    • Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma
    • Standal T, Hjorth-Hansen H, Rasmussen T, et al. Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma. Haematologica 2004; 89: 174-82.
    • (2004) Haematologica , vol.89 , pp. 174-182
    • Standal, T.1    Hjorth-Hansen, H.2    Rasmussen, T.3
  • 190
    • 33847368961 scopus 로고    scopus 로고
    • Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: A role for vascular endothelial cell growth factor and osteopontin
    • Tanaka Y, Abe M, Hiasa M, et al. Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin. Clin Cancer Res 2007; 13: 816-23.
    • (2007) Clin Cancer Res , vol.13 , pp. 816-823
    • Tanaka, Y.1    Abe, M.2    Hiasa, M.3
  • 191
    • 33644865319 scopus 로고    scopus 로고
    • The involvement of osteopontin and its receptors in multiple myeloma cell survival, migration and invasion in the murine 5T33MM model
    • Caers J, Gunthert U, De Raeve H, et al. The involvement of osteopontin and its receptors in multiple myeloma cell survival, migration and invasion in the murine 5T33MM model. Br J Haematol 2006; 132: 469-77.
    • (2006) Br J Haematol , vol.132 , pp. 469-477
    • Caers, J.1    Gunthert, U.2    de Raeve, H.3
  • 192
    • 0028118893 scopus 로고
    • Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro
    • Liaw L, Almeida M, Hart CE, et al. Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro. Circ Res 1994; 74: 214-24.
    • (1994) Circ Res , vol.74 , pp. 214-224
    • Liaw, L.1    Almeida, M.2    Hart, C.E.3
  • 193
    • 0037051673 scopus 로고    scopus 로고
    • Osteopontin induces angiogenesis of murine neuroblastoma cells in mice
    • Takahashi F, Akutagawa S, Fukumoto H, et al. Osteopontin induces angiogenesis of murine neuroblastoma cells in mice. Int J Cancer 2002; 98: 707-12.
    • (2002) Int J Cancer , vol.98 , pp. 707-712
    • Takahashi, F.1    Akutagawa, S.2    Fukumoto, H.3
  • 194
    • 0142026839 scopus 로고    scopus 로고
    • Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth
    • Hirama M, Takahashi F, Takahashi K, et al. Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth. Cancer Lett 2003; 198: 107-17.
    • (2003) Cancer Lett , vol.198 , pp. 107-117
    • Hirama, M.1    Takahashi, F.2    Takahashi, K.3
  • 195
    • 74949111983 scopus 로고    scopus 로고
    • Osteoclasts are important for bone angiogenesis
    • Cackowski FC, Anderson JL, Patrene KD, et al. Osteoclasts are important for bone angiogenesis. Blood 2010; 115: 140-9.
    • (2010) Blood , vol.115 , pp. 140-149
    • Cackowski, F.C.1    Anderson, J.L.2    Patrene, K.D.3
  • 196
    • 28544451084 scopus 로고    scopus 로고
    • Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients
    • Colla S, Morandi F, Lazzaretti M, et al. Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients. Leukemia 2005; 19: 2166-76.
    • (2005) Leukemia , vol.19 , pp. 2166-2176
    • Colla, S.1    Morandi, F.2    Lazzaretti, M.3
  • 197
    • 0035976914 scopus 로고    scopus 로고
    • Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells
    • Philip S, Bulbule A, Kundu GC. Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells. J Biol Chem 2001; 276: 44926-35.
    • (2001) J Biol Chem , vol.276 , pp. 44926-44935
    • Philip, S.1    Bulbule, A.2    Kundu, G.C.3
  • 198
    • 0030988805 scopus 로고    scopus 로고
    • Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival
    • Singhal H, Bautista DS, Tonkin KS, et al. Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival. Clin Cancer Res 1997; 3: 605-11.
    • (1997) Clin Cancer Res , vol.3 , pp. 605-611
    • Singhal, H.1    Bautista, D.S.2    Tonkin, K.S.3
  • 199
    • 0037096898 scopus 로고    scopus 로고
    • Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer
    • Rudland PS, Platt-Higgins A, El-Tanani M, et al. Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer. Cancer Res 2002; 62: 3417-27.
    • (2002) Cancer Res , vol.62 , pp. 3417-341727
    • Rudland, P.S.1    Platt-Higgins, A.2    El-Tanani, M.3
  • 200
    • 0142215535 scopus 로고    scopus 로고
    • Enhanced production of osteopontin in multiple myeloma: Clinical and pathogenic implications
    • Saeki Y, Mima T, Ishii T, et al. Enhanced production of osteopontin in multiple myeloma: clinical and pathogenic implications. Br J Haematol 2003; 123: 263-70.
    • (2003) Br J Haematol , vol.123 , pp. 263-270
    • Saeki, Y.1    Mima, T.2    Ishii, T.3
  • 201
    • 0036682303 scopus 로고    scopus 로고
    • Plasma osteopontin: Associations with survival and metastasis to bone in men with hormonerefractory prostate carcinoma
    • Hotte SJ, Winquist EW, Stitt L, et al. Plasma osteopontin: associations with survival and metastasis to bone in men with hormonerefractory prostate carcinoma. Cancer 2002; 95: 506-12.
    • (2002) Cancer , vol.95 , pp. 506-512
    • Hotte, S.J.1    Winquist, E.W.2    Stitt, L.3
  • 203
    • 33644860763 scopus 로고    scopus 로고
    • Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure
    • Dobreva I, Waeber G, James RW, Widmann C. Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure. J Biol Chem 2006; 281: 199-205.
    • (2006) J Biol Chem , vol.281 , pp. 199-205
    • Dobreva, I.1    Waeber, G.2    James, R.W.3    Widmann, C.4
  • 204
    • 0036479785 scopus 로고    scopus 로고
    • Neutrophils as a key cellular target for angiostatin: Implications for regulation of angiogenesis and inflammation
    • Benelli R, Morini M, Carrozzino F, et al. Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation. FASEB J 2002; 16: 267-9.
    • (2002) FASEB J , vol.16 , pp. 267-269
    • Benelli, R.1    Morini, M.2    Carrozzino, F.3
  • 205
    • 0141688295 scopus 로고    scopus 로고
    • Neutrophils and angiogenesis: Potential initiators of the angiogenic cascade
    • Benelli R, Albini A, Noonan D. Neutrophils and angiogenesis: potential initiators of the angiogenic cascade. Chem Immunol Allergy 2003; 83: 167-81.
    • (2003) Chem Immunol Allergy , vol.83 , pp. 167-181
    • Benelli, R.1    Albini, A.2    Noonan, D.3
  • 206
    • 24044522259 scopus 로고    scopus 로고
    • Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis
    • Li A, Varney ML, Valasek J, et al. Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis. Angiogenesis 2005; 8: 63-71.
    • (2005) Angiogenesis , vol.8 , pp. 63-71
    • Li, A.1    Varney, M.L.2    Valasek, J.3
  • 207
    • 0036310021 scopus 로고    scopus 로고
    • Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma
    • Huang S, Mills L, Mian B, et al. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol 2002; 161: 125-34.
    • (2002) Am J Pathol , vol.161 , pp. 125-134
    • Huang, S.1    Mills, L.2    Mian, B.3
  • 208
    • 0142183449 scopus 로고    scopus 로고
    • Endothelial cells in the bone marrow of patients with multiple myeloma
    • Vacca A, Ria R, Semeraro F, et al. Endothelial cells in the bone marrow of patients with multiple myeloma. Blood 2003; 102: 3340-8.
    • (2003) Blood , vol.102 , pp. 3340-3348
    • Vacca, A.1    Ria, R.2    Semeraro, F.3
  • 209
    • 1842452785 scopus 로고    scopus 로고
    • CXCR3-binding chemokines in multiple myeloma
    • Pellegrino A, Antonaci F, Russo F, et al. CXCR3-binding chemokines in multiple myeloma. Cancer Lett 2004; 207: 221-7.
    • (2004) Cancer Lett , vol.207 , pp. 221-227
    • Pellegrino, A.1    Antonaci, F.2    Russo, F.3
  • 210
    • 28244452125 scopus 로고    scopus 로고
    • Tumor-derived interleukin- 8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway
    • Bendre MS, Margulies AG, Walser B, et al. Tumor-derived interleukin- 8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway. Cancer Res 2005; 65: 11001-9.
    • (2005) Cancer Res , vol.65 , pp. 11001-11009
    • Bendre, M.S.1    Margulies, A.G.2    Walser, B.3
  • 211
    • 58249119700 scopus 로고    scopus 로고
    • Increased bone marrow microvascular density in haematological malignancies is associated with differential regulation of angiogenic factors
    • Negaard HF, Iversen N, Bowitz-Lothe IM, et al. Increased bone marrow microvascular density in haematological malignancies is associated with differential regulation of angiogenic factors. Leukemia 2009; 23: 162-9.
    • (2009) Leukemia , vol.23 , pp. 162-169
    • Negaard, H.F.1    Iversen, N.2    Bowitz-Lothe, I.M.3
  • 212
    • 34147094593 scopus 로고    scopus 로고
    • Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression
    • Kline M, Donovan K, Wellik L, et al. Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression. Leuk Res 2007; 31: 591-8.
    • (2007) Leuk Res , vol.31 , pp. 591-598
    • Kline, M.1    Donovan, K.2    Wellik, L.3
  • 213
    • 84880325461 scopus 로고    scopus 로고
    • The significance of non correlation between interleukin-8 serum levels with bone marrow microvascular density in patients with myeloma multiple
    • Pappa CA, Tsirakis G, Boula A, et al. The significance of non correlation between interleukin-8 serum levels with bone marrow microvascular density in patients with myeloma multiple. Pathol Oncol Res 2013; 19(3): 539-43.
    • (2013) Pathol Oncol Res , vol.19 , Issue.3 , pp. 539-543
    • Pappa, C.A.1    Tsirakis, G.2    Boula, A.3
  • 214
    • 84863319981 scopus 로고    scopus 로고
    • Serum concentration of interleukin 15, interleukin 2 receptor and TNF receptor in patients with polymyositis and dermatomyositis: Correlation to disease activity
    • Mielnik P, Chwalinska-Sadowska H, Wiesik-Szewczyk E, et al. Serum concentration of interleukin 15, interleukin 2 receptor and TNF receptor in patients with polymyositis and dermatomyositis: correlation to disease activity. Rheumatol Int 2012; 32: 639-43.
    • (2012) Rheumatol Int , vol.32 , pp. 639-643
    • Mielnik, P.1    Chwalinska-Sadowska, H.2    Wiesik-Szewczyk, E.3
  • 215
    • 84862921558 scopus 로고    scopus 로고
    • Increased serum soluble IL-15R levels in T-cell large granular lymphocyte leukemia
    • Chen J, Petrus M, Bamford R, et al. Increased serum soluble IL-15R levels in T-cell large granular lymphocyte leukemia. Blood 2012; 119: 137-43.
    • (2012) Blood , vol.119 , pp. 137-143
    • Chen, J.1    Petrus, M.2    Bamford, R.3
  • 216
    • 0035169507 scopus 로고    scopus 로고
    • Interleukin 15: Biology and relevance to human disease
    • Fehniger TA, Caligiuri MA. Interleukin 15: biology and relevance to human disease. Blood 2001; 97: 14-32.
    • (2001) Blood , vol.97 , pp. 14-32
    • Fehniger, T.A.1    Caligiuri, M.A.2
  • 217
    • 0035669354 scopus 로고    scopus 로고
    • Interleukin-15 expression is associated with malignant potential in colon cancer cells
    • Kuniyasu H, Oue N, Nakae D, et al. Interleukin-15 expression is associated with malignant potential in colon cancer cells. Pathobiology 2001; 69: 86-95.
    • (2001) Pathobiology , vol.69 , pp. 86-95
    • Kuniyasu, H.1    Oue, N.2    Nakae, D.3
  • 218
    • 0033677954 scopus 로고    scopus 로고
    • Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer
    • Kuniyasu H, Yasui W, Shinohara H, et al. Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer. Am J Pathol 2000; 157: 1523-35.
    • (2000) Am J Pathol , vol.157 , pp. 1523-1535
    • Kuniyasu, H.1    Yasui, W.2    Shinohara, H.3
  • 219
    • 0142219338 scopus 로고    scopus 로고
    • Production of interleukin 15 by human colon cancer cells is associated with induction ofmucosal hyperplasia, angiogenesis, and metastasis
    • Kuniyasu H, Ohmori H, Sasaki T, et al. Production of interleukin 15 by human colon cancer cells is associated with induction ofmucosal hyperplasia, angiogenesis, and metastasis. Clin Cancer Res 2003; 9: 4802-10.
    • (2003) Clin Cancer Res , vol.9 , pp. 4802-4810
    • Kuniyasu, H.1    Ohmori, H.2    Sasaki, T.3
  • 220
    • 80053366231 scopus 로고    scopus 로고
    • Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer
    • Mengus C, Le Magnen C, Trella E, et al. Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer. J Transl Med. 2011; 9: 162.
    • (2011) J Transl Med , vol.9 , pp. 162
    • Mengus, C.1    Magnen, C.L.2    Trella, E.3
  • 221
    • 34247869006 scopus 로고    scopus 로고
    • Serum levels of interleukin- 15 and interleukin-10 and their correlation with proliferating cell nuclear antigen in multiple myeloma
    • Pappa C, Miyakis S, Tsirakis G, et al. Serum levels of interleukin- 15 and interleukin-10 and their correlation with proliferating cell nuclear antigen in multiple myeloma. Cytokine 2007; 37: 171-5.
    • (2007) Cytokine , vol.37 , pp. 171-175
    • Pappa, C.1    Miyakis, S.2    Tsirakis, G.3
  • 222
    • 84871390838 scopus 로고    scopus 로고
    • Lack of correlation between angiogenic cytokines and serum insulin-like growth factor-1 in patients with multiple myeloma
    • Pappa CA, Tsirakis G, Psarakis FE, et al. Lack of correlation between angiogenic cytokines and serum insulin-like growth factor-1 in patients with multiple myeloma. Med Oncol 2013; 30: 363.
    • (2013) Med Oncol , vol.30 , pp. 363
    • Pappa, C.A.1    Tsirakis, G.2    Psarakis, F.E.3
  • 223
    • 77955862810 scopus 로고    scopus 로고
    • Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma
    • Prabhala RH, Pelluru D, Fulciniti M, et al. Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma. Blood 2010; 115: 5385-92.
    • (2010) Blood , vol.115 , pp. 5385-5392
    • Prabhala, R.H.1    Pelluru, D.2    Fulciniti, M.3
  • 224
    • 0028858556 scopus 로고
    • Human IL-17: A novel cytokine derived from T cells
    • Yao Z, Painter SL, Fanslow WC, et al. Human IL-17: a novel cytokine derived from T cells. J Immunol 1995; 155: 5483-6.
    • (1995) J Immunol , vol.155 , pp. 5483-5486
    • Yao, Z.1    Painter, S.L.2    Fanslow, W.C.3
  • 225
    • 0037849915 scopus 로고    scopus 로고
    • Interleukin-17 promotes angiogenesis and tumor growth
    • Numasaki M, Fukushi J, Ono M, et al. Interleukin-17 promotes angiogenesis and tumor growth. Blood 2003; 101: 2620-7.
    • (2003) Blood , vol.101 , pp. 2620-2627
    • Numasaki, M.1    Fukushi, J.2    Ono, M.3
  • 226
    • 0036345395 scopus 로고    scopus 로고
    • Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours
    • Vermeulen PB, Gasparini G, Fox SB, et al. Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur J Cancer 2002; 38: 1564-79
    • (2002) Eur J Cancer , vol.38 , pp. 1564-1579
    • Vermeulen, P.B.1    Gasparini, G.2    Fox, S.B.3
  • 227
    • 18044377011 scopus 로고    scopus 로고
    • Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells
    • Takahashi H, Numasaki M, Lotze MT, Sasaki H. Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells. Immunol Lett 2005; 98: 189-93.
    • (2005) Immunol Lett , vol.98 , pp. 189-193
    • Takahashi, H.1    Numasaki, M.2    Lotze, M.T.3    Sasaki, H.4
  • 228
    • 2342468719 scopus 로고    scopus 로고
    • Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts
    • Numasaki M, Lotze MT, Sasaki H. Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts. Immunol Lett 2004; 93: 39-43.
    • (2004) Immunol Lett , vol.93 , pp. 39-43
    • Numasaki, M.1    Lotze, M.T.2    Sasaki, H.3
  • 229
    • 84880265689 scopus 로고    scopus 로고
    • Expression of interleukin-17 and its clinical significance in gastric cancer patients
    • Meng XY, Zhou CH, Ma J, et al. Expression of interleukin-17 and its clinical significance in gastric cancer patients. Med Oncol 2012; 29: 3024-8.
    • (2012) Med Oncol , vol.29 , pp. 3024-3028
    • Meng, X.Y.1    Zhou, C.H.2    Ma, J.3
  • 230
    • 0028845730 scopus 로고
    • Cloning of a new cytokine that induces IFN-gamma production by T cells
    • Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995; 378: 88-91.
    • (1995) Nature , vol.378 , pp. 88-91
    • Okamura, H.1    Tsutsi, H.2    Komatsu, T.3
  • 231
    • 84860476030 scopus 로고    scopus 로고
    • Increased numbers of T helper 17 cells and the correlation with clinicopathological characteristics in multiple myeloma
    • Shen CJ, Yuan ZH, Liu YX, Hu GY. Increased numbers of T helper 17 cells and the correlation with clinicopathological characteristics in multiple myeloma. J Int Med Res 2012; 40: 556-64.
    • (2012) J Int Med Res , vol.40 , pp. 556-564
    • Shen, C.J.1    Yuan, Z.H.2    Liu, Y.X.3    Hu, G.Y.4
  • 232
    • 0032747002 scopus 로고    scopus 로고
    • Interleukin-18
    • Dinarello CA. Interleukin-18. Methods 1999; 19: 121-32.
    • (1999) Methods , vol.19 , pp. 121-132
    • Dinarello, C.A.1
  • 233
    • 0035802928 scopus 로고    scopus 로고
    • Enhanced IL-18 expression in common skin tumors
    • Park H, Byun D, Kim TS, et al. Enhanced IL-18 expression in common skin tumors. Immunol Lett 2001; 79: 215-9.
    • (2001) Immunol Lett , vol.79 , pp. 215-219
    • Park, H.1    Byun, D.2    Kim, T.S.3
  • 234
    • 34248180686 scopus 로고    scopus 로고
    • Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma
    • Ye ZB, Ma T, Li H, et al. Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma. World J Gastroenterol 2007; 13: 1747-51.
    • (2007) World J Gastroenterol , vol.13 , pp. 1747-1751
    • Ye, Z.B.1    Ma, T.2    Li, H.3
  • 235
    • 0034873384 scopus 로고    scopus 로고
    • Serum levels of interleukin- 18 and sICAM-1 in patients affected by breast cancer: Preliminary considerations
    • Merendino RA, Gangemi S, Ruello A, et al. Serum levels of interleukin- 18 and sICAM-1 in patients affected by breast cancer: preliminary considerations. Int J Biol Markers 2001; 16: 126-9.
    • (2001) Int J Biol Markers , vol.16 , pp. 126-129
    • Merendino, R.A.1    Gangemi, S.2    Ruello, A.3
  • 236
    • 0034669955 scopus 로고    scopus 로고
    • IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL-4-induced IL-4 receptor gene expression
    • So EY, Park HH, Lee CE. IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL-4-induced IL-4 receptor gene expression. J Immunol 2000; 165: 5472-9.
    • (2000) J Immunol , vol.165 , pp. 5472-5479
    • So, E.Y.1    Park, H.H.2    Lee, C.E.3
  • 237
    • 33744792284 scopus 로고    scopus 로고
    • Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaBmediated transcriptional repression
    • Cho ML, Min SY, Chang SH, et al. Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaBmediated transcriptional repression. Immunol Lett 2006; 105: 159-66.
    • (2006) Immunol Lett , vol.105 , pp. 159-166
    • Cho, M.L.1    Min, S.Y.2    Chang, S.H.3
  • 238
    • 34447532208 scopus 로고    scopus 로고
    • Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways
    • Amin MA, Mansfield PJ, Pakozdi A, et al. Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways. Arthritis Rheum 2007; 56: 1787-97.
    • (2007) Arthritis Rheum , vol.56 , pp. 1787-1797
    • Amin, M.A.1    Mansfield, P.J.2    Pakozdi, A.3
  • 239
    • 33646474845 scopus 로고    scopus 로고
    • IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway
    • Kim J, Kim C, Kim TS, et al. IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway. Biochem Biophys Res Commun 2006; 344: 1284-9.
    • (2006) Biochem Biophys Res Commun , vol.344 , pp. 1284-1289
    • Kim, J.1    Kim, C.2    Kim, T.S.3
  • 240
    • 33847350645 scopus 로고    scopus 로고
    • Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines
    • Kim KE, Song H, Kim TS, et al. Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines. Oncogene 2007; 26: 1468-76.
    • (2007) Oncogene , vol.26 , pp. 1468-1476
    • Kim, K.E.1    Song, H.2    Kim, T.S.3
  • 241
    • 39149101824 scopus 로고    scopus 로고
    • The dual effects of interleukin-18 in tumor progression
    • Park S, Cheon S, Cho D. The dual effects of interleukin-18 in tumor progression. Cell Mol Immunol 2007; 4: 329-35.
    • (2007) Cell Mol Immunol , vol.4 , pp. 329-335
    • Park, S.1    Cheon, S.2    Cho, D.3
  • 242
    • 0347626018 scopus 로고    scopus 로고
    • Interleukin-18 in multiple myeloma patients: Serum levels in relation to response to treatment and survival
    • Alexandrakis MG, Passam FH, Sfiridaki K, et al. Interleukin-18 in multiple myeloma patients: serum levels in relation to response to treatment and survival. Leuk Res 2004; 28: 259-66.
    • (2004) Leuk Res , vol.28 , pp. 259-266
    • Alexandrakis, M.G.1    Passam, F.H.2    Sfiridaki, K.3
  • 243
    • 0036835015 scopus 로고    scopus 로고
    • Interleukin-18 inhibits lodging and subsequent growth of human multiple myeloma cells in the bone marrow
    • Yamashita K, Iwasaki T, Tsujimura T, et al. Interleukin-18 inhibits lodging and subsequent growth of human multiple myeloma cells in the bone marrow. Oncol Rep 2002; 9: 1237-44.
    • (2002) Oncol Rep , vol.9 , pp. 1237-1244
    • Yamashita, K.1    Iwasaki, T.2    Tsujimura, T.3
  • 244
    • 0035071329 scopus 로고    scopus 로고
    • Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu
    • Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001; 12: 53-72.
    • (2001) Cytokine Growth Factor Rev , vol.12 , pp. 53-72
    • Nakanishi, K.1    Yoshimoto, T.2    Tsutsui, H.3    Okamura, H.4
  • 245
    • 0034097566 scopus 로고    scopus 로고
    • Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis
    • Grimberg A, Cohen P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 2000; 183: 1-9.
    • (2000) J Cell Physiol , vol.183 , pp. 1-9
    • Grimberg, A.1    Cohen, P.2
  • 247
    • 0033906634 scopus 로고    scopus 로고
    • Structure and function of the type 1 insulin-like growth factor receptor
    • Adams TE, Epa VC, Garrett TP, Ward CW. Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 2000; 57: 1050-93.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1050-10593
    • Adams, T.E.1    Epa, V.C.2    Garrett, T.P.3    Ward, C.W.4
  • 249
    • 18144451249 scopus 로고    scopus 로고
    • In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells
    • Asosingh K, Günthert U, Bakkus MH, et al. In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells. Cancer Res 2000; 60: 3096-104.
    • (2000) Cancer Res , vol.60 , pp. 3096-3104
    • Asosingh, K.1    Günthert, U.2    Bakkus, M.H.3
  • 250
    • 20344393906 scopus 로고    scopus 로고
    • CD221 (IGF-1R) is aberrantly expressed in multiple myeloma, in relation to disease severity
    • Bataille R, Robillard N, Avet-Loiseau H, Harousseau JL, Moreau P. CD221 (IGF-1R) is aberrantly expressed in multiple myeloma, in relation to disease severity. Haematologica 2005; 90: 706-7.
    • (2005) Haematologica , vol.90 , pp. 706-707
    • Bataille, R.1    Robillard, N.2    Avet-Loiseau, H.3    Harousseau, J.L.4    Moreau, P.5
  • 251
    • 33644976163 scopus 로고    scopus 로고
    • IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma
    • Chng WJ, Gualberto A, Fonseca R. IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma. Leukemia 2006; 20: 174-6.
    • (2006) Leukemia , vol.20 , pp. 174-176
    • Chng, W.J.1    Gualberto, A.2    Fonseca, R.3
  • 252
    • 0036892647 scopus 로고    scopus 로고
    • Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor
    • Standal T, Borset M, Lenhoff S, et al. Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor. Blood 2002; 100: 3925-9.
    • (2002) Blood , vol.100 , pp. 3925-3929
    • Standal, T.1    Borset, M.2    Lenhoff, S.3
  • 253
    • 0036625066 scopus 로고    scopus 로고
    • Insulinlike growth factor-I signaling in multiple myeloma: Downstream elements, functional correlates, and pathway cross-talk
    • Qiang YW, Kopantzev E, Rudikoff S. Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk. Blood 2002; 99: 4138-46.
    • (2002) Blood , vol.99 , pp. 4138-4146
    • Qiang, Y.W.1    Kopantzev, E.2    Rudikoff, S.3
  • 254
    • 0034667606 scopus 로고    scopus 로고
    • Insulin-like growth factor I is a dual effector of multiple myeloma cell growth
    • Ge NL, Rudikoff S. Insulin-like growth factor I is a dual effector of multiple myeloma cell growth. Blood 2000; 96: 2856-61.
    • (2000) Blood , vol.96 , pp. 2856-2861
    • Ge, N.L.1    Rudikoff, S.2
  • 255
    • 0034531866 scopus 로고    scopus 로고
    • Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway
    • Ferlin M, Noraz N, Hertogh C, et al. Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway. Br J Haematol 2000; 111: 626-34.
    • (2000) Br J Haematol , vol.111 , pp. 626-634
    • Ferlin, M.1    Noraz, N.2    Hertogh, C.3
  • 256
    • 12144290914 scopus 로고    scopus 로고
    • Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
    • Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 2004; 5: 221-30.
    • (2004) Cancer Cell , vol.5 , pp. 221-230
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 257
    • 1942456523 scopus 로고    scopus 로고
    • Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: Study in the 5T33MM model
    • Menu E, Kooijman R, Van Valckenborgh E, et al. Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model. Br J Cancer 2004; 90: 1076-83.
    • (2004) Br J Cancer , vol.90 , pp. 1076-1083
    • Menu, E.1    Kooijman, R.2    van Valckenborgh, E.3
  • 258
    • 63849130567 scopus 로고    scopus 로고
    • Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation
    • Greco C, Vitelli G, Vercillo G, et al. Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation. J Exp Clin Cancer Res 2009; 28: 35.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 35
    • Greco, C.1    Vitelli, G.2    Vercillo, G.3
  • 259
    • 33746224376 scopus 로고    scopus 로고
    • Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron
    • Lee SD, Huang CY, Shu WT, et al. Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron. Clin Chim Acta 2006; 370: 50-6.
    • (2006) Clin Chim Acta , vol.370 , pp. 50-56
    • Lee, S.D.1    Huang, C.Y.2    Shu, W.T.3
  • 260
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000; 342: 1350-8.
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 261
    • 0025215307 scopus 로고
    • Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin
    • Lyons RM, Gentry LE, Purchio AF, Moses HL. Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J Cell Biol 1990; 110: 1361-7.
    • (1990) J Cell Biol , vol.110 , pp. 1361-1367
    • Lyons, R.M.1    Gentry, L.E.2    Purchio, A.F.3    Moses, H.L.4
  • 262
    • 0030026437 scopus 로고    scopus 로고
    • Transforming growth factor-beta1: Differential effects on multiple myeloma versus normal B cells
    • Urashima M, Ogata A, Chauhan D, et al. Transforming growth factor-beta1: differential effects on multiple myeloma versus normal B cells. Blood 1996; 87: 1928-38.
    • (1996) Blood , vol.87 , pp. 1928-1938
    • Urashima, M.1    Ogata, A.2    Chauhan, D.3
  • 263
    • 0037293932 scopus 로고    scopus 로고
    • Differential levels of soluble endoglin (CD105) in myeloid malignancies
    • Calabrò L, Fonsatti E, Bellomo G, et al. Differential levels of soluble endoglin (CD105) in myeloid malignancies. J Cell Physiol 2003; 194: 171-5.
    • (2003) J Cell Physiol , vol.194 , pp. 171-175
    • Calabrò, L.1    Fonsatti, E.2    Bellomo, G.3
  • 265
    • 0030579203 scopus 로고    scopus 로고
    • TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    • Oshima M, Oshima H, Taketo MM. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol 1996; 179: 297-302.
    • (1996) Dev Biol , vol.179 , pp. 297-302
    • Oshima, M.1    Oshima, H.2    Taketo, M.M.3
  • 266
    • 30944444113 scopus 로고    scopus 로고
    • Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
    • Levy L, Hill CS. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev 2006; 17: 41-58.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 41-58
    • Levy, L.1    Hill, C.S.2
  • 267
    • 9344245148 scopus 로고    scopus 로고
    • Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment
    • Hayashi T, Hideshima T, Nguyen AN, et al. Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. Clin Cancer Res 2004; 10: 7540-6.
    • (2004) Clin Cancer Res , vol.10 , pp. 7540-7546
    • Hayashi, T.1    Hideshima, T.2    Nguyen, A.N.3
  • 268
    • 0034907326 scopus 로고    scopus 로고
    • Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin
    • Takahashi N, Kawanishi-Tabata R, et al. Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin. Clin Cancer Res 2001; 7: 524-32.
    • (2001) Clin Cancer Res , vol.7 , pp. 524-532
    • Takahashi, N.1    Kawanishi-Tabata, R.2
  • 269
    • 0032499618 scopus 로고    scopus 로고
    • Expression of endoglin mRNA and protein in human vascular smooth muscle cells
    • Adam PJ, Clesham GJ, Weissberg PL. Expression of endoglin mRNA and protein in human vascular smooth muscle cells. Biochem Biophys Res Commun 1998; 247: 33-7.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 33-37
    • Adam, P.J.1    Clesham, G.J.2    Weissberg, P.L.3
  • 270
    • 0031993988 scopus 로고    scopus 로고
    • Tumoural vascularity as a prognostic factor in cancer patients: The evidence continues to grow
    • Weidner N. Tumoural vascularity as a prognostic factor in cancer patients: the evidence continues to grow. J Pathol 1998; 184: 119-22.
    • (1998) J Pathol , vol.184 , pp. 119-122
    • Weidner, N.1
  • 271
    • 0034688954 scopus 로고    scopus 로고
    • Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer
    • Li C, Guo B, Wilson PB, et al. Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer. Int J Cancer 2000; 89: 122-6.
    • (2000) Int J Cancer , vol.89 , pp. 122-126
    • Li, C.1    Guo, B.2    Wilson, P.B.3
  • 272
    • 0032908133 scopus 로고    scopus 로고
    • Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells
    • Miller DW, Graulich W, Karges B, et al. Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells. Int J Cancer 1999; 81: 568-72.
    • (1999) Int J Cancer , vol.81 , pp. 568-572
    • Miller, D.W.1    Graulich, W.2    Karges, B.3
  • 273
    • 78650255998 scopus 로고    scopus 로고
    • The role of the TGF-β coreceptor endoglin in cancer
    • Pérez-Gómez E, Del Castillo G, Juan Francisco S, et al. The role of the TGF-β coreceptor endoglin in cancer. Sci World J 2010; 10: 2367-84.
    • (2010) Sci World J , vol.10 , pp. 2367-2384
    • Pérez-Gómez, E.1    Castillo, G.D.2    Francisco, S.J.3
  • 274
    • 4344652820 scopus 로고    scopus 로고
    • Highlights on endoglin (CD105): From basic findings towards clinical applications in human cancer
    • Fonsatti E, Maio M. Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer. J Transl Med. 2004; 2: 18.
    • (2004) J Transl Med , vol.2 , pp. 18
    • Fonsatti, E.1    Maio, M.2
  • 275
    • 33744985816 scopus 로고    scopus 로고
    • Soluble endoglin contributes to the pathogenesis of preeclampsia
    • Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 2006; 12: 642-9.
    • (2006) Nat Med , vol.12 , pp. 642-649
    • Venkatesha, S.1    Toporsian, M.2    Lam, C.3
  • 276
    • 0035017536 scopus 로고    scopus 로고
    • Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies
    • Fonsatti E, Del Vecchio L, Altomonte M, et al. Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies. J Cell Physiol 2001; 188: 1-7.
    • (2001) J Cell Physiol , vol.188 , pp. 1-7
    • Fonsatti, E.1    Vecchio, L.D.2    Altomonte, M.3
  • 277
    • 18544412471 scopus 로고    scopus 로고
    • Comparison of microvessel density before and after peripheral blood stem cell transplantation in multiple myeloma patients and its clinical implications: Multicenter trial
    • Oh HS, Choi JH, Park CK, et al. Comparison of microvessel density before and after peripheral blood stem cell transplantation in multiple myeloma patients and its clinical implications: multicenter trial. Int J Hematol 2002; 76: 465-70.
    • (2002) Int J Hematol , vol.76 , pp. 465-470
    • Oh, H.S.1    Choi, J.H.2    Park, C.K.3


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