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Volumn 60, Issue 1, 2016, Pages 43-57

The complex immunological and inflammatory network of adipose tissue in obesity

Author keywords

Immune cells; Inflammation; Obesity; Weight gain; Weight loss

Indexed keywords

ADIPOCYTOKINE;

EID: 84952983645     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500272     Document Type: Review
Times cited : (149)

References (135)
  • 2
    • 33847025198 scopus 로고    scopus 로고
    • Obesity: a medical history
    • Haslam, D., Obesity: a medical history. Obesity Rev. 2007, 8(Suppl 1), 31-36.
    • (2007) Obesity Rev. , vol.8 , pp. 31-36
    • Haslam, D.1
  • 3
    • 84928649086 scopus 로고    scopus 로고
    • Adiposity and metabolic dysfunction in polycystic ovary syndrome
    • Sam, S., Adiposity and metabolic dysfunction in polycystic ovary syndrome. Hormone Mol. Biol. Clin. Invest 2015, 21, 107-116.
    • (2015) Hormone Mol. Biol. Clin. Invest , vol.21 , pp. 107-116
    • Sam, S.1
  • 4
    • 84952981154 scopus 로고    scopus 로고
    • Release 18 July
    • Obesity in Australia. Release 18 July 2015 Available from: www.modi.monash.edu.au/obesity-facts-figures/obesity-in-australia/.
    • (2015)
  • 5
    • 25844457693 scopus 로고    scopus 로고
    • Obesity
    • Haslam, D. W., James, W. P., Obesity. Lancet 2005, 366, 1197-1209.
    • (2005) Lancet , vol.366 , pp. 1197-1209
    • Haslam, D.W.1    James, W.P.2
  • 6
    • 2942657650 scopus 로고    scopus 로고
    • Medical consequences of obesity
    • Bray, G. A. Medical consequences of obesity. J. Clin. Endocrinol. Met. 2004, 89, 2583-2589.
    • (2004) J. Clin. Endocrinol. Met. , vol.89 , pp. 2583-2589
    • Bray, G.A.1
  • 7
    • 80051937900 scopus 로고    scopus 로고
    • The number of years lived with obesity and the risk of all-cause and cause-specific mortality
    • Abdullah, A., Wolfe, R., Stoelwinder, J. U., de Courten, M. et al., The number of years lived with obesity and the risk of all-cause and cause-specific mortality. Int. J. Epidemiol. 2011, 40, 985-996.
    • (2011) Int. J. Epidemiol. , vol.40 , pp. 985-996
    • Abdullah, A.1    Wolfe, R.2    Stoelwinder, J.U.3    de Courten, M.4
  • 10
    • 35348874911 scopus 로고    scopus 로고
    • Developmental origin of fat: tracking obesity to its source
    • Gest, S., Tseng, Y. H., Kahn, C. R., Developmental origin of fat: tracking obesity to its source. Cell 2007, 131, 242-256.
    • (2007) Cell , vol.131 , pp. 242-256
    • Gest, S.1    Tseng, Y.H.2    Kahn, C.R.3
  • 11
    • 84858964200 scopus 로고    scopus 로고
    • Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders
    • Lehr, S., Hartwig, S., Sell, H., Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteomics. Clin. App. 2012, 6, 91-101.
    • (2012) Proteomics. Clin. App. , vol.6 , pp. 91-101
    • Lehr, S.1    Hartwig, S.2    Sell, H.3
  • 12
    • 65649111494 scopus 로고    scopus 로고
    • The origins of brown adipose tissue
    • Enerback, S., The origins of brown adipose tissue. New England J. Med. 2009, 360, 2021-2023.
    • (2009) New England J. Med. , vol.360 , pp. 2021-2023
    • Enerback, S.1
  • 13
    • 85050578809 scopus 로고    scopus 로고
    • Insights into brown adipose tissue physiology as revealed by imaging studies
    • Izzi-Engbeaya, C., Salem, V., Atkar, R. S., Dhillo, W. S., Insights into brown adipose tissue physiology as revealed by imaging studies, Adipocyte 2014, 4, 1-12.
    • (2014) Adipocyte , vol.4 , pp. 1-12
    • Izzi-Engbeaya, C.1    Salem, V.2    Atkar, R.S.3    Dhillo, W.S.4
  • 14
    • 84932630517 scopus 로고    scopus 로고
    • Can brown fat win the battle against white fat?
    • Elattar, S., Satyanarayana, A., Can brown fat win the battle against white fat? J. Cell Physiol. 2015, 230, 2311-2317
    • (2015) J. Cell Physiol. , vol.230 , pp. 2311-2317
    • Elattar, S.1    Satyanarayana, A.2
  • 15
    • 67650215124 scopus 로고    scopus 로고
    • Brown fat in humans: turning up the heat on obesity
    • Seale, P., Lazar, M. A., Brown fat in humans: turning up the heat on obesity, Diabetes 2009, 7, 1482-1484.
    • (2009) Diabetes , vol.7 , pp. 1482-1484
    • Seale, P.1    Lazar, M.A.2
  • 16
    • 84907683854 scopus 로고    scopus 로고
    • Ebf2 is a selective marker of brown and beige adipogenic precursor cells
    • Wang, W., Kissig, M., Rajakumari, S., Huang, L. et al., Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc. Natl. Acad. Sci. USA 2014, 111, 14466-14471.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 14466-14471
    • Wang, W.1    Kissig, M.2    Rajakumari, S.3    Huang, L.4
  • 17
    • 84899759104 scopus 로고    scopus 로고
    • White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ
    • Giordano, A., Smorlesi, A., Frontini, A., Barbatelli, G. et al., White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ, Eur. J. Endocrinol. 2014, 170, R159-R171.
    • (2014) Eur. J. Endocrinol. , vol.170 , pp. R159-R171
    • Giordano, A.1    Smorlesi, A.2    Frontini, A.3    Barbatelli, G.4
  • 18
    • 84933053291 scopus 로고    scopus 로고
    • Adipose cells promotes resistance of breast cancer cells to transtuzumab-mediated antibody-dependent cellular cytotoxicity
    • Duong, M. N., Cleret, A., Matera, E-L., Chettab, K. et al., Adipose cells promotes resistance of breast cancer cells to transtuzumab-mediated antibody-dependent cellular cytotoxicity, Br. Cancer Res. 2015, 17, 57-65.
    • (2015) Br. Cancer Res. , vol.17 , pp. 57-65
    • Duong, M.N.1    Cleret, A.2    Matera, E.-L.3    Chettab, K.4
  • 20
    • 84904730042 scopus 로고    scopus 로고
    • Adipose tissue immune response: novel triggers and consequences for chronic inflammatory conditions
    • Ghigliotti, G., Barisione, C., Garibaldi, S., Fabbi, P. et al., Adipose tissue immune response: novel triggers and consequences for chronic inflammatory conditions, Inflammation. 2014, 37, 1337-1353.
    • (2014) Inflammation , vol.37 , pp. 1337-1353
    • Ghigliotti, G.1    Barisione, C.2    Garibaldi, S.3    Fabbi, P.4
  • 22
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil, G. S., Shargill, N. S., Spiegelman, B. M., Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259, 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 23
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal, K. T., Wiesbrock, S. M., Marino, M. W., Hotamisligil, G. S., Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389, 610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 24
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil, G. A., Amer, P., Caro, J. F., Atkinson, R. L. et al., Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 1995, 95, 2409-2415.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2409-2415
    • Hotamisligil, G.A.1    Amer, P.2    Caro, J.F.3    Atkinson, R.L.4
  • 25
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to liporotein lipase
    • Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J. et al., The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to liporotein lipase. J. Clin. Invest. 1995, 95, 2111-2119.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4
  • 26
    • 84908053578 scopus 로고    scopus 로고
    • Adipose tissue changes in obesity and the impact on metabolic function
    • Sam, S., Mazzone, T., Adipose tissue changes in obesity and the impact on metabolic function. Transl. Res. 2014, 164, 284-292.
    • (2014) Transl. Res. , vol.164 , pp. 284-292
    • Sam, S.1    Mazzone, T.2
  • 27
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M. et al., Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003, 112, 1796-1808.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3    Rosenbaum, M.4
  • 28
    • 84881029152 scopus 로고    scopus 로고
    • Chronid adipose tissue inflammation: all immune cells on the stage
    • Clidir, G., Akincilar, S. C., Tergaonkar, V., Chronid adipose tissue inflammation: all immune cells on the stage. Trends in Mol. Med. 2013, 19, 487-500.
    • (2013) Trends in Mol. Med. , vol.19 , pp. 487-500
    • Clidir, G.1    Akincilar, S.C.2    Tergaonkar, V.3
  • 29
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M., Edwards, J. P., Exploring the full spectrum of macrophage activation. Nature Rev. Immunol. 2008, 8, 958-969.
    • (2008) Nature Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 30
    • 77957828290 scopus 로고    scopus 로고
    • In obesity and weight loss, all roads lead to the mighty macrophage
    • Red Eagle, A., Chawla, A., In obesity and weight loss, all roads lead to the mighty macrophage. J. Clin. Invest. 2010, 120, 3437-3440.
    • (2010) J. Clin. Invest. , vol.120 , pp. 3437-3440
    • Red Eagle, A.1    Chawla, A.2
  • 31
    • 84918563183 scopus 로고    scopus 로고
    • Macrophage polarization in obesity and type-2 diabetes: weighing down our understanding of macrophage function
    • Kraakman, M. J., Murphy, A. J., Jandeleit-Dahm, K., Kammoun, H. L., Macrophage polarization in obesity and type-2 diabetes: weighing down our understanding of macrophage function. Front. Immunol. 2014, 5, 470-480.
    • (2014) Front. Immunol. , vol.5 , pp. 470-480
    • Kraakman, M.J.1    Murphy, A.J.2    Jandeleit-Dahm, K.3    Kammoun, H.L.4
  • 32
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng, C. N., Bodzin, J. L., Saltiel, A. R., Obesity induces a phenotypic switch in adipose tissue macrophage polarization, J. Clin. Invest. 2007, 117, 175-184.
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 33
    • 85052356059 scopus 로고    scopus 로고
    • Plasma concentrations of macrophage migration inhibitory factor are associated with insulin resistance and are elevated in Pima Indians compared to Caucasians
    • Vozarova, B., Metz, C., Stefan, N., Hanson, R. et al., Plasma concentrations of macrophage migration inhibitory factor are associated with insulin resistance and are elevated in Pima Indians compared to Caucasians. Diabetologia 2002, 45, 1739-1741
    • (2002) Diabetologia , vol.45 , pp. 1739-1741
    • Vozarova, B.1    Metz, C.2    Stefan, N.3    Hanson, R.4
  • 34
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng, C. N., Deyoung, S. M., Bodzin, J. L., Saltiel, A. R., Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007, 56, 16-23.
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 35
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu, H., Barnes, G. T., Yang, Q., Tan, G. et al., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003 112, 1821-1830.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4
  • 36
    • 84883157734 scopus 로고    scopus 로고
    • Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis
    • Giordano, A., Murano, I., Mondini, E., Perugini, J. et al., Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis. J. Lipid Res. 2013, 54, 2423-2436.
    • (2013) J. Lipid Res. , vol.54 , pp. 2423-2436
    • Giordano, A.1    Murano, I.2    Mondini, E.3    Perugini, J.4
  • 37
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda, H., Tateya, S., Tamori, Y., Kotani, K. et al., MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 2006, 116, 1494-1505.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3    Kotani, K.4
  • 38
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti, S., Mitchell, G., Barbatelli, G., Murano, I. et al., Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid. Res. 2005, 46, 2347-2355.
    • (2005) J. Lipid. Res. , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3    Murano, I.4
  • 39
    • 84862688466 scopus 로고    scopus 로고
    • Human adipose tissue macrophages display activation of cancer-related pathways
    • Mayi, T. H., Daoudi, M., Derudas, B., Gross, B. et al., Human adipose tissue macrophages display activation of cancer-related pathways. J. Biol. Chem. 2012, 287, 21904-21913.
    • (2012) J. Biol. Chem. , vol.287 , pp. 21904-21913
    • Mayi, T.H.1    Daoudi, M.2    Derudas, B.3    Gross, B.4
  • 40
    • 77957838795 scopus 로고    scopus 로고
    • Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    • Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J. F. et al., Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue, J. Clin. Invest. 2010, 120, 3466-3479.
    • (2010) J. Clin. Invest. , vol.120 , pp. 3466-3479
    • Kosteli, A.1    Sugaru, E.2    Haemmerle, G.3    Martin, J.F.4
  • 41
    • 23644450775 scopus 로고    scopus 로고
    • Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    • Cancello, R., Henegar, C., Viguerie, N., Taleb, S. et al., Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005, 54, 2277-2286.
    • (2005) Diabetes , vol.54 , pp. 2277-2286
    • Cancello, R.1    Henegar, C.2    Viguerie, N.3    Taleb, S.4
  • 42
    • 70350565467 scopus 로고    scopus 로고
    • Neutrophil activation in morbid obesity, chronic activation of acute inflammation
    • Nijhuis, J., Rensen, S. S., Slaats, Y., van Dielen, F. M. et al., Neutrophil activation in morbid obesity, chronic activation of acute inflammation. Obesity 2009, 17, 2014-2018.
    • (2009) Obesity , vol.17 , pp. 2014-2018
    • Nijhuis, J.1    Rensen, S.S.2    Slaats, Y.3    van Dielen, F.M.4
  • 43
    • 84911946949 scopus 로고    scopus 로고
    • Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance
    • Wang, Q., Xie, Z., Zhang, W., Zhou, J. et al., Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes 2014, 63, 4172-4185.
    • (2014) Diabetes , vol.63 , pp. 4172-4185
    • Wang, Q.1    Xie, Z.2    Zhang, W.3    Zhou, J.4
  • 44
    • 84868671526 scopus 로고    scopus 로고
    • Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
    • Talukdar, S., Oh da, Y., Bandyopadhyay, G., Li, D. et al., Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat. Med. 2012, 18, 1407-1412.
    • (2012) Nat. Med. , vol.18 , pp. 1407-1412
    • Talukdar, S.1    Oh da, Y.2    Bandyopadhyay, G.3    Li, D.4
  • 45
    • 84920582329 scopus 로고    scopus 로고
    • Obesity is associated with more activated neutrophils in African American male youth
    • Xu, X., Su, S., Wang, X., Barnes, V. et al., Obesity is associated with more activated neutrophils in African American male youth. Int. J. Obesity. 2015, 39, 26-32.
    • (2015) Int. J. Obesity. , vol.39 , pp. 26-32
    • Xu, X.1    Su, S.2    Wang, X.3    Barnes, V.4
  • 47
    • 68349160704 scopus 로고    scopus 로고
    • Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
    • Liu, J., Divoux, A., Sun, J., Zhang, J. et al., Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat. Med. 2009, 15, 940-945.
    • (2009) Nat. Med. , vol.15 , pp. 940-945
    • Liu, J.1    Divoux, A.2    Sun, J.3    Zhang, J.4
  • 48
    • 78649813518 scopus 로고    scopus 로고
    • Adipose tissue as a dedicated reservoir of functional mast cell progenitors
    • Poglio, S., De Toni-Costes, F., Arnaud, E., Laharrague, P. et al., Adipose tissue as a dedicated reservoir of functional mast cell progenitors. Stem Cells 2010, 28, 2065-2072.
    • (2010) Stem Cells , vol.28 , pp. 2065-2072
    • Poglio, S.1    De Toni-Costes, F.2    Arnaud, E.3    Laharrague, P.4
  • 49
    • 80155151233 scopus 로고    scopus 로고
    • Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese mice
    • Altintas, M.M., Rossetti, M. A., Nayer, B., Puig, A. et al., Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese mice. Lipids Health Dis. 2011, 10, 198-207
    • (2011) Lipids Health Dis , vol.10 , pp. 198-207
    • Altintas, M.M.1    Rossetti, M.A.2    Nayer, B.3    Puig, A.4
  • 50
    • 38949201718 scopus 로고    scopus 로고
    • Human mast cells release oncostatin M on contact with activated T cells: possible biologic relevance
    • Salamon, P., Shoham, N. G., Puxeddu, I., Paitan, Y. et al., Human mast cells release oncostatin M on contact with activated T cells: possible biologic relevance. J. Allergy Clin. Immunol. 2008, 121, 448-455 e445.
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 448-455 e445
    • Salamon, P.1    Shoham, N.G.2    Puxeddu, I.3    Paitan, Y.4
  • 51
    • 84864299769 scopus 로고    scopus 로고
    • Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans
    • Shi, M. A., Shi, G. P., Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans. Front. Immunol. 2012, 3, 7-15.
    • (2012) Front. Immunol. , vol.3 , pp. 7-15
    • Shi, M.A.1    Shi, G.P.2
  • 54
    • 43449108892 scopus 로고    scopus 로고
    • The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean population
    • Kim, D. J., Noh, J. H., Lee, B. W., Choi, Y. H. et al., The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean population. J. Korean Med. Sci. 2008, 23, 193-198.
    • (2008) J. Korean Med. Sci. , vol.23 , pp. 193-198
    • Kim, D.J.1    Noh, J.H.2    Lee, B.W.3    Choi, Y.H.4
  • 55
    • 79955526579 scopus 로고    scopus 로고
    • Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils
    • Suzukawa, M., Nagase, H., Ogahara, I., Han, K. et al., Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J. Immunol. 2011, 186, 5254-5260.
    • (2011) J. Immunol. , vol.186 , pp. 5254-5260
    • Suzukawa, M.1    Nagase, H.2    Ogahara, I.3    Han, K.4
  • 56
    • 84952984418 scopus 로고    scopus 로고
    • Leptin applications in 2015: what have we learned about leptin and obesity
    • Farr, O. M., Gavrieli, A., Mantzoros, C. S., Leptin applications in 2015: what have we learned about leptin and obesity? Curr. Opin Endocrinol. Diabetes Obes. 2015, 22, 353-359.
    • (2015) Curr. Opin Endocrinol. Diabetes Obes , vol.22 , pp. 353-359
    • Farr, O.M.1    Gavrieli, A.2    Mantzoros, C.S.3
  • 58
    • 52649167708 scopus 로고    scopus 로고
    • CD4 T cells: fates, functions, and faults
    • Zhu, J., Paul, W. E., CD4 T cells: fates, functions, and faults. Blood. 2008, 112, 1557-1569.
    • (2008) Blood , vol.112 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2
  • 59
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer, S., Chan, Y., Paltser, G., Truong, D. et al., Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 2009, 15, 921-929.
    • (2009) Nat. Med. , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3    Truong, D.4
  • 60
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura, S., Manabe, I., Nagasaki, M., Eto, K. et al., CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 2009, 15, 914-920.
    • (2009) Nat. Med. , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4
  • 61
    • 77956396699 scopus 로고    scopus 로고
    • Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance
    • Yang, H., Youm, Y. H., Vandanmagsar, B., Ravussin, A. et al., Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol. 2010, 185, 1836-1845.
    • (2010) J. Immunol. , vol.185 , pp. 1836-1845
    • Yang, H.1    Youm, Y.H.2    Vandanmagsar, B.3    Ravussin, A.4
  • 62
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A. et al., Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 2009, 15, 930-939.
    • (2009) Nat. Med. , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4
  • 63
    • 33847312289 scopus 로고    scopus 로고
    • A key role of leptin in the control of regulatory T cell proliferation
    • De Rosa, V., Procaccini, C., Cali, G., Pirozzi, G. et al., A key role of leptin in the control of regulatory T cell proliferation. Immunity 2007, 26, 241-255.
    • (2007) Immunity , vol.26 , pp. 241-255
    • De Rosa, V.1    Procaccini, C.2    Cali, G.3    Pirozzi, G.4
  • 64
    • 84876461373 scopus 로고    scopus 로고
    • Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk
    • Wagner, N. M., Brandhorst, G., Czepluch, F., Lankeit, M. et al., Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk Obesity 2013, 21, 461-468.
    • (2013) Obesity , vol.21 , pp. 461-468
    • Wagner, N.M.1    Brandhorst, G.2    Czepluch, F.3    Lankeit, M.4
  • 66
    • 84929514176 scopus 로고    scopus 로고
    • Obesity exacerbates imiquimod-induced psoriasis-like epidermal hyperplasia and interleukin 17 and interleukin 22 production in mice
    • Kanemaru, K., Matsuyuki, A., Nakamura, Y., Fukami, K., Obesity exacerbates imiquimod-induced psoriasis-like epidermal hyperplasia and interleukin 17 and interleukin 22 production in mice. Exp. Dermatol. 2015, 24, 436-442.
    • (2015) Exp. Dermatol. , vol.24 , pp. 436-442
    • Kanemaru, K.1    Matsuyuki, A.2    Nakamura, Y.3    Fukami, K.4
  • 67
    • 74949123784 scopus 로고    scopus 로고
    • Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice
    • Pini, M., Fantuzzi, G., Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice. J. Leuk. Biol. 2010, 87, 51-58.
    • (2010) J. Leuk. Biol. , vol.87 , pp. 51-58
    • Pini, M.1    Fantuzzi, G.2
  • 68
    • 84903895968 scopus 로고    scopus 로고
    • Vitamin A supplementation reduces IL-17 and RORc gene expression in atherosclerotic patients
    • Mottaghi, A., Ebrahimof, S., Angoorani, P., Saboor-Yaraghi, A. A., Vitamin A supplementation reduces IL-17 and RORc gene expression in atherosclerotic patients. Scand. J. Immunol. 2014, 80, 151-157.
    • (2014) Scand. J. Immunol. , vol.80 , pp. 151-157
    • Mottaghi, A.1    Ebrahimof, S.2    Angoorani, P.3    Saboor-Yaraghi, A.A.4
  • 69
    • 84898465181 scopus 로고    scopus 로고
    • Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type 2 diabetes
    • Zhao, R., Tang, D., Yi, S., Li, W. et al., Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type 2 diabetes. PloS One 2014, 9, e85770.
    • (2014) PloS One , vol.9 , pp. e85770
    • Zhao, R.1    Tang, D.2    Yi, S.3    Li, W.4
  • 70
    • 84899439713 scopus 로고    scopus 로고
    • Increased peripheral proinflammatory T helper subsets contribute to cardiovascular complications in diabetic patients
    • Zhao, R. X., Li, W. J., Lu, Y. R., Qin, J. et al., Increased peripheral proinflammatory T helper subsets contribute to cardiovascular complications in diabetic patients. Mediators Inflamm. 2014, 2014, 596967.
    • (2014) Mediators Inflamm , vol.2014 , pp. 596967
    • Zhao, R.X.1    Li, W.J.2    Lu, Y.R.3    Qin, J.4
  • 71
    • 84901367595 scopus 로고    scopus 로고
    • T cell-derived IL-22 amplifies IL-1beta-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes
    • Dalmas, E., Venteclef, N., Caer, C., Poitou, C. et al., T cell-derived IL-22 amplifies IL-1beta-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes. Diabetes 2014, 63, 1966-1977.
    • (2014) Diabetes , vol.63 , pp. 1966-1977
    • Dalmas, E.1    Venteclef, N.2    Caer, C.3    Poitou, C.4
  • 72
    • 84880617814 scopus 로고    scopus 로고
    • Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
    • e361-363
    • Fabbrini, E., Cella, M., McCartney, S. A., Fuchs, A. et al., Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterol. 2013, 145, 366-374 e361-363.
    • (2013) Gastroenterol , vol.145 , pp. 366-374
    • Fabbrini, E.1    Cella, M.2    McCartney, S.A.3    Fuchs, A.4
  • 73
    • 0037434974 scopus 로고    scopus 로고
    • Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
    • Treiner, E., Duban, L., Bahram, S., Radosavljevic, M. et al., Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 2003, 422, 164-169.
    • (2003) Nature , vol.422 , pp. 164-169
    • Treiner, E.1    Duban, L.2    Bahram, S.3    Radosavljevic, M.4
  • 74
    • 65949112929 scopus 로고    scopus 로고
    • Stepwise development of MAIT cells in mouse and human
    • Martin, E., Treiner, E., Duban, L., Guerri, L. et al., Stepwise development of MAIT cells in mouse and human. PLoS Biol. 2009, 7, E54.
    • (2009) PLoS Biol , vol.7 , pp. E54
    • Martin, E.1    Treiner, E.2    Duban, L.3    Guerri, L.4
  • 75
    • 84922693685 scopus 로고    scopus 로고
    • MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
    • Kurioka, A., Ussher, J. E., Cosgrove, C., Clough, C. et al., MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets. Mucosal Immunol. 2015, 8, 429-440.
    • (2015) Mucosal Immunol , vol.8 , pp. 429-440
    • Kurioka, A.1    Ussher, J.E.2    Cosgrove, C.3    Clough, C.4
  • 76
    • 84897937905 scopus 로고    scopus 로고
    • Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases
    • Serriari, N. E., Eoche, M., Lamotte, L., Lion, J. et al., Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases. Clin. Exp. Immunol. 2014, 176, 266-274.
    • (2014) Clin. Exp. Immunol. , vol.176 , pp. 266-274
    • Serriari, N.E.1    Eoche, M.2    Lamotte, L.3    Lion, J.4
  • 77
    • 84926318323 scopus 로고    scopus 로고
    • Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients
    • Magalhaes, I., Pingris, K., Poitou, C., Bessoles, S. et al., Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients. J. Clin. Invest. 2015, 125, 1752-1762.
    • (2015) J. Clin. Invest. , vol.125 , pp. 1752-1762
    • Magalhaes, I.1    Pingris, K.2    Poitou, C.3    Bessoles, S.4
  • 79
    • 79961167339 scopus 로고    scopus 로고
    • Leptin activates human B cells to secrete TNF-alpha, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway
    • Agrawal, S., Gollapudi, S., Su, H., Gupta, S., Leptin activates human B cells to secrete TNF-alpha, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway. J. Clin. Immunol. 2011, 31, 472-478.
    • (2011) J. Clin. Immunol. , vol.31 , pp. 472-478
    • Agrawal, S.1    Gollapudi, S.2    Su, H.3    Gupta, S.4
  • 80
    • 84887419072 scopus 로고    scopus 로고
    • Adipose natural regulatory B cells negatively control adipose tissue inflammation
    • Nishimura, S., Manabe, I., Takaki, S., Nagasaki, M. et al., Adipose natural regulatory B cells negatively control adipose tissue inflammation. Cell Met. 2013, doi:10.1016/j.cmet.2013.09.017.
    • (2013) Cell Met
    • Nishimura, S.1    Manabe, I.2    Takaki, S.3    Nagasaki, M.4
  • 81
    • 65649117802 scopus 로고    scopus 로고
    • Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    • Duffaut, C., Galitzky, J., Lafontan, M., Bouloumie, A., Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem. Biophys. Res. Comm. 2009, 384, 482-485.
    • (2009) Biochem. Biophys. Res. Comm. , vol.384 , pp. 482-485
    • Duffaut, C.1    Galitzky, J.2    Lafontan, M.3    Bouloumie, A.4
  • 82
    • 84055183917 scopus 로고    scopus 로고
    • Inflammatory mediators hold the key to dendritic cell suppression and tumor progression
    • Sheng, K. C., Wright, M. D., Apostolopoulos, V., Inflammatory mediators hold the key to dendritic cell suppression and tumor progression. Curr. Med. Chem. 2011, 18, 5507-5518.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 5507-5518
    • Sheng, K.C.1    Wright, M.D.2    Apostolopoulos, V.3
  • 83
    • 84898669986 scopus 로고    scopus 로고
    • Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells
    • Chen, Y., Tian, J., Tian, X., Tang, X. et al., Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells. PloS One. 2014, 9, e92450.
    • (2014) PloS One. , vol.9
    • Chen, Y.1    Tian, J.2    Tian, X.3    Tang, X.4
  • 84
    • 84865461206 scopus 로고    scopus 로고
    • Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients
    • Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V. et al., Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes. 2012, 61, 2238-2247.
    • (2012) Diabetes , vol.61 , pp. 2238-2247
    • Bertola, A.1    Ciucci, T.2    Rousseau, D.3    Bourlier, V.4
  • 86
    • 84864474722 scopus 로고    scopus 로고
    • On the armament and appearances of human myeloid-derived suppressor cells
    • Poschke, I., Kiessling, R., On the armament and appearances of human myeloid-derived suppressor cells. Clin. Immunol. 2012, 144, 250-268.
    • (2012) Clin. Immunol. , vol.144 , pp. 250-268
    • Poschke, I.1    Kiessling, R.2
  • 88
    • 84929497622 scopus 로고    scopus 로고
    • Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2
    • Hale, M., Itani, F., Buchta, C. M., Wald, G. et al., Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2. PloS One 2015, 10, e0118784.
    • (2015) PloS One , vol.10 , pp. e0118784
    • Hale, M.1    Itani, F.2    Buchta, C.M.3    Wald, G.4
  • 89
    • 84880241715 scopus 로고    scopus 로고
    • Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages
    • Okwan-Duodu, D., Umpierrez, G. E., Brawley, O. W., Diaz, R., Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages. Am. J. Cancer. Res. 2013, 3, 21-33.
    • (2013) Am. J. Cancer. Res. , vol.3 , pp. 21-33
    • Okwan-Duodu, D.1    Umpierrez, G.E.2    Brawley, O.W.3    Diaz, R.4
  • 90
    • 84875280888 scopus 로고    scopus 로고
    • Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
    • Deng, T., Lyon, C. J., Minze, L. J., Lin, J. et al., Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metabol. 2013, 17, 411-422.
    • (2013) Cell Metabol , vol.17 , pp. 411-422
    • Deng, T.1    Lyon, C.J.2    Minze, L.J.3    Lin, J.4
  • 92
    • 0026331625 scopus 로고
    • Molecular mapping of the mouse ob mutation
    • Friedman, J. M., Leibel, R. L., Siegel, D. S., Walsh, J. et al., Molecular mapping of the mouse ob mutation. Genomics 1991, 11, 1054-1062.
    • (1991) Genomics , vol.11 , pp. 1054-1062
    • Friedman, J.M.1    Leibel, R.L.2    Siegel, D.S.3    Walsh, J.4
  • 93
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M. et al., Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372, 425-432
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4
  • 94
    • 0031965266 scopus 로고    scopus 로고
    • Leptin regulates proinflammatory immune responses
    • Loffreda, S., Yang, S. Q., Lin, H. Z., Karp, C. L. et al., Leptin regulates proinflammatory immune responses. FASEB J. 1998, 12, 57-65.
    • (1998) FASEB J. , vol.12 , pp. 57-65
    • Loffreda, S.1    Yang, S.Q.2    Lin, H.Z.3    Karp, C.L.4
  • 95
    • 0035109175 scopus 로고    scopus 로고
    • Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?
    • Caldefie-Chezet, F., Poulin, A., Tridon, A., Sion, B. et al., Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J. Leukocyte Biol. 2001, 69, 414-423.
    • (2001) J. Leukocyte Biol. , vol.69 , pp. 414-423
    • Caldefie-Chezet, F.1    Poulin, A.2    Tridon, A.3    Sion, B.4
  • 96
    • 0043198155 scopus 로고    scopus 로고
    • Leptin regulates functional capacities of polymorphonuclear neutrophils
    • Caldefie-Chezet, F., Poulin, A., Vasson, M. P., Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radical Res. 2003, 37, 809-817
    • (2003) Free Radical Res , vol.37 , pp. 809-817
    • Caldefie-Chezet, F.1    Poulin, A.2    Vasson, M.P.3
  • 98
    • 44649173850 scopus 로고    scopus 로고
    • The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophags
    • Zhang, J., Wu, Y., Zhang, Y., Leroith, D. et al., The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophags. Mol. Endocrin. 2008, 22, 1416-1426.
    • (2008) Mol. Endocrin , vol.22 , pp. 1416-1426
    • Zhang, J.1    Wu, Y.2    Zhang, Y.3    Leroith, D.4
  • 99
    • 84896836585 scopus 로고    scopus 로고
    • The induction of lipocalin-2 expression in vivo and in vitro
    • Zhao, P., Elks, C. M., Stephens, J. M., The induction of lipocalin-2 expression in vivo and in vitro. J. Biol. Chem. 2014, 289, 5960-5969.
    • (2014) J. Biol. Chem. , vol.289 , pp. 5960-5969
    • Zhao, P.1    Elks, C.M.2    Stephens, J.M.3
  • 100
    • 22944434929 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    • Yang, Q., Graham, T. E., Mody, N., Preitner, F. et al., Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005, 436, 356-362.
    • (2005) Nature , vol.436 , pp. 356-362
    • Yang, Q.1    Graham, T.E.2    Mody, N.3    Preitner, F.4
  • 101
    • 84895741552 scopus 로고    scopus 로고
    • RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance
    • Moraees-Vieira, P. M., Yore, M. M., Dwyer, P. M., Syed, I. et al., RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 2014, 19, 512-526.
    • (2014) Cell Metab , vol.19 , pp. 512-526
    • Moraees-Vieira, P.M.1    Yore, M.M.2    Dwyer, P.M.3    Syed, I.4
  • 102
    • 78049297991 scopus 로고    scopus 로고
    • Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
    • Fisher, F. M., Chui, P. C., Antonellis, P. J., Bina, H. A. et al., Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes 2010, 59, 2781-2789.
    • (2010) Diabetes , vol.59 , pp. 2781-2789
    • Fisher, F.M.1    Chui, P.C.2    Antonellis, P.J.3    Bina, H.A.4
  • 103
    • 23044473651 scopus 로고    scopus 로고
    • Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity
    • Hida, K., Wada, J., Eguchi, J., Zhang, H. et al., Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc. Natl. Acas. Sci. USA 2005, 102, 10610-10615.
    • (2005) Proc. Natl. Acas. Sci. USA , vol.102 , pp. 10610-10615
    • Hida, K.1    Wada, J.2    Eguchi, J.3    Zhang, H.4
  • 104
    • 36048981001 scopus 로고    scopus 로고
    • Resistin- and obesity-associated metabolic diseases
    • Lazar, M. A., Resistin- and obesity-associated metabolic diseases. Horm. Metab. Res. 2007, 39, 710-716.
    • (2007) Horm. Metab. Res. , vol.39 , pp. 710-716
    • Lazar, M.A.1
  • 105
    • 33846527541 scopus 로고    scopus 로고
    • Visfatin, and adipocytokine with proinflammatory and immunomodulating properties
    • Moschen, A. R., Kaser, A., Enrich, B., Masheimer, B. et al., Visfatin, and adipocytokine with proinflammatory and immunomodulating properties, J. Immunol. 2007, 178, 1748-1758.
    • (2007) J. Immunol. , vol.178 , pp. 1748-1758
    • Moschen, A.R.1    Kaser, A.2    Enrich, B.3    Masheimer, B.4
  • 106
    • 0035187244 scopus 로고    scopus 로고
    • The export of major histocompatibility complex class I molecules from the endoplasmic reticulum of rat brown adipose cells is acutely stimulated by insulin
    • Malide, D., Yewdell, J. W., Bennink, J. R., Cushman, S. W., The export of major histocompatibility complex class I molecules from the endoplasmic reticulum of rat brown adipose cells is acutely stimulated by insulin. Mol. Biol. Cell. 2001, 12, 101-114.
    • (2001) Mol. Biol. Cell. , vol.12 , pp. 101-114
    • Malide, D.1    Yewdell, J.W.2    Bennink, J.R.3    Cushman, S.W.4
  • 107
    • 80052301263 scopus 로고    scopus 로고
    • High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of IL-22
    • Wang, Z., Yang, L., Jiang, Y., Ling, Z-Q. et al., High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of IL-22. PLoS One 2011, 6, e23737.
    • (2011) PLoS One , vol.6 , pp. e23737
    • Wang, Z.1    Yang, L.2    Jiang, Y.3    Ling, Z.-Q.4
  • 108
    • 84871871453 scopus 로고    scopus 로고
    • A novel function of adipocytes in lipid antigen presentation to iNKT cells
    • Huh, J. Y., Kim, J. I., Park, Y. J., Hwang, I. J. et al., A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol. Cell Biol. 2013, 33, 328-339.
    • (2013) Mol. Cell Biol. , vol.33 , pp. 328-339
    • Huh, J.Y.1    Kim, J.I.2    Park, Y.J.3    Hwang, I.J.4
  • 109
    • 84974627512 scopus 로고    scopus 로고
    • Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes Front
    • Ye, J., Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes Front. Med. 2014, 9, 139-145.
    • (2014) Med. , vol.9 , pp. 139-145
    • Ye, J.1
  • 110
    • 84926640381 scopus 로고    scopus 로고
    • An investigation into the therapeutic effects of statins with metformin on polycystic ovary syndrome: a meta-analysis of randomised controlled trials
    • Sun, J., Yuan, Y., Cai, R., Sun, H. et al., An investigation into the therapeutic effects of statins with metformin on polycystic ovary syndrome: a meta-analysis of randomised controlled trials. BMJ Open. 2015, 5, e007280.
    • (2015) BMJ Open , vol.5 , pp. e007280
    • Sun, J.1    Yuan, Y.2    Cai, R.3    Sun, H.4
  • 111
    • 84877874329 scopus 로고    scopus 로고
    • Treadmill exercise promotes interleukin 15 expression in skeletal muscle and interleukin 15 receptor alpha expression in adipose tissue of high-fat diet rats
    • Yang, H., Chang, J., Chen, W., Zhao, L. et al., Treadmill exercise promotes interleukin 15 expression in skeletal muscle and interleukin 15 receptor alpha expression in adipose tissue of high-fat diet rats. Endocrine. 2013, 43, 579-585.
    • (2013) Endocrine , vol.43 , pp. 579-585
    • Yang, H.1    Chang, J.2    Chen, W.3    Zhao, L.4
  • 112
    • 83755178604 scopus 로고    scopus 로고
    • IL-15 regulates homeostasis and terminal maturation of NKT cells
    • Gordy, L. E., Bezbradica, J. S., Flyak, A. I., Spencer, C. T. et al., IL-15 regulates homeostasis and terminal maturation of NKT cells. J. Immunol. 2011, 187, 6335-6345.
    • (2011) J. Immunol. , vol.187 , pp. 6335-6345
    • Gordy, L.E.1    Bezbradica, J.S.2    Flyak, A.I.3    Spencer, C.T.4
  • 113
    • 84863094058 scopus 로고    scopus 로고
    • Interleukin-15 treatment induces weight loss independent of lymphocytes
    • Barra, N. G., Chew, M. V., Reid, S., Ashkar, A. A., Interleukin-15 treatment induces weight loss independent of lymphocytes. PloS One. 2012, 7, e39553.
    • (2012) PloS One , vol.7 , pp. e39553
    • Barra, N.G.1    Chew, M.V.2    Reid, S.3    Ashkar, A.A.4
  • 114
    • 84866520055 scopus 로고    scopus 로고
    • Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
    • Lynch, L., Nowak, M., Varghese, B., Clark, J. et al., Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity. 2012, 37, 574-587.
    • (2012) Immunity , vol.37 , pp. 574-587
    • Lynch, L.1    Nowak, M.2    Varghese, B.3    Clark, J.4
  • 115
    • 84888346690 scopus 로고    scopus 로고
    • Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice
    • Hams, E., Locksley, R. M., McKenzie, A. N., Fallon, P. G., Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J. Immunol. 2013, 191, 5349-5353.
    • (2013) J. Immunol. , vol.191 , pp. 5349-5353
    • Hams, E.1    Locksley, R.M.2    McKenzie, A.N.3    Fallon, P.G.4
  • 116
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • Trapani, J. A., Smyth, M. J., Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2002, 2, 735-747.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 735-747
    • Trapani, J.A.1    Smyth, M.J.2
  • 117
    • 84920034829 scopus 로고    scopus 로고
    • Perforin is a novel immune regulator of obesity-related insulin resistance
    • Revelo, X. S., Tsai, S., Lei, H., Luck, H. et al., Perforin is a novel immune regulator of obesity-related insulin resistance. Diabetes 2015, 64, 90-103.
    • (2015) Diabetes , vol.64 , pp. 90-103
    • Revelo, X.S.1    Tsai, S.2    Lei, H.3    Luck, H.4
  • 118
    • 84873408369 scopus 로고    scopus 로고
    • Targeting eosinophils in allergy, inflammation and beyond
    • Fulkerson, P. C., Rothenberg, M. E., Targeting eosinophils in allergy, inflammation and beyond. Nat. Rev. Drug, Discov. 2013, 12, 117-129.
    • (2013) Nat. Rev. Drug, Discov. , vol.12 , pp. 117-129
    • Fulkerson, P.C.1    Rothenberg, M.E.2
  • 119
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu, D., Molofsky, A. B., Liang, H. E., Ricardo-Gonzalez, R. R. et al., Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011, 332, 243-247.
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1    Molofsky, A.B.2    Liang, H.E.3    Ricardo-Gonzalez, R.R.4
  • 120
    • 84902094655 scopus 로고    scopus 로고
    • Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    • Qiu, Y., Nguyen, K. D., Odegaard, J. I., Cui, X. et al., Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 2014, 157, 1292-1308.
    • (2014) Cell , vol.157 , pp. 1292-1308
    • Qiu, Y.1    Nguyen, K.D.2    Odegaard, J.I.3    Cui, X.4
  • 121
    • 0036066485 scopus 로고    scopus 로고
    • high white blood cell count is associated with a worsening of insuling sensitivity and predicts the development of type 2 diabetes
    • Vozarova, B., Weyer, C., Lindsday, R. S., Pratley, R. E. et al., high white blood cell count is associated with a worsening of insuling sensitivity and predicts the development of type 2 diabetes. Diabetes 2002, 51, 455-461.
    • (2002) Diabetes , vol.51 , pp. 455-461
    • Vozarova, B.1    Weyer, C.2    Lindsday, R.S.3    Pratley, R.E.4
  • 122
    • 66649105191 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals
    • Sourris, K. C., Lyons, J. G., de Courten, M. P. J., Dougherty, S. L. et al., c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals. Diabetes 2009, 58, 1259-1266
    • (2009) Diabetes , vol.58 , pp. 1259-1266
    • Sourris, K.C.1    Lyons, J.G.2    de Courten, M.P.J.3    Dougherty, S.L.4
  • 123
    • 14644397903 scopus 로고    scopus 로고
    • The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
    • Ozawa, K., Miyazaki, M., Matsuhisa, M., Takano, K. et al., The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 2005, 54, 657-663.
    • (2005) Diabetes , vol.54 , pp. 657-663
    • Ozawa, K.1    Miyazaki, M.2    Matsuhisa, M.3    Takano, K.4
  • 124
    • 19944430402 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
    • Nakatani, Y., Kaneto, H., Kawamori, D., Yoshiuchi, K. et al., Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J. Biol. Chem. 2005, 280, 847-851.
    • (2005) J. Biol. Chem. , vol.280 , pp. 847-851
    • Nakatani, Y.1    Kaneto, H.2    Kawamori, D.3    Yoshiuchi, K.4
  • 125
    • 0036227062 scopus 로고    scopus 로고
    • Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance
    • Kurucz, I., Morva, A., Vaag, A., Eriksson, K. F. et al., Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance. Diabetes 2002, 51, 1102-1109.
    • (2002) Diabetes , vol.51 , pp. 1102-1109
    • Kurucz, I.1    Morva, A.2    Vaag, A.3    Eriksson, K.F.4
  • 126
    • 0042822096 scopus 로고    scopus 로고
    • Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism
    • Bruce, C. R., Carey, A. L., Hawley, J. A., Febbraio, M. A., Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. Diabetes 2003, 52, 2338-2345.
    • (2003) Diabetes , vol.52 , pp. 2338-2345
    • Bruce, C.R.1    Carey, A.L.2    Hawley, J.A.3    Febbraio, M.A.4
  • 127
    • 84863572997 scopus 로고    scopus 로고
    • Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?
    • Rodrigues-Krause, J., Krause, M., O'Hagan, C., De Vito, G. et al., Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter? Cell Stress Chaperones 2012, 17, 293-302.
    • (2012) Cell Stress Chaperones , vol.17 , pp. 293-302
    • Rodrigues-Krause, J.1    Krause, M.2    O'Hagan, C.3    De Vito, G.4
  • 128
    • 78049248428 scopus 로고    scopus 로고
    • The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity
    • Henstridge, D. C., Forbes, J. M., Penfold, S. A., Formosa, M. F. et al., The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity. Metabol. Clin. Exp. 2010, 59, 1556-1561
    • (2010) Metabol. Clin. Exp. , vol.59 , pp. 1556-1561
    • Henstridge, D.C.1    Forbes, J.M.2    Penfold, S.A.3    Formosa, M.F.4
  • 130
    • 84901376570 scopus 로고    scopus 로고
    • Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance
    • Henstridge, D. C., Bruce, C. R., Drew, B. G., Tory, K. et al., Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes 2014, 63, 1881-1894.
    • (2014) Diabetes , vol.63 , pp. 1881-1894
    • Henstridge, D.C.1    Bruce, C.R.2    Drew, B.G.3    Tory, K.4
  • 131
    • 2942526828 scopus 로고    scopus 로고
    • Absence of an effect of liposuction on insulin action and risk factors for coronary hearth disease
    • Klein, S., Fontana, L., Young, V. L., Coggan, A. R. et al., Absence of an effect of liposuction on insulin action and risk factors for coronary hearth disease. N. Engl. J. Med. 2004, 350, 2549-2557.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2549-2557
    • Klein, S.1    Fontana, L.2    Young, V.L.3    Coggan, A.R.4
  • 132
    • 0035403205 scopus 로고    scopus 로고
    • Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    • Vozarova, B., Weyer, C., Hanson, K., Tataranni, P. A. et al., Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obesity Res. 2001, 9, 414-417
    • Obesity Res. 2001 , vol.9 , pp. 414-417
    • Vozarova, B.1    Weyer, C.2    Hanson, K.3    Tataranni, P.A.4
  • 133
    • 79952598936 scopus 로고    scopus 로고
    • Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity
    • Zhou, Q., Leeman, S. E., Amar, S., Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity. Proc. Natl. Acad. Sci. USA 2010, 108, 2867-2872.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 2867-2872
    • Zhou, Q.1    Leeman, S.E.2    Amar, S.3
  • 134
  • 135
    • 84913616176 scopus 로고    scopus 로고
    • Physical and immunological aspects of exercise in chronic diseases
    • Apostolopoulos, V., Borkoles, E., Polman, R., Stojanovska, L., Physical and immunological aspects of exercise in chronic diseases. Immunotherapy 2014, 6, 1145-1157
    • (2014) Immunotherapy , vol.6 , pp. 1145-1157
    • Apostolopoulos, V.1    Borkoles, E.2    Polman, R.3    Stojanovska, L.4


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