메뉴 건너뛰기




Volumn 16, Issue 1, 2015, Pages

High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction

Author keywords

Chromatin states; DNA methylation; GWAS; Next generation sequencing; Quantitative trait loci; Single nucleotide polymorphism

Indexed keywords

BLOOD; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; FEMALE; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN GENOME; MALE; METABOLISM; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84952976271     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0842-7     Document Type: Article
Times cited : (106)

References (64)
  • 1
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science. 2001;293:1089-93.
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 2
    • 0031201685 scopus 로고    scopus 로고
    • Exploring and explaining epigenetic effects
    • Henikoff S, Matzke MA. Exploring and explaining epigenetic effects. Trends Genet. 1997;13:293-5.
    • (1997) Trends Genet , vol.13 , pp. 293-295
    • Henikoff, S.1    Matzke, M.A.2
  • 3
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger SL. The complex language of chromatin regulation during transcription. Nature. 2007;447:407-12.
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 4
    • 84855956247 scopus 로고    scopus 로고
    • Epigenetics and the environment: emerging patterns and implications
    • Feil R, Fraga MF. Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet. 2011;13:97-109.
    • (2011) Nat Rev Genet , vol.13 , pp. 97-109
    • Feil, R.1    Fraga, M.F.2
  • 5
    • 77953469917 scopus 로고    scopus 로고
    • Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    • Petronis A. Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature. 2010;465:721-7.
    • (2010) Nature , vol.465 , pp. 721-727
    • Petronis, A.1
  • 7
    • 84867063994 scopus 로고    scopus 로고
    • DNA methylation studies using twins: what are they telling us?
    • Bell JT, Spector TD. DNA methylation studies using twins: what are they telling us? Genome Biol. 2012;13:172.
    • (2012) Genome Biol , vol.13 , pp. 172
    • Bell, J.T.1    Spector, T.D.2
  • 8
    • 77957911410 scopus 로고    scopus 로고
    • Allele-specific methylation in the human genome: implications for genetic studies of complex disease
    • Meaburn EL, Schalkwyk LC, Mill J. Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics. 2010;5:578-82.
    • (2010) Epigenetics , vol.5 , pp. 578-582
    • Meaburn, E.L.1    Schalkwyk, L.C.2    Mill, J.3
  • 9
    • 46249117780 scopus 로고    scopus 로고
    • Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation
    • Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E, et al. Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet. 2008;40:904-8.
    • (2008) Nat Genet , vol.40 , pp. 904-908
    • Kerkel, K.1    Spadola, A.2    Yuan, E.3    Kosek, J.4    Jiang, L.5    Hod, E.6
  • 10
    • 84874217134 scopus 로고    scopus 로고
    • The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue
    • Drong AW, Nicholson G, Hedman AK, Meduri E, Grundberg E, Small KS, et al. The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. PLoS One. 2013;8:e55923.
    • (2013) PLoS One , vol.8 , pp. e55923
    • Drong, A.W.1    Nicholson, G.2    Hedman, A.K.3    Meduri, E.4    Grundberg, E.5    Small, K.S.6
  • 11
    • 84885759732 scopus 로고    scopus 로고
    • Imputation-based genomic coverage assessments of current human genotyping arrays
    • Nelson SC, Doheny KF, Pugh EW, Romm JM, Ling H, Laurie CA, et al. Imputation-based genomic coverage assessments of current human genotyping arrays. G3 (Bethesda). 2013;3:1795-807.
    • (2013) G3 (Bethesda) , vol.3 , pp. 1795-1807
    • Nelson, S.C.1    Doheny, K.F.2    Pugh, E.W.3    Romm, J.M.4    Ling, H.5    Laurie, C.A.6
  • 12
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genomewide DNA methylation analysis
    • Laird PW. Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet. 2010;11:191-203.
    • (2010) Nat Rev Genet , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 13
    • 79960556965 scopus 로고    scopus 로고
    • Epigenome-wide association studies for common human diseases
    • Rakyan VK, Down TA, Balding DJ, Beck S. Epigenome-wide association studies for common human diseases. Nat Rev Genet. 2011;12:529-41.
    • (2011) Nat Rev Genet , vol.12 , pp. 529-541
    • Rakyan, V.K.1    Down, T.A.2    Balding, D.J.3    Beck, S.4
  • 14
    • 77649204292 scopus 로고    scopus 로고
    • Genetic control of individual differences in gene-specific methylation in human brain
    • Zhang D, Cheng L, Badner JA, Chen C, Chen Q, Luo W, et al. Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet. 2010;86:411-9.
    • (2010) Am J Hum Genet , vol.86 , pp. 411-419
    • Zhang, D.1    Cheng, L.2    Badner, J.A.3    Chen, C.4    Chen, Q.5    Luo, W.6
  • 15
    • 77953223693 scopus 로고    scopus 로고
    • Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
    • Gibbs JR, van der Brug MP, Hernandez DG, Traynor BJ, Nalls MA, Lai S-L, et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet. 2010;6:e1000952.
    • (2010) PLoS Genet , vol.6 , pp. e1000952
    • Gibbs, J.R.1    Brug, M.P.2    Hernandez, D.G.3    Traynor, B.J.4    Nalls, M.A.5    Lai, S.-L.6
  • 16
    • 79960688508 scopus 로고    scopus 로고
    • DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
    • Bell JT, Pai AA, Pickrell JK, Gaffney DJ, Pique-Regi R, Degner JF, et al. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol. 2011;12:R10.
    • (2011) Genome Biol , vol.12 , pp. R10
    • Bell, J.T.1    Pai, A.A.2    Pickrell, J.K.3    Gaffney, D.J.4    Pique-Regi, R.5    Degner, J.F.6
  • 17
    • 84921320301 scopus 로고    scopus 로고
    • Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue
    • Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, et al. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun. 2014;5:3365.
    • (2014) Nat Commun , vol.5 , pp. 3365
    • Shi, J.1    Marconett, C.N.2    Duan, J.3    Hyland, P.L.4    Li, P.5    Wang, Z.6
  • 19
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009;41:178-86.
    • (2009) Nat Genet , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5    Onyango, P.6
  • 20
    • 77957932941 scopus 로고    scopus 로고
    • Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
    • Harris RA, Wang T, Coarfa C, Nagarajan RP, Hong C, Downey SL, et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol. 2010;28:1097-105.
    • (2010) Nat Biotechnol , vol.28 , pp. 1097-1105
    • Harris, R.A.1    Wang, T.2    Coarfa, C.3    Nagarajan, R.P.4    Hong, C.5    Downey, S.L.6
  • 21
    • 77449127799 scopus 로고    scopus 로고
    • MBD-isolated genome sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome
    • Serre D, Lee BH, Ting AH. MBD-isolated genome sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic Acids Res. 2010;38:391-9.
    • (2010) Nucleic Acids Res , vol.38 , pp. 391-399
    • Serre, D.1    Lee, B.H.2    Ting, A.H.3
  • 22
    • 77955433253 scopus 로고    scopus 로고
    • Whole genome DNA methylation analysis based on high throughput sequencing technology
    • Li N, Ye M, Li Y, Yan Z, Butcher LM, Sun J, et al. Whole genome DNA methylation analysis based on high throughput sequencing technology. Methods. 2010;52:203-12.
    • (2010) Methods , vol.52 , pp. 203-212
    • Li, N.1    Ye, M.2    Li, Y.3    Yan, Z.4    Butcher, L.M.5    Sun, J.6
  • 23
    • 84864612696 scopus 로고    scopus 로고
    • NIH Intramural Sequencing Center, Margulies EH, et al. Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites
    • Hogart A, Lichtenberg J, Ajay SS, Anderson S. NIH Intramural Sequencing Center, Margulies EH, et al. Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res. 2012;22:1407-18.
    • (2012) Genome Res , vol.22 , pp. 1407-1418
    • Hogart, A.1    Lichtenberg, J.2    Ajay, S.S.3    Anderson, S.4
  • 24
    • 79960115813 scopus 로고    scopus 로고
    • High resolution detection and analysis of CpG dinucleotides methylation using MBD-Seq technology
    • Lan X, Adams C, Landers M, Dudas M, Krissinger D, Marnellos G, et al. High resolution detection and analysis of CpG dinucleotides methylation using MBD-Seq technology. PLoS One. 2011;6:e22226.
    • (2011) PLoS One , vol.6 , pp. e22226
    • Lan, X.1    Adams, C.2    Landers, M.3    Dudas, M.4    Krissinger, D.5    Marnellos, G.6
  • 25
    • 78651251739 scopus 로고    scopus 로고
    • Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias
    • Nair SS, Coolen MW, Stirzaker C, Song JZ, Statham AL, Strbenac D, et al. Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias. Epigenetics. 2011;6:34-44.
    • (2011) Epigenetics , vol.6 , pp. 34-44
    • Nair, S.S.1    Coolen, M.W.2    Stirzaker, C.3    Song, J.Z.4    Statham, A.L.5    Strbenac, D.6
  • 26
    • 84894036364 scopus 로고    scopus 로고
    • A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
    • McClay JL, Aberg KA, Clark SL, Nerella S, Kumar G, Xie LY, et al. A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects. Hum Mol Genet. 2014;23:1175-85.
    • (2014) Hum Mol Genet , vol.23 , pp. 1175-1185
    • McClay, J.L.1    Aberg, K.A.2    Clark, S.L.3    Nerella, S.4    Kumar, G.5    Xie, L.Y.6
  • 27
    • 84896732939 scopus 로고    scopus 로고
    • Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults
    • Aberg KA, McClay JL, Nerella S, Clark S, Kumar G, Chen W, et al. Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults. JAMA Psychiatry. 2014;71:255-64.
    • (2014) JAMA Psychiatry , vol.71 , pp. 255-264
    • Aberg, K.A.1    McClay, J.L.2    Nerella, S.3    Clark, S.4    Kumar, G.5    Chen, W.6
  • 28
    • 84864417548 scopus 로고    scopus 로고
    • Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
    • Howie B, Fuchsberger C, Stephens M, Marchini J, Abecasis GR. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet. 2012;44:955-9.
    • (2012) Nat Genet , vol.44 , pp. 955-959
    • Howie, B.1    Fuchsberger, C.2    Stephens, M.3    Marchini, J.4    Abecasis, G.R.5
  • 29
    • 84866358306 scopus 로고    scopus 로고
    • Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder
    • Bergen SE, O'Dushlaine CT, Ripke S, Lee PH, Ruderfer DM, Akterin S, et al. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry. 2012;17:880-6.
    • (2012) Mol Psychiatry , vol.17 , pp. 880-886
    • Bergen, S.E.1    O'Dushlaine, C.T.2    Ripke, S.3    Lee, P.H.4    Ruderfer, D.M.5    Akterin, S.6
  • 31
    • 84871404318 scopus 로고    scopus 로고
    • MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples
    • Aberg KA, McClay JL, Nerella S, Xie LY, Clark SL, Hudson AD, et al. MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples. Epigenomics. 2012;4:605-21.
    • (2012) Epigenomics , vol.4 , pp. 605-621
    • Aberg, K.A.1    McClay, J.L.2    Nerella, S.3    Xie, L.Y.4    Clark, S.L.5    Hudson, A.D.6
  • 34
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature. 2004;431:931-45.
    • (2004) Nature , vol.431 , pp. 931-945
  • 35
    • 84861153094 scopus 로고    scopus 로고
    • Matrix eQTL: ultra fast eQTL analysis via large matrix operations
    • Shabalin AA. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics. 2012;28:1353-8.
    • (2012) Bioinformatics , vol.28 , pp. 1353-1358
    • Shabalin, A.A.1
  • 36
    • 0034370950 scopus 로고    scopus 로고
    • On the adaptive control of the false discovery rate in multiple testing with independent statistics
    • Benjamini Y, Hochberg Y. On the adaptive control of the false discovery rate in multiple testing with independent statistics. J Educ Behav Stat. 2000;25:60-83.
    • (2000) J Educ Behav Stat , vol.25 , pp. 60-83
    • Benjamini, Y.1    Hochberg, Y.2
  • 38
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489:57-74.
    • (2012) Nature , vol.489 , pp. 57-74
  • 40
    • 77954238686 scopus 로고    scopus 로고
    • Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome
    • Shoemaker R, Deng J, Wang W, Zhang K. Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res. 2010;20:883-9.
    • (2010) Genome Res , vol.20 , pp. 883-889
    • Shoemaker, R.1    Deng, J.2    Wang, W.3    Zhang, K.4
  • 41
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007;316:1336-41.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3    Frayling, T.M.4    Elliott, K.S.5    Lango, H.6
  • 42
    • 84876458561 scopus 로고    scopus 로고
    • Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
    • Dayeh TA, Olsson AH, Volkov P, Almgren P, Rönn T, Ling C. Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia. 2013;56:1036-46.
    • (2013) Diabetologia , vol.56 , pp. 1036-1046
    • Dayeh, T.A.1    Olsson, A.H.2    Volkov, P.3    Almgren, P.4    Rönn, T.5    Ling, C.6
  • 44
    • 84865822182 scopus 로고    scopus 로고
    • Systematic localization of common disease-associated variation in regulatory DNA
    • Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, et al. Systematic localization of common disease-associated variation in regulatory DNA. Science. 2012;337:1190-5.
    • (2012) Science , vol.337 , pp. 1190-1195
    • Maurano, M.T.1    Humbert, R.2    Rynes, E.3    Thurman, R.E.4    Haugen, E.5    Wang, H.6
  • 46
    • 80053384370 scopus 로고    scopus 로고
    • Genome-wide association study identifies five new schizophrenia loci
    • Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011;43:969-76.
    • (2011) Nat Genet , vol.43 , pp. 969-976
  • 47
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • International Schizophrenia Consortium, Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;460:748-52.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3    Visscher, P.M.4    O'Donovan, M.C.5
  • 48
    • 69749090013 scopus 로고    scopus 로고
    • Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding
    • McKernan KJ, Peckham HE, Costa GL, McLaughlin SF, Fu Y, Tsung EF, et al. Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding. Genome Res. 2009;19:1527-41.
    • (2009) Genome Res , vol.19 , pp. 1527-1541
    • McKernan, K.J.1    Peckham, H.E.2    Costa, G.L.3    McLaughlin, S.F.4    Fu, Y.5    Tsung, E.F.6
  • 49
  • 50
    • 78649291183 scopus 로고    scopus 로고
    • Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage
    • Chavez L, Jozefczuk J, Grimm C, Dietrich J, Timmermann B, Lehrach H, et al. Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Res. 2010;20:1441-50.
    • (2010) Genome Res , vol.20 , pp. 1441-1450
    • Chavez, L.1    Jozefczuk, J.2    Grimm, C.3    Dietrich, J.4    Timmermann, B.5    Lehrach, H.6
  • 51
    • 46949098742 scopus 로고    scopus 로고
    • A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis
    • Down TA, Rakyan VK, Turner DJ, Flicek P, Li H, Kulesha E, et al. A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol. 2008;26:779-85.
    • (2008) Nat Biotechnol , vol.26 , pp. 779-785
    • Down, T.A.1    Rakyan, V.K.2    Turner, D.J.3    Flicek, P.4    Li, H.5    Kulesha, E.6
  • 52
    • 84865213776 scopus 로고    scopus 로고
    • Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines
    • Åberg K, Khachane AN, Rudolf G, Nerella S, Fugman DA, Tischfield JA, et al. Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines. Eur J Hum Genet. 2012;20:953-5.
    • (2012) Eur J Hum Genet , vol.20 , pp. 953-955
    • Åberg, K.1    Khachane, A.N.2    Rudolf, G.3    Nerella, S.4    Fugman, D.A.5    Tischfield, J.A.6
  • 55
    • 84873576566 scopus 로고    scopus 로고
    • Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
    • Liu Y, Aryee MJ, Padyukov L, Fallin MD, Hesselberg E, Runarsson A, et al. Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol. 2013;31:142-7.
    • (2013) Nat Biotechnol , vol.31 , pp. 142-147
    • Liu, Y.1    Aryee, M.J.2    Padyukov, L.3    Fallin, M.D.4    Hesselberg, E.5    Runarsson, A.6
  • 56
    • 77953397656 scopus 로고    scopus 로고
    • Comparison of the DNA methylation profiles of human peripheral blood cells and transformed B-lymphocytes
    • Sun YV, Turner ST, Smith JA, Hammond PI, Lazarus A, Van De Rostyne JL, et al. Comparison of the DNA methylation profiles of human peripheral blood cells and transformed B-lymphocytes. Hum Genet. 2010;127:651-8.
    • (2010) Hum Genet , vol.127 , pp. 651-658
    • Sun, Y.V.1    Turner, S.T.2    Smith, J.A.3    Hammond, P.I.4    Lazarus, A.5    Rostyne, J.L.6
  • 57
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Method. 1995;57:289-300.
    • (1995) J R Stat Soc Series B Method , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 59
    • 84865852567 scopus 로고    scopus 로고
    • Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors
    • Wang J, Zhuang J, Iyer S, Lin X, Whitfield TW, Greven MC, et al. Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Res. 2012;22:1798-812.
    • (2012) Genome Res , vol.22 , pp. 1798-1812
    • Wang, J.1    Zhuang, J.2    Iyer, S.3    Lin, X.4    Whitfield, T.W.5    Greven, M.C.6
  • 61
    • 20144364292 scopus 로고    scopus 로고
    • Prevalence of quadruplexes in the human genome
    • Huppert JL, Balasubramanian S. Prevalence of quadruplexes in the human genome. Nucleic Acids Res. 2005;33:2908-16.
    • (2005) Nucleic Acids Res , vol.33 , pp. 2908-2916
    • Huppert, J.L.1    Balasubramanian, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.