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Volumn 4, Issue 6, 2012, Pages 605-621

MBD-seq as a cost-effective approach for methylome-wide association studies: Demonstration in 1500 case-control samples

Author keywords

MBD; methylome wide association studies; next generation sequencing; principal component analysis; pyrosequencing

Indexed keywords

DNA; METHYL CPG BINDING PROTEIN;

EID: 84871404318     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.12.59     Document Type: Article
Times cited : (87)

References (74)
  • 1
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genomewide DNA methylation analysis
    • Laird PW. Principles and challenges of genomewide DNA methylation analysis. Nat. Rev. Genet. 11, 191-203 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 2
    • 78049402859 scopus 로고    scopus 로고
    • Molecular signals of epigenetic states
    • Bonasio R, Tu S, Reinberg D. Molecular signals of epigenetic states. Science 330, 612-616 (2010).
    • (2010) Science , vol.330 , pp. 612-616
    • Bonasio, R.1    Tu, S.2    Reinberg, D.3
  • 3
    • 0018185292 scopus 로고
    • Molecular basis of base substitution hotspots in Escherichia coli
    • Coulondre C, Miller JH, Farabaugh PJ, Gilbert W. Molecular basis of base substitution hotspots in Escherichia coli. Nature 274, 775-780 (1978). (Pubitemid 8406156)
    • (1978) Nature , vol.274 , Issue.5673 , pp. 775-780
    • Coulondre, C.1    Miller, J.H.2    Farabaugh, P.J.3    Gilbert, W.4
  • 4
    • 78149433116 scopus 로고    scopus 로고
    • Role of epigenetics in Alzheimer's and Parkinson's disease
    • Kwok JB. Role of epigenetics in Alzheimer's and Parkinson's disease. Epigenomics 2, 671-682 (2010).
    • (2010) Epigenomics , vol.2 , pp. 671-682
    • Kwok, J.B.1
  • 5
    • 84855961987 scopus 로고    scopus 로고
    • Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases
    • Hedrich CM, Tsokos GC. Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol. Med. 17, 714-724 (2011).
    • (2011) Trends Mol. Med. , vol.17 , pp. 714-724
    • Hedrich, C.M.1    Tsokos, G.C.2
  • 6
    • 77956058729 scopus 로고    scopus 로고
    • Epigenetics and cardiovascular disease
    • Ordovas JM, Smith CE. Epigenetics and cardiovascular disease. Nat. Rev. Cardiol. 7, 510-519 (2010).
    • (2010) Nat. Rev. Cardiol. , vol.7 , pp. 510-519
    • Ordovas, J.M.1    Smith, C.E.2
  • 7
    • 84857443720 scopus 로고    scopus 로고
    • Cellular epigenetic stability and cancer
    • Sarkies P, Sale JE. Cellular epigenetic stability and cancer. Trends Genet. 28, 118-127 (2012).
    • (2012) Trends Genet. , vol.28 , pp. 118-127
    • Sarkies, P.1    Sale, J.E.2
  • 8
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • DOI 10.1038/nature05919, PII NATURE05919
    • Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature 447, 433-440 (2007). (Pubitemid 46816750)
    • (2007) Nature , vol.447 , Issue.7143 , pp. 433-440
    • Feinberg, A.P.1
  • 9
    • 82555191051 scopus 로고    scopus 로고
    • Cancer immunology -analysis of host and tumor factors for personalized medicine
    • Ogino S, Galon J, Fuchs CS, Dranoff G. Cancer immunology -analysis of host and tumor factors for personalized medicine. Nat. Rev. Clin. Oncol. 8, 711-719 (2011).
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 711-719
    • Ogino, S.1    Galon, J.2    Fuchs, C.S.3    Dranoff, G.4
  • 10
    • 77953469917 scopus 로고    scopus 로고
    • Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    • Petronis A. Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature 465, 721-727 (2010).
    • (2010) Nature , vol.465 , pp. 721-727
    • Petronis, A.1
  • 11
    • 0026005763 scopus 로고
    • Estradiol down regulates the binding activity of an avian vitellogenin gene repressor (MDBP-2) and triggers a gradual demethylation of the mCpG pair of its DNA binding site
    • Jost JP, Saluz HP, Pawlak A. Estradiol down regulates the binding activity of an avian vitellogenin gene repressor (MDBP 2) and triggers a gradual demethylation of the mCpG pair of its DNA binding site. Nucleic Acids Res. 19, 5771-5775 (1991). (Pubitemid 21912987)
    • (1991) Nucleic Acids Research , vol.19 , Issue.20 , pp. 5771-5775
    • Jost, J.-P.1    Saluz, H.-P.2    Pawlak, A.3
  • 12
    • 0028966928 scopus 로고
    • Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver
    • Yokomori N, Moore R, Negishi M. Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver. Proc. Natl Acad. Sci. USA 92, 1302-1306 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 1302-1306
    • Yokomori, N.1    Moore, R.2    Negishi, M.3
  • 14
    • 0347123629 scopus 로고    scopus 로고
    • Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    • DOI 10.1016/j.nut.2003.09.011
    • Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20, 63-68 (2004). (Pubitemid 38091581)
    • (2004) Nutrition , vol.20 , Issue.1 , pp. 63-68
    • Waterland, R.A.1    Jirtle, R.L.2
  • 15
    • 0027458127 scopus 로고
    • Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging
    • Cooney CA. Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging. Growth. Dev. Aging 57, 261-273 (1993). (Pubitemid 23363343)
    • (1993) Growth, Development and Aging , vol.57 , Issue.4 , pp. 261-273
    • Cooney, C.A.1
  • 16
    • 0033988813 scopus 로고    scopus 로고
    • DNA methyltransferase Dnmt1 associates with histone deacetylase activity
    • DOI 10.1038/71750
    • Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet. 24, 88-91 (2000). (Pubitemid 30041428)
    • (2000) Nature Genetics , vol.24 , Issue.1 , pp. 88-91
    • Fuks, F.1    Burgers, W.A.2    Brehm, A.3    Hughes-Davies, L.4    Kouzarides, T.5
  • 17
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird PW. The power and the promise of DNA methylation markers. Nat. Rev. Cancer 3, 253-266 (2003). (Pubitemid 37328861)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.4 , pp. 253-266
    • Laird, P.W.1
  • 18
    • 79960556965 scopus 로고    scopus 로고
    • Epigenome-wide association studies for common human diseases
    • Rakyan VK, Down TA, Balding DJ, Beck S. Epigenome-wide association studies for common human diseases. Nat. Rev. Genet. 12, 529-541 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 529-541
    • Rakyan, V.K.1    Down, T.A.2    Balding, D.J.3    Beck, S.4
  • 19
    • 84856306090 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiling using Infinium(R) assay
    • Bibikova M, Le J, Barnes B et al. Genome-wide DNA methylation profiling using Infinium(R) assay. Epigenomics 1, 177-200 (2009).
    • (2009) Epigenomics , vol.1 , pp. 177-200
    • Bibikova, M.1    Le Barnes J, B.2
  • 20
    • 78649969065 scopus 로고    scopus 로고
    • The DNA methylome of human peripheral blood mononuclear cells
    • Li Y, Zhu J, Tian G et al. The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol. 8, e1000533 (2010).
    • (2010) PLoS Biol. , vol.8
    • Li, Y.1    Zhu, J.2    Tian, G.3
  • 21
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5 methylcytosine residues in individual DNA strands
    • Frommer M, McDonald LE, Millar DS et al. A genomic sequencing protocol that yields a positive display of 5 methylcytosine residues in individual DNA strands. Proc. Natl Acad. Sci. USA 89, 1827-1831 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 22
    • 66449121652 scopus 로고    scopus 로고
    • Finding the fifth base: Genome-wide sequencing of cytosine methylation
    • Lister R, Ecker Jr. Finding the fifth base: genome-wide sequencing of cytosine methylation. Genome Res. 19, 959-966 (2009).
    • (2009) Genome Res. , vol.19 , pp. 959-966
    • Lister, R.1    Ecker, J.R.2
  • 23
    • 77957932941 scopus 로고    scopus 로고
    • Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
    • Harris RA, Wang T, Coarfa C et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat. Biotechnol. 28, 1097-1105 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1097-1105
    • Harris, R.A.1    Wang, T.2    Coarfa, C.3
  • 24
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B et al. The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores. Nat. Genet. 41, 178-186 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3
  • 25
    • 84865213776 scopus 로고    scopus 로고
    • Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines
    • Aberg K, Khachane AN, Rudolf G et al. Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines. Eur. J. Hum. Genet. 20(9), 953-955 (2012).
    • (2012) Eur. J. Hum. Genet. , vol.20 , Issue.9 , pp. 953-955
    • Aberg, K.1    Khachane, A.N.2    Rudolf, G.3
  • 26
    • 77449127799 scopus 로고    scopus 로고
    • MBD-isolated genome sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome
    • Serre D, Lee BH, Ting AH. MBD-isolated genome sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic Acids Res. 38, 391-399 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. 391-399
    • Serre, D.1    Lee, B.H.2    Ting, A.H.3
  • 27
    • 78049426840 scopus 로고    scopus 로고
    • DNA methylation profiling using HpaII tiny fragment enrichment by ligation-mediated PCR (HELP)
    • Suzuki M, Greally JM. DNA methylation profiling using HpaII tiny fragment enrichment by ligation-mediated PCR (HELP). Methods 52, 218-222 (2010).
    • (2010) Methods , vol.52 , pp. 218-222
    • Suzuki, M.1    Greally, J.M.2
  • 29
    • 78651251739 scopus 로고    scopus 로고
    • Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias
    • Nair SS, Coolen MW, Stirzaker C et al. Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias. Epigenetics 6, 34-44 (2011).
    • (2011) Epigenetics , vol.6 , pp. 34-44
    • Nair, S.S.1    Coolen, M.W.2    Stirzaker, C.3
  • 30
    • 77957937011 scopus 로고    scopus 로고
    • Quantitative comparison of genome-wide DNA methylation mapping technologies
    • Bock C, Tomazou EM, Brinkman AB et al. Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat. Biotechnol. 28, 1106-1114 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1106-1114
    • Bock, C.1    Tomazou, E.M.2    Brinkman, A.B.3
  • 31
    • 84864612696 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal over-representation of ETS transcription factor binding sites
    • Hogart A, Lichtenberg J, Ajay SS, Anderson SM, Margulies EH, Bodine DM. Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal over-representation of ETS transcription factor binding sites. Genome Res. 22(8), 1407-1418 (2012).
    • (2012) Genome Res. , vol.22 , Issue.8 , pp. 1407-1418
    • Hogart, A.1    Lichtenberg, J.2    Ajay, S.S.3    Anderson, S.M.4    Margulies, E.H.5    Bodine, D.M.6
  • 32
    • 79960115813 scopus 로고    scopus 로고
    • High resolution detection and analysis of CpG dinucleotides methylation using MBD-Seq technology
    • Lan X, Adams C, Landers M et al. High resolution detection and analysis of CpG dinucleotides methylation using MBD-Seq technology. PLoS One 6, e22226 (2011).
    • (2011) PLoS One , vol.6
    • Lan, X.1    Adams, C.2    Landers, M.3
  • 33
    • 84866358306 scopus 로고    scopus 로고
    • Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared to bipolar disorder
    • Bergen SE, O'Dushlaine CT, Ripke S et al. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared to bipolar disorder. Mol. Psychiatry 17(9), 880-886 (2012).
    • (2012) Mol. Psychiatry , vol.17 , Issue.9 , pp. 880-886
    • Bergen, S.E.1    O'Dushlaine, C.T.2    Ripke, S.3
  • 34
    • 80053384370 scopus 로고    scopus 로고
    • Genome-wide association study of schizophrenia identifies five novel loci
    • Schizophrenia Psychiatric Genome-Wide Association Study Consortium
    • Schizophrenia Psychiatric Genome-Wide Association Study Consortium. Genome-wide association study of schizophrenia identifies five novel loci. Nat. Genet. 43, 969-976 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 969-976
  • 35
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • International Schizophrenia Consortium.
    • International Schizophrenia Consortium. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748-752 (2009).
    • (2009) Nature , vol.460 , pp. 748-752
  • 36
    • 69749090013 scopus 로고    scopus 로고
    • Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding
    • McKernan KJ, Peckham HE, Costa GL et al. Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding. Genome Res. 19(9), 1527-1541 (2009).
    • (2009) Genome Res. , vol.19 , Issue.9 , pp. 1527-1541
    • McKernan, K.J.1    Peckham, H.E.2    Costa, G.L.3
  • 37
    • 70449711243 scopus 로고    scopus 로고
    • Computation for ChIP-seq and RNA-seq studies
    • Pepke S, Wold B, Mortazavi A. Computation for ChIP-seq and RNA-seq studies. Nat. Methods. 6(11 Suppl.), S22-S32 (2009).
    • (2009) Nat. Methods. , vol.6 , Issue.11 SUPPL.
    • Pepke, S.1    Wold, B.2    Mortazavi, A.3
  • 38
    • 53849146020 scopus 로고    scopus 로고
    • Model-based analysis of ChIP-Seq (MACS)
    • Zhang Y, Liu T, Meyer CA et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9(9), R137 (2008).
    • (2008) Genome Biol. , vol.9 , Issue.9
    • Zhang, Y.1    Liu, T.2    Meyer, C.A.3
  • 40
    • 78649291183 scopus 로고    scopus 로고
    • Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage
    • Chavez L, Jozefczuk J, Grimm C et al. Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Res. 20(10), 1441-1450 (2010).
    • (2010) Genome Res. , vol.20 , Issue.10 , pp. 1441-1450
    • Chavez, L.1    Jozefczuk, J.2    Grimm, C.3
  • 41
    • 83655163970 scopus 로고    scopus 로고
    • BM-Map: Bayesian mapping of multireads for next-generation sequencing data
    • Ji Y, Xu Y, Zhang Q et al. BM-Map: Bayesian mapping of multireads for next-generation sequencing data. Biometrics 67(4), 1215-1224 (2011).
    • (2011) Biometrics , vol.67 , Issue.4 , pp. 1215-1224
    • Ji, Y.1    Xu, Y.2    Zhang, Q.3
  • 43
    • 45549096818 scopus 로고    scopus 로고
    • Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
    • Bock C, Walter J, Paulsen M, Lengauer T. Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping. Nucleic Acids Res. 36(10), e55 (2008).
    • (2008) Nucleic Acids Res. , vol.36 , Issue.10
    • Bock, C.1    Walter, J.2    Paulsen, M.3    Lengauer, T.4
  • 45
    • 0034730140 scopus 로고    scopus 로고
    • Singular value decomposition for genome-wide expression data processing and modeling
    • Alter O, Brown PO, Botstein D. Singular value decomposition for genome-wide expression data processing and modeling. Proc. Natl Acad. Sci. USA 97(18), 10101-10106 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.18 , pp. 10101-10106
    • Alter, O.1    Brown, P.O.2    Botstein, D.3
  • 46
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • DOI 10.1038/ng1847, PII NG1847
    • Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 38(8), 904-909 (2006). (Pubitemid 44141658)
    • (2006) Nature Genetics , vol.38 , Issue.8 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 47
    • 0000071395 scopus 로고
    • Some distance properties of latent root and vector methods used in multivariate analysis
    • Gower JC. Some distance properties of latent root and vector methods used in multivariate analysis. Biometrika 53, 325-338 (1966).
    • (1966) Biometrika , vol.53 , pp. 325-338
    • Gower, J.C.1
  • 48
    • 53549104134 scopus 로고    scopus 로고
    • MEDME: An experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment
    • Pelizzola M, Koga Y, Urban AE et al. MEDME: an experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Res. 18(10), 1652-1659 (2008).
    • (2008) Genome Res. , vol.18 , Issue.10 , pp. 1652-1659
    • Pelizzola, M.1    Koga, Y.2    Urban, A.E.3
  • 50
    • 74549167140 scopus 로고    scopus 로고
    • Methylation induced gene silencing of HtrA3 in smoking-related lung cancer
    • Beleford D, Liu Z, Rattan R et al. Methylation induced gene silencing of HtrA3 in smoking-related lung cancer. Clin. Cancer Res. 16(2), 398-409 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.2 , pp. 398-409
    • Beleford, D.1    Liu, Z.2    Rattan, R.3
  • 51
    • 0026470248 scopus 로고
    • Smoking and schizophrenia
    • Lohr JB, Flynn K. Smoking and schizophrenia. Schizophr Res. 8(2), 93-102 (1992).
    • (1992) Schizophr Res. , vol.8 , Issue.2 , pp. 93-102
    • Lohr, J.B.1    Flynn, K.2
  • 52
    • 84860814711 scopus 로고    scopus 로고
    • Genome-wide screen for metabolic syndrome susceptibility loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits
    • Kristiansson K, Perola M, Tikkanen E et al. Genome-wide screen for metabolic syndrome susceptibility loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ. Cardiovasc. Genet. 5(2), 242-249 (2012).
    • (2012) Circ. Cardiovasc. Genet. , vol.5 , Issue.2 , pp. 242-249
    • Kristiansson, K.1    Perola, M.2    Tikkanen, E.3
  • 53
    • 77955651636 scopus 로고    scopus 로고
    • Epigenetic alterations in aging
    • Gonzalo S. Epigenetic alterations in aging. J. Appl. Physiol. 109(2), 586-597 (2010).
    • (2010) J. Appl. Physiol. , vol.109 , Issue.2 , pp. 586-597
    • Gonzalo, S.1
  • 54
    • 80855144438 scopus 로고    scopus 로고
    • Epigenetic-aging-signature to determine age in different tissues
    • Koch CM, Wagner W. Epigenetic-aging-signature to determine age in different tissues. Aging (Albany NY). 3(10), 1018-1027 (2011).
    • (2011) Aging (Albany NY). , vol.3 , Issue.10 , pp. 1018-1027
    • Koch, C.M.1    Wagner, W.2
  • 55
    • 79959509099 scopus 로고    scopus 로고
    • Epigenetic predictor of age
    • Bocklandt S, Lin W, Sehl ME et al. Epigenetic predictor of age. PLoS One 6(6), e14821 (2011).
    • (2011) PLoS One , vol.6 , Issue.6
    • Bocklandt, S.1    Lin, W.2    Sehl, M.E.3
  • 56
    • 84860572791 scopus 로고    scopus 로고
    • Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
    • Bell JT, Tsai PC, Yang TP et al. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet. 8(4), e1002629 (2012).
    • (2012) PLoS Genet. , vol.8 , Issue.4
    • Bell, J.T.1    Tsai, P.C.2    Yang, T.P.3
  • 57
    • 84861483398 scopus 로고    scopus 로고
    • Methylation profile of DNA repetitive elements in human testicular germ cell tumor
    • Ushida H, Kawakami T, Minami K et al. Methylation profile of DNA repetitive elements in human testicular germ cell tumor. Mol Carcinog. 51(9), 711-722 (2011).
    • (2011) Mol Carcinog. , vol.51 , Issue.9 , pp. 711-722
    • Ushida, H.1    Kawakami, T.2    Minami, K.3
  • 58
    • 79960255428 scopus 로고    scopus 로고
    • DNA methylation in repetitive elements and Alzheimer disease
    • Bollati V, Galimberti D, Pergoli L et al. DNA methylation in repetitive elements and Alzheimer disease. Brain Behav Immun. 25(6), 1078-1083 (2011).
    • (2011) Brain Behav Immun. , vol.25 , Issue.6 , pp. 1078-1083
    • Bollati, V.1    Galimberti, D.2    Pergoli, L.3
  • 59
    • 69449085661 scopus 로고    scopus 로고
    • Differential repetitive DNA methylation in multiple myeloma molecular subgroups
    • Bollati V, Fabris S, Pegoraro V et al. Differential repetitive DNA methylation in multiple myeloma molecular subgroups. Carcinogenesis. 30(8), 1330-1335 (2009).
    • (2009) Carcinogenesis. , vol.30 , Issue.8 , pp. 1330-1335
    • Bollati, V.1    Fabris, S.2    Pegoraro, V.3
  • 61
    • 70149099610 scopus 로고    scopus 로고
    • Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    • Christensen BC, Houseman EA, Marsit CJ et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet. 5(8), e1000602 (2009).
    • (2009) PLoS Genet. , vol.5 , Issue.8
    • Christensen, B.C.1    Houseman, E.A.2    Marsit, C.J.3
  • 63
    • 0023119242 scopus 로고
    • Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
    • Monk M, Boubelik M, Lehnert S. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99(3), 371-382 (1987). (Pubitemid 17048855)
    • (1987) Development , vol.99 , Issue.3 , pp. 371-382
    • Monk, M.1    Boubelik, M.2    Lehnert, S.3
  • 65
    • 0027354081 scopus 로고
    • Gene methylation patterns and expression
    • Yeivin A, Razin A. Gene methylation patterns and expression. EXS 64, 523-568 (1993).
    • (1993) EXS , vol.64 , pp. 523-568
    • Yeivin, A.1    Razin, A.2
  • 66
    • 0035874481 scopus 로고    scopus 로고
    • The marks, mechanisms and memory of epigenetic states in mammals
    • DOI 10.1042/0264-6021:3560001
    • Rakyan VK, Preis J, Morgan HD, Whitelaw E. The marks, mechanisms and memory of epigenetic states in mammals. Biochem J. 356(Pt 1), 1-10 (2001). (Pubitemid 34275701)
    • (2001) Biochemical Journal , vol.356 , Issue.1 , pp. 1-10
    • Rakyan, V.K.1    Preis, J.2    Morgan, H.D.3    Whitelaw, E.4
  • 67
    • 75849139815 scopus 로고    scopus 로고
    • Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades
    • Lavon I, Refael M, Zelikovitch B, Shalom E, Siegal T. Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades. Neuro Oncol. 12(2), 173-180 (2010).
    • (2010) Neuro Oncol. , vol.12 , Issue.2 , pp. 173-180
    • Lavon, I.1    Refael, M.2    Zelikovitch, B.3    Shalom, E.4    Siegal, T.5
  • 68
    • 53349103842 scopus 로고    scopus 로고
    • Diet and the epigenetic (re)programming of phenotypic differences in behavior
    • McGowan PO, Meaney MJ, Szyf M. Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res. 1237, 12-24 (2008).
    • (2008) Brain Res. , vol.1237 , pp. 12-24
    • McGowan, P.O.1    Meaney, M.J.2    Szyf, M.3
  • 71
    • 46249117780 scopus 로고    scopus 로고
    • Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation
    • Kerkel K, Spadola A, Yuan E et al. Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet. 40(7), 904-908 (2008).
    • (2008) Nat Genet. , vol.40 , Issue.7 , pp. 904-908
    • Kerkel, K.1    Spadola, A.2    Yuan, E.3
  • 72
    • 84859098571 scopus 로고    scopus 로고
    • The SVA package for removing batch effects and other unwanted variation in high-throughput experiments
    • Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD. The SVA package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28(6), 882-883 (2012).
    • (2012) Bioinformatics , vol.28 , Issue.6 , pp. 882-883
    • Leek, J.T.1    Johnson, W.E.2    Parker, H.S.3    Jaffe, A.E.4    Storey, J.D.5
  • 73
    • 84871456341 scopus 로고    scopus 로고
    • Center for Biomarker Research and Personalized Medicine
    • Center for Biomarker Research and Personalized Medicine. www.biomarker.vcu.edu
  • 74
    • 84871402887 scopus 로고    scopus 로고
    • UCSC Genome Bioinformatics.
    • UCSC Genome Bioinformatics. http://genome.ucsc.edu


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.