Viscosity Analysis of Dual Variable Domain Immunoglobulin Protein Solutions: Role of Size, Electroviscous Effect and Protein-Protein Interactions

Pharmaceutical Research

Volumn 33, Issue 1, 2016, Pages 155-166

  Raut, Ashlesha S ^a   Kalonia, Devendra S ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

bispecific antibody; charge; excluded volume; hydration; monoclonal antibody; protein formulation

Indexed keywords

DUAL VARIABLE DOMAIN IMMUNOGLOBULIN; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; SOLVENT; UNCLASSIFIED DRUG; BUFFER; PROTEIN; SOLUTION AND SOLUBILITY;

ARTICLE; DIELECTRIC CONSTANT; DRUG SOLUBILITY; ELECTROPHORETIC MOBILITY; IONIC STRENGTH; LIGHT SCATTERING; MAGNETIC FIELD; MOLECULAR SIZE; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SOLUTE; STATIC ELECTRICITY; VISCOMETRY; VISCOSITY; ZETA POTENTIAL; ALGORITHM; CHEMISTRY; HUMAN; SOLUTION AND SOLUBILITY;

ALGORITHMS; ANTIBODIES, MONOCLONAL; BUFFERS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULINS, INTRAVENOUS; MOLECULAR WEIGHT; PHARMACEUTICAL SOLUTIONS; PROTEINS; SOLUTIONS; STATIC ELECTRICITY; VISCOSITY;

EID: 84952874150     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-015-1772-5     Document Type: Article

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