Rheological characterization and injection forces of concentrated protein formulations: An alternative predictive model for non-Newtonian solutions

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 2, 2014, Pages 318-328

  Allmendinger, Andrea ^a,b   Fischer, Stefan ^a   Huwyler, Joerg ^b   Mahler, Hanns Christian ^a   Schwarb, Edward ^a   Zarraga, Isidro E ^c   Mueller, Robert ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c GENENTECH INC   (United States)

Author keywords

High protein concentration; Injection device; Injection forces; Monoclonal antibody formulation; Non Newtonian; Rheology; Shear thinning behavior; Subcutaneous drug administration; Viscosity

Indexed keywords

ACETIC ACID; ARGININE; CITRATE SODIUM; GLYCINE; HISTIDINE; MANNITOL; METHIONINE; MONOCLONAL ANTIBODY; POLYSORBATE 20; POLYSORBATE 80; PROTEIN DERIVATIVE; SODIUM DIHYDROGEN PHOSPHATE; SORBITOL; SUCROSE; ANTIBODY; EXCIPIENT;

ARTICLE; DRUG FORMULATION; FLOW KINETICS; FLOW MEASUREMENT; FORCE; INJECTION; MATHEMATICAL MODEL; MEASUREMENT; SHEAR RATE; SYRINGE; SYRINGE NEEDLE; VISCOSITY; CHEMICAL MODEL; CHEMISTRY; DEVICES; DRUG DELIVERY SYSTEM; EQUIPMENT DESIGN; MECHANICAL STRESS; MEDICINAL CHEMISTRY; NEEDLE; PHARMACEUTICS; PROCEDURES; SHEAR STRENGTH; SUBCUTANEOUS DRUG ADMINISTRATION;

ANTIBODIES; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; EXCIPIENTS; INJECTIONS, SUBCUTANEOUS; MODELS, CHEMICAL; NEEDLES; RHEOLOGY; SHEAR STRENGTH; STRESS, MECHANICAL; SYRINGES; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY;

EID: 84902385462     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.01.009     Document Type: Article

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