Observation of small cluster formation in concentrated monoclonal antibody solutions and its implications to solution viscosity

Biophysical Journal

Volumn 106, Issue 8, 2014, Pages 1763-1770

  Yearley, Eric J ^a,b   Godfrin, Paul D ^a,b   Perevozchikova, Tatiana ^a,b   Zhang, Hailiang ^a,c   Falus, Peter ^d   Porcar, Lionel ^d   Nagao, Michihiro ^a,e   Curtis, Joseph E ^a   Gawande, Pradad ^f   Taing, Rosalynn ^g   Zarraga, Isidro E ^g   Wagner, Norman J ^b   Liu, Yun ^a,b  

^a NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d INSTITUT LAUE LANGEVIN   (France)

^e INDIANA UNIVERSITY   (United States)

^f Theranos Inc   (United States)

^g GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROLYTE; INORGANIC SALT; MONOCLONAL ANTIBODY; PROTEIN AGGREGATE; SOLUTION AND SOLUBILITY;

CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; PROTEIN MULTIMERIZATION; SMALL ANGLE SCATTERING; SOLUTION AND SOLUBILITY; VISCOSITY; X RAY DIFFRACTION;

ANTIBODIES, MONOCLONAL; ELECTROLYTES; HUMANS; MODELS, MOLECULAR; PROTEIN AGGREGATES; PROTEIN MULTIMERIZATION; SALTS; SCATTERING, SMALL ANGLE; SOLUTIONS; VISCOSITY; X-RAY DIFFRACTION;

EID: 84898925651     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2014.02.036     Document Type: Article

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