Berberine inhibits invasion and metastasis of colorectal cancer cells via COX-2/PGE2 mediated JAK2/STAT3 signaling pathway

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Liu, Xuan ^a   Ji, Qing ^a   Ye, Naijing ^a   Sui, Hua ^a   Zhou, Lihong ^a   Zhu, Huirong ^a   Fan, Zhongze ^a   Cai, Jianfeng ^b   Li, Qi ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLORO N2 [1 (5 FLUORO 2 PYRIMIDINYL)ETHYL] N4 (5 METHYL 1H PYRAZOL 3 YL) 2,4 PYRIMIDINEDIAMINE; BERBERINE; CYCLOOXYGENASE 2; FLUOROURACIL; GELATINASE A; GELATINASE B; JANUS KINASE 2; PROSTAGLANDIN E2; STAT3 PROTEIN; ANTINEOPLASTIC AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CELL VIABILITY; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; COX 2 GENE; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; JAK2 GENE; MALE; METASTASIS; MMP 2 GENE; MMP 9 GENE; MOUSE; NONHUMAN; ONCOGENE; PGE2 GENE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT3 GENE; TUMOR INVASION; ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; CHEMISTRY; COLON; COLORECTAL NEOPLASMS; COPTIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASM METASTASIS; PATHOLOGY; PREVENTION AND CONTROL; RECTUM; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BERBERINE; CELL LINE, TUMOR; CELL MOVEMENT; COLON; COLORECTAL NEOPLASMS; COPTIS; CYCLOOXYGENASE 2; DINOPROSTONE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JANUS KINASE 2; MALE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RECTUM; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84952807525     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123478     Document Type: Article

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