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Volumn 104, Issue 5, 2013, Pages 604-610

Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; FLUOROURACIL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NORCANTHARIDIN; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

EID: 84876418822     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12120     Document Type: Article
Times cited : (52)

References (28)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249-57.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008; 358: 2039-49.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 6
    • 39549102220 scopus 로고    scopus 로고
    • STAT3: a critical transcription activator in angiogenesis
    • Chen Z, Han ZC. STAT3: a critical transcription activator in angiogenesis. Med Res Rev 2008; 28: 185-200.
    • (2008) Med Res Rev , vol.28 , pp. 185-200
    • Chen, Z.1    Han, Z.C.2
  • 7
    • 0037358192 scopus 로고    scopus 로고
    • Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF
    • Masson-Gadais B, Houle F, Laferriere J, Huot J. Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 2003; 8: 37-52.
    • (2003) Cell Stress Chaperones , vol.8 , pp. 37-52
    • Masson-Gadais, B.1    Houle, F.2    Laferriere, J.3    Huot, J.4
  • 8
    • 34548443831 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition
    • Holmes K, Roberts OL, Thomas AM, Cross MJ. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal 2007; 19: 2003-12.
    • (2007) Cell Signal , vol.19 , pp. 2003-2012
    • Holmes, K.1    Roberts, O.L.2    Thomas, A.M.3    Cross, M.J.4
  • 9
    • 40249116837 scopus 로고    scopus 로고
    • Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
    • Kitamura T, Asai N, Enomoto A et al. Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Nat Cell Biol 2008; 10: 329-37.
    • (2008) Nat Cell Biol , vol.10 , pp. 329-337
    • Kitamura, T.1    Asai, N.2    Enomoto, A.3
  • 11
    • 0024428817 scopus 로고
    • Medical uses of mylabris in ancient China and recent studies
    • Wang GS. Medical uses of mylabris in ancient China and recent studies. J Ethnopharmacol 1989; 26: 147-62.
    • (1989) J Ethnopharmacol , vol.26 , pp. 147-162
    • Wang, G.S.1
  • 12
    • 40949101023 scopus 로고    scopus 로고
    • Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling
    • Yi T, Yi Z, Cho SG et al. Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. Cancer Res 2008; 68: 1843-50.
    • (2008) Cancer Res , vol.68 , pp. 1843-1850
    • Yi, T.1    Yi, Z.2    Cho, S.G.3
  • 15
    • 33745305095 scopus 로고    scopus 로고
    • Anti-angiogenic drugs: from bench to clinical trials
    • Quesada AR, Munoz-Chapuli R, Medina MA. Anti-angiogenic drugs: from bench to clinical trials. Med Res Rev 2006; 26: 483-530.
    • (2006) Med Res Rev , vol.26 , pp. 483-530
    • Quesada, A.R.1    Munoz-Chapuli, R.2    Medina, M.A.3
  • 16
    • 84866438722 scopus 로고    scopus 로고
    • Norcantharidin anti-angiogenesis activity possibly through an endothelial cell pathway in human colorectal cancer
    • Yu T, Hou F, Liu M et al. Norcantharidin anti-angiogenesis activity possibly through an endothelial cell pathway in human colorectal cancer. Asian Pac J Cancer Prev 2012; 13: 499-503.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 499-503
    • Yu, T.1    Hou, F.2    Liu, M.3
  • 17
    • 18744408486 scopus 로고    scopus 로고
    • Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells
    • Fan YZ, Fu JY, Zhao ZM, Chen CQ. Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells. World J Gastroenterol 2005; 11: 2431-7.
    • (2005) World J Gastroenterol , vol.11 , pp. 2431-2437
    • Fan, Y.Z.1    Fu, J.Y.2    Zhao, Z.M.3    Chen, C.Q.4
  • 18
    • 84860295704 scopus 로고    scopus 로고
    • Norcantharidin: A potential antiangiogenic agent for gallbladder cancers in vitro and in vivo
    • Zhang JT, Fan YZ, Chen CQ, Zhao ZM, Sun W. Norcantharidin: A potential antiangiogenic agent for gallbladder cancers in vitro and in vivo. Int J Oncol 2012; 40: 1501-14.
    • (2012) Int J Oncol , vol.40 , pp. 1501-1514
    • Zhang, J.T.1    Fan, Y.Z.2    Chen, C.Q.3    Zhao, Z.M.4    Sun, W.5
  • 19
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005; 438: 967-74.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 20
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438: 932-6.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 21
    • 41749102871 scopus 로고    scopus 로고
    • Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2
    • Lu N, Gao Y, Ling Y et al. Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. Life Sci 2008; 82: 956-63.
    • (2008) Life Sci , vol.82 , pp. 956-963
    • Lu, N.1    Gao, Y.2    Ling, Y.3
  • 22
    • 0035966004 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation
    • Meadows KN, Bryant P, Pumiglia K. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J Biol Chem 2001; 276: 49289-98.
    • (2001) J Biol Chem , vol.276 , pp. 49289-49298
    • Meadows, K.N.1    Bryant, P.2    Pumiglia, K.3
  • 23
    • 0034668187 scopus 로고    scopus 로고
    • Signaling angiogenesis via p42/p44 MAP kinase and hypoxia
    • Berra E, Milanini J, Richard DE et al. Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. Biochem Pharmacol 2000; 60: 1171-8.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1171-1178
    • Berra, E.1    Milanini, J.2    Richard, D.E.3
  • 24
    • 0033558798 scopus 로고    scopus 로고
    • VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
    • Gupta K, Kshirsagar S, Li W et al. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 1999; 247: 495-504.
    • (1999) Exp Cell Res , vol.247 , pp. 495-504
    • Gupta, K.1    Kshirsagar, S.2    Li, W.3
  • 25
    • 0038724937 scopus 로고    scopus 로고
    • Role of Raf in vascular protection from distinct apoptotic stimuli
    • Alavi A, Hood JD, Frausto R, Stupack DG, Cheresh DA. Role of Raf in vascular protection from distinct apoptotic stimuli. Science 2003; 301: 94-6.
    • (2003) Science , vol.301 , pp. 94-96
    • Alavi, A.1    Hood, J.D.2    Frausto, R.3    Stupack, D.G.4    Cheresh, D.A.5
  • 26
    • 0033393771 scopus 로고    scopus 로고
    • Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
    • Eliceiri BP, Paul R, Schwartzberg PL, Hood JD, Leng J, Cheresh DA. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999; 4: 915-24.
    • (1999) Mol Cell , vol.4 , pp. 915-924
    • Eliceiri, B.P.1    Paul, R.2    Schwartzberg, P.L.3    Hood, J.D.4    Leng, J.5    Cheresh, D.A.6
  • 27
    • 0032498640 scopus 로고    scopus 로고
    • Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
    • Eliceiri BP, Klemke R, Stromblad S, Cheresh DA. Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol 1998; 140: 1255-63.
    • (1998) J Cell Biol , vol.140 , pp. 1255-1263
    • Eliceiri, B.P.1    Klemke, R.2    Stromblad, S.3    Cheresh, D.A.4
  • 28
    • 0037189380 scopus 로고    scopus 로고
    • Tumor regression by targeted gene delivery to the neovasculature
    • Hood JD, Bednarski M, Frausto R et al. Tumor regression by targeted gene delivery to the neovasculature. Science 2002; 296: 2404-7.
    • (2002) Science , vol.296 , pp. 2404-2407
    • Hood, J.D.1    Bednarski, M.2    Frausto, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.