Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene

Molecular Immunology

Volumn 45, Issue 1, 2008, Pages 137-143

  Song, Yuhua ^a,b   Qian, Lu ^a   Song, Santai ^b   Chen, Liyong ^a   Zhang, Yan ^a,c   Yuan, Guogang ^a   Zhang, Hao ^a   Xia, Qing ^a   Hu, Meiru ^a   Yu, Ming ^a   Shi, Ming ^a   Jiang, Zefei ^b   Guo, Ning ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b Beijing 307 Hospital   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Fra 1; Metastasis; MMP 9; Stat3; Transcription

Indexed keywords

ANTIBIOTIC G 418; GELATINASE B; STAT3 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FRA 1;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL ACTIVATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA DETERMINATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VIVO STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BASE SEQUENCE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MATRIX METALLOPROTEINASE 9; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FOS; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS);

EID: 34548290968     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.04.031     Document Type: Article

References (35)

1. Adiseshaiah P., Peddakama S., Zhang Q., Kalvakolanu D.V., and Reddy S.P. Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. Oncogene 24 (2005) 4193-4205
2. Andersen H., Mahmood S., Tkach V., Cohn M., Kustikova O., Grigorian M., Berezin V., Bock E., Lukanidin E., and Tulchinsky E. The ability of Fos family members to produce phenotypic changes in epithelioid cells is not directly linked to their transactivation potentials. Oncogene 21 (2002) 4843-4848
3. Belguise K., Kersual N., Galtier F., and Chalbos D. FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells. Oncogene 24 (2005) 1434-1444
4. Berclaz G., Altermatt H.J., Rohrbach V., Siragusa A., Dreher E., and Smith P.D. EGFR dependent expression of STAT3 (but not STAT1) in breast cancer. Int. J. Oncol. 19 (2001) 1155-1160
5. Casalino L., De Cesare D., and Verde P. Accumulation of Fra-1 in ras-transformed cells depends on both transcriptional autoregulation and MEK-dependent posttranslational stabilization. Mol. Cell Biol. 23 (2003) 4401-4415
6. Chapman R.S., Lourenco P., Tonner E., Flint D., Selbert S., Takeda K., Akira S., Clarke A.R., and Watson C.J. The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Adv. Exp. Med. Biol. 480 (2000) 129-138
7. Chiappetta G., Tallini G., De Biasio M.C., Pentimalli F., de Nigris F., Losito S., Fedele M., Battista S., Verde P., Santoro M., and Fusco A. FRA-1 expression in hyperplastic and neoplastic thyroid diseases. Clin. Cancer Res. 6 (2000) 4300-4306
8. Debinski W., and Gibo D.M. Fos-related antigen 1 modulates malignant features of glioma cells. Mol. Cancer Res. 3 (2005) 237-249
9. Fini M.E., Bartlett J.D., Matsubara M., Rinehart W.B., Mody M.K., Girard M.T., and Rainville M. The rabbit gene for 92-kDa matrix metalloproteinase. Role of AP1 and AP2 in cell type-specific transcription. J. Biol. Chem. 269 (1994) 28620-28628
10. Grandis J.R., Drenning S.D., Zeng Q., Watkins S.C., Melhem M.F., Endo S., Johnson D.E., Huang L., He Y., and Kim J.D. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 4227-4232
11. Huhtala P., Chow L.T., and Tryggvason K. Structure of the human type IV collagenase gene. J. Biol. Chem. 265 (1990) 11077-11082
12. Itoh M., Murata T., Suzuki T., Shindoh M., Nakajima K., Imai K., and Yoshida K. Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. Oncogene 25 (2006) 1195-1204
13. Ivanov V.N., Bhoumik A., Krasilnikov M., Raz R., Owen-Schaub L.B., Levy D., Horvath C.M., and Ronai Z. Cooperation between STAT3 and c-jun suppresses Fas transcription. Mol. Cell. 7 (2001) 517-528
14. Jochum W., Passegue E., and Wagner E.F. AP-1 in mouse development and tumorigenesis. Oncogene 20 (2001) 2401-2412
15. Kustikova O., Kramerov D., Grigorian M., Berezin V., Bock E., Lukanidin E., and Tulchinsky E. Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells. Mol. Cell Biol. 18 (1998) 7095-7105
16. Lelievre E., Mattot V., Huber P., Vandenbunder B., and Soncin F. ETS1 lowers capillary endothelial cell density at confluence and induces the expression of VE-cadherin. Oncogene 19 (2000) 2438-2446
17. Ma Z., Qin H., and Benveniste E.N. Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-gamma and IFN-beta: critical role of STAT-1alpha. J. Immunol. 167 (2001) 5150-5159
18. Mangone F.R., Brentani M.M., Nonogaki S., Begnami M.D., Campos A.H., Walder F., Carvalho M.B., Soares F.A., Torloni H., Kowalski L.P., and Federico M.H. Overexpression of Fos-related antigen-1 in head and neck squamous cell carcinoma. Int. J. Exp. Pathol. 86 (2005) 205-212
19. Mechta F., Lallemand D., Pfarr C.M., and Yaniv M. Transformation by ras modifies AP1 composition and activity. Oncogene 14 (1997) 837-847
20. Milde-Langosch K. The Fos family of transcription factors and their role in tumourigenesis. Eur. J. Cancer 41 (2005) 2449-2461
21. Milde-Langosch K., Roder H., Andritzky B., Aslan B., Hemminger G., Brinkmann A., Bamberger C.M., Loning T., and Bamberger A.M. The role of the AP-1 transcription factors c-Fos, FosB, Fra-1 and Fra-2 in the invasion process of mammary carcinomas. Breast Cancer Res. Treat. 86 (2004) 139-152
22. Niu G., Bowman T., Huang M., Shivers S., Reintgen D., Daud A., Chang A., Kraker A., Jove R., and Yu H. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene 21 (2002) 7001-7010
23. Niu G., Wright K.L., Huang M., Song L., Haura E., Turkson J., Zhang S., Wang T., Sinibaldi D., Coppola D., Heller R., Ellis L.M., Karras J., Bromberg J., Pardoll D., Jove R., and Yu H. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21 (2002) 2000-2008
24. Reddy S.P., and Mossman B.T. Role and regulation of activator protein-1 in toxicant-induced responses of the lung. Am. J. Physiol. Lung Cell Mol. Physiol. 283 (2002) L1161-L1178
25. Schuringa J.J., Timmer H., Luttickhuizen D., Vellenga E., and Kruijer W. c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element (IRE). Cytokine 14 (2001) 78-87
26. Serewko M.M., Popa C., Dahler A.L., Smith L., Strutton G.M., Coman W., Dicker A.J., and Saunders N.A. Alterations in gene expression and activity during squamous cell carcinoma development. Cancer Res. 62 (2002) 3759-3765
27. Shaulian E., and Karin M. AP-1 in cell proliferation and survival. Oncogene 20 (2001) 2390-2400
28. Shaulian E., and Karin M. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4 (2002) E131-E136
29. Shouda T., Hiraoka K., Komiya S., Hamada T., Zenmyo M., Iwasaki H., Isayama T., Fukushima N., Nagata K., and Yoshimura A. Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells. Cancer Lett. 231 (2006) 176-184
30. Tkach V., Tulchinsky E., Lukanidin E., Vinson C., Bock E., and Berezin V. Role of the Fos family members, c-Fos, Fra-1 and Fra-2, in the regulation of cell motility. Oncogene 22 (2003) 5045-5054
31. Tulchinsky E. Fos family members: regulation, structure and role in oncogenic transformation. Histol. Histopathol. 15 (2000) 921-928
32. Wisdon R., and Verma I.M. Transformation by Fos proteins requires a C-terminal transactivation domain. Mol. Cell Biol. 13 (1993) 7429-7438
33. Xu Q., Briggs J., Park S., Niu G., Kortylewski M., Zhang S., Gritsko T., Turkson J., Kay H., Semenza G.L., Cheng J.Q., Jove R., and Yu H. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 24 (2005) 5552-5560
34. Young M.R., Yang H.S., and Colburn N.H. Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4. Trends Mol. Med. 9 (2003) 36-41
35. Zajchowski D.A., Bartholdi M.F., Gong Y., Webster L., Liu H.L., Munishkin A., Beauheim C., Harvey S., Ethier S.P., and Johnson P.H. Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells. Cancer Res. 61 (2001) 5168-5178