The role of gut microbiota and diet in experimental autoimmune encephalitis and multiple sclerosis

Clinical and Experimental Neuroimmunology

Volumn 6, Issue , 2015, Pages 30-37

  Okuno, Tatsusada ^a   Nakatsuji, Yuji ^a   Kinoshita, Makoto ^b   Takata, Kazushiro ^b   Koda, Toru ^a   Yamashita, Kazuya ^a   Nanba, Akiko ^a   Mochizuki, Hideki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA GENERAL MEDICAL CENTER   (Japan)

Author keywords

diet; experimental autoimmune encephalomyelitis; gut microbiota; multiple sclerosis; regulatory T cell; Th17

Indexed keywords

PROBIOTIC AGENT; SHORT CHAIN FATTY ACID;

ALLERGIC ENCEPHALITIS; AUTOIMMUNE DISEASE; BACTERIUM; COMMENSAL; DIET; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEEDING BEHAVIOR; HUMAN; IMMUNE SYSTEM; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE FLORA; KLUYVEROMYCES MARXIANUS; METABOLITE; MICROFLORA; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PEDIOCOCCUS ACIDILACTICI; PRIORITY JOURNAL; PROPHYLAXIS; REGULATORY T LYMPHOCYTE; REVIEW; TH17 CELL;

EID: 84952330956     PISSN: None     EISSN: 17591961     Source Type: Journal    
DOI: 10.1111/cen3.12270     Document Type: Review

References (59)

1. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG,. Multiple sclerosis. N Engl J Med. 2000; 13: 938-52.
2. Weiner HL,. The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann Neurol. 2009; 3: 239-48.
3. Sawcer S,. The complex genetics of multiple sclerosis: pitfalls and prospects. Brain. 2008; 131: 3118-31.
4. Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL,. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat Rev Genet. 2008; 7: 516-26.
5. International Multiple Sclerosis Consortium. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011; 7359: 214-9.
6. Compston A, Coles A,. Multiple sclerosis. Lancet. 2008; 9648: 1502-17.
7. Simpson S Jr, Blizzard L, Otahal P, Van der Mei I, Taylor B,. Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011; 10: 1132-41.
8. Trojano M, Lucchese G, Graziano G, et al., Geographical variations in sex ratio trends over time in multiple sclerosis. PLoS One. 2012; 10: e48078.
9. Royal W 3rd, Mia Y, Li H, Naunton K,. Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis. J Neuroimmunol. 2009; 1-2: 135-41.
10. Kang SW, Kim SH, Lee N, et al., 1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region. J Immunol. 2012; 11: 5276-82.
11. Strachan DP,. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax. 2000; 55: S2-10.
12. Yoshimura S, Isobe N, Matsushita T, et al., Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients. PLoS One. 2014; 4: e95367.
13. Pedrini MJ, Seewann A, Bennett KA, et al., Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females. J Neurol Neurosurg Psychiatry. 2015; 6: 603-7.
14. Pugliatti M, Riise T, Sotgiu MA, et al., Increasing incidence of multiple sclerosis in the province of Sassari, northern Sardinia. Neuroepidemiology. 2005; 3: 129-34.
15. Nicoletti A, Lo Fermo S, Reggio E, et al., A possible spatial and temporal cluster of multiple sclerosis in the town of Linguaglossa Sicily. J Neurol. 2005; 8: 921-5.
16. Grimaldi LM, Palmeri B, Salemi G, et al., High prevalence and fast rising incidence of multiple sclerosis in Caltanissetta, Sicily, southern Italy. Neuroepidemiology. 2007; 1: 28-32.
17. Kotzamani D, Panou T, Mastorodemos V, et al., Rising incidence of multiple sclerosis in females associated with urbanization. Neurology. 2012; 22: 1728-35.
18. Kinoshita M, Takeda K,. Microbial and dietary factors modulating intestinal regulatory T cell homeostasis. FEBS Lett. 2014; 22: 4182-7.
19. Atarashi K, Nishimura J, Shima T, et al., ATP drives lamina propria T(H)17 cell differentiation. Nature. 2008; 7214: 808-12.
20. Ivanov II, Atarashi K, Manel N, et al., Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009; 3: 485-98.
21. Schnupf P, Gaboriau-Routhiau V, Gros M, et al., Growth and host interaction of mouse segmented filamentous bacteria in vitro. Nature. 2015; 7545: 99-103.
22. Kusu T, Kayama H, Kinoshita M, et al., Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol. 2013; 2: 774-83.
23. Atarashi K, Tanoue T, Shima T, et al., Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011; 6015: 337-41.
24. Round JL, Lee SM, Li J, et al., The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 2011; 6032: 974-7.
25. Mazmanian SK, Round JL, Kasper DL,. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature. 2008; 7195: 620-5.
26. Mucida D, Park Y, Kim G, et al., Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science. 2007; 5835: 256-60.
27. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY,. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004; 4: 527-38.
28. Kinoshita M, Kayama H, Kusu T, et al., Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol. 2012; 6: 2869-78.
29. Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H,. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 2012; 2: e32094.
30. Zelante T, Iannitti RG, Cunha C, et al., Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 2013; 2: 372-85.
31. Mezrich JD, Fechner JH, Zhang X, Johnson BP, Burlingham WJ, Bradfield CA,. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol. 2010; 6: 3190-8.
32. Thorburn AN, Macia L, Mackay CR,. Diet, metabolites, and "western-lifestyle" inflammatory diseases. Immunity. 2014; 6: 833-42.
33. Oh DY, Talukdar S, Bae EJ, et al., GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010; 5: 687-98.
34. Smith PM, Howitt MR, Panikov N, et al., The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013; 6145: 569-73.
35. Arpaia N, Campbell C, Fan X, et al., Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 7480: 451-5.
36. Furusawa Y, Obata Y, Fukuda S, et al., Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013; 7480: 446-50.
37. Kim SV, Xiang WV, Kwak C, et al., GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science. 2013; 6139: 1456-9.
38. Atarashi K, Tanoue T, Oshima K, et al., Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013; 7461: 232-6.
39. Esplugues E, Huber S, Gagliani N, et al., Control of TH17 cells occurs in the small intestine. Nature. 2011; 7357: 514-8.
40. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK,. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA. 2011; 108: 4615-22.
41. Berer K, Mues M, Koutrolos M, et al., Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011; 7374: 538-41.
42. Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, et al., Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J Immunol. 2009; 10: 6041-50.
43. Yokote H, Miyake S, Croxford JL, Oki S, Mizusawa H, Yamamura T,. NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol. 2008; 6: 1714-23.
44. Takata K, Kinoshita M, Okuno T, et al., The lactic acid bacterium Pediococcus acidilactici suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cells. PLoS One. 2011; 11: e27644.
45. Lavasani S, Dzhambazov B, Nouri M, et al., A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. PLoS One. 2010; 2: e9009.
46. Ezendam J, de Klerk A, Gremmer ER, van Loveren H,. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008; 3: 424-31.
47. Maassen C, Claassen E,. Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity. Vaccine. 2008; 26: 2056-7.
48. Hsiao EY, McBride SW, Hsien S, et al., Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2014; 7: 1451-63.
49. Ochoa-Reparaz J, Mielcarz DW, Wang Y, et al., A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol. 2010; 5: 487-95.
50. Wang Y, Kasper LH,. The role of microbiome in central nervous system disorders. Brain Behav Immun. 2014; 38: 1-12.
51. Ochoa-Reparaz J, Rynda A, Ascon MA, et al., IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen. J Immunol. 2008; 2: 954-68.
52. Rezende RM, Oliveira RP, Medeiros SR, et al., Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4 + LAP+ regulatory T cells. J Autoimmun. 2013; 40: 45-57.
53. Takata K, Tomita T, Okuno T, et al., Dietary yeasts reduce inflammation in central nerve system via microflora. Ann Clin Transl Neurol. 2015; 1: 56-66.
54. Correale J, Farez M, Razzitte G,. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann Neurol. 2008; 2: 187-99.
55. Correale J,. Helminth/Parasite treatment of multiple sclerosis. Curr Treat Options Neurol. 2014; 6: 296.
56. Miyake S, Kim S, Suda W, et al., Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters. PLoS One. 2015; 9: e0137429.
57. Rumah KR, Linden J, Fischetti VA, Vartanian T,. Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PLoS One. 2013; 10: e76359.
58. Bhargava P, Mowry EM,. Gut microbiome and multiple sclerosis. Curr Neurol Neurosci Rep. 2014; 10: 492.
59. Mielcarz DW, Kasper LH,. The gut microbiome in multiple sclerosis. Curr Treat Options Neurol. 2015; 4: 344.