메뉴 건너뛰기




Volumn 181, Issue 2, 2008, Pages 954-968

IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen

Author keywords

[No Author keywords available]

Indexed keywords

AP 331; AUTOANTIGEN; BACTERIAL VECTOR; GAMMA INTERFERON; H 647; H 696; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 21; PROTEOLIPID PROTEIN; SALMONELLOSIS VACCINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; COLONIZATION FACTOR ANTIGENS; CYTOKINE; FIMBRIA PROTEIN;

EID: 49049106824     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.2.954     Document Type: Article
Times cited : (65)

References (54)
  • 1
    • 34447127480 scopus 로고    scopus 로고
    • Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica serovar Typhi strains used as live oral vaccines in humans
    • Sztein, M. B. 2007. Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica serovar Typhi strains used as live oral vaccines in humans. Clin. Infect. Dis. 45: S15-S19.
    • (2007) Clin. Infect. Dis. , vol.45
    • Sztein, M.B.1
  • 3
    • 0027018296 scopus 로고
    • Role of T cells, TNF-α and IFN-γ in recall of immunity to oral challenge with virulent salmonellae in mice vaccinated with live attenuated aro-Salmonella vaccines
    • Mastroeni, P., B. Villarreal-Ramos, and C. E. Hormaeche. 1992. Role of T cells, TNF-α and IFN-γ in recall of immunity to oral challenge with virulent salmonellae in mice vaccinated with live attenuated aro-Salmonella vaccines. Microb. Pathog. 13: 477-491.
    • (1992) Microb. Pathog. , vol.13 , pp. 477-491
    • Mastroeni, P.1    Villarreal-Ramos, B.2    Hormaeche, C.E.3
  • 5
    • 0343978503 scopus 로고    scopus 로고
    • Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella
    • VanCott, J. L., H. F. Staats, D. W. Pascual, M. Roberts, S. N. Chatfield, M. Yamamoto, M. Coste, P. B. Carter, H. Kiyono, and J. R. McGhee. 1996. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J. Immunol. 156: 1504-1514.
    • (1996) J. Immunol. , vol.156 , pp. 1504-1514
    • Vancott, J.L.1    Staats, H.F.2    Pascual, D.W.3    Roberts, M.4    Chatfield, S.N.5    Yamamoto, M.6    Coste, M.7    Carter, P.B.8    Kiyono, H.9    McGhee, J.R.10
  • 6
    • 0032723006 scopus 로고    scopus 로고
    • Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response
    • Pascual, D. W., D. M. Hone, S. Hall, F. W. van Ginkel, M. Yamamoto, N. Walters, K. Fujihashi, R. J. Powell, S. Wu, J. L. Vancott, et al. 1999. Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infect. Immun. 67: 6249-6256.
    • (1999) Infect. Immun. , vol.67 , pp. 6249-6256
    • Pascual, D.W.1    Hone, D.M.2    Hall, S.3    Van Ginkel, F.W.4    Yamamoto, M.5    Walters, N.6    Fujihashi, K.7    Powell, R.J.8    Wu, S.9    Vancott, J.L.10
  • 7
    • 0036076260 scopus 로고    scopus 로고
    • Fimbriated Salmonella enterica serovar Typhimurium abates initial inflammatory responses by macrophages
    • Pascual, D. W., T. Trunkle, and J. Sura. 2002. Fimbriated Salmonella enterica serovar Typhimurium abates initial inflammatory responses by macrophages. Infect. Immun. 70: 4273-4281.
    • (2002) Infect. Immun. , vol.70 , pp. 4273-4281
    • Pascual, D.W.1    Trunkle, T.2    Sura, J.3
  • 8
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra, M., and R. Martin. 2005. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23: 683-747.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 9
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: A complicated picture of autoimmunity
    • DOI 10.1038/ni1507, PII NI1507
    • McFarland, H. F., and R. Martin. 2007. Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 8: 913-919. (Pubitemid 47300005)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 10
    • 0033961796 scopus 로고    scopus 로고
    • Kinetics and cellular origin of cytokines in the central nervous system: Insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
    • Juedes, A. E., P. Hjelmstrom, C. M. Bergman, A. L. Neild, and N. H. Ruddle. 2000. Kinetics and cellular origin of cytokines in the central nervous system: insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J. Immunol. 164: 419-426.
    • (2000) J. Immunol. , vol.164 , pp. 419-426
    • Juedes, A.E.1    Hjelmstrom, P.2    Bergman, C.M.3    Neild, A.L.4    Ruddle, N.H.5
  • 11
    • 0032530033 scopus 로고    scopus 로고
    • Chemokine regulation of experimental autoimmune encephalomyelitis: Temporal and spatial expression patterns govern disease pathogenesis
    • Karpus, W. J., and R. M. Ransohoff. 1998. Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis. J. Immunol. 161: 2667-2671.
    • (1998) J. Immunol. , vol.161 , pp. 2667-2671
    • Karpus, W.J.1    Ransohoff, R.M.2
  • 12
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 15
    • 35348960243 scopus 로고    scopus 로고
    • Th17: The third member of the effector T cell trilogy
    • DOI 10.1016/j.coi.2007.07.020, PII S0952791507001331, Autoimmunity / Allergy and Hypersenditivity
    • Bettelli, E., T. Korn, and V. K. Kuchroo. 2007. Th17: the third member of the effector T cell trilogy. Curr. Opin. Immunol. 19: 652-657. (Pubitemid 350236805)
    • (2007) Current Opinion in Immunology , vol.19 , Issue.6 , pp. 652-657
    • Bettelli, E.1    Korn, T.2    Kuchroo, V.K.3
  • 17
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • DOI 10.1016/j.immuni.2006.01.001, PII S1074761306000045
    • Veldhoen, M., R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger. 2006. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189. (Pubitemid 43214587)
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 18
    • 27744460743 scopus 로고    scopus 로고
    • A live diarrheal vaccine imprints a Th2 cell bias and acts as an anti-inflammatory vaccine
    • Jun, S., W. Gilmore, G. Callis, A. Rynda, A. Haddad, and D. W. Pascual. 2005. A live diarrheal vaccine imprints a Th2 cell bias and acts as an anti-inflammatory vaccine. J. Immunol. 175: 6733-6740. (Pubitemid 41598917)
    • (2005) Journal of Immunology , vol.175 , Issue.10 , pp. 6733-6740
    • Jun, S.1    Gilmore, W.2    Callis, G.3    Rynda, A.4    Haddad, A.5    Pascual, D.W.6
  • 19
    • 33846527540 scopus 로고    scopus 로고
    • Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis
    • Ochoa-Repáraz, J., C. Riccardi, A. Rynda, S. Jun, G. Callis, and D. W. Pascual. 2007. Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis. J. Immunol. 178: 1791-1799. (Pubitemid 46154651)
    • (2007) Journal of Immunology , vol.178 , Issue.3 , pp. 1791-1799
    • Ochoa-Reparaz, J.1    Riccardi, C.2    Rynda, A.3    Jun, S.4    Callis, G.5    Pascual, D.W.6
  • 20
    • 0028788549 scopus 로고
    • Immune responses to novel Escherichia coli and Salmonella typhimurium vectors that express colonization factor antigen I (CFA/I) of enterotoxigenic E. coli in the absence of the CFA/I positive regulator cfaR
    • Wu, S., D. W. Pascual, J. L. VanCott, J. R. McGhee, D. R. Maneval, Jr., M. M. Levine, and D. M. Hone. 1995. Immune responses to novel Escherichia coli and Salmonella typhimurium vectors that express colonization factor antigen I (CFA/I) of enterotoxigenic E. coli in the absence of the CFA/I positive regulator cfaR. Infect. Immun. 63: 4933-4938.
    • (1995) Infect. Immun. , vol.63 , pp. 4933-4938
    • Wu, S.1    Pascual, D.W.2    Vancott, J.L.3    McGhee, J.R.4    Maneval Jr., D.R.5    Levine, M.M.6    Hone, D.M.7
  • 21
  • 23
    • 27744601980 scopus 로고    scopus 로고
    • Partially assembled K99 fimbriae are required for protection
    • DOI 10.1128/IAI.73.11.7274-7280.2005
    • Ascón, M. A., J. Ochoa-Repáraz, N. Walters, and D. W. Pascual. 2005. Partially assembled K99 fimbriae required for protection. Infect. Immun. 73: 7274-7280. (Pubitemid 41587626)
    • (2005) Infection and Immunity , vol.73 , Issue.11 , pp. 7274-7280
    • Ascon, M.A.1    Ochoa-Reparaz, J.2    Walters, N.3    Pascual, D.W.4
  • 24
    • 0035399591 scopus 로고    scopus 로고
    • Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vector
    • Pascual, D. W., M. White, T. Larson, and N. Walters. 2001. Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vector. J. Immunol. 167: 407-415.
    • (2001) J. Immunol. , vol.167 , pp. 407-415
    • Pascual, D.W.1    White, M.2    Larson, T.3    Walters, N.4
  • 25
    • 0031587927 scopus 로고    scopus 로고
    • Expression of recombinant rat interleukin-13 and generation of a neutralizing rat IL-13 antiserum
    • Lakkis, F. G., E. N. Cruet, G. M. Nassar, K. F. Badr, and D. W. Pascual. 1997. Expression of recombinant rat interleukin-13 and generation of a neutralizing rat IL-13 antiserum. Biochem. Biophys. Res. Commun. 235: 529-532.
    • (1997) Biochem. Biophys. Res. Commun. , vol.235 , pp. 529-532
    • Lakkis, F.G.1    Cruet, E.N.2    Nassar, G.M.3    Badr, K.F.4    Pascual, D.W.5
  • 26
    • 19744362921 scopus 로고    scopus 로고
    • + Thcell- Mediated alveolar bone destruction in vivo
    • + Thcell- mediated alveolar bone destruction in vivo. Infect. Immun. 73: 3453-3461.
    • (2005) Infect. Immun. , vol.73 , pp. 3453-3461
    • Teng, Y.T.1    Mahamed, D.2    Singh, B.3
  • 28
    • 0036838536 scopus 로고    scopus 로고
    • + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169: 4712-4716.
    • (2002) J. Immunol. , vol.169 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 31
    • 0034177889 scopus 로고    scopus 로고
    • IL-4, IL-10, IL-13, and TGF-β from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis
    • Young, D. A., L. D. Lowe, S. S. Booth, M. J. Whitters, L. Nicholson, V. K. Kuchroo, and M. Collins. 2000. IL-4, IL-10, IL-13, and TGF-β from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. J. Immunol. 164: 3563-3572.
    • (2000) J. Immunol. , vol.164 , pp. 3563-3572
    • Young, D.A.1    Lowe, L.D.2    Booth, S.S.3    Whitters, M.J.4    Nicholson, L.5    Kuchroo, V.K.6    Collins, M.7
  • 33
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192: 295-302.
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 39
    • 24744452162 scopus 로고    scopus 로고
    • Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury
    • Offner, H., S. Subramanian, C. Wang, M. Afentoulis, A. A. Vandenbark, J. Huan, and G. G. Burrows. 2005. Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury. J. Immunol. 175: 4103-4111. (Pubitemid 41292074)
    • (2005) Journal of Immunology , vol.175 , Issue.6 , pp. 4103-4111
    • Offner, H.1    Subramanian, S.2    Wang, C.3    Afentoulis, M.4    Vandenbark, A.A.5    Huan, J.6    Burrows, G.G.7
  • 41
    • 35348983341 scopus 로고    scopus 로고
    • Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    • Zenewicz, L. A., G. D. Yancopoulos, D. M. Valenzuela, A. J. Murphy, M. Karow, and R. A. Flavell. 2007. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27: 647-659.
    • (2007) Immunity , vol.27 , pp. 647-659
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3    Murphy, A.J.4    Karow, M.5    Flavell, R.A.6
  • 42
    • 40049103352 scopus 로고    scopus 로고
    • IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
    • Kreymborg, K., R. Etzensperger, L. Dumoutier, S. Haak, A. Rebollo, T. Buch, F. L. Heppner, J. C. Renauld, and B. Becher. 2007. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 179: 8098-8104.
    • (2007) J. Immunol. , vol.179 , pp. 8098-8104
    • Kreymborg, K.1    Etzensperger, R.2    Dumoutier, L.3    Haak, S.4    Rebollo, A.5    Buch, T.6    Heppner, F.L.7    Renauld, J.C.8    Becher, B.9
  • 43
    • 30944452780 scopus 로고    scopus 로고
    • Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    • DOI 10.1016/j.cellimm.2005.11.002, PII S000887490500242X
    • Hofstetter, H. H., S. M. Ibrahim, D. Koczan, N. Kruse, A. Weishaupt, K. V. Toyka, and R. Gold. 2005. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell. Immunol. 237: 123-130. (Pubitemid 43117208)
    • (2005) Cellular Immunology , vol.237 , Issue.2 , pp. 123-130
    • Hofstetter, H.H.1    Ibrahim, S.M.2    Koczan, D.3    Kruse, N.4    Weishaupt, A.5    Toyka, K.V.6    Gold, R.7
  • 45
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • DOI 10.1084/jem.20060285
    • Sutton, C., C. Brereton, B. Keogh, K. H. Mills, and E. C. Lavelle. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203: 1685-1691. (Pubitemid 44036274)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.G.4    Lavelle, E.C.5
  • 47
    • 0028170342 scopus 로고
    • Effect of anti-interferon-gamma monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains
    • DOI 10.1016/0165-5728(94)90069-8
    • Duong, T. T., F. D. Finkelman, B. Singh, and G. H. Strejan. 1994. Effect of anti-interferon-γ monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains. J. Neuroimmunol. 53: 101-107. (Pubitemid 2125900)
    • (1994) Journal of Neuroimmunology , vol.53 , Issue.1 , pp. 101-107
    • Duong, T.T.1    Finkelman, F.D.2    Singh, B.3    Strejan, G.H.4
  • 48
    • 0029671318 scopus 로고    scopus 로고
    • Cutting edge: Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber, I. A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C. G. Fathman. 1996. Cutting edge: mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156: 5-7.
    • (1996) J. Immunol. , vol.156 , pp. 5-7
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3    Ridgway, W.4    Dinisco, C.5    Steinman, L.6    Dalton, D.7    Fathman, C.G.8
  • 49
    • 0034601012 scopus 로고    scopus 로고
    • Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    • Chu, C. Q., S. Wittmer, and D. K. Dalton. 2000. Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J. Exp. Med. 192: 123-128.
    • (2000) J. Exp. Med. , vol.192 , pp. 123-128
    • Chu, C.Q.1    Wittmer, S.2    Dalton, D.K.3
  • 50
    • 0030587910 scopus 로고    scopus 로고
    • Cutting edge: IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Willenborg, D. O., S. Fordham, C. C. Bernard, W. B. Cowden, and I. A. Ramshaw. 1996. Cutting edge: IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157: 3223-3227.
    • (1996) J. Immunol. , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 54
    • 0035695728 scopus 로고    scopus 로고
    • Treatment with anti-interferon-γ monoclonal antibodies modifies experimental autoimmune encephalomyelitis in interferon-γ receptor knockout mice
    • DOI 10.1006/exnr.2001.7815
    • Espejo, C., M. Penkowa, I. Sáez-Torres, J. Xaus, A. Celada, X. Montalban, and E. M. Martinez-Cáceres. 2001. Treatment with anti-interferon-γ monoclonal antibodies modifies experimental autoimmune encephalomyelitis in interferon-γreceptor knockout mice. Exp. Neurol. 172: 460-468. (Pubitemid 34075095)
    • (2001) Experimental Neurology , vol.172 , Issue.2 , pp. 460-468
    • Espejo, C.1    Penkowa, M.2    Saez-Torres, I.3    Xaus, J.4    Celada, A.5    Montalban, X.6    Martinez-Caceres, E.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.