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Volumn 16, Issue 6, 2014, Pages

Helminth/parasite treatment of multiple sclerosis

Author keywords

Autoimmune diseases; Autoimmunity; EAE; Environmental factors; Helminth; Helminth therapy; Hygiene hypothesis; Immunoregulation; Infections; Multiple sclerosis; Necator americanus; Parasite; Treatment; Trichura suis

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; GLYCOPROTEIN; GLYCOPROTEIN ES 62; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NITRIC OXIDE; PLACEBO; PROTEOLIPID PROTEIN; UNCLASSIFIED DRUG;

EID: 84899068251     PISSN: 10928480     EISSN: 15343138     Source Type: Journal    
DOI: 10.1007/s11940-014-0296-3     Document Type: Review
Times cited : (17)

References (71)
  • 1
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: A complicated picture of autoimmunity
    • DOI 10.1038/ni1507, PII NI1507
    • McFarland H, Martin R. Multiple Sclerosis: a complicated picture of autoimmunity. Nat Immunol. 2007;8:913-9. (Pubitemid 47300005)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 2
    • 8844239964 scopus 로고    scopus 로고
    • Environmental risk factors in multiple sclerosis aetiology
    • DOI 10.1016/S1474-4422(04)00933-0, PII S1474442204009330
    • Marrie RA. Environmental risk factors in multiple sclerosis. Lancet Neurol. 2004;3:709-18. (Pubitemid 39535256)
    • (2004) Lancet Neurology , vol.3 , Issue.12 , pp. 709-718
    • Marrie, R.A.1
  • 3
    • 45549092100 scopus 로고    scopus 로고
    • The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
    • DOI 10.1038/nrg2395, PII NRG2395
    • Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL. The genetics of multiple sclerosis: SNP to pathways to pathogenesis. Nat Rev Genet. 2008;9:516-26. (Pubitemid 351861542)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.7 , pp. 516-526
    • Oksenberg, J.R.1    Baranzini, S.E.2    Sawcer, S.3    Hauser, S.L.4
  • 5
    • 0022868088 scopus 로고
    • A population-based study of multiple sclerosis in twins
    • Ebers GC, Bulman DE, Sadovnik AD, Paty DW, Warren S, Hader W, et al. A population-based study of multiple sclerosis in twins. N Engl J Med. 1986;315:1638-42. (Pubitemid 17052896)
    • (1986) New England Journal of Medicine , vol.315 , Issue.26 , pp. 1638-1642
    • Ebers, G.C.1    Bulman, D.E.2    Sadovnick, A.D.3
  • 6
    • 0035321573 scopus 로고    scopus 로고
    • The prevalence of multiple sclerosis in the world: An update
    • Rosati G. The prevalence of multiple sclerosis in the world: an update. Neurol Sci. 2011;22:117-39.
    • (2011) Neurol Sci , vol.22 , pp. 117-139
    • Rosati, G.1
  • 7
    • 0018163186 scopus 로고
    • Migration and risk of multiple sclerosis
    • Alter M, Kahana E, Lowenson R. Migration and risk of multiple sclerosis. Neurology. 1978;28:1089-93. (Pubitemid 9012847)
    • (1978) Neurology , vol.28 , Issue.11 , pp. 1089-1093
    • Alter, M.1    Kahana, E.2    Loewenson, R.3
  • 8
    • 84890084194 scopus 로고    scopus 로고
    • Environmental factors in multiple sclerosis
    • Ascherio A. Environmental factors in multiple sclerosis. Expert Rev Neurother. 2013;13 Suppl 12:3-9.
    • (2013) Expert Rev Neurother , vol.13 , Issue.SUPPL. 12 , pp. 3-9
    • Ascherio, A.1
  • 9
    • 20444395122 scopus 로고    scopus 로고
    • Infections and autoimmunity-good or bad?
    • Christen U, von Herrath MG. Infections and autoimmunity-good or bad? J Immunol. 2005;174:7481-6.
    • (2005) J Immunol , vol.174 , pp. 7481-7486
    • Christen, U.1    Von Herrath, M.G.2
  • 10
    • 33747705430 scopus 로고    scopus 로고
    • The risk of relapses in multiple sclerosis during systemic infections
    • DOI 10.1212/01.wnl.0000233834.09743.3b, PII 0000611420060822000025
    • Correale J, Fiol M, Gilmore W. The risk of relapses in multiple sclerosis during systemic infections. Neurology. 2006;67:652-9. (Pubitemid 44273613)
    • (2006) Neurology , vol.67 , Issue.4 , pp. 652-659
    • Correale, J.1    Fiol, M.2    Gilmore, W.3
  • 11
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347:911-20.
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 13
    • 33845695229 scopus 로고    scopus 로고
    • Multiple sclerosis and the hygiene hypothesis
    • DOI 10.1212/01.wnl.0000247663.40297.2d, PII 0000611420061212000045
    • Fleming JO, Cook TD. Multiple sclerosis and the hygiene hypothesis. Neurology. 2006;67:2085-6. (Pubitemid 44967402)
    • (2006) Neurology , vol.67 , Issue.11 , pp. 2085-2086
    • Fleming, J.O.1    Cook, T.D.2
  • 15
    • 79953306426 scopus 로고    scopus 로고
    • The impact of parasite infections on the course of multiple sclerosis
    • This paper clearly showed that helminths were indeed contributing to improve symptoms in MS patients, as clearance of parasites resulted in increased
    • • Correale J, Farez M. The impact of parasite infections on the course of multiple sclerosis. J Neuroimmunol. 2011;233:6-11. This paper clearly showed that helminths were indeed contributing to improve symptoms in MS patients, as clearance of parasites resulted in increased
    • (2011) J Neuroimmunol , vol.233 , pp. 6-11
    • Correale, J.1    Farez, M.2
  • 16
    • 84867176113 scopus 로고    scopus 로고
    • Helminth Infections and host immune regulation
    • This is an excellent review documenting how helminth infections modulate immune responses of the host, and describing the development of therapeutic possibilities from the study of helminth infections severity of symptoms
    • •• McSorley HJ, Maizels RM. Helminth Infections and host immune regulation. Clin Microbiol Rev. 2012;25:585-608. This is an excellent review documenting how helminth infections modulate immune responses of the host, and describing the development of therapeutic possibilities from the study of helminth infections severity of symptoms
    • (2012) Clin Microbiol Rev , vol.25 , pp. 585-608
    • McSorley, H.J.1    Maizels, R.M.2
  • 17
    • 84865305082 scopus 로고    scopus 로고
    • Susceptibility and immunity to helminth parasites
    • This paper describes the orchestration of different immunological pathways involved in susceptibility and immunity to helminth parasites
    • • Maizels RM, Hewitson JP, Smith KA. Susceptibility and immunity to helminth parasites. Curr Opin Immunol. 2012;24:459-66. This paper describes the orchestration of different immunological pathways involved in susceptibility and immunity to helminth parasites
    • (2012) Curr Opin Immunol , vol.24 , pp. 459-466
    • Maizels, R.M.1    Hewitson, J.P.2    Smith, K.A.3
  • 18
    • 52249091980 scopus 로고    scopus 로고
    • T-cell regulation in helminth parasite infections:Implications for inflammatory diseases
    • Maizels RM, Yazdanbakhsh M. T-cell regulation in helminth parasite infections:implications for inflammatory diseases. Chem Immunol Allergy. 2008;94:112-23.
    • (2008) Chem Immunol Allergy , vol.94 , pp. 112-123
    • Maizels, R.M.1    Yazdanbakhsh, M.2
  • 19
    • 78149238566 scopus 로고    scopus 로고
    • Natural helper cells: A new player in the innate response against helminth infection
    • Koyasu S, Moro K, Tanabe M, Takeuchi T. Natural helper cells: a new player in the innate response against helminth infection. Adv Immunol. 2010;108:21-44.
    • (2010) Adv Immunol , vol.108 , pp. 21-44
    • Koyasu, S.1    Moro, K.2    Tanabe, M.3    Takeuchi, T.4
  • 21
    • 45449115587 scopus 로고    scopus 로고
    • The intestinal epithelium: Sensors to effectors in nematode infection
    • DOI 10.1038/mi.2008.21, PII MI200821
    • Artis D, Grencis RK. The intestinal epithelium: sensors to effectors in nematode infection. Mucosal Immunol. 2008;1:252-64. (Pubitemid 351850532)
    • (2008) Mucosal Immunology , vol.1 , Issue.4 , pp. 252-264
    • Artis, D.1    Grencis, R.K.2
  • 22
    • 0037134046 scopus 로고    scopus 로고
    • Allergy, parasites and the hygiene hypothesis
    • Yazdanbakhsh M, Kremsner PG, van Ree R. Allergy, parasites and the hygiene hypothesis. Science. 2002;19:490-4.
    • (2002) Science , vol.19 , pp. 490-494
    • Yazdanbakhsh, M.1    Kremsner, P.G.2    Van Ree, R.3
  • 23
    • 40949083060 scopus 로고    scopus 로고
    • Infection with the roundworm Toxocara canis leads to exacerbation of experimental allergic airway inflammation
    • DOI 10.1111/j.1365-2222.2007.02908.x
    • Pinelli E, Brandes S, Dormans J, Gremmer E, van Loveren H. Infection with the roudworn Toxocara canis leads to exacerbation of experimental allergic airway inflammation. Clin Exp Allergy. 2008;38:649-58. (Pubitemid 351406060)
    • (2008) Clinical and Experimental Allergy , vol.38 , Issue.4 , pp. 649-658
    • Pinelli, E.1    Brandes, S.2    Dormans, J.3    Gremmer, E.4    Van Loveren, H.5
  • 25
    • 0030961515 scopus 로고    scopus 로고
    • Depression of antigen-specific interleukin-5 and interferon-γ responses in human lymphatic filariasis as a function of clinical status and age
    • Sartono E, Kruize YCM, KUrniawan-Atmadja A, Maizels RM, Yazdanbakhsh M. Depression of antigen-specific interleukin-5 and interferon-γ responses in human lymphatic filariasis as a function of clinical satus and age. J Infect Dis. 1997;175:1276-80. (Pubitemid 27176529)
    • (1997) Journal of Infectious Diseases , vol.175 , Issue.5 , pp. 1276-1280
    • Sartono, E.1    Kruize, Y.C.M.2    Kurniawan, A.3    Maizels, R.M.4    Yazdanbakhsh, M.5
  • 27
    • 58149337013 scopus 로고    scopus 로고
    • Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-β
    • Satoguina JS, Adjobimey T, Arndts K, Hoch J, Oldenburg J, Layland LE, et al. Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-β. Eur J Immunol. 2008;38:3101-13.
    • (2008) Eur J Immunol , vol.38 , pp. 3101-3113
    • Satoguina, J.S.1    Adjobimey, T.2    Arndts, K.3    Hoch, J.4    Oldenburg, J.5    Layland, L.E.6
  • 28
    • 0042825468 scopus 로고    scopus 로고
    • Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis
    • DOI 10.1128/IAI.71.9.4996-5004.2003
    • La Flamme AC, Ruddenklau K, Bäckström BT. Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis. Infect Immun. 2003;71:4996-5004. (Pubitemid 37070742)
    • (2003) Infection and Immunity , vol.71 , Issue.9 , pp. 4996-5004
    • La, F.A.C.1    Ruddenklau, K.2    Backstrom, B.T.3
  • 29
    • 0037254145 scopus 로고    scopus 로고
    • Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization
    • DOI 10.1093/intimm/dxg012
    • Sewell D, Qing Z, Reinke E, Elliot D, Weinstock J, Sandor M, et al. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int Immunol. 2003;15:59-69. (Pubitemid 36163769)
    • (2003) International Immunology , vol.15 , Issue.1 , pp. 59-69
    • Sewell, D.1    Qing, Z.2    Reinke, E.3    Elliot, D.4    Weinstock, J.5    Sandor, M.6    Fabry, Z.7
  • 30
    • 68149125252 scopus 로고    scopus 로고
    • Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses
    • Walsh KP, Brady MT, Finlay CM, Boon L, Mills KH. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J Immunol. 2009;183:1577-86.
    • (2009) J Immunol , vol.183 , pp. 1577-1586
    • Walsh, K.P.1    Brady, M.T.2    Finlay, C.M.3    Boon, L.4    Mills, K.H.5
  • 32
    • 76649116552 scopus 로고    scopus 로고
    • Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation
    • Wilson MS, Taylor MD, O'Gorman MT, Balic A, Barr TA, Filbery K, et al. Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation. Eur J Immunol. 2010;40:1682-96.
    • (2010) Eur J Immunol , vol.40 , pp. 1682-1696
    • Wilson, M.S.1    Taylor, M.D.2    O'Gorman, M.T.3    Balic, A.4    Barr, T.A.5    Filbery, K.6
  • 33
  • 34
    • 58849154974 scopus 로고    scopus 로고
    • Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of por-inflammatory mediators
    • Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T. Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of por-inflammatory mediators. Int J Parasitol. 2009;39:457-64.
    • (2009) Int J Parasitol , vol.39 , pp. 457-464
    • Osada, Y.1    Shimizu, S.2    Kumagai, T.3    Yamada, S.4    Kanazawa, T.5
  • 37
    • 84860360330 scopus 로고    scopus 로고
    • Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation
    • Kuijk LM, Klaver EJ, Kooij G, van der Pol SM, Heijnen P, Bruijns SC, et al. Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation. Mol Immunol. 2012;51:210-8.
    • (2012) Mol Immunol , vol.51 , pp. 210-218
    • Kuijk, L.M.1    Klaver, E.J.2    Kooij, G.3    Van Der Pol, S.M.4    Heijnen, P.5    Bruijns, S.C.6
  • 38
    • 79953785034 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis evolution was not modified by multiple infections with Strongyloides venezuelensis
    • Chiuso-Minicucci F, VAN DB, Zorzella-Pezavento SF, Peres RS, Ishikawa LL, Rosa LC, et al. Experimental autoimmune encephalomyelitis evolution was not modified by multiple infections with Strongyloides venezuelensis. Parasite Immunol. 2011;33:303-8.
    • (2011) Parasite Immunol , vol.33 , pp. 303-308
    • Chiuso-Minicucci, F.1    Van, D.B.2    Zorzella-Pezavento, S.F.3    Peres, R.S.4    Ishikawa, L.L.5    Rosa, L.C.6
  • 40
    • 79952108207 scopus 로고    scopus 로고
    • Infection of non-encapsualted species of Trichinella ameliorates experimental autoimmune encephalomyelitis involving suppression of Th17 and Th1 response
    • Wu Z, Nagano I, Asano K, Takahashi Y. Infection of non-encapsualted species of Trichinella ameliorates experimental autoimmune encephalomyelitis involving suppression of Th17 and Th1 response. Parasitol Res. 2010;107:1173-88.
    • (2010) Parasitol Res , vol.107 , pp. 1173-1188
    • Wu, Z.1    Nagano, I.2    Asano, K.3    Takahashi, Y.4
  • 41
    • 39849095840 scopus 로고    scopus 로고
    • Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response
    • Zheng X, Hu X, Zhou G, Lu Z, Qiu W, Bao J, et al. Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response. J Neuroimmunol. 2008;194:107-14.
    • (2008) J Neuroimmunol , vol.194 , pp. 107-114
    • Zheng, X.1    Hu, X.2    Zhou, G.3    Lu, Z.4    Qiu, W.5    Bao, J.6
  • 43
    • 84873444060 scopus 로고    scopus 로고
    • Immunomodulatory effects of helminths and protozoa in multiple sclerosis and experimental autoimmune encephalomyelitis
    • Hasseldam H, Hansen CS, Johansen FF. Immunomodulatory effects of helminths and protozoa in multiple sclerosis and experimental autoimmune encephalomyelitis. Parasite Immunol. 2013;35:103-8.
    • (2013) Parasite Immunol , vol.35 , pp. 103-108
    • Hasseldam, H.1    Hansen, C.S.2    Johansen, F.F.3
  • 44
    • 34247255906 scopus 로고    scopus 로고
    • Helminth Infection Enhances Disease in a Murine TH2 Model of Colitis
    • DOI 10.1053/j.gastro.2007.01.038, PII S0016508507001771
    • Hunter MM, Wang A, Hirota CL, McKay DM. Helminth infection enhances disease in a murine TH2 model of colitis. Gastroenterology. 2007;132:1320-30. (Pubitemid 46627574)
    • (2007) Gastroenterology , vol.132 , Issue.4 , pp. 1320-1330
    • Hunter, M.M.1    Wang, A.2    Mckay, D.M.3
  • 45
    • 33847679709 scopus 로고    scopus 로고
    • Association between parasite infection and immune responses in multiple sclerosis
    • DOI 10.1002/ana.21067
    • Correale J, Farez M. Association between parasite infection and immune responses in multiple sclerosis. Ann Neurol. 2007;61:97-108. (Pubitemid 46363837)
    • (2007) Annals of Neurology , vol.61 , Issue.2 , pp. 97-108
    • Correale, J.1    Farez, M.2
  • 46
    • 51549118693 scopus 로고    scopus 로고
    • Helminth infections associated with multiple sclerosis induce regulatory B cells
    • Correale J, Farez M, Razzitte G. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann Neurol. 2008;64:187-99.
    • (2008) Ann Neurol , vol.64 , pp. 187-199
    • Correale, J.1    Farez, M.2    Razzitte, G.3
  • 47
    • 73349085552 scopus 로고    scopus 로고
    • Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, place-bo- controlled clinical trial
    • Bager P, Arnved J, Rønborg S, Wohlfahrt J, Poulsen LK, Westergaard T, et al. Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, place-bo- controlled clinical trial. J Allergy Clin Immunol. 2010;125:123-30.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 123-130
    • Bager, P.1    Arnved, J.2    Rønborg, S.3    Wohlfahrt, J.4    Poulsen, L.K.5    Westergaard, T.6
  • 48
    • 17144402166 scopus 로고    scopus 로고
    • Trichuris suis therapy for active ulcerative colitis: A randomized controlled trial
    • DOI 10.1053/j.gastro.2005.01.005
    • Summers RW, Elliot DE, Urban Jr JF, Thompson RA, Weinstrock JV. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology. 2005;128:825-32. (Pubitemid 40523535)
    • (2005) Gastroenterology , vol.128 , Issue.4 , pp. 825-832
    • Summers, R.W.1    Elliott, D.E.2    Urban Jr., J.F.3    Thompson, R.A.4    Weinstock, J.V.5
  • 50
    • 79953299582 scopus 로고    scopus 로고
    • Probiotic helminth administration in relapsing-remitting multiple sclerosis: A phase 1 study
    • This paper describes the first human study using Trichura suis ova in relapsing remitting multiple sclerosis. Treatment was well-tolerated and favorable trends were observed in MRI and immunological assessments
    • .• Fleming JO, Isaak A, Lee JE, Luzzio CC, Carrithers MS, Cook TD, et al. Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study. Mult Scler. 2011;17:743-54. This paper describes the first human study using Trichura suis ova in relapsing remitting multiple sclerosis. Treatment was well-tolerated and favorable trends were observed in MRI and immunological assessments
    • (2011) Mult Scler , vol.17 , pp. 743-754
    • Fleming, J.O.1    Isaak, A.2    Lee, J.E.3    Luzzio, C.C.4    Carrithers, M.S.5    Cook, T.D.6
  • 51
    • 79952427391 scopus 로고    scopus 로고
    • Effect of hookworm infection on wheat challenge in celiac disease-a randomised double-blinded placebo controlled trial
    • Daveson AJ, Jones DM, Gaze S, McSorley H, Clouston A, Pascoe A, et al. Effect of hookworm infection on wheat challenge in celiac disease-a randomised double-blinded placebo controlled trial. PLos ONE. 2011;6:e17366.
    • (2011) PLos ONE , vol.6
    • Daveson, A.J.1    Jones, D.M.2    Gaze, S.3    McSorley, H.4    Clouston, A.5    Pascoe, A.6
  • 52
    • 84877109765 scopus 로고    scopus 로고
    • Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta
    • Graepel R, Leung G, Wang A, Villemaire M, Jirik FR, Sharkey KA, et al. Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta. Int J Parasitol. 2013;43:593-601.
    • (2013) Int J Parasitol , vol.43 , pp. 593-601
    • Graepel, R.1    Leung, G.2    Wang, A.3    Villemaire, M.4    Jirik, F.R.5    Sharkey, K.A.6
  • 53
    • 84873730193 scopus 로고    scopus 로고
    • Helminth therapy in multiple sclerosis
    • This is an excellent review on helminth therapy in multiple sclerosis
    • •• Fleming JO. Helminth therapy in multiple sclerosis. Int J Parasitol. 2013;43:259-74. This is an excellent review on helminth therapy in multiple sclerosis
    • (2013) Int J Parasitol , vol.43 , pp. 259-274
    • Fleming, J.O.1
  • 54
    • 84873719095 scopus 로고    scopus 로고
    • Prerequisites for the pharmaceutical industry to develop and commercialise helminthes and helminth-derived product therapy
    • Tilp C, Kapur V, Loging W, Erb KJ. Prerequisites for the pharmaceutical industry to develop and commercialise helminthes and helminth-derived product therapy. Int J Parasitol. 2013;43:319-25.
    • (2013) Int J Parasitol , vol.43 , pp. 319-325
    • Tilp, C.1    Kapur, V.2    Loging, W.3    Erb, K.J.4
  • 56
    • 84864359739 scopus 로고    scopus 로고
    • Immune monitoring of trichuris suis egg therapy in multiple sclerosis patients
    • Benzel F, Erdur H, Kholer S, Frentsch M, Thiel A, Harms L, et al. Immune monitoring of trichuris suis egg therapy in multiple sclerosis patients. J Helminthol. 2012;86:339-47.
    • (2012) J Helminthol , vol.86 , pp. 339-347
    • Benzel, F.1    Erdur, H.2    Kholer, S.3    Frentsch, M.4    Thiel, A.5    Harms, L.6
  • 57
    • 84899084516 scopus 로고    scopus 로고
    • Temporal changes in MRI activity, inflammation, immunomodualtion and gene expression in relapsing-remitting multiple sclerosis subjects treated with helminth probiotic Trichuris suis
    • Fleming J, Isaak A, Hardin LV, Huston J, Boland J, Broman AT, et al. Temporal changes in MRI activity, inflammation, immunomodualtion and gene expression in relapsing-remitting multiple sclerosis subjects treated with helminth probiotic Trichuris suis . Neurology. 2012;78:S30.004.
    • (2012) Neurology , vol.78
    • Fleming, J.1    Isaak, A.2    Hardin, L.V.3    Huston, J.4    Boland, J.5    Broman, A.T.6
  • 58
    • 84891713532 scopus 로고    scopus 로고
    • Trichuris suis ova in relapsing-remitting multiple sclerosis and clinically isolated syndrome (TRIONS): Study protocol for a randomized controlled trial
    • doi:10.1186/1745-6215-14-112.
    • Rosche B, Wernecke KD, Ohlaraun S, Dörr JM, Paul F. Trichuris suis ova in relapsing-remitting multiple sclerosis and clinically isolated syndrome (TRIONS): study protocol for a randomized controlled trial. Trials. 2013;14:112. doi:10.1186/1745-6215-14-112.
    • (2013) Trials , vol.14 , pp. 112
    • Rosche, B.1    Wernecke, K.D.2    Ohlaraun, S.3    Dörr, J.M.4    Paul, F.5
  • 60
    • 12344254603 scopus 로고    scopus 로고
    • Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis
    • DOI 10.1016/j.vaccine.2004.09.038, PII S0264410X04006954
    • Elias D, Akuffo H, Pawlowski A, Haile M, Schön T, Britton S. Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis . Vaccine. 2005;23:1326-34. (Pubitemid 40127324)
    • (2005) Vaccine , vol.23 , Issue.11 , pp. 1326-1334
    • Elias, D.1    Akuffo, H.2    Pawlowski, A.3    Haile, M.4    Schon, T.5    Britton, S.6
  • 62
    • 0030060748 scopus 로고    scopus 로고
    • Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni
    • Sabin EA, Araujo MI, Carvalho EM, Pearce EJ. Impairment of tetanus toxoid-specific Th1-like immune responses in human infected with Schistosoma mansoni. J Infect Dis. 1996;173:269-72. (Pubitemid 26006833)
    • (1996) Journal of Infectious Diseases , vol.173 , Issue.1 , pp. 269-272
    • Sabin, E.A.1    Araujo, M.I.2    Carvalho, E.M.3    Pearce, E.J.4
  • 63
  • 64
    • 1842691090 scopus 로고    scopus 로고
    • Does whipworm increase the pathogenicity of Campylobacter jejuni? A clinical correlate of an experimental observation
    • Shin J, Gardiner GW, Deitel W, Kandel G. Does whipworm increase the pathogenicity of Campylobacter jejuni? A clinical correlate of an experimental observation. Can J Gastroenterol. 2004;18:175-7. (Pubitemid 38477235)
    • (2004) Canadian Journal of Gastroenterology , vol.18 , Issue.3 , pp. 175-177
    • Shin, J.L.1    Gardiner, G.W.2    Deitel, W.3    Kandel, G.4
  • 65
    • 0037263753 scopus 로고    scopus 로고
    • Enhancement of disease and pathology by synergy of Trichuris suis and Campylobacter jejuni in the colon of immunologically naive swine
    • Mansfield LS, Gauthier DT, Abner SR, Jones KM, Wilder SR, Urban JF. Enhancement of disease and pathology by synergy of Trichuris suis and Campylobacter jejuni in the colon of immunologically naive swine. Am J Trop Med Hyg. 2003;63:70- 80.
    • (2003) Am J Trop Med Hyg , vol.63 , pp. 70-80
    • Mansfield, L.S.1    Gauthier, D.T.2    Abner, S.R.3    Jones, K.M.4    Wilder, S.R.5    Urban, J.F.6
  • 66
    • 84860281130 scopus 로고    scopus 로고
    • Helminthic therapy: Improving mucosal barrier function
    • Wolff MJ, Braodhurst MJ, Loke P. Helminthic therapy: improving mucosal barrier function. Trends Parasitol. 2012;28:187-94.
    • (2012) Trends Parasitol , vol.28 , pp. 187-194
    • Wolff, M.J.1    Braodhurst, M.J.2    Loke, P.3
  • 67
    • 58649122678 scopus 로고    scopus 로고
    • An update on the use of helminths to treat Crohn's and other autoimmune diseases
    • Reddy A, Fried B. An update on the use of helminths to treat Crohn's and other autoimmune diseases. Parasitol Res. 2009;104:217-21.
    • (2009) Parasitol Res , vol.104 , pp. 217-221
    • Reddy, A.1    Fried, B.2
  • 68
    • 59449106343 scopus 로고    scopus 로고
    • Parasitic helminthes: A pharmacopeia of anti-inflammatory molecules
    • Johnston MJG, MacDonald JA, McKay DM. Parasitic helminthes: a pharmacopeia of anti-inflammatory molecules. Parasitology. 2009;136:125-47.
    • (2009) Parasitology , vol.136 , pp. 125-147
    • Johnston, M.J.G.1    MacDonald, J.A.2    McKay, D.M.3
  • 70
    • 84869047053 scopus 로고    scopus 로고
    • The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites
    • Pineda MA, McGrath MA, Smith PC, Al-Riyami L, Rzepecka J, Gracie JA, et al. The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites. Arthritis Rheum. 2012;64:3168-78.
    • (2012) Arthritis Rheum , vol.64 , pp. 3168-3178
    • Pineda, M.A.1    McGrath, M.A.2    Smith, P.C.3    Al-Riyami, L.4    Rzepecka, J.5    Gracie, J.A.6
  • 71
    • 0034805790 scopus 로고    scopus 로고
    • A factor of inducing IgE from a filarial parasite prevents insulin-dependent diabetes mellitus in nonobese diabetic mice
    • DOI 10.1006/bbrc.2001.5471
    • Imai S, Tezuka H, Fujita K. A factor inducing IgE from a filarial parasite prevents insulin-dependent diabetes mellitus in nonobese diabetic mice. Biochem Biophys Res Commun. 2001;286:1051-8. (Pubitemid 32924878)
    • (2001) Biochemical and Biophysical Research Communications , vol.286 , Issue.5 , pp. 1051-1058
    • Imai, S.1    Tezuka, H.2    Fujita, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.