Evaluating enzymatic synthesis of small molecule drugs

Metabolic Engineering

Volumn 33, Issue , 2016, Pages 138-147

  Moura, Matthew ^a   Finkle, Justin ^b   Stainbrook, Sarah ^b   Greene, Jennifer ^a   Broadbelt, Linda J ^a,b   Tyo, Keith E J ^a,b  

^a Northwestern University   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Computational biology; Drug synthesis; Metabolic engineering; Pharmaceutical production; Predictive biochemistry

Indexed keywords

BIOCHEMISTRY; BIOINFORMATICS; BIOSYNTHESIS; METABOLIC ENGINEERING; MOLECULES; SUBSTRATES;

BIOCHEMICAL COUPLING; BIOCHEMICAL PATHWAY; BIOCHEMICAL REACTIONS; COMMODITY CHEMICALS; COMPUTATIONAL BIOLOGY; DRUG SYNTHESIS; PHARMACEUTICAL PRODUCTION; SMALL-MOLECULE DRUGS;

SYNTHESIS (CHEMICAL);

DRUG; ENZYME; LEVO TERT LEUCINE; PYRAZINAMIDE; SMALL MOLECULE DRUG; TENOFOVIR; UNCLASSIFIED DRUG; MULTIENZYME COMPLEX; PEPTIDE;

ARTICLE; BIOCHEMISTRY; BIOSYNTHESIS; DRUG METABOLISM; DRUG SYNTHESIS; ENDEMIC DISEASE; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN IMMUNODEFICIENCY VIRUS; MOLECULE; PRECURSOR; PRIORITY JOURNAL; THERMODYNAMICS; TUBERCULOSIS; BIOLOGICAL MODEL; COMPUTER SIMULATION; ESCHERICHIA COLI; GENETICS; METABOLIC FLUX ANALYSIS; METABOLISM; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; SOFTWARE;

BIOSYNTHETIC PATHWAYS; COMPUTER SIMULATION; ESCHERICHIA COLI; METABOLIC FLUX ANALYSIS; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; PEPTIDES; PHARMACEUTICAL PREPARATIONS; SIGNAL TRANSDUCTION; SOFTWARE;

EID: 84951989340     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2015.11.006     Document Type: Article

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