Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients

Blood

Volumn 92, Issue 5, 1998, Pages 1549-1555

  Rooney, Cliona M ^a   Smith, Colton A ^b   Ng, Catherine Y C ^b   Loftin, Susan K ^b   Sixbey, John W ^b   Gan, Yanjun ^b   Srivastava, Deo Kumar ^b   Bowman, Laura C ^b   Krance, Robert A ^b   Brenner, Malcolm K ^b   Heslop, Helen E ^b  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; VIRUS DNA;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ANTIVIRAL ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS; FEMALE; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNOPROPHYLAXIS; INFANT; LYMPHOMA; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; RECIPIENT; VIRUS CARCINOGENESIS;

EID: 0032170108     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.5.1549     Document Type: Article

References (38)

1. Barber LD, Parham P: Peptide binding to major histocompatibility complex molecules. Annu Rev Cell Biol 9:163, 1993
2. Janeway CA, Bottomly K: Signals and signs for lymphocyte responses. Cell 76:275, 1994
3. Lanzavecchia A: Identifying strategies for immune intervention. Science 260:937, 1993
4. Nanda NK, Sercarz EE: Induction of anti-self-immunity to cure cancer. Cell 82:13, 1995
5. Cheever MA, Disis ML, Bernhard H, Gralow JR, Hand SL, Huseby ES, Qin HL, Takahashi M, Chen W: Immunity to oncogenic proteins. Immunol Rev 145:33, 1995
6. Houghton AN: Cancer antigens: Immune recognition of self and altered self. J Exp Med 180:1, 1994
7. Riddell SR, Greenberg PD: Principles for adoptive T cell therapy of human viral diseases. Annu Rev Immunol 13:545, 1995
8. Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, Riddell SR: Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 333:1038, 1995
9. Rickinson AB, Moss DJ: Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Annu Rev Immunol 15:405, 1997
10. Ambinder RF, Browning PJ, Lorenzana I, Leventhal BG, Cosenza H, Mann RB, Macmahon EME, Medina R, Cardona V, Grufferman S, Olshan A, Levin A, Petersen EA, Blattner W, Levine PH: Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States. Blood 81:462, 1993
11. Straus SE, Cohen JI, Tosato G, Meier J: Epstein-Barr virus infections: Biology, pathogenesis and management. Ann Intern Med 118:45, 1992
12. Rickinson AB, Kieff E: Epstein-Barr virus, in Fields BN, Knipe DM, Howley PM (eds): Fields Virology. Philadelphia, PA, Lipincott-Raven, 1996, p 2397
13. Skinner JC, Gilbert EF, Hong R, Bozdech MJ, Flynn B, Borcherding W, Haiez GR, Arya S, Trigg ME, Finlay JL, Sondel PM: B cell lymphoproliferative disorders following T cell depleted allogeneic bone marrow transplantation. Am J Pediatr Hematol Oncol 10:112, 1988
14. Shapiro RS, McClain K. Frizzera G, Gajl-Peczalska KJ, Kersey JH, Blazar BR, Arthur DC, Patton DF, Greenberg JS, Burke B, Ramsay NKC, McGlave P, Filipovich AH: Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation. Blood 71:1234, 1988
15. Lucas K, Small T, Heller G. Dupont B, O'Reilly RJ: The development of cellular immunity to Epstein-Barr virus after allogeneic bone marrow transplantation. Blood 87:2594, 1996
16. Zutter MM, Martin PJ, Sale GE, Shulman HM, Fisher L, Thomas ED, Durnam DM: Epstein-Barr virus lymphoproliferation after bone marrow transplantation. Blood 72:520, 1988
17. Gerritsen EJ, Stam ED, Hermans J, van den Berg H, Haraldsson A, van Tol MJ, van den Bergh RL, Waaijer JL, Kroes AC, Kluin PM, Vosssen JM: Risk factors for developing EBV-related B cell lymphoproliferative disorders (BLPD) after non-HLA-identical BMT in children. Bone Marrow Transplant 18:377, 1996
18. Heslop HE, Rooney CM: Adoptive immunotherapy of EBV lymphoproliferative diseases. Immunol Rev 157:217, 1997
19. Papadopoulos EB, Ladanyi M, Emanuel D, MacKinnon S, Boulad F, Carabasi MH, Castro-Malaspina H, Childs BH, Gillio AP, Small TN, Young JW, Kernan NA, O'Reilly RJ: Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation. N Engl J Med 330:1185, 1994
20. Heslop HE, Brenner MK, Rooney CM: Donor T cells to treat EBV-associated lymphoma. N Engl J Med 331:679, 1994
21. Rooney CM, Smith CA, Ng C, Loftin SK, Li C, Krance RA, Brenner MK, Heslop HE: Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr virus-related lymphoproliferation. Lancet 345:9, 1995
22. Heslop HE, Ng CYC, Li C, Smith CA, Loftin SK, Krance RA, Brenner MK, Rooney CM: Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. Nat Med 2:551, 1996
23. Hongeng S, Krance RA, Bowman LC, Srivastava DK, Cunningham JM, Horwitz EM, Brenner MK, Heslop HE: Outcomes of transplantation with matched-sibling and unrelated-donor bone marrow in children with leukemia. Lancet 350:767, 1997
24. Heslop HE, Brenner MK, Rooney CM, Krance RA, Roberts WM, Rochester R, Smith CA, Turner V, Sixbey J, Moen R, Boyett JM: Administration of neomycin-resistance-gene-marked EBV-scecific cytotoxic T lymphocytes to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts. Hum Gene Ther 5:381, 1994
25. Smith CA, Ng CYC, Heslop HE, Holladay MS, Richardson S, Turner EV, Loftin SK, Li C, Brenner MK, Rooney CM: Production of genetically modified EBV-specific cytotoxic T cells for adoptive transfer to patients at high risk of EBV-associated lymphoproliferative disease. J Hematother 4:73, 1995
26. Brenner MK, Rill DR, Holladay MS, Heslop HE, Moen RC, Buschle M, Krance RA, Santana VM, Anderson WF, Ihle JN: Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients. Lancet 342:1134, 1993
27. Bagasra O, Seshamma T, Pomerantz RJ: Polymerase chain reaction in situ: Intracellular amplification and detection of HIV-1 proviral DNA and other specific genes. J Immunol Methods 158:131, 1993
28. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED: Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 18:295, 1974
29. Bourgault I, Gomez A, Gomard E, Levy JP: Limiting-dilution analysis of the HLA restriction of anti-Epstein-Barr virus-specific cytolytic T lymphocytes. Clin Exp Immunol 84:501, 1991
30. Rooney CM, Loftin SK, Holladay MS, Brenner MK, Krance RA, Heslop HE: Early identification of Epstein-Barr virus-associated posttransplant lymphoproliferative disease. Br J Haematol 89:98, 1995
31. Savoie A, Perpete C, Carpentier L, Joncas J, Alfieri C: Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease. Blood 83:2715, 1994
32. Riddler SA, Breinig MC, McKnight JLC: Increased levels of circulating Epstein-Barr virus (EBV)-infected lymphocytes and decreased EBV nuclear antigen antibody responses are associated with the development of posttransplant lymphoproliferative disease in solid-organ transplant recipients. Blood 84:972, 1994
33. Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD: Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238, 1992
34. Matloubian M, Concepcion RJ, Ahmed R: CD4+ T cells are required to sustain CD8+ cytotoxic T cell responses during chronic viral infection. J Virol 68:8056, 1994
35. Cardin RD, Brooks JW, Sarawar SR, Doherty PC: Progressive loss of CD8(+) T cell-mediated control of a gamma-herpesvirus in the absence of CD4(+) T cells. J Exp Med 184:863, 1996
36. Romani N, Gruner S, Brang D, Kampgen E, Lenz A, Trockenbacher B, Konwalinka G, Fritsch PO, Steinman RM, Schuler G: Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83, 1994
37. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 392:245, 1998
38. Roskrow MA, Suzuki N, Brenner MK, Rooney CM: Genetically modified dendritic cells generate primary and memory tumor antigen-specific cytotoxic T lymphocytes. Blood 10:87a, 1996 (abstr, suppl 1)