Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation

Cornea

Volumn 35, Issue 1, 2016, Pages 105-113

  Lee, Whayoung ^a   Miyagawa, Yuko ^a   Long, Cassandra ^a   Ekser, Burcin ^b   Walters, Eric ^c   Ramsoondar, Jagdeece ^d   Ayares, David ^d   Tector, A Joseph ^b   Cooper, David K C ^a   Hara, Hidetaka ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c National Swine Resource and Research Center   (United States)

^d REVIVICOR INC   (United States)

Author keywords

anti pig; antibody; cornea; immune response; N glycolylneuraminic acid; pig; porcine; xenotransplantation

Indexed keywords

GALACTOSYLGALACTOSE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; N GLYCOLOYLNEURAMINIC ACID; N-GLYCOLYLNEURAMINIC ACID; NEURAMINIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN BINDING; AORTIC TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA TRANSPLANTATION; CORNEAL TISSUE; ENDOTHELIUM CELL; FLOW CYTOMETRY; GALACTOSYLTRANSFERASE GENE KNOCKOUT PIG; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; NONHUMAN; PIG; PRIORITY JOURNAL; ANIMAL; CELL CULTURE; CORNEA; CORNEAL DISEASES; METABOLISM; PATHOLOGY; XENOGRAFT;

ANIMALS; CELLS, CULTURED; CORNEA; CORNEAL DISEASES; CORNEAL TRANSPLANTATION; FLOW CYTOMETRY; HUMANS; NEURAMINIC ACIDS; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84951905622     PISSN: 02773740     EISSN: 15364798     Source Type: Journal    
DOI: 10.1097/ICO.0000000000000635     Document Type: Article

References (27)

1. Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science. 2003;299:411-414.
2. Lutz AJ, Li P, Estrada JL, et al. Double knockout pigs deficient in Nglycolylneuraminic acid and galactose alpha-1,3-galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation. 2013;20: 27-35.
3. Zhu A, Hurst R. Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum. Xenotransplantation. 2002;9:376-381.
4. Salama A, Evanno G, Harb J, et al. Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation. Xenotransplantation. 2015; 22:85-94.
5. Miwa Y, Kobayashi T, Nagasaka T, et al. Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-to-human xenotransplantation? Xenotransplantation. 2004;11:247-253.
6. Padler-Karavani V, Varki A. Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk. Xenotransplantation. 2011;18:1-5.
7. Bardor M, Nguyen DH, Diaz S, et al. Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells. J Biol Chem. 2005;80:4228-4237.
8. Bouhours D, Pourcel C, Bouhours JE. Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gala1-3Gal), blood group H determinant and N-glycolylneuraminic acid. Glycoconj J. 1996;13:947-953.
9. Burlak C, Paris LL, Lutz AJ, et al. Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs. Am J Transplant. 2014;14:1895-1900.
10. Hara H, Cooper DK. The immunology of corneal xenotransplantation: a review of the literature. Xenotransplantation. 2010;17:338-349.
11. Choi HJ, Kim MK, Lee HJ, et al. Efficacy of pig-to-rhesus lamellar corneal xenotransplantation. Invest Ophthalmol Vis Sci. 2011;52: 6643-6650.
12. Vabres B, Le Bas-Bernardet S, Riochet D, et al. hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model. Xenotransplantation. 2014;21:431-443.
13. Scobie L, Padler-Karavani V, Le Bas-Bernardet S, et al. Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts. J Immunol. 2013;191: 2907-2915.
14. Stone KR, Abdel-Motal UM, Walgenbach AW, et al. Replacement of human anterior cruciate ligaments with pig ligaments: a model for antinon-gal antibody response in long-term xenotransplantation. Transplantation. 2007;83:211-219.
15. Cohen D, Miyagawa Y, Mehra R, et al. Distribution of non-gal antigens in pig cornea: relevance to corneal xenotransplantation. Cornea. 2014; 33:390-397.
16. Hara H, Koike N, Long C, et al. Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs. Invest Ophthalmol Vis Sci. 2011;52:5278-5286.
17. Choi HJ, Lee JJ, Kim DH, et al. Blockade of CD40-CD154 costimulatory pathway promotes long-term survival of full-thickness porcine corneal grafts in nonhuman primates: clinically applicable xenocorneal transplantation. Am J Transplant. 2015;15:628-641.
18. Kim YG, Oh JY, Gil GC, et al. Identification of alpha-Gal and non-Gal epitopes in pig corneal endothelial cells and keratocytes by using mass spectrometry. Curr Eye Res. 2009;34:877-895.
19. Fujita M, Mehra R, Lee SE, et al. Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells. Ophthalmic Res. 2013;49:127-138.
20. Hara H, Long C, Lin YJ, et al. In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transpl Int. 2008;21:1163-1174.
21. Lee SE, Mehra R, Fujita M, et al. Characterization of porcine corneal endothelium for xenotransplantation. Semin Ophthalmol. 2014;29:127-135.
22. Burlak C, Bern M, Brito AE, et al. N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens. Xenotransplantation. 2013;20:277-291.
23. Barone A, Benktander J, Teneberg S, et al. Characterization of acid and non-acid glycosphingolipids of porcine heart valve cusps as potential immune targets in biological heart valve grafts. Xenotransplantation. 2014;21:510-522.
24. Byrne GW, Du Z, Stalboerger P, et al. Cloning and expression of porcine beta1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen. Xenotransplantation. 2014;21:543-554.
25. Park HM, Kim YW, Kim KJ, et al. Comparative N-linked glycan analysis of wild-type and alpha1,3-galactosyltransferase gene knock-out pig fibroblasts using mass spectrometry approaches. Mol Cells. 2015;38: 65-74.
26. Park JY, Park MR, Kwon DN, et al. Alpha 1,3-galactosyltransferase deficiency in pigs increases sialyltransferase activities that potentially raise non-gal xenoantigenicity. J Biomed Biotechnol. 2011;2011:560850.
27. Samraj AN, Pearce OM, Laubli H, et al. A red meat-derived glycan promotes inflammation and cancer progression. Proc Natl Acad Sci U S A. 2015;112:542-547.