Efficacy of pig-to-rhesus lamellar corneal xenotransplantation

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 9, 2011, Pages 6643-6650

  Choi, Hyuk Jin ^a,b,c   Kim, Mee Kum ^b,c   Lee, Hyun Ju ^c   Ko, Jung Hwa ^c   Jeong, So Hee ^c   Lee, Jae Il ^a   Oh, Byoung Chol ^d   Kang, Hee Jung ^e   Wee, Won Ryang ^b,c  

^a Seoul National University Hospital Healthcare System Gangnam Center   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Seoul National University Biomedical Research Institute   (South Korea)

^d Seoul National University Hospital   (South Korea)

^e Hallym University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; DEXAMETHASONE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LEVOFLOXACIN; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; PREDNISOLONE ACETATE; ALPHA GALACTOSIDASE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; CORNEA THICKNESS; CORNEA TRANSPLANTATION; DRUG DOSE REDUCTION; EDEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT REJECTION; HISTOLOGY; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; INTRAOCULAR PRESSURE; MACROPHAGE; MEMORY T LYMPHOCYTE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; RHESUS MONKEY; SLIT LAMP; SWINE; T LYMPHOCYTE SUBPOPULATION; THERAPY EFFECT; XENOGRAFT; ANIMAL; AQUEOUS HUMOR; BLOOD; CD4+ T LYMPHOCYTE; CORNEA; FLUORESCENT ANTIBODY TECHNIQUE; GRAFT SURVIVAL; IMMUNOLOGY; MACACA MULATTA; MINIPIG; PATHOLOGY; PHYSIOLOGY;

ALPHA-GALACTOSIDASE; ANIMALS; AQUEOUS HUMOR; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COMPLEMENT SYSTEM PROTEINS; CORNEA; CORNEAL TRANSPLANTATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MACACA MULATTA; MACROPHAGES; SWINE; SWINE, MINIATURE; TRANSPLANTATION, HETEROLOGOUS;

EID: 80054787867     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7273     Document Type: Article

References (31)

1. Zeng Y, Yang J, Huang K, Lee Z, Lee X. A comparison of biomechanical properties between human and porcine cornea. J Biomech. 2001;34:533-537.
2. Amano S, Shimomura N, Kaji Y, Ishii K, Yamagami S, Araie M. Antigenicity of porcine cornea as xenograft. Curr Eye Res. 2003; 26:313-318.
3. Lee HI, Kim MK, Oh JY, et al. Gal alpha(1-3)Gal expression of the cornea in vitro, in vivo and in xenotransplantation. Xenotransplantation. 2007;14:612-618.
4. Cooper DK. Clinical xenotransplantion: how close are we? Lancet. 2003;362:557-559.
5. Sprangers B, Waer M, Billiau AD. Xenotransplantation: where are we in 2008? Kidney Int. 2008;74:14-21.
6. Cozzi E, Gianello P, Soulillou JP. A new start for xenotransplantation research in the European Union. Xenotransplantation. 2007; 14:196-197.
7. Soulillou JP. How and when will cardiac xenotransplantation enter the clinic?-the recurrent debate has gained in realism. Nat Clin Pract Cardiovasc Med. 2005;2:550-551.
8. Cooper DK, Casu A. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes: 4, pre-clinical efficacy and complication data required to justify a clinical trial. Xenotransplantation. 2009;16:229-238.
9. Hering BJ, Cooper DK, Cozzi E, et al. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes: executive summary. Xenotransplantation. 2009;16:196-202.
10. Pierson RN 3rd, Dorling A, Ayares D, et al. Current status of xenotransplantation and prospects for clinical application. Xenotransplantation. 2009;16:263-280.
11. Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med. 2005;11:1295-1298.
12. Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med. 2005;11:29-31.
13. Hara H, Cooper DK. The immunology of corneal xenotransplantation: a review of the literature. Xenotransplantation. 2010;17:338-349.
14. Xu YG, Xu YS, Huang C, Feng Y, Li Y, Wang W. Development of a rabbit corneal equivalent using an acellular corneal matrix of a porcine substrate. Mol Vis. 2008;14:2180-2189.
15. Shah A, Brugnano J, Sun S, Vase A, Orwin E. The development of a tissue-engineered cornea: biomaterials and culture methods. Pediatr Res. 2008;63:535-544.
16. Lin XC, Hui YN, Wang YS, Meng H, Zhang YJ, Jin Y. Lamellar keratoplasty with a graft of lyophilized acellular porcine corneal stroma in the rabbit. Vet Ophthalmol. 2008;11:61-66.
17. Fu Y, Fan X, Chen P, Shao C, Lu W. Reconstruction of a tissueengineered cornea with porcine corneal acellular matrix as the scaffold. Cells Tissues Organs. 2010;191:193-202.
18. Oh JY, Kim MK, Lee HJ, Ko JH, Wee WR, Lee JH. Processing porcine cornea for biomedical applications. Tissue Eng Part C Methods. 2009;15:635-645.
19. Hashimoto Y, Funamoto S, Sasaki S, et al. Preparation and characterization of decellularized cornea using high-hydrostatic pressurization for corneal tissue engineering. Biomaterials. 2010;31: 3941-3948.
20. Pang K, Du L, Wu X. A rabbit anterior cornea replacement derived from acellular porcine cornea matrix, epithelial cells and keratocytes. Biomaterials. 2010;31:7257-7265.
21. Cursiefen C. Immune privilege and angiogenic privilege of the cornea. Chem Immunol Allergy. 2007;92:50-57.
22. Zhiqiang P, Cun S, Ying J, Ningli W, Li W. WZS-pig is a potential donor alternative in corneal xenotransplantation. Xenotransplantation. 2007;14:603-611.
23. Niederkorn JY, Stevens C, Mellon J, Mayhew E. CD4+ T-cellindependent rejection of corneal allografts. Transplantation. 2006;81:1171-1178.
24. Oh JY, Kim MK, Ko JH, et al. Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation. Xenotransplantation. 2009;16:74-82.
25. Oh JY, Kim MK, Ko JH, et al. Histological differences in fullthickness vs. lamellar corneal pig-to-rabbit xenotransplantation. Vet Ophthalmol. 2009;12:78-82.
26. Kim MK, Oh JY, Lee HI, et al. Susceptibility of porcine keratocytes to immune-mediated damage in xeno-related rejection. Transplant Proc. 2008;40:564-569.
27. Oh JY, Kim MK, Lee HJ, et al. Complement depletion with cobra venom factor delays acute cell-mediated rejection in pig-tomouse corneal xenotransplantation. Xenotransplantation. 2010;17:140-146.
28. Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science. 2003;299:411-414.
29. Schuurman HJ, Pino-Chavez G, Phillips MJ, Thomas L, White DJ, Cozzi E. Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donors. Transplantation. 2002;73:1146-1151.
30. Niemann H, Verhoeyen E, Wonigeit K, et al. Cytomegalovirus early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection. Transplantation. 2001;72:1898-1906.
31. Cozzi E, White DJ. The generation of transgenic pigs as potential organ donors for humans. Nat Med. 1995;1:964-966.