Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs

American Journal of Transplantation

Volumn 14, Issue 8, 2014, Pages 1895-1900

  Burlak, C ^a   Paris, L L ^a   Lutz, A J ^a   Sidner, R A ^a   Estrada, J ^a   Li, P ^a   Tector, M ^b   Tector, A J ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY HEALTH   (United States)

Author keywords

Antibody mediated rejection; crossmatch; genetically modified pigs; xenotransplantation

Indexed keywords

ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; ALPHA 1,3 GALACTOSYLTRANSFERASE; CARBOHYDRATE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; ALPHA-1,3-GALACTOSYLTRANSFERASE 1, PORCINE; ANTIBODY; EPITOPE; GALACTOSYLTRANSFERASE; PROTEIN BINDING;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CHIMPANZEE; DNA MODIFICATION; GALACTOSYLTRANSFERASE GENE KNOCKOUT PIG; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; ADOLESCENT; ADULT; AGED; ANIMAL; CHEMISTRY; CYTOLOGY; FEMALE; GENETICS; GRAFT REJECTION; MALE; MIDDLE AGED; MONONUCLEAR CELL; PAN TROGLODYTES; PIG; TRANSGENIC ANIMAL; XENOGRAFT;

ADOLESCENT; ADULT; AGED; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES; CARBOHYDRATES; EPITOPES; FEMALE; GALACTOSYLTRANSFERASES; GENE DELETION; GRAFT REJECTION; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PAN TROGLODYTES; PROTEIN BINDING; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84904632010     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12744     Document Type: Article

References (28)

1. Burlak C, Wang Z-Y, Chihara RK, et al. Identification of human preformed antibody targets in GTKO pigs. Xenotransplantation 2012; 19: 92-101.
2. Byrne GW, Stalboerger PG, Du Z, Davis TR, McGregor CGA., Identification of new carbohydrate and membrane protein antigens in cardiac xenotransplantation. Transplantation 2011; 91: 287-292.
3. Reemtsma K, McCracken BH, Schlegel JU., Renal heterotransplantation in man. Ann Surg 1964; 160: 384-408. Available at: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC1408776/. Accessed February 7, 2014.
4. Starzl TE, Marchioro TL, Peters GN, Kirkpatrick CH., Renal heterotransplantation from baboon to man: Experience with 6 cases. Transplantation 1964; 2: 752-776. Available at: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2972727/. Accessed February 7, 2014.
5. Hardy MA, ed. Xenograft 25. Amsterdam: Elsevier Science Publishers B.V., 1989.
6. Cowan PJ, Cooper DKC, d'Apice AJF., Kidney xenotransplantation. Kidney Int 2014; 85: 265-275.
7. Lin SS, Weidner BC, Byrne GW, et al. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J Clin Invest 1998; 101: 1745-1756. Available at: http://www.jci.org/articles/view/2134. Accessed February 7, 2014.
8. Galili U., α1, 3Galactosyltransferase knockout pigs produce the natural anti-Gal antibody and simulate the evolutionary appearance of this antibody in primates. Xenotransplantation 2013; 20: 267-276.
9. Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295-1298.
10. Yamada K, Yazawa K, Shimizu A, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of α1, 3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2004; 11: 32-34. Available at: http://www.nature.com/doifinder/10.1038/nm1172. Accessed February 7, 2014.
11. Varki A, Gagneux P., Human-specific evolution of sialic acid targets: Explaining the malignant malaria mystery ? Proc Natl Acad Sci U S A 2009; 106: 14739-14740. Available at: http://www.pnas.org/content/106/35/14739.long. Accessed February 7, 2014.
12. Kwon D-N, Lee K, Kang M-J, et al. Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs. Sci Rep 2013; 3: 1981.
13. Scobie L, Padler-Karavani V, Le Bas-Bernardet S, et al. Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts. J Immunol 2013; 191: 2907-2915.
14. Lutz AJ, Li P, Estrada JL, et al. Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation 2013; 20: 27-35.
15. Lai L., Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 1089-1092.
16. Kolber-Simonds D, Lai LX, Watt SR, et al. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci U S A 2004; 101: 7335-7340.
17. Hauschild J, Petersen B, Santiago Y, et al. Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci U S A 2011; 108: 12013-12017.
18. Li P, Estrada JL, Burlak C, Tector AJ., Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases. J Immunol 2006; 176: 2448-2454.
19. Porter KA, Marchioro TL, Starzl TE., Pathological changes in six treated baboon-to-man renal heterotransplants. Br J Urol 1965; 37: 274-284.
20. Starzl TE., Experience in renal transplantation. Philadelphia: WB Saunders Company, 1964.
21. Jordan SC, Vo AA, Peng A, Toyoda M, Tyan D., Intravenous gammaglobulin (IVIG): A novel approach to improve transplant rates and outcomes in highly HLA-sensitized patients. Am J Transplant 2006; 6: 459-466.
22. Shimizu A, Hisashi Y, Kuwaki K, et al. Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha 1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol 2008; 172: 1471-1481.
23. Byrne GW, Davies WR, Oi K, et al. Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival. Transplantation 2006; 82: 1787-1791. Available at: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink. fcgi?dbfrom=pubmed&id=17198277&retmode=ref&cmd=prlinks. Accessed February 7, 2014.
24. Tan W, Carlson DF, Lancto CA, et al. Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci U S A 2013; 110: 16526-16531.
25. Sharma A, Naziruddin B, Cui C, et al. Pig cells that lack the gene for alpha 1-3 galactosyltransferase express low levels of the gal antigen. Transplantation 2003; 75: 430-436.
26. Diswall M, Ångström J, Karlsson H, et al. Structural characterization of alpha 1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies. Xenotransplantation 2010; 17: 48-60.
27. Puga Yung GL, Li Y, Borsig L, et al. Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1, 3galactosyltransferase knock-out pigs. Xenotransplantation 2012; 19: 196-206.
28. Milland J, Christiansen D, Lazarus BD, Taylor SG, Xing P-X, Sandrin MS., The molecular basis for Galα(1,3)Gal expression in animals with a deletion of the α1,3galactosyltransferase gene. J Immunol [Internet] 2006; 176: 2448-2454. Available at: http://www.jimmunol.org/content/176/4/2448.short. Accessed February 7, 2014.