Alpha 1,3-galactosyltransferase deficiency in pigs increases sialyltransferase activities that potentially raise non-gal xenoantigenicity

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Park, Jong Yi ^a   Park, Mi Ryung ^a   Kwon, Deug Nam ^a   Kang, Min Hui ^a   Oh, Mihye ^a   Han, Jae Woong ^a   Cho, Ssang Goo ^a   Park, Chankyu ^a   Kim, Dong Ku ^a   Song, Hyuk ^b   Oh, Jae Wook ^a   Kim, Jin Hoi ^a  

^a Konkuk University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; ALPHA 2,3 SIALYLTRANSFERASE; ALPHA 2,6 SIALYLTRANSFERASE; CYTIDINE PHOSPHATE N ACETYLNEURAMINIC ACID; EPITOPE; GLYCOCONJUGATE; ISOCITRATE DEHYDROGENASE (NAD); LECTIN; N GLYCOLOYLNEURAMINIC ACID; SIALIC ACID; SIALYLTRANSFERASE; UNCLASSIFIED DRUG; ALPHA 1,3 GALACTOSYLTRANSFERASE 1, PORCINE; ALPHA-1,3-GALACTOSYLTRANSFERASE 1, PORCINE; BETA D GALACTOSIDE ALPHA 2 6 SIALYLTRANSFERASE; BETA-D-GALACTOSIDE ALPHA 2-6-SIALYLTRANSFERASE; CMPACETYLNEURAMINATE MONOOXYGENASE; GALACTOSYLTRANSFERASE; GLYCOPROTEIN; HETEROPHILE ANTIGEN; ISOCITRATE DEHYDROGENASE; MIXED FUNCTION OXIDASE; N-GLYCOLYLNEURAMINIC ACID; NEURAMINIC ACID DERIVATIVE; SIALIDASE; TRANS SIALIDASE; TRANS-SIALIDASE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; ANIMAL; ENZYMOLOGY; GENETICS; LIVER; METABOLISM;

SUIDAE;

ANIMALS; ANTIGENS, HETEROPHILE; EPITOPES; GALACTOSYLTRANSFERASES; GENE DELETION; GLYCOCONJUGATES; GLYCOPROTEINS; ISOCITRATE DEHYDROGENASE; LIVER; MIXED FUNCTION OXYGENASES; NEURAMINIC ACIDS; NEURAMINIDASE; SIALYLTRANSFERASES; SWINE;

EID: 84855175325     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/560850     Document Type: Article

References (28)

1. Sandrin M. S., McKenzie I. F., Gal (1,3)Gal, the major xenoantigen(s) recognised in pigs by human natural antibodies Immunological Reviews 1994 141 169 190
2. Galili U., Shohet S. B., Kobrin E., Stults C. L., Macher B. A., Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells Journal of Biological Chemistry 1988 263 33 17755 17762
3. Dai Y., Vaught T. D., Boone J., Chen S. H., Phelps C. J., Ball S., Monahan J. A., Jobst P. M., McCreath K. J., Lamborn A. E., Cowell-Lucero J. L., Wells K. D., Colman A., Polejaeva I. A., Ayares D. L., Targeted disruption of the 1,3-galactosyltransferase gene in cloned pigs Nature Biotechnology 2002 20 3 251 255 (Pubitemid 34205417)
4. Lai L., Kolber-Simonds D., Park K. W., Cheong H. T., Greenstein J. L., Im G. S., Samuel M., Bonk A., Rieke A., Day B. N., Murphy C. N., Carter D. B., Hawley R. J., Prather R. S., Production of -1,3-galactosyltransferase knockout pigs by nuclear transfer cloning Science 2002 295 5557 1089 1092 (Pubitemid 34132242)
5. Kuwaki K., Tseng Y. L., Dor F. J., Shimizu A., Houser S. L., Sanderson T. M., Lancos C. J., Prabharasuth D. D., Cheng J., Moran K., Hisashi Y., Mueller N., Yamada K., Greenstein J. L., Hawley R. J., Patience C., Awwad M., Fishman J. A., Robson S. C., Schuurman H. J., Sachs D. H., Cooper D. K. C., Heart transplantation in baboons using 1,3-galactosyltransferase gene-knockout pigs as donors: initial experience Nature Medicine 2005 11 1 29 31 (Pubitemid 40215833)
6. Ahn K. S., Kim Y. J., Kim M., Lee B. H., Heo S. Y., Kang M. J., Kang Y. K., Lee J. W., Lee K. K., Kim J. H., Nho W. G., Hwang S. S., Woo J. S., Park J. K., Park S. B., Shim H., Resurrection of an alpha-1,3-galactosyltransferase gene-targeted miniature pig by recloning using postmortem ear skin fibroblasts Theriogenology 2011 75 5 933 939
7. Ezzelarab M., Ayares D., Cooper D. K. C., Carbohydrates in xenotransplantation Immunology and Cell Biology 2005 83 4 396 404 (Pubitemid 41044617)
8. Shimizu A., Hisashi Y., Kuwaki K., Tseng Y. L., Dor F. J. M. F., Houser S. L., Robson S. C., Schuurman H. J., Cooper D. K. C., Sachs D. H., Yamada K., Colvin R. B., Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from 1,3-galactosyltransferase gene-knockout pigs in baboons The American Journal of Pathology 2008 172 6 1471 1481 (Pubitemid 351793341)
9. Ezzelarab M., Ayares D., Cooper D. K., Carbohydrates in xenotransplantation Immunology and Cell Biology 2005 83 4 396 404 (Pubitemid 41044617)
10. Muchmore E. A., Milewski M., Varki A., Diaz S., Biosynthesis of N-glycolyneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool Journal of Biological Chemistry 1989 264 34 20216 20223 (Pubitemid 20009198)
11. Kawano T., Kozutsumi Y., Kawasaki T., Suzuki A., Biosynthesis of N-glycolylneuraminic acid-containing glycoconjugates. Purification and characterization of the key enzyme of the cytidine monophospho-N- acetylneuraminic acid hydroxylation system Journal of Biological Chemistry 1994 269 12 9024 9029
12. Tanemura M., Miyagawa S., Koyota S., Koma M., Matsuda H., Tsuji S., Shirakura R., Taniguchi N., Reduction of the major swine xenoantigen, the -galactosyl epitope by transfection of the 2,3-sialyltransferase gene Journal of Biological Chemistry 1998 273 26 16421 16425 (Pubitemid 28311423)
13. Sasaki K., Watanabe E., Kawashima K., Sekine S., Dohi T., Oshima M., Hanai N., Nishi T., Hasegawa M., Expression cloning of a novel Gal (1-3/1-4)GlcNAc 2,3- sialyltransferase using lectin resistance selection Journal of Biological Chemistry 1993 268 30 22782 22787 (Pubitemid 23318339)
14. Lee S. Y., Park J. Y., Choi Y. J., Cho S. K., Jong D. A., Kwon D. N., Hwang K. C., Kang S. J., Paik S. S., Han G. S., Hoon T. L., Kim J. H., Comparative proteomic analysis associated with term placental insufficiency in cloned pig Proteomics 2007 7 8 1303 1315 (Pubitemid 46716052)
15. Park M. R., Cho S. K., Lee S. Y., Choi Y. J., Park J. Y., Kwon D. N., Son W. J., Paik S. S., Kim T., Han Y. M., Kim J. H., A rare and often unrecognized cerebromeningitis and hemodynamic disorder: a major cause of sudden death in somatic cell cloned piglets Proteomics 2005 5 7 1928 1939 (Pubitemid 40686237)
16. Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R., The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach Glycobiology 2005 15 8 805 817 (Pubitemid 41417983)
17. Kelm S., Schauer R., Sialic acids in molecular and cellular interactions International Review of Cytology 1997 175 137 240 (Pubitemid 27309809)
18. Traving C., Schauer R., Structure, function and metabolism of sialic acids Cellular and Molecular Life Sciences 1998 54 12 1330 1349 (Pubitemid 29015295)
19. Varki A., Diversity in the sialic acids Glycobiology 1992 2 1 25 40
20. Haseley S. R., Talaga P., Kamerling J. P., Vliegenthart J. F., Characterization of the carbohydrate binding specificity and kinetic parameters of lectins by using surface plasmon resonance Analytical Biochemistry 1999 274 2 203 210 (Pubitemid 29489490)
21. Imberty A., Gautier C., Lescar J., Pérez S., Wyns L., Loris R., An unusual carbohydrate binding site revealed by the structures of two Maackia amurensis lectins complexed with sialic acid-containing oligosaccharides Journal of Biological Chemistry 2000 275 23 17541 17548 (Pubitemid 30430796)
22. Shibuya N., Goldstein I. J., Broekaert W. F., Nsimba-Lubaki M., Peeters B., Peumans W. J., The elderberry (Sambucus nigra L.) bark lectin recognizes the Neu5Ac(alpha 2-6)Gal/GalNAc sequence Journal of Biological Chemistry 1987 262 4 1596 1601
23. Shinkel T. A., Chen C. G., Salvaris E., Henion T. R., Barlow H., Galili U., Pearse M. J., D'Apice A. J. F., Changes in cell surface glycosylation in 1,3-galactosyltransferase knockout and 1,2-fucosyltransferase transgenic mice Transplantation 1997 64 2 197 204 (Pubitemid 27332658)
24. Tanemura M., Galili U., Differential expression of -Gal epitopes on pig and mouse organs Transplantation Proceedings 2000 32 5 843 (Pubitemid 30601765)
25. Miyagawa S., Takeishi S., Yamamoto A., Ikeda K., Matsunari H., Yamada M., Okabe M., Miyoshi E., Fukuzawa M., Nagashima H., Survey of glycoantigens in cells from 1-3galactosyltransferase knockout pig using a lectin microarray Xenotransplantation 2010 17 1 61 70
26. Hamamoto T., Kurosawa N., Lee Y. C., Tsuji S., Donor substrate specificities of Gal 1,4GlcNAc 2,6-sialyltransferase and Gal 1,3GalNAc 2,3-sialyltransferase: comparison of N-acetyl and N- glycolylneuraminic acids Biochimica et Biophysica Acta 1995 1244 1 223 228
27. Fedy A. E., Yang N., Martinez A., Leiros H. K. S., Steen I. H., Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability Journal of Molecular Biology 2007 372 1 130 149 (Pubitemid 47223223)
28. Song K. H., Kang Y. J., Jin U. H., Park Y. I., Kim S. M., Seong H. H., Hwang S., Yang B. S., Im G. S., Min K. S., Kim J. H., Chang Y. C., Kim N. H., Lee Y. C., Kim C. H., Cloning and functional characterization of pig CMP- N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation Biochemical Journal 2010 427 1 179 188