Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated

Chemical Research in Toxicology

Volumn 28, Issue 12, 2015, Pages 2292-2303

  Lassila, Toni ^a   Hokkanen, Juho ^b   Aatsinki, Sanna Mari ^b   Mattila, Sampo ^a   Turpeinen, Miia ^a,c   Tolonen, Ari ^b  

^a UNIVERSITY OF OULU   (Finland)

^b Admescope Ltd   (Finland)

^c OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; CARBOXYLIC ACID DERIVATIVE; GLUCURONIDE; ACETIC ACID DERIVATIVE; CARBOXYLIC ACID; GEMFIBROZIL; MONTELUKAST; QUINOLINE DERIVATIVE; TOLMETIN; ZOMEPIRAC;

ACYLATION; ARTICLE; CELL MIGRATION; CONJUGATE; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG HALF LIFE; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLITE; MITOCHONDRIAL TOXICITY; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; TOXIC HEPATITIS;

ACETATES; ACYL COENZYME A; ACYLATION; CARBOXYLIC ACIDS; CHROMATOGRAPHY, LIQUID; DRUG-INDUCED LIVER INJURY; GEMFIBROZIL; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; QUINOLINES; TOLMETIN;

EID: 84951310338     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00315     Document Type: Article

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