The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles

Drug Metabolism and Disposition

Volumn 41, Issue 11, 2013, Pages 1923-1933

  Horng, Howard ^a   Benet, Leslie Z ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AMINE; BUFFER; CYSTEINE; DRUG METABOLITE; GLUTATHIONE; GLYCINE; LYSINE; MEFENAMIC ACID; MEFENAMIC ACID 1 O ACYL GLUCURONIDE; MEFENAMIC ACID ACYL ADENYLATE; MEFENAMIC ACID ACYL COENZYME A; NUCLEOPHILE; TAURINE; THIOESTER; THIOL GROUP; UNCLASSIFIED DRUG;

ACYLATION; AMIDATION; ANIMAL CELL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROPHILICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ACETYLCYSTEINE; ACYL COENZYME A; ACYLATION; ADENOSINE MONOPHOSPHATE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; GLUCURONATES; GLUTATHIONE; MALE; MEFENAMIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS;

EID: 84886540118     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.053223     Document Type: Article

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