Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes

Chemical Research in Toxicology

Volumn 21, Issue 9, 2008, Pages 1749-1759

  Grillo, Mark P ^a,b   Hua, Fengmei ^a  

^a PFIZER INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORNEOL; IBUPROFEN; IBUPROFEN ACYL GLUTATHIONE THIOESTER; IBUPROFEN DERIVATIVE; LAURIC ACID; PIVALIC ACID; UNCLASSIFIED DRUG; VALPROIC ACID;

ACYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG METABOLISM; ENANTIOSELECTIVITY; GLUCURONIDATION; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; BORNANES; CHROMATOGRAPHY, LIQUID; GLUTATHIONE; HEPATOCYTES; IBUPROFEN; LAURIC ACIDS; MALE; MASS SPECTROMETRY; MOLECULAR CONFORMATION; PENTANOIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; SULFURIC ACID ESTERS; TIME FACTORS; VALPROIC ACID;

RATTUS;

EID: 53549096792     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx800098h     Document Type: Article

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