Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl- glutathione adduct formation in vitro and in vivo in rat

Drug Metabolism and Disposition

Volumn 40, Issue 8, 2012, Pages 1515-1526

  Grillo, Mark P ^a   Lohr, Michelle Tadano ^b   Wait, Jill C M ^c  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BIOMARIN PHARMACEUTICAL INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; DRUG METABOLITE; GLUTATHIONE; MEFENAMIC ACID; MEFENAMIC ACID 1 BETA O ACYL GLUCURONIDE; MEFENAMIC ACID S ACYL COENZYME A; MEFENAMYL S ACYLGLUTATHIONE; THIOESTER; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSACYLATION;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; GLUTATHIONE; HEPATOCYTES; HUMANS; MEFENAMIC ACID; RATS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84863945079     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046102     Document Type: Article

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