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Volumn 100, Issue 12, 2015, Pages 4425-4433

Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; APOLIPOPROTEIN B; CARBON DIOXIDE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRACER; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; FAT INTAKE; FATTY ACID; LIPID; PALMITIC ACID DERIVATIVE;

EID: 84951160663     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-2649     Document Type: Article
Times cited : (108)

References (45)
  • 1
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 2012;142:1592-1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 2
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011;34:274-285.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 3
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40:1387-1395. 4.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 4
    • 84875216097 scopus 로고    scopus 로고
    • PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI family heart study
    • Graff M, North KE, Franceschini N, et al. PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: the NHLBI family heart study. Int J Obes (Lond). 2013; 37:432-438.
    • (2013) Int J Obes (Lond) , vol.37 , pp. 432-438
    • Graff, M.1    North, K.E.2    Franceschini, N.3
  • 5
    • 46249093117 scopus 로고    scopus 로고
    • Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome
    • Adiels M, Olofsson SO, Taskinen MR, Boren J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008;28: 1225-1236.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1225-1236
    • Adiels, M.1    Olofsson, S.O.2    Taskinen, M.R.3    Boren, J.4
  • 6
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    • Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology. 2008;134:424-431.
    • (2008) Gastroenterology , vol.134 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 7
    • 79953847765 scopus 로고    scopus 로고
    • Sex differences in lipid and lipoprotein metabolism: It?s not just about sex hormones
    • Wang X, Magkos F, Mittendorfer B. Sex differences in lipid and lipoprotein metabolism: it?s not just about sex hormones. J Clin Endocrinol Metab. 2011;96:885-893.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 885-893
    • Wang, X.1    Magkos, F.2    Mittendorfer, B.3
  • 8
    • 84863981285 scopus 로고    scopus 로고
    • Determinants of VLDL-triglycerides production
    • Nielsen S, Karpe F. Determinants of VLDL-triglycerides production. Curr Opin Lipidol. 2012;23:321-326.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 321-326
    • Nielsen, S.1    Karpe, F.2
  • 9
    • 34948881786 scopus 로고    scopus 로고
    • The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: Studies in the postprandial state
    • Hodson L, Bickerton AS, McQuaid SE, et al. The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state. Diabetes. 2007;56:2433-2441.
    • (2007) Diabetes , vol.56 , pp. 2433-2441
    • Hodson, L.1    Bickerton, A.S.2    McQuaid, S.E.3
  • 10
    • 84894327806 scopus 로고    scopus 로고
    • Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
    • Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology. 2014;146:726-735.
    • (2014) Gastroenterology , vol.146 , pp. 726-735
    • Lambert, J.E.1    Ramos-Roman, M.A.2    Browning, J.D.3    Parks, E.J.4
  • 11
    • 79957922310 scopus 로고    scopus 로고
    • Hepatic fatty acid partitioning
    • Hodson L, Frayn KN. Hepatic fatty acid partitioning. Curr Opin Lipidol. 2011;22:216-224.
    • (2011) Curr Opin Lipidol , vol.22 , pp. 216-224
    • Hodson, L.1    Frayn, K.N.2
  • 12
    • 82455175350 scopus 로고    scopus 로고
    • Youngwomenpartition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men
    • Marinou K, Adiels M, Hodson L, Frayn KN, Karpe F, Fielding BA. Youngwomenpartition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men. Br J Nutr. 2011;105:857-865.
    • (2011) Br J Nutr , vol.105 , pp. 857-865
    • Marinou, K.1    Adiels, M.2    Hodson, L.3    Frayn, K.N.4    Karpe, F.5    Fielding, B.A.6
  • 13
    • 0141988894 scopus 로고    scopus 로고
    • Gender differences in postprandial ketone bodies in normolipidemic subjects and in untreated patients with familial combined hyperlipidemia
    • Halkes CJ, van Dijk H, Verseyden C, et al. Gender differences in postprandial ketone bodies in normolipidemic subjects and in untreated patients with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 2003;23:1875-1880.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1875-1880
    • Halkes, C.J.1    Van Dijk, H.2    Verseyden, C.3
  • 15
    • 84860469242 scopus 로고    scopus 로고
    • Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
    • Min HK, Kapoor A, Fuchs M, et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012;15:665-674.
    • (2012) Cell Metab , vol.15 , pp. 665-674
    • Min, H.K.1    Kapoor, A.2    Fuchs, M.3
  • 16
    • 84920401295 scopus 로고    scopus 로고
    • Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
    • Jiang C, Xie C, Li F, et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest. 2015;125: 386-402.
    • (2015) J Clin Invest , vol.125 , pp. 386-402
    • Jiang, C.1    Xie, C.2    Li, F.3
  • 17
    • 31444436445 scopus 로고    scopus 로고
    • The in vivo effects of the Pro12Ala PPAR-2 polymorphism on adipose tissue NEFA metabolism: The first use of the Oxford Biobank
    • Tan GD, Neville MJ, Liverani E, et al. The in vivo effects of the Pro12Ala PPAR-2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank. Diabetologia. 2006;49: 158-168.
    • (2006) Diabetologia , vol.49 , pp. 158-168
    • Tan, G.D.1    Neville, M.J.2    Liverani, E.3
  • 18
    • 84922857566 scopus 로고    scopus 로고
    • Lower resting and total energy expenditure in postmenopausal compared with premenopausal women matched for abdominal obesity
    • Hodson L, Harnden K, Banerjee R, et al. Lower resting and total energy expenditure in postmenopausal compared with premenopausal women matched for abdominal obesity. J Nutr Sci. 2014;3:e3.
    • (2014) J Nutr Sci , vol.3 , pp. e3
    • Hodson, L.1    Harnden, K.2    Banerjee, R.3
  • 19
    • 58249121843 scopus 로고    scopus 로고
    • Differences in partitioning of meal fatty acids into blood lipid fractions: A comparison of linoleate, oleate, and palmitate
    • Hodson L, McQuaid SE, Karpe F, Frayn KN, Fielding BA. Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. Am J Physiol Endocrinol Metab. 2009;296:E64-E71.
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. E64-E71
    • Hodson, L.1    McQuaid, S.E.2    Karpe, F.3    Frayn, K.N.4    Fielding, B.A.5
  • 20
    • 84899076449 scopus 로고    scopus 로고
    • The storage stability and concentration of acetoacetate differs between blood fractions
    • McNeil CA, Pramfalk C, Humphreys SM, Hodson L. The storage stability and concentration of acetoacetate differs between blood fractions. Clin Chim Acta. 2014;433C:278-283.
    • (2014) Clin Chim Acta , vol.433 C , pp. 278-283
    • McNeil, C.A.1    Pramfalk, C.2    Humphreys, S.M.3    Hodson, L.4
  • 21
    • 0024523769 scopus 로고
    • Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry
    • Lund E, Sisfontes L, Reihner E, Bjorkhem I. Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry. Scand J Clin Lab Invest. 1989;49:165-171.
    • (1989) Scand J Clin Lab Invest , vol.49 , pp. 165-171
    • Lund, E.1    Sisfontes, L.2    Reihner, E.3    Bjorkhem, I.4
  • 22
    • 0029112257 scopus 로고
    • Sterol absorption and sterol balance in phytosterolemia evaluated by deuteriumlabeled sterols: Effect of sitostanol treatment
    • Lutjohann D, Bjorkhem I, Beil UF, von Bergmann K. Sterol absorption and sterol balance in phytosterolemia evaluated by deuteriumlabeled sterols: effect of sitostanol treatment. J Lipid Res. 1995;36: 1763-1773.
    • (1995) J Lipid Res , vol.36 , pp. 1763-1773
    • Lutjohann, D.1    Bjorkhem, I.2    Beil, U.F.3    Von Bergmann, K.4
  • 23
    • 79952378989 scopus 로고    scopus 로고
    • Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE. 3Leiden mice without affecting liver or plasma triglyceride levels
    • van der Hoorn J, Linden D, Lindahl U, et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE. 3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011;162:1553-1563.
    • (2011) Br J Pharmacol , vol.162 , pp. 1553-1563
    • Van Der Hoorn, J.1    Linden, D.2    Lindahl, U.3
  • 24
    • 33644909215 scopus 로고    scopus 로고
    • Lipoprotein profiles in plasma and interstitial fluid analyzed with an automated gel-filtration system
    • Parini P, Johansson L, Broijersen A, Angelin B, Rudling M. Lipoprotein profiles in plasma and interstitial fluid analyzed with an automated gel-filtration system. Eur J Clin Invest. 2006;36:98-104.
    • (2006) Eur J Clin Invest , vol.36 , pp. 98-104
    • Parini, P.1    Johansson, L.2    Broijersen, A.3    Angelin, B.4    Rudling, M.5
  • 26
    • 61749100743 scopus 로고    scopus 로고
    • Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
    • Semple RK, Sleigh A, Murgatroyd PR, et al. Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. J Clin Invest. 2009;119:315-322.
    • (2009) J Clin Invest , vol.119 , pp. 315-322
    • Semple, R.K.1    Sleigh, A.2    Murgatroyd, P.R.3
  • 28
    • 77950602541 scopus 로고    scopus 로고
    • Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptorand liver X receptor-controlled metabolic pathways in mice
    • Herrema H, Meissner M, van Dijk TH, et al. Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptorand liver X receptor-controlled metabolic pathways in mice. Hepatology. 2010;51:806-816.
    • (2010) Hepatology , vol.51 , pp. 806-816
    • Herrema, H.1    Meissner, M.2    Van Dijk, T.H.3
  • 29
    • 0032464788 scopus 로고    scopus 로고
    • Lipoprotein lipase and the disposition of dietary fatty acids
    • Fielding BA, Frayn KN. Lipoprotein lipase and the disposition of dietary fatty acids. Br J Nutr. 1998;80:495-502.
    • (1998) Br J Nutr , vol.80 , pp. 495-502
    • Fielding, B.A.1    Frayn, K.N.2
  • 30
    • 13744263104 scopus 로고    scopus 로고
    • Temporal pattern of de novo lipogenesis in the postprandial state in healthy men
    • TimlinMT,Parks EJ. Temporal pattern of de novo lipogenesis in the postprandial state in healthy men. Am J Clin Nutr. 2005;81:35-42.
    • (2005) Am J Clin Nutr , vol.81 , pp. 35-42
    • Timlin, M.T.1    Parks, E.J.2
  • 31
    • 0016792786 scopus 로고
    • Effect of chorionic gonadotropin, triamcinolone, progesterone and estrogen on enzymes of placenta and liver in rats
    • Diamant YZ, Neuman S, Shafrir E. Effect of chorionic gonadotropin, triamcinolone, progesterone and estrogen on enzymes of placenta and liver in rats. Biochim Biophys Acta. 1975;385:257-267.
    • (1975) Biochim Biophys Acta , vol.385 , pp. 257-267
    • Diamant, Y.Z.1    Neuman, S.2    Shafrir, E.3
  • 32
    • 63349089791 scopus 로고    scopus 로고
    • Effects of ovariectomy on PPAR, SREBP-1c, and SCD-1 gene expression in the rat liver
    • Paquette A, Wang D, Jankowski M, Gutkowska J, Lavoie JM. Effects of ovariectomy on PPAR-, SREBP-1c, and SCD-1 gene expression in the rat liver. Menopause. 2008;15:1169-1175.
    • (2008) Menopause , vol.15 , pp. 1169-1175
    • Paquette, A.1    Wang, D.2    Jankowski, M.3    Gutkowska, J.4    Lavoie, J.M.5
  • 33
    • 1642505593 scopus 로고    scopus 로고
    • Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse
    • Hewitt KN, Pratis K, Jones ME, Simpson ER. Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse. Endocrinology. 2004;145:1842-1848.
    • (2004) Endocrinology , vol.145 , pp. 1842-1848
    • Hewitt, K.N.1    Pratis, K.2    Jones, M.E.3    Simpson, E.R.4
  • 34
    • 0344874201 scopus 로고    scopus 로고
    • Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease
    • Diraison F, Moulin P, Beylot M. Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab. 2003;29:478-485.
    • (2003) Diabetes Metab , vol.29 , pp. 478-485
    • Diraison, F.1    Moulin, P.2    Beylot, M.3
  • 35
    • 84929347096 scopus 로고    scopus 로고
    • Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant
    • Mancina RM, Matikainen N, Maglio C, et al. Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant. J Clin Endocrinol Metab. 2015;100: E821-E825.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. E821-E825
    • Mancina, R.M.1    Matikainen, N.2    Maglio, C.3
  • 36
    • 0025728697 scopus 로고
    • The plasma level of 7-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7-hydroxylase in man
    • Axelson M, Bjorkhem I, Reihner E, Einarsson K. The plasma level of 7-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7-hydroxylase in man. FEBS Lett. 1991;284:216-218.
    • (1991) FEBS Lett , vol.284 , pp. 216-218
    • Axelson, M.1    Bjorkhem, I.2    Reihner, E.3    Einarsson, K.4
  • 37
    • 84863586988 scopus 로고    scopus 로고
    • Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men
    • Sarac I, Backhouse K, Shojaee-Moradie F, et al. Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men. J Clin Endocrinol Metab. 2012;97:2475-2481.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2475-2481
    • Sarac, I.1    Backhouse, K.2    Shojaee-Moradie, F.3
  • 38
    • 0017738601 scopus 로고
    • A possible role for malonyl- CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
    • McGarry JD, Mannaerts GP, Foster DW. A possible role for malonyl- CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest. 1977;60:265-270.
    • (1977) J Clin Invest , vol.60 , pp. 265-270
    • McGarry, J.D.1    Mannaerts, G.P.2    Foster, D.W.3
  • 39
    • 33646796762 scopus 로고    scopus 로고
    • The elevation of ingested lipids within plasma chylomicrons is prolonged in men compared with women
    • Knuth ND, Horowitz JF. The elevation of ingested lipids within plasma chylomicrons is prolonged in men compared with women. J Nutr. 2006;136:1498-1503.
    • (2006) J Nutr , vol.136 , pp. 1498-1503
    • Knuth, N.D.1    Horowitz, J.F.2
  • 40
    • 42249105232 scopus 로고    scopus 로고
    • Reduced oxidation of dietary fat after a short term high-carbohydrate diet
    • Roberts R, Bickerton AS, Fielding BA, et al. Reduced oxidation of dietary fat after a short term high-carbohydrate diet.AmJ Clin Nutr. 2008;87:824-831.
    • (2008) AmJ Clin Nutr , vol.87 , pp. 824-831
    • Roberts, R.1    Bickerton, A.S.2    Fielding, B.A.3
  • 42
    • 34447511196 scopus 로고    scopus 로고
    • Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    • Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women.JAMA. 2007;298:299-308.
    • (2007) JAMA , vol.298 , pp. 299-308
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3    Tybjaerg-Hansen, A.4
  • 43
    • 20844451381 scopus 로고    scopus 로고
    • ACAT2is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver
    • Parini P, DavisM,Lada AT, et al.ACAT2is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation. 2004;110:2017-2023.
    • (2004) Circulation , vol.110 , pp. 2017-2023
    • Parini, P.1    Davismlada, A.T.2
  • 44
    • 77951986878 scopus 로고    scopus 로고
    • Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol- associated steatosis by enhancing hepatic triglyceride mobilization
    • AlgerHM,Brown JM, Sawyer JK, et al. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol- associated steatosis by enhancing hepatic triglyceride mobilization. J Biol Chem. 2010;285:14267-14274.
    • (2010) J Biol Chem , vol.285 , pp. 14267-14274
    • Alger, H.M.1    Brown, J.M.2    Sawyer, J.K.3
  • 45
    • 70350761428 scopus 로고    scopus 로고
    • ACAT2 and human hepatic cholesterol metabolism: Identification of important gender-related differences in normolipidemic, non-obese Chinese patients
    • Parini P, Jiang ZY, Einarsson C, et al. ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients. Atherosclerosis. 2009;207:266-271.
    • (2009) Atherosclerosis , vol.207 , pp. 266-271
    • Parini, P.1    Jiang, Z.Y.2    Einarsson, C.3


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