Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 7, 2012, Pages 2475-2481

  Sarac, Ivana ^a   Backhouse, Katharine ^a   Shojaee Moradie, Fariba ^a   Stolinski, Michael ^a   Robertson, M Denise ^a   Bell, Jimmy D ^b   Thomas, E Louise ^b   Hovorka, Roman ^c   Wright, John ^a   Umpleby, A Margot ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; PALMITIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN 1; VERY LOW DENSITY LIPOPROTEIN 2; VERY LOW DENSITY LIPOPROTEIN TRIGLYCERIDE;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS; CARDIOVASCULAR RISK; CATABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; GLUCOSE BLOOD LEVEL; HIGH RISK POPULATION; HUMAN; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; ISOTOPE LABELING; LIPID TRANSPORT; LIPOGENESIS; MALE; METABOLIC CLEARANCE RATE; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; OXIDATION; POSTMENOPAUSE; PRIORITY JOURNAL; SEX DIFFERENCE; SUBCUTANEOUS FAT; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; CASE CONTROL STUDY; ENERGY METABOLISM; KINETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; SEXUAL DEVELOPMENT; URINE;

BODY COMPOSITION; CASE-CONTROL STUDIES; ENERGY METABOLISM; FATTY ACIDS; FEMALE; HUMANS; KINETICS; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; OBESITY; POSTMENOPAUSE; SEX CHARACTERISTICS; TRIGLYCERIDES;

EID: 84863586988     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-3248     Document Type: Article

References (34)

1. Castelli WP, Anderson K, Wilson PW, Levy D 1992 Lipids and risk of coronary heart disease. The Framingham Study. Ann Epidemiol 2:23-28
2. Kannel WB, Hjortland MC, McNamara PM, Gordon T 1976 Menopause and risk of cardiovascular disease: the Framingham study. Ann Intern Med 85:447-452
3. Milewicz A, Tworowska U, Demissie M 2001 Menopausal obesity-myth or fact? Climacteric 4:273-283
4. Hubert HB, Feinleib M, McNamara PM, Castelli WP 1983 Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 67:968-977 (Pubitemid 13080473)
5. Magkos F, Patterson BW, Mohammed BS, Klein S, Mittendorfer B 2007 Women produce fewer but triglyceride-richer very low-density lipoproteins than men. J Clin Endocrinol Metab 92:1311-1318 (Pubitemid 46556403)
6. Mittendorfer B, Patterson BW, Klein S 2003 Effect of sex and obesity on basal VLDL-triacylglycerol kinetics. Am J Clin Nutr 77:573-579 (Pubitemid 36258564)
7. Malmstrom R, Packard CJ, Caslake M, Bedford D, Stewart P, Yki-Jarvinen H, Shepherd J, Taskinen MR 1998 Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects. Diabetes 47:779-787 (Pubitemid 28201808)
8. Adiels M, Packard C, Caslake MJ, Stewart P, Soro A, Westerbacka J, Wennberg B, Olofsson SO, Taskinen MR, Borén J 2005 A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions. J Lipid Res 46:58-67 (Pubitemid 40066671)
9. Adiels M, Taskinen MR, Packard C, Caslake MJ, Soro-Paavonen A, Westerbacka J, Vehkavaara S, Häkkinen A, Olofsson SO, Yki-Järvinen H, Borén J 2006 Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia 49:755-765 (Pubitemid 43357551)
10. Gill JM, Brown JC, Bedford D, Wright DM, Cooney J, Hughes DA, Packard CJ, Caslake MJ 2004 Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects. Atherosclerosis 176:49-56 (Pubitemid 39078644)
11. Dixon JL, Ginsberg HN 1993 Regulation of hepatic production of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells. J Lipid Res 34:167-179 (Pubitemid 23067522)
12. Sniderman A, Brown BG, Stewart BF, Cianflone K 1992 From familial combined hyperlipidaemia to hyperapo B: unravelling the overproduction of hepatic apolipoprotein B. Curr Opin Lipidol 3:137-142
13. Mittendorfer B, Horowitz JF, Klein S 2001 Gender differences in lipid and glucose kinetics during short-term fasting. Am J Physiol Endocrinol Metab 281:E1333-E1339
14. Marinou K, Adiels M, Hodson L, Frayn KN, Karpe F, Fielding BA 2011 Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men. Br J Nutr 105:857-865
15. Nielsen S, Guo Z, Albu JB, Klein S, O'Brien PC, Jensen MD 2003 Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest 111:981-998
16. Sidossis LS, Coggan AR, Gastaldelli A, Wolfe RR 1995 A new correction factor for use in tracer estimations of plasma fatty acid oxidation. Am J Physiol 269(4 Pt 1):E649-E656
17. Thomas EL, Hamilton G, Patel N, O'Dwyer R, Doré CJ, Goldin RD, Bell JD, Taylor-Robinson SD 2005 Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut 54:122-127 (Pubitemid 40007230)
18. Naressi A, Couturier C, Devos JM, Janssen M, Mangeat C, de Beer R, Graveron-Demilly D 2001 Java-based graphical user interface for the MRUI quantitation package. MAGMA 12:141-152 (Pubitemid 32510133)
19. Watts GF, Mandalia S, Brunt JN, Slavin BM, Coltart DJ, Lewis B 1993 Independent associations between plasma lipoprotein subfraction levels and the course of coronary artery disease in the St. Thomas' Atherosclerosis Regression Study (STARS). Metabolism 42:1461-1467 (Pubitemid 23335880)
20. Ackermans MT, Ruiter AF, Endert E 1998 Determination of glycerol concentrations and glycerol isotopic enrichments in human plasma by gas chromatography/mass spectrometry. Anal Biochem 258:80-86 (Pubitemid 28163147)
21. Patterson BW, Mittendorfer B, Elias N, Satyanarayana R, Klein S 2002 Use of isotopically labeled tracers to measure very low density lipoprotein- triglyceride turnover. J Lipid Res 43:223-233 (Pubitemid 34184009)
22. Pearson TC, Guthrie DL, Simpson J, Chinn S, Barosi G, Ferrant A, Lewis SM, Najean Y 1995 Interpretation of measured red cell mass and plasma volume in adults: Expert Panel on Radionuclides of the International Council for Standardization in Haematology. Br J Haematol 89:748-756
23. Frayn KN 1983 Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634 (Pubitemid 13044099)
24. Levy JC, Matthews DR, Hermans MP 1998 Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21:2191-2192 (Pubitemid 28549174)
25. Magkos F, Fabbrini E, Mohammed BS, Patterson BW, Klein S, Mittendorfer B 2010 Estrogen deficiency after menopause does not result in male very-low-density lipoprotein metabolism phenotype. J Clin Endocrinol Metab 95:3377-3384
26. Koutsari C, Basu R, Rizza RA, Nair KS, Khosla S, Jensen MD 2011 Non-oxidative free fatty acid disposal is greater in young women than men. J Clin Endocrinol Metab 96:541-547
27. Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE 1997 Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46:1579-1585 (Pubitemid 27411233)
28. Kotronen A, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H 2008 Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome. Diabetologia 51:130-138 (Pubitemid 50003448)
29. Lewis GF, Uffelman KD, Szeto LW, Weller B, Steiner G 1995 Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 95:158-166
30. Wahren J, Sato Y, Ostman J, Hagenfeldt L, Felig P 1984 Turnover and splanchnic metabolism of free fatty acids and ketones in insulindependent diabetics at rest and in response to exercise. J Clin Invest 73:1367-1376
31. Barrows BR, Parks EJ 2006 Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J Clin Endocrinol Metab 91:1446-1452
32. Desmeules A, Couillard C, Tchernof A, Bergeron J, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Després JP, Bouchard C 2003 Post-heparin lipolytic enzyme activities, sex hormones and sex hormone-binding globulin (SHBG) in men and women: The HERITAGE Family Study. Atherosclerosis 171:343-350 (Pubitemid 37486087)
33. Thompson GR, Naoumova RP, Watts GF 1996 Role of cholesterol in regulating apolipoprotein B secretion by the liver. J Lipid Res 37:439-447 (Pubitemid 26134353)
34. Packard CJ, Shepherd J 1997 Lipoprotein heterogeneity and apolipoprotein B metabolism. Arterioscler Thromb Vasc Biol 17:3542-3556 (Pubitemid 28028567)