메뉴 건너뛰기




Volumn 1862, Issue 5, 2016, Pages 1008-1017

Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID)

Author keywords

Brain; Dementia; Homocysteine; Hyperhomocysteinemia; Vascular cognitive impairment

Indexed keywords

COLLAGEN; CYSTATHIONINE BETA SYNTHASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HOMOCYSTEIC ACID; HOMOCYSTEINE; SUPEROXIDE;

EID: 84950161678     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2015.11.015     Document Type: Article
Times cited : (102)

References (125)
  • 2
    • 0342680135 scopus 로고    scopus 로고
    • Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues
    • Albrecht J., Dolinska M., Hilgier W., Lipkowski A.W., Nowacki J. Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues. Neurochem. Int. 2000, 36:341-347.
    • (2000) Neurochem. Int. , vol.36 , pp. 341-347
    • Albrecht, J.1    Dolinska, M.2    Hilgier, W.3    Lipkowski, A.W.4    Nowacki, J.5
  • 3
    • 0023022693 scopus 로고
    • Effect of l-homocysteine and derivatives on the high-affinity uptake of taurine and GABA into synaptosomes and cultured neurons and astrocytes
    • Allen I.C., Schousboe A., Griffiths R. Effect of l-homocysteine and derivatives on the high-affinity uptake of taurine and GABA into synaptosomes and cultured neurons and astrocytes. Neurochem. Res. 1986, 11:1487-1496.
    • (1986) Neurochem. Res. , vol.11 , pp. 1487-1496
    • Allen, I.C.1    Schousboe, A.2    Griffiths, R.3
  • 4
    • 0037112386 scopus 로고    scopus 로고
    • Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice
    • Baumbach G.L., Sigmund C.D., Bottiglieri T., Lentz S.R. Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ. Res. 2002, 91:931-937.
    • (2002) Circ. Res. , vol.91 , pp. 931-937
    • Baumbach, G.L.1    Sigmund, C.D.2    Bottiglieri, T.3    Lentz, S.R.4
  • 5
    • 34249291912 scopus 로고    scopus 로고
    • Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet
    • Bernardo A., McCord M., Troen A.M., Allison J.D., McDonald M.P. Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Neurobiol. Aging 2007, 28:1195-1205.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1195-1205
    • Bernardo, A.1    McCord, M.2    Troen, A.M.3    Allison, J.D.4    McDonald, M.P.5
  • 6
    • 84904348791 scopus 로고    scopus 로고
    • Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis
    • Beydoun M.A., Beydoun H.A., Gamaldo A.A., Teel A., Zonderman A.B., Wang Y. Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health 2014, 14:643.
    • (2014) BMC Public Health , vol.14 , pp. 643
    • Beydoun, M.A.1    Beydoun, H.A.2    Gamaldo, A.A.3    Teel, A.4    Zonderman, A.B.5    Wang, Y.6
  • 9
    • 12344309062 scopus 로고    scopus 로고
    • Homocysteine and stroke: evidence on a causal link from mendelian randomisation
    • Casas J.P., Bautista L.E., Smeeth L., Sharma P., Hingorani A.D. Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet 2005, 365:224-232.
    • (2005) Lancet , vol.365 , pp. 224-232
    • Casas, J.P.1    Bautista, L.E.2    Smeeth, L.3    Sharma, P.4    Hingorani, A.D.5
  • 10
    • 0034649324 scopus 로고    scopus 로고
    • Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine
    • Chambers J.C., Ueland P.M., Obeid O.A., Wrigley J., Refsum H., Kooner J.S. Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000, 102:2479-2483.
    • (2000) Circulation , vol.102 , pp. 2479-2483
    • Chambers, J.C.1    Ueland, P.M.2    Obeid, O.A.3    Wrigley, J.4    Refsum, H.5    Kooner, J.S.6
  • 11
    • 0036350569 scopus 로고    scopus 로고
    • Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries
    • Chen C., Conklin B.S., Ren Z., Zhong D.S. Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries. J. Surg. Res. 2002, 102:22-30.
    • (2002) J. Surg. Res. , vol.102 , pp. 22-30
    • Chen, C.1    Conklin, B.S.2    Ren, Z.3    Zhong, D.S.4
  • 12
    • 77954466984 scopus 로고    scopus 로고
    • Folic acid potentiates the effect of memantine on spatial learning and neuronal protection in an Alzheimer's disease transgenic model
    • Chen T.F., Huang R.F., Lin S.E., Lu J.F., Tang M.C., Chiu M.J. Folic acid potentiates the effect of memantine on spatial learning and neuronal protection in an Alzheimer's disease transgenic model. J. Alzheimers Dis. 2010, 20:607-615.
    • (2010) J. Alzheimers Dis. , vol.20 , pp. 607-615
    • Chen, T.F.1    Huang, R.F.2    Lin, S.E.3    Lu, J.F.4    Tang, M.C.5    Chiu, M.J.6
  • 16
    • 0031597388 scopus 로고    scopus 로고
    • Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease
    • Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 1998, 55:1449-1455.
    • (1998) Arch. Neurol. , vol.55 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 17
    • 0030789201 scopus 로고    scopus 로고
    • Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells
    • Dalton M.L., Gadson P.F., Wrenn R.W., Rosenquist T.H. Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells. FASEB J. 1997, 11:703-711.
    • (1997) FASEB J. , vol.11 , pp. 703-711
    • Dalton, M.L.1    Gadson, P.F.2    Wrenn, R.W.3    Rosenquist, T.H.4
  • 19
    • 51649112963 scopus 로고    scopus 로고
    • Murine models of hyperhomocysteinemia and their vascular phenotypes
    • Dayal S., Lentz S.R. Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler. Thromb. Vasc. Biol. 2008, 28:1596-1605.
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 1596-1605
    • Dayal, S.1    Lentz, S.R.2
  • 20
    • 84859889194 scopus 로고    scopus 로고
    • Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
    • de Jager C.A., Oulhaj A., Jacoby R., Refsum H., Smith A.D. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int. J. Geriatr. Psychiatry 2012, 27:592-600.
    • (2012) Int. J. Geriatr. Psychiatry , vol.27 , pp. 592-600
    • de Jager, C.A.1    Oulhaj, A.2    Jacoby, R.3    Refsum, H.4    Smith, A.D.5
  • 23
    • 33846211794 scopus 로고    scopus 로고
    • Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial
    • Durga J., van Boxtel M.P., Schouten E.G., Kok F.J., Jolles J., Katan M.B., Verhoef P. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007, 369:208-216.
    • (2007) Lancet , vol.369 , pp. 208-216
    • Durga, J.1    van Boxtel, M.P.2    Schouten, E.G.3    Kok, F.J.4    Jolles, J.5    Katan, M.B.6    Verhoef, P.7
  • 25
    • 0023160360 scopus 로고
    • Binding of [3H]muscimol to calf cerebrocortical synaptic membranes and the effects of sulphur-containing convulsant and non-convulsant compounds
    • Egbuta J.O., Griffiths R. Binding of [3H]muscimol to calf cerebrocortical synaptic membranes and the effects of sulphur-containing convulsant and non-convulsant compounds. Neurochem. Res. 1987, 12:589-595.
    • (1987) Neurochem. Res. , vol.12 , pp. 589-595
    • Egbuta, J.O.1    Griffiths, R.2
  • 26
    • 0025954937 scopus 로고
    • 2+ and the potentiation by serum albumin
    • 2+ and the potentiation by serum albumin. Brain Res. 1991, 560:282-290.
    • (1991) Brain Res. , vol.560 , pp. 282-290
    • Eimerl, S.1    Schramm, M.2
  • 27
    • 33746603896 scopus 로고    scopus 로고
    • Inhibition of sulfur compounds and antioxidants on MMP-2 and -9 at the activity level found during neonatal hypoxia-reoxygenation
    • Emara M., Cheung P.Y. Inhibition of sulfur compounds and antioxidants on MMP-2 and -9 at the activity level found during neonatal hypoxia-reoxygenation. Eur. J. Pharmacol. 2006, 544:168-173.
    • (2006) Eur. J. Pharmacol. , vol.544 , pp. 168-173
    • Emara, M.1    Cheung, P.Y.2
  • 28
    • 0037070773 scopus 로고    scopus 로고
    • Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    • Erkinjuntti T., Kurz A., Gauthier S., Bullock R., Lilienfeld S., Damaraju C.V. Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. Lancet 2002, 359:1283-1290.
    • (2002) Lancet , vol.359 , pp. 1283-1290
    • Erkinjuntti, T.1    Kurz, A.2    Gauthier, S.3    Bullock, R.4    Lilienfeld, S.5    Damaraju, C.V.6
  • 29
    • 21244477915 scopus 로고    scopus 로고
    • Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects
    • Ernest S., Hosack A., O'Brien W.E., Rosenblatt D.S., Nadeau J.H. Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects. Physiol. Genomics 2005, 21:404-410.
    • (2005) Physiol. Genomics , vol.21 , pp. 404-410
    • Ernest, S.1    Hosack, A.2    O'Brien, W.E.3    Rosenblatt, D.S.4    Nadeau, J.H.5
  • 30
    • 0030670874 scopus 로고    scopus 로고
    • Neuropathological assessment of the lesions of significance in vascular dementia
    • Esiri M.M., Wilcock G.K., Morris J.H. Neuropathological assessment of the lesions of significance in vascular dementia. J. Neurol. Neurosurg. Psychiatry 1997, 63:749-753.
    • (1997) J. Neurol. Neurosurg. Psychiatry , vol.63 , pp. 749-753
    • Esiri, M.M.1    Wilcock, G.K.2    Morris, J.H.3
  • 32
    • 77957356998 scopus 로고    scopus 로고
    • Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension
    • Firbank M.J., Narayan S.K., Saxby B.K., Ford G.A., O'Brien J.T. Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension. Int. Psychogeriatr. 2010, 1-8.
    • (2010) Int. Psychogeriatr. , pp. 1-8
    • Firbank, M.J.1    Narayan, S.K.2    Saxby, B.K.3    Ford, G.A.4    O'Brien, J.T.5
  • 33
    • 84858141219 scopus 로고    scopus 로고
    • Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials
    • Ford A.H., Almeida O.P. Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials. J. Alzheimers Dis. 2012, 29:133-149.
    • (2012) J. Alzheimers Dis. , vol.29 , pp. 133-149
    • Ford, A.H.1    Almeida, O.P.2
  • 36
    • 0028226786 scopus 로고
    • Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-d-aspartate receptors
    • Gorman A., Griffiths R. Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-d-aspartate receptors. Neuroscience 1994, 59:299-308.
    • (1994) Neuroscience , vol.59 , pp. 299-308
    • Gorman, A.1    Griffiths, R.2
  • 37
    • 0842305029 scopus 로고    scopus 로고
    • Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity
    • Gortz P., Hoinkes A., Fleischer W., Otto F., Schwahn B., Wendel U., Siebler M. Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity. J. Neurol. Sci. 2004, 218:109-114.
    • (2004) J. Neurol. Sci. , vol.218 , pp. 109-114
    • Gortz, P.1    Hoinkes, A.2    Fleischer, W.3    Otto, F.4    Schwahn, B.5    Wendel, U.6    Siebler, M.7
  • 38
    • 0024314299 scopus 로고
    • Inhibition by excitatory sulphur amino acids of the high-affinity l-glutamate transporter in synaptosomes and in primary cultures of cortical astrocytes and cerebellar neurons
    • Griffiths R., Grieve A., Dunlop J., Damgaard I., Fosmark H., Schousboe A. Inhibition by excitatory sulphur amino acids of the high-affinity l-glutamate transporter in synaptosomes and in primary cultures of cortical astrocytes and cerebellar neurons. Neurochem. Res. 1989, 14:333-343.
    • (1989) Neurochem. Res. , vol.14 , pp. 333-343
    • Griffiths, R.1    Grieve, A.2    Dunlop, J.3    Damgaard, I.4    Fosmark, H.5    Schousboe, A.6
  • 40
    • 84923370285 scopus 로고    scopus 로고
    • Endothelial cells and human cerebral small vessel disease
    • Hainsworth A.H., Oommen A.T., Bridges L.R. Endothelial cells and human cerebral small vessel disease. Brain Pathol. 2015, 25:44-50.
    • (2015) Brain Pathol. , vol.25 , pp. 44-50
    • Hainsworth, A.H.1    Oommen, A.T.2    Bridges, L.R.3
  • 41
    • 0027288252 scopus 로고
    • Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
    • Hajjar K.A. Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J. Clin. Invest. 1993, 91:2873-2879.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2873-2879
    • Hajjar, K.A.1
  • 42
    • 0021041780 scopus 로고
    • Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons
    • Harker L.A., Harlan J.M., Ross R. Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons. Circ. Res. 1983, 53:731-739.
    • (1983) Circ. Res. , vol.53 , pp. 731-739
    • Harker, L.A.1    Harlan, J.M.2    Ross, R.3
  • 43
    • 0026486960 scopus 로고
    • Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism
    • Harpel P.C., Chang V.T., Borth W. Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:10193-10197.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 10193-10197
    • Harpel, P.C.1    Chang, V.T.2    Borth, W.3
  • 44
  • 46
    • 4544378765 scopus 로고    scopus 로고
    • Dopaminergic neurotoxicity of homocysteine and its derivatives in primary mesencephalic cultures
    • Heider I., Lehmensiek V., Lenk T., Muller T., Storch A. Dopaminergic neurotoxicity of homocysteine and its derivatives in primary mesencephalic cultures. J. Neural Transm. 2004, 1-13. Suppl.
    • (2004) J. Neural Transm. , pp. 1-13
    • Heider, I.1    Lehmensiek, V.2    Lenk, T.3    Muller, T.4    Storch, A.5
  • 47
    • 0036094732 scopus 로고    scopus 로고
    • Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease
    • Hogervorst E., Ribeiro H.M., Molyneux A., Budge M., Smith A.D. Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease. Arch. Neurol. 2002, 59:787-793.
    • (2002) Arch. Neurol. , vol.59 , pp. 787-793
    • Hogervorst, E.1    Ribeiro, H.M.2    Molyneux, A.3    Budge, M.4    Smith, A.D.5
  • 48
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine studies collaboration, homocysteine and risk of ischemic heart disease and stroke: a meta-analysis
    • Homocysteine studies collaboration, homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002, 288:2015-2022.
    • (2002) JAMA , vol.288 , pp. 2015-2022
  • 50
    • 2342639015 scopus 로고    scopus 로고
    • Extracellular concentration of homocysteine in human cell lines is influenced by specific inhibitors of cyst(e)ine transport
    • Hultberg B. Extracellular concentration of homocysteine in human cell lines is influenced by specific inhibitors of cyst(e)ine transport. Clin. Chem. Lab. Med. 2004, 42:378-383.
    • (2004) Clin. Chem. Lab. Med. , vol.42 , pp. 378-383
    • Hultberg, B.1
  • 51
    • 27844568426 scopus 로고    scopus 로고
    • Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (part I)
    • Iosifescu D.V., Papakostas G.I., Lyoo I.K., Lee H.K., Renshaw P.F., Alpert J.E., Nierenberg A., Fava M. Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (part I). Psychiatry Res. 2005, 140:291-299.
    • (2005) Psychiatry Res. , vol.140 , pp. 291-299
    • Iosifescu, D.V.1    Papakostas, G.I.2    Lyoo, I.K.3    Lee, H.K.4    Renshaw, P.F.5    Alpert, J.E.6    Nierenberg, A.7    Fava, M.8
  • 52
    • 0031821779 scopus 로고    scopus 로고
    • Homocysteine and vitamins in cardiovascular disease
    • Jacobsen D.W. Homocysteine and vitamins in cardiovascular disease. Clin. Chem. 1998, 44:1833-1843.
    • (1998) Clin. Chem. , vol.44 , pp. 1833-1843
    • Jacobsen, D.W.1
  • 54
    • 0141500252 scopus 로고    scopus 로고
    • Homocysteine-induced brain lipid peroxidation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition
    • Jara-Prado A., Ortega-Vazquez A., Martinez-Ruano L., Rios C., Santamaria A. Homocysteine-induced brain lipid peroxidation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition. Neurotox. Res. 2003, 5:237-243.
    • (2003) Neurotox. Res. , vol.5 , pp. 237-243
    • Jara-Prado, A.1    Ortega-Vazquez, A.2    Martinez-Ruano, L.3    Rios, C.4    Santamaria, A.5
  • 55
    • 84937392787 scopus 로고    scopus 로고
    • Brain atrophy in cognitively impaired elderly: the importance of long-chain omega-3 fatty acids and B vitamin status in a randomized controlled trial
    • Jerneren F., Elshorbagy A.K., Oulhaj A., Smith S.M., Refsum H., Smith A.D. Brain atrophy in cognitively impaired elderly: the importance of long-chain omega-3 fatty acids and B vitamin status in a randomized controlled trial. Am. J. Clin. Nutr. 2015, 102:215-221.
    • (2015) Am. J. Clin. Nutr. , vol.102 , pp. 215-221
    • Jerneren, F.1    Elshorbagy, A.K.2    Oulhaj, A.3    Smith, S.M.4    Refsum, H.5    Smith, A.D.6
  • 58
    • 77958534673 scopus 로고    scopus 로고
    • Experimental models of vascular dementia and vascular cognitive impairment. A systematic review
    • Jiwa N.S., Garrard P., Hainsworth A.H. Experimental models of vascular dementia and vascular cognitive impairment. A systematic review. J. Neurochem. 2010, 115:814-828.
    • (2010) J. Neurochem. , vol.115 , pp. 814-828
    • Jiwa, N.S.1    Garrard, P.2    Hainsworth, A.H.3
  • 60
    • 57449117345 scopus 로고    scopus 로고
    • A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease
    • Kang J.H., Cook N., Manson J., Buring J.E., Albert C.M., Grodstein F. A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am. J. Clin. Nutr. 2008, 88:1602-1610.
    • (2008) Am. J. Clin. Nutr. , vol.88 , pp. 1602-1610
    • Kang, J.H.1    Cook, N.2    Manson, J.3    Buring, J.E.4    Albert, C.M.5    Grodstein, F.6
  • 61
    • 55749102084 scopus 로고    scopus 로고
    • Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study
    • Khan U., Crossley C., Kalra L., Rudd A., Wolfe C.D., Collinson P., Markus H.S. Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study. Stroke 2008, 39:2943-2949.
    • (2008) Stroke , vol.39 , pp. 2943-2949
    • Khan, U.1    Crossley, C.2    Kalra, L.3    Rudd, A.4    Wolfe, C.D.5    Collinson, P.6    Markus, H.S.7
  • 62
    • 33846601836 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine in cerebral small vessel disease
    • Khan U., Hassan A., Vallance P., Markus H.S. Asymmetric dimethylarginine in cerebral small vessel disease. Stroke 2007, 38:411-413.
    • (2007) Stroke , vol.38 , pp. 411-413
    • Khan, U.1    Hassan, A.2    Vallance, P.3    Markus, H.S.4
  • 63
    • 0036845131 scopus 로고    scopus 로고
    • Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain
    • Kim J.M., Lee H., Chang N. Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain. J. Nutr. 2002, 132:3418-3421.
    • (2002) J. Nutr. , vol.132 , pp. 3418-3421
    • Kim, J.M.1    Lee, H.2    Chang, N.3
  • 65
    • 0029860742 scopus 로고    scopus 로고
    • Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes
    • Kokame K., Kato H., Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J. Biol. Chem. 1996, 271:29659-29665.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29659-29665
    • Kokame, K.1    Kato, H.2    Miyata, T.3
  • 68
    • 14944372489 scopus 로고    scopus 로고
    • Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia
    • Lee H., Kim J.M., Kim H.J., Lee I., Chang N. Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia. J. Nutr. 2005, 135:544-548.
    • (2005) J. Nutr. , vol.135 , pp. 544-548
    • Lee, H.1    Kim, J.M.2    Kim, H.J.3    Lee, I.4    Chang, N.5
  • 69
    • 20044391979 scopus 로고    scopus 로고
    • Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine
    • Lee S.J., Kim K.M., Namkoong S., Kim C.K., Kang Y.C., Lee H., Ha K.S., Han J.A., Chung H.T., Kwon Y.G., Kim Y.M. Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine. J. Biol. Chem. 2005, 280:5781-5788.
    • (2005) J. Biol. Chem. , vol.280 , pp. 5781-5788
    • Lee, S.J.1    Kim, K.M.2    Namkoong, S.3    Kim, C.K.4    Kang, Y.C.5    Lee, H.6    Ha, K.S.7    Han, J.A.8    Chung, H.T.9    Kwon, Y.G.10    Kim, Y.M.11
  • 72
    • 0031437426 scopus 로고    scopus 로고
    • Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. Implications for homocystinuria
    • Liu G., Nellaiappan K., Kagan H.M. Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. Implications for homocystinuria. J. Biol. Chem. 1997, 272:32370-32377.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32370-32377
    • Liu, G.1    Nellaiappan, K.2    Kagan, H.M.3
  • 73
    • 37548999379 scopus 로고    scopus 로고
    • Homocysteine induces connective tissue growth factor expression in vascular smooth muscle cells
    • Liu X., Luo F., Li J., Wu W., Li L., Chen H. Homocysteine induces connective tissue growth factor expression in vascular smooth muscle cells. J. Thromb. Haemost. 2008, 6:184-192.
    • (2008) J. Thromb. Haemost. , vol.6 , pp. 184-192
    • Liu, X.1    Luo, F.2    Li, J.3    Wu, W.4    Li, L.5    Chen, H.6
  • 76
    • 17344368557 scopus 로고    scopus 로고
    • Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells
    • Majors A., Ehrhart L.A., Pezacka E.H. Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 1997, 17:2074-2081.
    • (1997) Arterioscler. Thromb. Vasc. Biol. , vol.17 , pp. 2074-2081
    • Majors, A.1    Ehrhart, L.A.2    Pezacka, E.H.3
  • 77
    • 37349042862 scopus 로고    scopus 로고
    • Genes, endothelial function and cerebral small vessel disease in man
    • Markus H.S. Genes, endothelial function and cerebral small vessel disease in man. Exp. Physiol. 2008, 93:121-127.
    • (2008) Exp. Physiol. , vol.93 , pp. 121-127
    • Markus, H.S.1
  • 80
    • 67651225118 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency
    • Mikael L.G., Wang X.L., Wu Q., Jiang H., Maclean K.N., Rozen R. Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency. Mol. Genet. Metab. 2009, 98:187-194.
    • (2009) Mol. Genet. Metab. , vol.98 , pp. 187-194
    • Mikael, L.G.1    Wang, X.L.2    Wu, Q.3    Jiang, H.4    Maclean, K.N.5    Rozen, R.6
  • 81
    • 38949100728 scopus 로고    scopus 로고
    • Vascular cognitive impairment: current concepts and clinical developments
    • Moorhouse P., Rockwood K. Vascular cognitive impairment: current concepts and clinical developments. Lancet Neurol. 2008, 7:246-255.
    • (2008) Lancet Neurol. , vol.7 , pp. 246-255
    • Moorhouse, P.1    Rockwood, K.2
  • 82
    • 0009566277 scopus 로고    scopus 로고
    • Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    • MRC-CFAS Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 2001, 357:169-175.
    • (2001) Lancet , vol.357 , pp. 169-175
  • 83
    • 84877678495 scopus 로고    scopus 로고
    • Selective homocysteine lowering gene transfer improves infarct healing, attenuates remodelling, and enhances diastolic function after myocardial infarction in mice
    • Muthuramu I., Jacobs F., Singh N., Gordts S.C., De Geest B. Selective homocysteine lowering gene transfer improves infarct healing, attenuates remodelling, and enhances diastolic function after myocardial infarction in mice. PLoS ONE 2013, 8:e63710.
    • (2013) PLoS ONE , vol.8 , pp. e63710
    • Muthuramu, I.1    Jacobs, F.2    Singh, N.3    Gordts, S.C.4    De Geest, B.5
  • 84
    • 84929192651 scopus 로고    scopus 로고
    • Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress
    • (Berl)
    • Muthuramu I., Singh N., Amin R., Nefyodova E., Debasse M., Van H., Jacobs I.,.F., De Geest B. Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress. J. Mol. Med. 2015, 93:609-618. (Berl).
    • (2015) J. Mol. Med. , vol.93 , pp. 609-618
    • Muthuramu, I.1    Singh, N.2    Amin, R.3    Nefyodova, E.4    Debasse, M.5    Van, H.6    Jacobs, I.F.7    De Geest, B.8
  • 86
    • 0027319970 scopus 로고
    • Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M., Ozawa T., Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J. Clin. Invest. 1993, 92:1381-1386.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1381-1386
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 89
    • 0345535616 scopus 로고    scopus 로고
    • Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
    • Outinen P.A., Sood S.K., Pfeifer S.I., Pamidi S., Podor T.J., Li J., Weitz J.I., Austin R.C. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood 1999, 94:959-967.
    • (1999) Blood , vol.94 , pp. 959-967
    • Outinen, P.A.1    Sood, S.K.2    Pfeifer, S.I.3    Pamidi, S.4    Podor, T.J.5    Li, J.6    Weitz, J.I.7    Austin, R.C.8
  • 90
    • 77953533246 scopus 로고    scopus 로고
    • Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges
    • Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010, 9:689-701.
    • (2010) Lancet Neurol. , vol.9 , pp. 689-701
    • Pantoni, L.1
  • 91
    • 78149262357 scopus 로고    scopus 로고
    • Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats
    • Pirchl M., Ullrich C., Humpel C. Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats. Eur. J. Neurosci. 2010, 32:1516-1527.
    • (2010) Eur. J. Neurosci. , vol.32 , pp. 1516-1527
    • Pirchl, M.1    Ullrich, C.2    Humpel, C.3
  • 92
    • 84924650926 scopus 로고    scopus 로고
    • White matter hyperintensities, cognitive impairment and dementia: an update
    • Prins N.D., Scheltens P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat. Rev. Neurol. 2015, 11:157-165.
    • (2015) Nat. Rev. Neurol. , vol.11 , pp. 157-165
    • Prins, N.D.1    Scheltens, P.2
  • 95
    • 2942549553 scopus 로고    scopus 로고
    • Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels
    • Riba R., Nicolaou A., Troxler M., Homer-Vaniasinkam S., Naseem K.M. Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels. Atherosclerosis 2004, 175:69-75.
    • (2004) Atherosclerosis , vol.175 , pp. 69-75
    • Riba, R.1    Nicolaou, A.2    Troxler, M.3    Homer-Vaniasinkam, S.4    Naseem, K.M.5
  • 96
    • 0037183976 scopus 로고    scopus 로고
    • Tyrphostins protect neuronal cells from oxidative stress
    • Sagara Y., Ishige K., Tsai C., Maher P. Tyrphostins protect neuronal cells from oxidative stress. J. Biol. Chem. 2002, 277:36204-36215.
    • (2002) J. Biol. Chem. , vol.277 , pp. 36204-36215
    • Sagara, Y.1    Ishige, K.2    Tsai, C.3    Maher, P.4
  • 97
    • 79952069518 scopus 로고    scopus 로고
    • The role of vitamin B in stroke prevention: a journey from observational studies to clinical trials and critique of the VITAmins TO Prevent Stroke (VITATOPS)
    • Saposnik G. The role of vitamin B in stroke prevention: a journey from observational studies to clinical trials and critique of the VITAmins TO Prevent Stroke (VITATOPS). Stroke 2011, 42:838-842.
    • (2011) Stroke , vol.42 , pp. 838-842
    • Saposnik, G.1
  • 98
    • 65249094749 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial
    • Saposnik G., Ray J.G., Sheridan P., McQueen M., Lonn E. Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke 2009, 40:1365-1372.
    • (2009) Stroke , vol.40 , pp. 1365-1372
    • Saposnik, G.1    Ray, J.G.2    Sheridan, P.3    McQueen, M.4    Lonn, E.5
  • 102
    • 22244435580 scopus 로고    scopus 로고
    • Proteomic analysis of homocysteine inhibition of microvascular endothelial cell angiogenesis
    • Shastry S., Tyagi N., Hayden M.R., Tyagi S.C. Proteomic analysis of homocysteine inhibition of microvascular endothelial cell angiogenesis. Cell Mol. Biol. (Noisy-le-Grand) 2004, 50:931-937.
    • (2004) Cell Mol. Biol. (Noisy-le-Grand) , vol.50 , pp. 931-937
    • Shastry, S.1    Tyagi, N.2    Hayden, M.R.3    Tyagi, S.C.4
  • 103
    • 16644370461 scopus 로고    scopus 로고
    • Homocysteine induces metalloproteinase and shedding of beta-1 integrin in microvessel endothelial cells
    • Shastry S., Tyagi S.C. Homocysteine induces metalloproteinase and shedding of beta-1 integrin in microvessel endothelial cells. J. Cell. Biochem. 2004, 93:207-213.
    • (2004) J. Cell. Biochem. , vol.93 , pp. 207-213
    • Shastry, S.1    Tyagi, S.C.2
  • 104
    • 84860906878 scopus 로고    scopus 로고
    • Cerebral subcortical small vessel disease and its relation to cognition in elderly subjects: a pathological study in the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort
    • Smallwood A., Oulhaj A., Joachim C., Christie S., Sloan C., Smith A.D., Esiri M. Cerebral subcortical small vessel disease and its relation to cognition in elderly subjects: a pathological study in the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort. Neuropathol. Appl. Neurobiol. 2012, 38:337-343.
    • (2012) Neuropathol. Appl. Neurobiol. , vol.38 , pp. 337-343
    • Smallwood, A.1    Oulhaj, A.2    Joachim, C.3    Christie, S.4    Sloan, C.5    Smith, A.D.6    Esiri, M.7
  • 105
    • 48249091668 scopus 로고    scopus 로고
    • The worldwide challenge of the dementias: a role for B vitamins and homocysteine?
    • Smith A.D. The worldwide challenge of the dementias: a role for B vitamins and homocysteine?. Food Nutr. Bull. 2008, 29:S143-S172.
    • (2008) Food Nutr. Bull. , vol.29 , pp. S143-S172
    • Smith, A.D.1
  • 108
    • 84877577810 scopus 로고    scopus 로고
    • Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation
    • Sudduth T.L., Powell D.K., Smith C.D., Greenstein A., Wilcock D.M. Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. J. Cereb. Blood Flow Metab. 2013, 33:708-715.
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , pp. 708-715
    • Sudduth, T.L.1    Powell, D.K.2    Smith, C.D.3    Greenstein, A.4    Wilcock, D.M.5
  • 109
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans
    • Tawakol A., Omland T., Gerhard M., Wu J.T., Creager M.A. Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 1997, 95:1119-1121.
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 110
    • 25644434756 scopus 로고    scopus 로고
    • The central nervous system in animal models of hyperhomocysteinemia
    • Troen A.M. The central nervous system in animal models of hyperhomocysteinemia. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2005, 29:1140-1151.
    • (2005) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.29 , pp. 1140-1151
    • Troen, A.M.1
  • 114
    • 54049142899 scopus 로고    scopus 로고
    • Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study
    • van Dijk E.J., Prins N.D., Vrooman H.A., Hofman A., Koudstaal P.J., Breteler M.M. Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study. Stroke 2008, 39:2712-2719.
    • (2008) Stroke , vol.39 , pp. 2712-2719
    • van Dijk, E.J.1    Prins, N.D.2    Vrooman, H.A.3    Hofman, A.4    Koudstaal, P.J.5    Breteler, M.M.6
  • 115
    • 84880711717 scopus 로고    scopus 로고
    • Defective homocysteine metabolism: potential implications for skeletal muscle malfunction
    • Veeranki S., Tyagi S.C. Defective homocysteine metabolism: potential implications for skeletal muscle malfunction. Int. J. Mol. Sci. 2013, 14:15074-15091.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 15074-15091
    • Veeranki, S.1    Tyagi, S.C.2
  • 118
    • 77952990224 scopus 로고    scopus 로고
    • Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials
    • Wald D.S., Kasturiratne A., Simmonds M. Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials. Am. J. Med. 2010, 123:522-527.
    • (2010) Am. J. Med. , vol.123 , pp. 522-527
    • Wald, D.S.1    Kasturiratne, A.2    Simmonds, M.3
  • 119
    • 0030610589 scopus 로고    scopus 로고
    • Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine
    • Wang H., Yoshizumi M., Lai K., Tsai J.C., Perrella M.A., Haber E., Lee M.E. Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J. Biol. Chem. 1997, 272:25380-25385.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25380-25385
    • Wang, H.1    Yoshizumi, M.2    Lai, K.3    Tsai, J.C.4    Perrella, M.A.5    Haber, E.6    Lee, M.E.7
  • 120
    • 2642513835 scopus 로고    scopus 로고
    • Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice
    • Wang L., Jhee K.H., Hua X., DiBello P.M., Jacobsen D.W., Kruger W.D. Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circ. Res. 2004, 94:1318-1324.
    • (2004) Circ. Res. , vol.94 , pp. 1318-1324
    • Wang, L.1    Jhee, K.H.2    Hua, X.3    DiBello, P.M.4    Jacobsen, D.W.5    Kruger, W.D.6
  • 122
    • 0036144873 scopus 로고    scopus 로고
    • Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice
    • Weiss N., Heydrick S., Zhang Y.Y., Bierl C., Cap A., Loscalzo J. Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2002, 22:34-41.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 34-41
    • Weiss, N.1    Heydrick, S.2    Zhang, Y.Y.3    Bierl, C.4    Cap, A.5    Loscalzo, J.6
  • 123
    • 20444410004 scopus 로고    scopus 로고
    • Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan study
    • Wright C.B., Paik M.C., Brown T.R., Stabler S.P., Allen R.H., Sacco R.L., DeCarli C. Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan study. Stroke 2005, 36:1207-1211.
    • (2005) Stroke , vol.36 , pp. 1207-1211
    • Wright, C.B.1    Paik, M.C.2    Brown, T.R.3    Stabler, S.P.4    Allen, R.H.5    Sacco, R.L.6    DeCarli, C.7
  • 124
    • 84878927242 scopus 로고    scopus 로고
    • Neuroprotective effects of NMDA and group I metabotropic glutamate receptor antagonists against neurodegeneration induced by homocysteine in rat hippocampus: in vivo study
    • Yeganeh F., Nikbakht F., Bahmanpour S., Rastegar K., Namavar R. Neuroprotective effects of NMDA and group I metabotropic glutamate receptor antagonists against neurodegeneration induced by homocysteine in rat hippocampus: in vivo study. J. Mol. Neurosci. 2013, 50:551-557.
    • (2013) J. Mol. Neurosci. , vol.50 , pp. 551-557
    • Yeganeh, F.1    Nikbakht, F.2    Bahmanpour, S.3    Rastegar, K.4    Namavar, R.5
  • 125
    • 0042878460 scopus 로고    scopus 로고
    • Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes
    • Zeng X., Dai J., Remick D.G., Wang X. Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ. Res. 2003, 93:311-320.
    • (2003) Circ. Res. , vol.93 , pp. 311-320
    • Zeng, X.1    Dai, J.2    Remick, D.G.3    Wang, X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.