Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels

Atherosclerosis

Volumn 175, Issue 1, 2004, Pages 69-75

  Riba, Rocio ^a   Nicolaou, Anna ^a   Troxler, Max ^b   Homer Vaniasinkam, Shervanthi ^b   Naseem, Khalid M ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

Homocysteine; Nitric oxide; Platelets

Indexed keywords

ADENOSINE DIPHOSPHATE; FIBRINOGEN; HOMOCYSTEINE; NITRIC OXIDE; PADGEM PROTEIN; S NITROSOGLUTATHIONE; THROMBIN;

AGED; ARTICLE; CELL ACTIVITY; CLAUDICATION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EX VIVO STUDY; HUMAN; HYPERHOMOCYSTEINEMIA; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION;

ADENOSINE DIPHOSPHATE; AGED; BLOOD PLATELETS; FIBRINOGEN; FLOW CYTOMETRY; HOMOCYSTEINE; HUMANS; INTERMITTENT CLAUDICATION; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE DONORS; P-SELECTIN; PERIPHERAL VASCULAR DISEASES; PLATELET ACTIVATION; S-NITROSOGLUTATHIONE; SULFHYDRYL COMPOUNDS;

EID: 2942549553     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2004.02.008     Document Type: Article

References (30)

1. Temple M.E., Luzier A.B., Kazierad D.J. Homocysteine as a risk factor for atherosclerosis. Ann. Pharmacother. 34:2000;57-65
2. Durand P., Lussier-Cacan S., Blache D. Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. FASEB J. 11:1997;1157-1168
3. Lenz S.R., Sobet C.G., Piegors D.J., Bhopaktar M.Y., Faraci F.M., Manilow M.R. Vascular dysfunction in monkeys with diet-induced hyperhomocysteinemia. J. Clin. Invest. 98:1996;24-29
4. Wall R.T., Harlan J.M., Harker L.A., Striker G.E. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb. Res. 18:1980;113-121
5. Silverman M.D., Tumuluri R.J., Davis M., Lopez G., Rosenbaum J.T., Lelkes P.I. Homocysteine unregulates vascular cell adhesion molecule-1 expression in cultured aortic endothelial cells and enhances monocyte adhesion. Arterioscler. Thromb. Vasc. Biol. 22:2002;587-592
6. Koga T., Claycombe K., Meydani M. Homocysteine increases monocyte and T-cell adhesion to human aortic endothelial cells. Atherosclerosis. 161:2002;365-374
7. Wang J., Dudman N.P., Wilcken D.E. Effect of homocysteine and related compounds on prostacyclin production by cultured human vascular endothelial cells. Thromb. Haemost. 70:1993;1047-1052
8. Stamler J.S., Osbourne J.A., Jaraki O., et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J. Clin. Invest. 91:1993;308-318
9. Weiss N, Keller C, Hoffman U, Loscalzo J. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vasc. Med. 2002;227-39.
10. Mujumdar V.S., Aru G.M., Tyagi S.C. Induction of oxidative stress by homocyst(e)ine impairs endothelial function. J. Cell Biochem. 82:2001;491-500
11. Rodgers G.M., Kane W.H. Activation of endogenous factor V by homocysteine-induce vascular endothelial cell activator. J. Clin. Invest. 11:1986;1909-1916
12. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ. Res. 88:2001;756-762
13. Lenz S.R., Sadler J.E. Inhibition of thrombomodulin surface expression and protein C activation by thrombogenic homocysteine. Blood. 88:1990;1900-1904
14. Durand P., Prost M., Banche D. Prothrombotic effects of folic-acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased N-3 polyunsaturated fatty acids. Atheroscelrosis. 121:1996;231-243
15. Di Minno G., Davi G., Margaglione M., et al. Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and a probucol-sensitive mechanism. J. Clin. Invest. 92:1993;1400-1406
16. Taylor L.M. Jr., DeFrang R.D., Harris E.J., Porter J.M. The association of elevated plasma homocysteine with the progression of symptomatic peripheral arterial disease. J. Vasc. Surg. 13:1991;128-136
17. de Graaf J.C., Banga J.D., Moncada S., Palmer R.M., de Groot P.G., Sixma J. Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions. Circulation. 85:1992;2284-2290
18. Ueland P.M., Refsum H., Stabler S.P., Manilow M.R., Andersson A., Allen R.H. Total homocysteine in plasma or serum: methods and clinical applications. Clin. Chem. 39:1993;1764-1779
19. Kenyon S.H., Waterfield C.J., Timbrell J.A., Nicolaou A. Methionine synthase activity in sulphur amino acid levels in rat liver tumour cells HTC and Phi-1. Biochem. Pharmacol. 63:2002;381-391
20. Janes S.L., Wilson D.J., Chronos N., Goodall A.H. Evaluation of whole blood flow cytometric detection of platelet bound fibrinogen on normal subjects and patients with activated platelets. Thromb. Haemost. 70:1993;659-666
21. Davi G., Di Minno G., Coppola A., et al. Oxidative stress and platelet activation in homozygous homocystinuria. Circulation. 104:2001;1124-1128
22. Chronos N.A.F., Wilson D.J., Janes S.L., Hutton R.A., Buller N.P., Goodall A.J. Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of a-granules or lysosomes from, human platelets. Clin. Sci. 87:1994;575-580
23. Chow K., Cheung F., Lao T.T. OK Effect of homocysteine on the production of nitric oxide in endothelial cells. Clin. Exp. Pharmacol. Physiol. 26:1999;817-818
24. Ungvari Z., Pacher P., Rischak K., Szoller L., Koller A. Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia. Arterio. Thromb. Vasc. Biol. 19:1999;1899-1904
25. Upchurch G.R., Welsh G.N., Fabian A.J., et al. homocysteine decreases the bioavailability of nitric oxide by a mechanism involving glutathione peroxidase. J. Biol. Chem. 272:1997;17012-17017
26. Mutus B., Rabini R.A., Staffolani R., Ricciotti R., Fumelli P., Moretti N. Homocysteine-induced inhibition of nitric oxide production in platelets: a study on healthy and diabetic subjects. Diabetologia. 44:2001;979-982
27. Tawakol A., Omland T., Gerhard M., Wu J.T., Creager M.A. Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilatation in humans. Circulation. 95:1997;1119-1121
28. Loscalzo J. The oxidant stress of hyperhomocysteinemia. J. Clin. Invest. 98:1996;5-7
29. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial cell injury form nitric oxide and superoxide. Proc. Natl. Acad. Sci., U.S.A. 87:1990;1620-1624
30. Signorello M.G., Pascale R., Leoncini G. Effect of homocysteine on arachidonic acid release in human platelets. Eur. J. Clin. Invest. 32:2002;279-284