Structure of cerebral arterioles in cystathionine β-synthase-deficient mice

Circulation Research

Volumn 91, Issue 10, 2002, Pages 931-937

  Baumbach, Gary L ^a   Sigmund, Curt D ^a   Bottiglieri, Teodoro ^b   Lentz, Steven R ^a,c  

^a UNIVERSITY OF IOWA   (United States)

^b BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cerebral arteriole; Hyperhomocysteinemia; Vascular hypertrophy

Indexed keywords

CYSTATHIONINE BETA SYNTHASE; METHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERIOLE; ARTERY COMPLIANCE; ARTERY WALL; ARTICLE; BRAIN ARTERY; CONTROLLED STUDY; DIET; HYPERHOMOCYSTEINEMIA; HYPERTROPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRESS STRAIN RELATIONSHIP; STROKE;

ANIMALS; ARTERIOLES; BASEMENT MEMBRANE; BLOOD PRESSURE; BRAIN; COLLAGEN; CYSTATHIONINE BETA-SYNTHASE; DIET; DISEASE MODELS, ANIMAL; ELASTIN; GENOTYPE; HETEROZYGOTE; HYPERHOMOCYSTEINEMIA; HYPERTROPHY; METHIONINE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; VASCULAR PATENCY;

EID: 0037112386     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000041408.64867.1D     Document Type: Article

References (38)

1. Eikelboom JW, Lonn E, Genest J Jr, Hankey G, Yusuf S. Homocyst(e)ine, and cardiovascular disease: A critical review of the epidemiologic evidence. Ann Intern Med. 1999;131:363-375.
2. Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI. Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke. 2000;31:1069-1075.
3. Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R. Promotion of vascular smooth muscle cell growth by homocysteine: A link to atherosclerosis. Proc Natl Acad Sci U S A. 1994;91:6369-6373.
4. Selhub J, Jacques PF, Bostom AG, D'Agostino RB, Wilson PWF, Belanger AJ, O'Leary DH, Wolf PA, Schaefer EJ, Rosenberg IH. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med. 1995;332:286-291.
5. Rolland PH, Friggi A, Barlatier A, Piquet P. Latrille V, Faye MM, Charpiot P, Bodard H, Ghiringhelli O, Calaf R, Luccioni R, Garcon D, Hyperhomocysteinemia-induced vascular damage in the minipig: Captopril-hydrochlorothiazide combination prevents elastic alterations. Circulation. 1995;91:1161-1174.
6. Folkow B, Hallbäck M, Lundgren Y, Sivertsson R, Weiss L. Importance of adaptive changes in vascular design for establishment of primary hypertension, studied in man and in spontaneously hypertensive rats. Circ Res. 1973;32:1-2-1-16.
7. Jones JV, Fitch W, MacKenzie ET, Strandgaard S, Harper AM. Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res. 1976;39:555-557.
8. Sadoshima S, Busija DW, Heistad DD. Mechanisms of protection against stroke in stroke-prone spontaneously hypertensive rats. Am J Physiol. 1983;244:H406-H412.
9. Fujishima M, Sadoshima S, Ogata J, Yoshida F, Shiokawa O, Ibayashi S, Omae T. Autoregulation of cerebral blood flow in young and aged spontaneously hypertensive rats (SHR). Gerontology. 1984;30:30-36.
10. Lentz SR, Erger RA, Dayal S, Maeda N, Malinow MR, Heistad DD, Faraci FM. Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Am J Physiol. 2000;279:H970-H975.
11. Dayal S, Bottiglieri T, Arning E, Maeda N, Malinow MR, Sigmund CD, Heistad DD, Faraci FM, Lentz SR. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res. 2001;88:1203-1209.
12. Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI, Yaghoubi M, Goldschmidt-Clermont PJ, Farber HW, Cohen R, Loscalzo J. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000;106:483-491.
13. Baumbach GL, Walmsley JG, Hart MN. Composition and mechanics of cerebral arterioles in hypertensive rats. Am J Pathol. 1988;133:464-471.
14. Baumbach GL, Hajdu MA. Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats. Hypertension, 1993;21:816-826.
15. Watanabe M, Osada J, Aratani Y, Kluckman K, Reddick R, Malinow MR, Maeda N. Mice deficient in cystathionine beta-synthase: Animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci USA. 1995;92:1585-1589.
16. Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD. Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest. 1996;97:1047-1055.
17. Harper SL, Bohlen HG. Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats. Hypertension. 1984;6:408-419.
18. Baumbach GL, Dobrin PB, Hart MN, Heistad DD. Mechanics of cerebral arterioles in hypertensive rats. Circ Res. 1988;62:56-64.
19. Mudd SH, Finkelstein JD, Refsum H, Ueland PM, Malinow MR, Lentz SR, Jacobsen DW, Brattström L, Wilcken B, Wilcken DEL, Blom HJ, Stabler SP, Allen RH, Selhub J, Rosenberg IH. Homocysteine and its disulfide derivatives: A suggested consensus terminology. Arterioscler Thromb Vasc Biol. 2000;20:1704-1706.
20. Martin SC, Hilton AC, Bartlett WA, Jones AF. Plasma total homocysteine measurement by ion-paired reversed-phase HPLC with electro-chemical detection. Biomedical Chromatography. 1999;13:81-82.
21. Weibel ER. Stereological Methods: Practical Methods for Biological Morphometry. New York, NY: Academic Press; 1979.
22. Abrahamson DR. Recent studies on the structure and pathology of basement membranes. J Pathol. 1986;149:257-278.
23. Bergel DH. The static elastic properties of the arterial wall. J Physiol (Lond). 1961;156:445-457.
24. Chao CL, Lee YT. Impairment of cerebrovascular reactivity by methionine-induced hyperhomocysteinemia and amelioration by quinapril treatment. Stroke. 2000;31:2907-2911.
25. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1774-1777.
26. Chillon JM, Ghoneim S, Baumbach GL. Effects of chronic nitric oxide synthase inhibition on cerebral arterioles in rats. Hypertension. 1997;30:1097-1104.
27. Baumbach GL. Effects of increased pulse pressure on cerebral arterioles. Hypertension. 1996;27:159-167.
28. Chillon JM, Baumbach GL. Autoregulation. Arterial and intracranial pressure. In: Edvinsson L, Krause DN, eds. Cerebral Blood Flow and Metabolism. Philadelphia, Pa: Lippincott, Williams & Wilkins: 2002:395-412.
29. Milnor WR. Hemodynamics. 1st Ed. Baltimore, Md: Williams and Wilkins; 1982.
30. Bortolotto LA, Safar ME, Billaud E, Lacroix C, Asmar R, London GM, Blacher J. Plasma homocysteine, aortic stiffness, and renal function in hypertensive patients. Hypertension. 1999;34:837-842.
31. Lambert J, van den Berg M, Steyn M, Rauwerda JA, Donker AJ, Stehouwer CD. Familial hyperhomocysteinaemia and endothelium-dependent vasodilatation and arterial distensibility of large arteries. Cardiovasc Res. 1999;42:743-751.
32. van Guldener C, Lambert J, Janssen MJ, Donker AJ, Stehouwer CD. Endothelium-dependent vasodilatation and distensibility of large arteries in chronic haemodialysis patients. Nephrol Dial Transplant. 1997;12(suppl 2):14-8.
33. van Guldener C, Lambert J, ter Wee PM, Donker AJ, Stehouwer CD. Carotid artery stiffness in patients with end-stage renal disease: No effect of long-term homocysteine-lowering therapy. Clin Nephrol. 2000;53:33-41.
34. Smilde TJ, van den Berkmortel FW, Boers GH, Wollersheim H, de Boo T, van Langen H, Stalenhoef AF. Carotid and femoral artery wall thickness and stiffness in patients at risk for cardiovascular disease, with special emphasis on hyperhomocysteinemia. Arterioscler Thromb Vasc Biol. 1998;18:1958-1963.
35. Delacrétaz E, Zanchi A, Nussberger J, Hayoz D, Aubert J-F, Brunner HR, Waeber B. Chronic nitric oxide synthase inhibition and carotid artery distensibility in renal hypertensive rats. Hypertension. 1995;26:332-336.
36. Laurent S, Girerd X, Mourad JJ, Lacolley P, Beck L, Boutouyrie P, Mignot JP, Safar M. Elastic modulus of the radial artery wall material is not increased in patients with essential hypertension. Arterioscler Thromb. 1994;14:1223-1231.
37. Cox RH. Comparison of arterial wall mechanics in normotensive and spontaneously hypertensive rats. Am J Physiol. 1979;237:H159-H167.
38. Vermeulen EG, Niessen HW, Bogels M, Stehouwer CD, Rauwerda JA, van Hinsbergh VW. Decreased smooth muscle cell/extracellular matrix ratio of media of femoral artery in patients with atherosclerosis and hyperhomocysteinemia. Arterioscler Thromb Vasc Biol. 2001;21:573-577.