Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: A candidate prodromal risk biomarker

Early Intervention in Psychiatry

Volumn 10, Issue 3, 2016, Pages 203-211

  Mcnamara, Robert K ^a   Jandacek, Ronald ^a   Tso, Patrick ^a   Blom, Thomas J ^a   Welge, Jeffrey A ^a   Strawn, Jeffrey R ^a   Adler, Caleb M ^a   Strakowski, Stephen M ^a   Delbello, Melissa P ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Arachidonic acid (AA); Eicosapentaenoic acid (EPA); Mania; Omega 3 index; Ultra high risk

Indexed keywords

BIOLOGICAL MARKER; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID;

ADOLESCENT; ADULT; ARTICLE; BIPOLAR DISORDER; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; ERYTHROCYTE LEVEL; FATTY ACID ANALYSIS; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PRODROMAL SYMPTOM; RISK FACTOR; ULTRA HIGH RISK PATIENT; CASE CONTROL STUDY; DEFICIENCY; ERYTHROCYTE; METABOLISM; YOUNG ADULT;

ADOLESCENT; BIOMARKERS; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHILD; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; ERYTHROCYTES; FEMALE; HUMANS; MALE; PRODROMAL SYMPTOMS; RISK FACTORS; YOUNG ADULT;

EID: 84950140413     PISSN: 17517885     EISSN: 17517893     Source Type: Journal    
DOI: 10.1111/eip.12282     Document Type: Article

References (78)

1. Perlis RH, Miyahara S, Marangell LB etal. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry 2004; 55: 875-881.
2. Perlis RH, Dennehy EB, Miklowitz DJ etal. Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study. Bipolar Disord 2009; 11: 391-400.
3. Smoller JW, Finn CT. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet 2003; 123C: 48-58.
4. DelBello MP, Geller B. Review of studies of child and adolescent offspring of bipolar parents. Bipolar Disord 2001; 3: 325-334.
5. Goodwin FK, Jamison KR. Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, 2nd edn. New York: Oxford University Press, 2007.
6. Mortensen PB, Pedersen CB, Melbye M, Mors O, Ewald H. Individual and familial risk factors for bipolar affective disorders in Denmark. Arch Gen Psychiatry 2003; 60: 1209-1215.
7. Egeland JA, Hostetter AM, Pauls DL, Sussex JN. Prodromal symptoms before onset of manic-depressive disorder suggested by first hospital admission histories. J Am Acad Child Adolesc Psychiatry 2000; 39: 1245-1252.
8. Howes OD, Lim S, Theologos G, Yung AR, Goodwin GM, McGuire P. A comprehensive review and model of putative prodromal features of bipolar affective disorder. Psychol Med 2011; 41: 1567-1577.
9. Skjelstad DV, Malt UF, Holte A. Symptoms and signs of the initial prodrome of bipolar disorder: a systematic review. J Affect Disord 2010; 126: 1-13.
10. Bechdolf A, Nelson B, Cotton SM etal. A preliminary evaluation of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord 2010; 127: 316-320.
11. Bechdolf A, Ratheesh A, Cotton SM etal. The predictive validity of bipolar at-risk (prodromal) criteria in help-seeking adolescents and young adults: a prospective study. Bipolar Disord 2014; 16: 493-504.
12. McGorry P, Keshavan M, Goldstone S etal. Biomarkers and clinical staging in psychiatry. World Psychiatry 2014; 13: 211-223.
13. McNamara RK, Nandagopal JJ, Strakowski SM, DelBello MP. Preventative strategies for early-onset bipolar disorder: towards a clinical staging model. CNS Drugs 2010; 24: 983-996.
14. McNamara RK, Vannest JJ, Valentine CJ. Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: mechanisms and implications for psychopathology. World J Psychiatr 2015; 5: 15-34.
15. Hibbeln JR. Fish consumption and major depression. Lancet 1998; 351: 1213.
16. Noaghiul S, Hibbeln JR. Cross-national comparisons of seafood consumption and rates of bipolar disorders. Am J Psychiatry 2003; 160: 2222-2227.
17. Peet M. International variations in the outcome of schizophrenia and the prevalence of depression in relation to national dietary practices: an ecological analysis. Br J Psychiatry 2004; 184: 404-408.
18. Clayton EH, Hanstock TL, Watson JF. Estimated intakes of meat and fish by children and adolescents in Australia and comparison with recommendations. Br J Nutr 2009; 101: 1731-1735.
19. Harel Z, Riggs S, Vaz R, White L, Menzies G. Omega-3 polyunsaturated fatty acids in adolescents: knowledge and consumption. J Adolesc Health 2001; 28: 10-15.
20. Lauritzen L, Harsløf LB, Hellgren LI, Pedersen MH, Mølgaard C, Michaelsen KF. Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys. Br J Nutr 2012; 107: 697-704.
21. Sichert-Hellert W, Wicher M, Kersting M. Age and time trends in fish consumption pattern of children and adolescents, and consequences for the intake of long-chain n-3 polyunsaturated fatty acids. Eur J Clin Nutr 2009; 63: 1071-1075.
22. Allen KL, Mori TA, Beilin L, Byrne SM, Hickling S, Oddy WH. Dietary intake in population-based adolescents: support for a relationship between eating disorder symptoms, low fatty acid intake and depressive symptoms. J Hum Nutr Diet 2013; 26: 459-469.
23. Oddy WH, Hickling S, Smith MA etal. Dietary intake of omega-3 fatty acids and risk of depressive symptoms in adolescents. Depress Anxiety 2011; 28: 582-588.
24. Swenne I, Rosling A, Tengblad S, Vessby B. Omega-3 polyunsaturated essential fatty acids are associated with depression in adolescents with eating disorders and weight loss. Acta Paediatr 2011; 100: 1610-1615.
25. Grosso G, Pajak A, Marventano S etal. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS ONE 2014; 9: e96905.
26. Sarris J, Mischoulon D, Schweitzer I. Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression. J Clin Psychiatry 2012; 73: 81-86.
27. McNamara RK, Strimpfel J, Jandacek R etal. Detection and treatment of long-chain omega-3 fatty acid deficiency in adolescents with SSRI-resistant major depressive disorder. Pharma Nutr 2014; 2: 38-46.
28. Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry 2006; 163: 1098-1100.
29. Clayton EH, Hanstock TL, Hirneth SJ, Kable CJ, Garg ML, Hazell PL. Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation. Eur J Clin Nutr 2009; 63: 1037-1040.
30. Wozniak J, Biederman J, Mick E etal. Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial. Eur Neuropsychopharmacol 2007; 17: 440-447.
31. Flock MR, Skulas-Ray AC, Harris WS, Etherton TD, Fleming JA, Kris-Etherton PM. Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. J Am Heart Assoc 2013; 2: e000513.
32. Harris WS, von Schacky C, Park Y. Standardizing methods for assessing omega-3 fatty acid biostatus. In: McNamara RK, ed. The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention. New York: Nova Science Publishers, Inc., 2013; 385-398.
33. Sands SA, Reid KJ, Windsor SL, Harris WS. The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes. Lipids 2005; 40: 343-347.
34. Harris WS, Von Schacky C. The omega-3 index: a new risk factor for death from coronary heart disease? Prev Med 2004; 39: 212-220.
35. Angst F, Stassen HH, Clayton PJ, Angst J. Mortality of patients with mood disorders: follow-up over 34-38 years. J Affect Disord 2002; 68: 167-181.
36. Osby U, Brandt L, Correia N, Ekbom A, Sparén P. Excess mortality in bipolar and unipolar disorder in Sweden. Arch Gen Psychiatry 2001; 58: 844-850.
37. Lin PY, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry 2010; 68: 140-147.
38. Pottala JV, Talley JA, Churchill SW, Lynch DA, von Schacky C, Harris WS. Red blood cell fatty acids are associated with depression in a case-control study of adolescents. Prostaglandins Leukot Essent Fatty Acids 2012; 86: 161-165.
39. Chiu CC, Huang SY, Su KP etal. Polyunsaturated fatty acid deficit in patients with bipolar mania. Eur Neuropsychopharmacol 2003; 13: 99-103.
40. Clayton EH, Hanstock TL, Hirneth SJ, Kable CJ, Garg ML, Hazell PL. Long-chain omega-3 polyunsaturated fatty acids in the blood of children and adolescents with juvenile bipolar disorder. Lipids 2008; 43: 1031-1038.
41. McNamara RK, Jandacek R, Rider T, Tso P, Dwivedi Y, Pandey GN. Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J Affect Disord 2010; 126: 303-311.
42. Ranjekar PK, Hinge A, Hegde MV etal. Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry Res 2003; 121: 109-122.
43. McNamara RK, Jandacek RJ, Tso P etal. First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: dissociation from clinical response to lithium or quetiapine. Psychiatry Res 2015 (in press).
44. Geller B, Zimerman B, Williams M etal. Reliability of the Washington University in St. Louis kiddie schedule for affective disorders and schizophrenia (WASH-U-KSADS) mania and rapid cycling sections. J Am Acad Child Adolesc Psychiatry 2001; 40: 450-455.
45. First MB, Spitzer RL, Gibbon M, Williams JBW Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I/P). Biometrics Research Department, New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032, 1995.
46. Maxwell E. Family Interview for Genetics Studies. Washington, DC: National Institutes of Mental Health, 1999.
47. Wechsler D. Wechsler Adult Intelligence Scale-Third Edition: Administration and Scoring Manual. San Antonio, TX: Psychological Corporation, 1997.
48. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978; 133: 429-435.
49. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 25: 56-61.
50. Duke P, Litt I, Gross R. Adolescents' self-assessment of sexual maturation. Pediatrics 1980; 66: 918-920.
51. Hoen WP, Lijmer JG, Duran M, Wanders RJ, van Beveren NJ, de Haan L. Red blood cell polyunsaturated fatty acids measured in red blood cells and schizophrenia: a meta-analysis. Psychiatry Res 2013; 207: 1-12.
52. Harsløf LB, Larsen LH, Ritz C etal. FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. Am J Clin Nutr 2013; 97: 1403-1410.
53. Koletzko B, Lattka E, Zeilinger S, Illig T, Steer C. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr 2011; 93: 211-219.
54. Steer CD, Hibbeln JR, Golding J, Davey Smith G. Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms. Hum Mol Genet 2012; 21: 1504-1512.
55. Seifuddin F, Mahon PB, Judy J etal. Meta-analysis of genetic association studies on bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2012; 159B: 508-518.
56. Howard TD, Mathias RA, Seeds MC etal. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. PLoS ONE 2014; 9: e97510.
57. Brenna JT, Salem N Jr, Sinclair AJ, Cunnane SC. International Society for the Study of Fatty Acids and Lipids, ISSFAL. Alpha-linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot Essent Fatty Acids 2009; 80: 85-91.
58. Wanders RJA. Peroxisomal biosynthesis of omega-3 fatty acids and human peroxisomal diseases. In: McNamara RK, ed. The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention. New York: Nova Science Publishers, Inc., 2013; 19-30.
59. Steinberg S, Chen L, Wei L etal. The PEX Gene Screen: molecular diagnosis of peroxisome biogenesis disorders in the Zellweger syndrome spectrum. Mol Genet Metab 2004; 83: 252-263.
60. Moser AB, Jones DS, Raymond GV, Moser HW. Plasma and red blood cell fatty acids in peroxisomal disorders. Neurochem Res 1999; 24: 187-197.
61. McNamara RK, Strawn JR, Stahl L etal. Long-chain omega-3 fatty acid deficits in youth with or at high or ultra-high risk for bipolar disorder are not due to impaired peroxisomal function. Biol Psychiatry 2014; 75: S319.
62. Davison KM, Kaplan BJ. Food intake and blood cholesterol levels of community-based adults with mood disorders. BMC Psychiatry 2012; 12: 10.
63. Jacka FN, Pasco JA, Mykletun A etal. Diet quality in bipolar disorder in a population based sample of women. J Affect Disord 2011; 129: 332-337.
64. Kilbourne AM, Rofey DL, McCarthy JF, Post EP, Welsh D, Blow FC. Nutrition and exercise behavior among patients with bipolar disorder. Bipolar Disord 2007; 9: 443-452.
65. Evans SJ, Ringrose RN, Harrington GJ, Mancuso P, Burant CF, McInnis MG. Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. J Psychiatr Res 2014; 57: 58-64.
66. Block RC, Harris WS, Reid KJ, Sands SA, Spertus JA. EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. Atherosclerosis 2008; 197: 821-828.
67. Carver JD, Benford VJ, Han B, Cantor AB. The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain Res Bull 2001; 56: 79-85.
68. Connor WE, Neuringer M, Lin DS. Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys. J Lipid Res 1990; 31: 237-247.
69. McNamara RK, Hahn CG, Jandacek R etal. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry 2007; 62: 17-24.
70. McNamara RK, Jandacek R, Rider T etal. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatric Res 2008; 160: 285-299.
71. Giedd JN, Lalonde FM, Celano MJ etal. Anatomical brain magnetic resonance imaging of typically developing children and adolescents. J Am Acad Child Adolesc Psychiatry 2009; 48: 465-470.
72. Paus T, Zijdenbos A, Worsley K etal. Structural maturation of neural pathways in children and adolescents: in vivo study. Science 1999; 283: 1908-1911.
73. Sowell ER, Thompson PM, Holmes CJ, Batth R, Jernigan TL, Toga AW. Localizing age-related changes in brain structure between childhood and adolescence using statistical parametric mapping. Neuroimage 1999; 9: 587-597.
74. Conklin SM, Gianaros PJ, Brown SM etal. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neurosci Lett 2007; 421: 209-212.
75. McNamara RK, Able JA, Jandacek R etal. Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. Am J Clin Nutr 2010; 91: 1060-1067.
76. Sublette ME, Milak MS, Hibbeln JR etal. Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression. Prostaglandins Leukot Essent Fatty Acids 2009; 80: 57-64.
77. Grayson DS, Kroenke CD, Neuringer M, Fair DA. Dietary omega-3 fatty acids modulate large-scale systems organization in the rhesus macaque brain. J Neurosci 2014; 34: 2065-2074.
78. Amminger GP, Schäfer MR, Papageorgiou K etal. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 2010; 67: 146-154.