Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 80, Issue 1, 2009, Pages 57-64

  Elizabeth Sublette, M ^a,b   Milak, Matthew S ^a,b   Hibbeln, Joseph R ^c   Freed, Peter J ^a,b   Oquendo, Maria A ^a,b   Malone, Kevin M ^d   Parsey, Ramin V ^a,b   John Mann, J ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Arachidonic acid; Bipolar Disorder; Docosahexaenoic acid; Eicosapentaenoic acid; Major Depressive Disorder; PET; PUFA

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; FLUORODEOXYGLUCOSE F 18; GLUCOSE; ICOSAPENTAENOIC ACID; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID;

ADULT; ARTICLE; BRAIN REGION; CINGULATE GYRUS; CLINICAL ARTICLE; DIET SUPPLEMENTATION; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; MAJOR DEPRESSION; MALE; PARIETAL LOBE; PHOSPHOLIPID BLOOD LEVEL; PILOT STUDY; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; TEMPORAL CORTEX;

ADULT; CEREBRAL CORTEX; DEPRESSIVE DISORDER, MAJOR; FATTY ACIDS, UNSATURATED; FLUORODEOXYGLUCOSE F18; GLUCOSE; HUMANS; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY;

EID: 59649095659     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2008.11.004     Document Type: Article

References (98)

1. McNamara R.K., and Carlson S.E. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot. Essent. Fatty Acids 75 (2006) 329-349
2. Innis S.M. Dietary (n-3) fatty acids and brain development. J. Nutr. 137 (2007) 855-859
3. Rao J.S., et al. n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol. Psychiatry 12 (2007) 36-46
4. De Vriese S.R., Christophe A.B., and Maes M. Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: further evidence that lowered n-PUFAs are related to major depression. Life Sci. 73 (2003) 3181-3187
5. Edwards R., Peet M., Shay J., and Horrobin D. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J. Affect. Disord. 48 (1998) 149-155
6. Maes M., Smith R., Christophe A., Cosyns P., Desnyder R., and Meltzer H. Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids. J. Affect. Disord. 38 (1996) 35-46
7. Mamalakis G., Tornaritis M., and Kafatos A. Depression and adipose essential polyunsaturated fatty acids. Prostaglandins Leukot. Essent. Fatty Acids 67 (2002) 311-318
8. Peet M., Murphy B., Shay J., and Horrobin D. Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol. Psychiatry 43 (1998) 315-319
9. Ranjekar P.K., et al. Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry Res. 121 (2003) 109-122
10. Adams P., Lawson S., Sanigorski A., and Sinclair A. Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 31 (1996) S157-S161
11. Huan M., et al. Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Biol. Psychiatry 56 (2004) 490-496
12. Sublette M.E., Hibbeln J.R., Galfalvy H., Oquendo M.A., and Mann J.J. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am. J. Psychiatry 163 (2006) 1100-1102
13. Sobczak S., et al. Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patients. Psychol. Med. 34 (2004) 103-112
14. Sublette M.E., et al. Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania. Bipolar Disord. 9 (2007) 759-765
15. Calabrese J., et al. Depression, immunocompetence, and prostaglandins of the E series. Psychiatry Res. 17 (1986) 41-47
16. Lieb J., Karmali R., and Horrobin D. Elevated levels of prostaglandin E2 and thromboxane B2 in depression. Prostaglandins Leukot. Med. 10 (1983) 361-367
17. Linnoila M., Whorton A., Rubinow D., Cowdry R., Ninan P., and Waters R. CSF prostaglandin levels in depressed and schizophrenic patients. Arch. Gen. Psychiatry 40 (1983) 405-406
18. Nishino S., Ueno R., Ohishi K., Sakai T., and Hayaishi O. Salivary prostaglandin concentrations: possible state indicators for major depression. Am. J. Psychiatry 146 (1989) 365-368
19. Ohishi K., Ueno R., Nishino S., Sakai T., and Hayaishi O. Increased level of salivary prostaglandins in patients with major depression. Biol. Psychiatry 23 (1988) 326-334
20. Rapoport S., and Bosetti F. Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?. Arch. Gen. Psychiatry 59 (2002) 592-596
21. Rubin D., and Laposata M. Cellular interactions between n-6 and n-3 fatty acids: a mass analysis of fatty acid elongation/desaturation, distribution among complex lipids, and conversion to eicosanoids. J. Lipid Res. 33 (1992) 1431-1440
22. Contreras M.A., and Rapoport S.I. Recent studies on interactions between n-3 and n-6 polyunsaturated fatty acids in brain and other tissues. Curr. Opin. Lipidol. 13 (2002) 267-272
23. Freeman M.P., et al. Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J. Clin. Psychiatry 67 (2006) 1954-1967
24. Esposito G., et al. Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography. Neuroimage 34 (2007) 1342-1351
25. Esposito G., et al. Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography. Neuroimage 34 (2007) 1342-1351
26. 11C]arachidonic acid in young healthy humans measured with positron emission tomography. J. Cerebr. Blood Flow Metab. 22 (2002) 1453-1462
27. 11C-arachidonic acid, blood volume, and blood flow in healthy aging: a study with partial-volume correction. J. Nucl. Med. 45 (2004) 1471-1479
28. Conklin S.M., et al. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neurosci. Lett. 421 (2007) 209-212
29. Puri B., Counsell S., Hamilton G., Richardson A., and Horrobin D. Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover. Int. J. Clin. Pract. 55 (2001) 560-563
30. Frangou S., Lewis M., Wollard J., and Simmons A. Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder. J. Psychopharmacol. 21 (2007) 435-439
31. Hirashima F., et al. Omega-3 fatty acid treatment and T(2) whole brain relaxation times in bipolar disorder. Am. J. Psychiatry 161 (2004) 1922-1924
32. McNamara R.K., et al. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol. Psychiatry 62 (2007) 17-24
33. McNamara R.K., et al. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res. 160 (2008) 285-299
34. Rapoport S.I., Rao J.S., and Igarashi M. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot. Essent. Fatty Acids 77 (2007) 251-261
35. Igarashi M., DeMar Jr. J.C., Ma K., Chang L., Bell J.M., and Rapoport S.I. Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. J. Lipid Res. 48 (2007) 1150-1158
36. Favreliere S., Barrier L., Durand G., Chalon S., and Tallineau C. Chronic dietary n-3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidylethanolamine differently in rat frontal cortex, striatum, and cerebellum. Lipids 33 (1998) 401-407
37. Levant B., Ozias M.K., and Carlson S.E. Specific brain regions of female rats are differentially depleted of docosahexaenoic acid by reproductive activity and an (n-3) fatty acid-deficient diet. J. Nutr. 137 (2007) 130-134
38. Xiao Y., Huang Y., and Chen Z.Y. Distribution, depletion and recovery of docosahexaenoic acid are region-specific in rat brain. Br. J. Nutr. 94 (2005) 544-550
39. Makrides M., Neumann M.A., Byard R.W., Simmer K., and Gibson R.A. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am. J. Clin. Nutr. 60 (1994) 189-194
40. Ximenes da Silva A., Lavialle F., Gendrot G., Guesnet P., Alessandri J.M., and Lavialle M. Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids. J. Neurochem. 81 (2002) 1328-1337
41. Yu N., Martin J.L., Stella N., and Magistretti P.J. Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes. Proc. Natl. Acad. Sci. USA 90 (1993) 4042-4046
42. Pifferi F., et al. (n-3) Polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats. J. Nutr. 135 (2005) 2241-2246
43. Magistretti P.J., and Pellerin L. The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies. Mol. Psychiatry 1 (1996) 445-452
44. Neuringer M., Connor W.E., Van Petten C., and Barstad L. Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J. Clin. Invest. 73 (1984) 272-276
45. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. fourth ed (1994), DSMIV, Washington, DC
46. First M., Williams J., Spitzer R., and Gibbon M. Structured Clinical Interview for DSM-IV Axis I Disorders (1997), American Psychiatric Publishing, Inc., Washington, DC
47. Hamilton M. Development of a rating scale for primary depressive illness. Br. J. Soc. Clin. Psychol. 6 (1967) 278-296
48. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23 (1960) 56-62
49. Beck A.T., Ward C.H., Mendelson M., Mock J., and Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatry 4 (1961) 561-571
50. Anderson A.D., Oquendo M.A., Parsey R.V., Milak M.S., Campbell C., and Mann J.J. Regional brain responses to serotonin in major depressive disorder. J. Affect. Disord. 82 (2004) 411-417
51. Kegeles L.S., et al. Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders. Am. J. Psychiatry 160 (2003) 76-82
52. Milak M.S., Parsey R.V., Keilp J., Oquendo M.A., Malone K.M., and Mann J.J. Neuroanatomic correlates of psychopathologic components of major depressive disorder. Arch. Gen. Psychiatry 62 (2005) 397-408
53. Oquendo M.A., et al. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder. Neuropsychopharmacology 30 (2005) 1163-1172
54. Oquendo M.A., et al. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Arch. Gen. Psychiatry 60 (2003) 14-22
55. Folch J., Lees M., and Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226 (1957) 497-509
56. Kim H.Y., and Salem Jr. N. Separation of lipid classes by solid phase extraction. J. Lipid Res. 31 (1990) 2285-2289
57. Morrison W.R., and Smith L.M. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 53 (1964) 600-608
58. Woods R.P., Cherry S.R., and Mazziotta J.C. Rapid automated algorithm for aligning and reslicing PET images. J. Comput. Assist. Tomogr. 16 (1992) 620-633
59. Mann J.J., Malone K.M., Diehl D.J., Perel J., Cooper T.B., and Mintun M.A. Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am. J. Psychiatry 153 (1996) 174-182
60. Friston K.J., Holmes A.P., Worsley K.J., Poline J.B., Frith C.D., and Francowiak R.S.J. Statistical parametric maps in functional imaging: a general linear approach. Hum. Brain Mapp. (1995) 189-210
61. M. Brett, The MNI brain and the Talairach atlas, 〈http://www.mrc-cbu.cam.ac.uk/Imaging/Common/mnispace.shtml (2006-10-06 12:19:07)〉.
62. Lancaster J.L., et al. Automated Talairach atlas labels for functional brain mapping. Hum. Brain Mapp. 10 (2000) 120-131
63. Porter N.A. Chemistry of lipid peroxidation. Methods Enzymol. 105 (1984) 273-282
64. Simon J.A., Fong J., Bernert Jr. J.T., and Browner W.S. Relation of smoking and alcohol consumption to serum fatty acids. Am. J. Epidemiol. 144 (1996) 325-334
65. Hurst E.M. Some cortical association systems related to auditory functions. J. Comp. Neurol. 112 (1959) 103-119
66. Horn N.R., Dolan M., Elliott R., Deakin J.F., and Woodruff P.W. Response inhibition and impulsivity: an fMRI study. Neuropsychologia 41 (2003) 1959-1966
67. Paulus M.P., Feinstein J.S., Leland D., and Simmons A.N. Superior temporal gyrus and insula provide response and outcome-dependent information during assessment and action selection in a decision-making situation. Neuroimage 25 (2005) 607-615
68. Gower E.C. Efferent projections from limbic cortex of the temporal pole to the magnocellular medial dorsal nucleus in the rhesus monkey. J. Comp. Neurol. 280 (1989) 343-358
69. Kondo H., Saleem K.S., and Price J.L. Differential connections of the temporal pole with the orbital and medial prefrontal networks in macaque monkeys. J. Comp. Neurol. 465 (2003) 499-523
70. Poremba A., Malloy M., Saunders R.C., Carson R.E., Herscovitch P., and Mishkin M. Species-specific calls evoke asymmetric activity in the monkey's temporal poles. Nature 427 (2004) 448-451
71. Wang W., Shinto L., Connor W.E., and Quinn J.F. Nutritional biomarkers in Alzheimer's disease: the association between carotenoids, n-3 fatty acids, and dementia severity. J. Alzheimers Dis. 13 (2008) 31-38
72. Kotani S., et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci. Res. 56 (2006) 159-164
73. Mayberg H.S., et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am. J. Psychiatry 156 (1999) 675-682
74. Petrides M., and Pandya D.N. Association fiber pathways to the frontal cortex from the superior temporal region in the rhesus monkey. J. Comp. Neurol. 273 (1988) 52-66
75. Romanski L.M., Bates J.F., and Goldman-Rakic P.S. Auditory belt and parabelt projections to the prefrontal cortex in the rhesus monkey. J. Comp. Neurol. 403 (1999) 141-157
76. Jacobson S., and Trojanowski J.Q. Prefrontal granular cortex of the rhesus monkey. I. Intrahemispheric cortical afferents. Brain Res. 132 (1977) 209-233
77. Muller-Preuss P., Newman J.D., and Jurgens U. Anatomical and physiological evidence for a relationship between the 'cingular' vocalization area and the auditory cortex in the squirrel monkey. Brain Res. 202 (1980) 307-315
78. Hackett T.A., Stepniewska I., and Kaas J.H. Prefrontal connections of the parabelt auditory cortex in macaque monkeys. Brain Res. 817 (1999) 45-58
79. Barbas H., Ghashghaei H., Dombrowski S.M., and Rempel-Clower N.L. Medial prefrontal cortices are unified by common connections with superior temporal cortices and distinguished by input from memory-related areas in the rhesus monkey. J. Comp. Neurol. 410 (1999) 343-367
80. Barbas H., Medalla M., Alade O., Suski J., Zikopoulos B., and Lera P. Relationship of prefrontal connections to inhibitory systems in superior temporal areas in the rhesus monkey. Cereb. Cortex 15 (2005) 1356-1370
81. Chao L.L., and Knight R.T. Prefrontal deficits in attention and inhibitory control with aging. Cereb. Cortex 7 (1997) 63-69
82. Chao L.L., and Knight R.T. Contribution of human prefrontal cortex to delay performance. J. Cogn. Neurosci. 10 (1998) 167-177
83. Frith C., and Dolan R. The role of the prefrontal cortex in higher cognitive functions. Brain Res. Cogn. Brain Res. 5 (1996) 175-181
84. Dolan R.J., Fletcher P., Frith C.D., Friston K.J., Frackowiak R.S., and Grasby P.M. Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia. Nature 378 (1995) 180-182
85. Vancassel S., et al. Cerebral asymmetry and behavioral lateralization in rats chronically lacking n-3 polyunsaturated fatty acids. Biol. Psychiatry 58 (2005) 805-811
86. Yuan Y., et al. Regional gray matter changes are associated with cognitive deficits in remitted geriatric depression: an optimized voxel-based morphometry study. Biol. Psychiatry (2008)
87. George M.S., Ketter T.A., Parekh P.I., Horwitz B., Herscovitch P., and Post R.M. Brain activity during transient sadness and happiness in healthy women. Am. J. Psychiatry 152 (1995) 341-351
88. Gemar M.C., Kapur S., Segal Z.V., Brown G.M., and Houle S. Effects of self-generated sad mood on regional cerebral activity: a PET study in normal subjects. Depression 4 (1996) 81-88
89. Drevets W.C., et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386 (1997) 824-827
90. Lane R.D., Reiman E.M., Ahern G.L., Schwartz G.E., and Davidson R.J. Neuroanatomical correlates of happiness, sadness, and disgust. Am. J. Psychiatry 154 (1997) 926-933
91. Yucel M., Wood S.J., Fornito A., Riffkin J., Velakoulis D., and Pantelis C. Anterior cingulate dysfunction: implications for psychiatric disorders?. J. Psychiatry Neurosci. 28 (2003) 350-354
92. Kimbrell T.A., et al. Regional cerebral glucose utilization in patients with a range of severities of unipolar depression. Biol. Psychiatry 51 (2002) 237-252
93. Neumeister A., et al. Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch. Gen. Psychiatry 61 (2004) 765-773
94. Liotti M., Mayberg H.S., McGinnis S., Brannan S.L., and Jerabek P. Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression. Am. J. Psychiatry 159 (2002) 1830-1840
95. Muller N., and Schwarz M.J. The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol. Psychiatry 12 (2007) 988-1000
96. Nieminen L.R., Makino K.K., Mehta N., Virkkunen M., Kim H.Y., and Hibbeln J.R. Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. Prostaglandins Leukot. Essent. Fatty Acids 75 (2006) 309-314
97. Brenner R.R., Ayala S., and Garda H.A. Effect of dexamethasone on the fatty acid composition of total liver microsomal lipids and phosphatidylcholine molecular species. Lipids 36 (2001) 1337-1345
98. Koletzko B., Demmelmair H., Schaeffer L., Illig T., and Heinrich J. Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements. Nestle Nutr. Workshop Ser. Pediatr. Program. 62 (2008) 35-49