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Volumn 36, Issue 12, 2015, Pages 1539-1549

Connexin 32 and luteolin play protective roles in nonalcoholic steatohepatitis development and its related hepatocarcinogenesis in rats

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 26; CONNEXIN 32; CYTOKINE; GAP JUNCTION PROTEIN; LUTEOLIN;

EID: 84949799095     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv143     Document Type: Article
Times cited : (48)

References (50)
  • 1
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    • Bedogni, G. et al. (2005) Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology, 42, 44-52.
    • (2005) Hepatology , vol.42 , pp. 44-52
    • Bedogni, G.1
  • 2
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning, J.D. et al. (2004) Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology, 40, 1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1
  • 3
    • 84878930738 scopus 로고    scopus 로고
    • Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
    • Anstee, Q.M. et al. (2013) Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nat. Rev. Gastroenterol. Hepatol., 10, 330-344.
    • (2013) Nat. Rev. Gastroenterol. Hepatol. , vol.10 , pp. 330-344
    • Anstee, Q.M.1
  • 4
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag, H.B. et al. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1
  • 5
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    • Marchesini, G. et al. (2001) Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes, 50, 1844-1850.
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1
  • 6
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    • Tilg, H. et al. (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology, 52, 1836-1846.
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1
  • 7
    • 84870042853 scopus 로고    scopus 로고
    • Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-a production
    • Tosello-Trampont, A.C. et al. (2012) Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-a production. J. Biol. Chem., 287, 40161-40172.
    • (2012) J. Biol. Chem. , vol.287 , pp. 40161-40172
    • Tosello-Trampont, A.C.1
  • 8
    • 84928203439 scopus 로고    scopus 로고
    • Influence of lifestyle-related diseases and age on the development and progression of non-alcoholic fatty liver disease
    • Shima, T. et al. (2015) Influence of lifestyle-related diseases and age on the development and progression of non-alcoholic fatty liver disease. Hepatol. Res., 45, 548-559.
    • (2015) Hepatol. Res. , vol.45 , pp. 548-559
    • Shima, T.1
  • 9
  • 10
    • 0019624299 scopus 로고
    • Junctional intercellular communication: the cell-to-cell membrane channel
    • Loewenstein, W.R. (1981) Junctional intercellular communication: the cell-to-cell membrane channel. Physiol. Rev., 61, 829-913.
    • (1981) Physiol. Rev. , vol.61 , pp. 829-913
    • Loewenstein, W.R.1
  • 11
    • 3042821628 scopus 로고    scopus 로고
    • Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals
    • Asamoto, M. et al. (2004) Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. Hepatology, 40, 205-210.
    • (2004) Hepatology , vol.40 , pp. 205-210
    • Asamoto, M.1
  • 12
    • 31544476877 scopus 로고    scopus 로고
    • Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat
    • Hokaiwado, N. et al. (2005) Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat. Toxicol. Pathol., 33, 695-701.
    • (2005) Toxicol. Pathol. , vol.33 , pp. 695-701
    • Hokaiwado, N.1
  • 13
    • 0025784401 scopus 로고
    • Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: direct measurement of communication in vivo
    • Krutovskikh, V.A. et al. (1991) Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: direct measurement of communication in vivo. Carcinogenesis, 12, 1701-1706.
    • (1991) Carcinogenesis , vol.12 , pp. 1701-1706
    • Krutovskikh, V.A.1
  • 14
    • 4644363864 scopus 로고    scopus 로고
    • Expression of gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma
    • Nakashima, Y. et al. (2004) Expression of gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. J. Gastroenterol., 39, 763-768.
    • (2004) J. Gastroenterol. , vol.39 , pp. 763-768
    • Nakashima, Y.1
  • 15
    • 84862736476 scopus 로고    scopus 로고
    • Age-dependent carcinogenic susceptibility in rat liver is related to potential of gap junctional intercellular communication
    • Naiki-Ito, A. et al. (2012) Age-dependent carcinogenic susceptibility in rat liver is related to potential of gap junctional intercellular communication. Toxicol. Pathol., 40, 715-721.
    • (2012) Toxicol. Pathol. , vol.40 , pp. 715-721
    • Naiki-Ito, A.1
  • 16
    • 0141863402 scopus 로고    scopus 로고
    • Overview of dietary flavonoids: nomenclature, occurrence and intake
    • Beecher, G.R. (2003) Overview of dietary flavonoids: nomenclature, occurrence and intake. J. Nutr., 133, 3248S-3254S.
    • (2003) J. Nutr. , vol.133 , pp. 3248S-3254S
    • Beecher, G.R.1
  • 17
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: bioavailability, metabolic effects, and safety
    • Ross, J.A. et al. (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu. Rev. Nutr., 22, 19-34.
    • (2002) Annu. Rev. Nutr. , vol.22 , pp. 19-34
    • Ross, J.A.1
  • 18
    • 0038807711 scopus 로고    scopus 로고
    • Flavonoids: promising anticancer agents
    • Ren, W. et al. (2003) Flavonoids: promising anticancer agents. Med. Res. Rev., 23, 519-534.
    • (2003) Med. Res. Rev. , vol.23 , pp. 519-534
    • Ren, W.1
  • 19
    • 84855974972 scopus 로고    scopus 로고
    • Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress
    • Gómez-Zorita, S. et al. (2012) Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress. Br. J. Nutr., 107, 202-210.
    • (2012) Br. J. Nutr. , vol.107 , pp. 202-210
    • Gómez-Zorita, S.1
  • 20
    • 84878146773 scopus 로고    scopus 로고
    • Quercetin decreases liver damage in mice with non-alcoholic steatohepatitis
    • Marcolin, E. et al. (2013) Quercetin decreases liver damage in mice with non-alcoholic steatohepatitis. Basic Clin. Pharmacol. Toxicol., 112, 385-391.
    • (2013) Basic Clin. Pharmacol. Toxicol. , vol.112 , pp. 385-391
    • Marcolin, E.1
  • 21
    • 62749165351 scopus 로고    scopus 로고
    • Distribution and biological activities of the flavonoid luteolin
    • López-Lázaro, M. (2009) Distribution and biological activities of the flavonoid luteolin. Mini Rev. Med. Chem., 9, 31-59.
    • (2009) Mini Rev. Med. Chem. , vol.9 , pp. 31-59
    • López-Lázaro, M.1
  • 22
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner, D.E. et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology, 41, 1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1
  • 23
    • 36248965792 scopus 로고    scopus 로고
    • Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication
    • Hokaiwado, N. et al. (2007) Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication. J. Membr. Biol., 218, 101-106.
    • (2007) J. Membr. Biol. , vol.218 , pp. 101-106
    • Hokaiwado, N.1
  • 24
    • 0035869694 scopus 로고    scopus 로고
    • Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice
    • Ogawa, K. et al. (2001) Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice. Int. J. Cancer, 91, 797-802.
    • (2001) Int. J. Cancer , vol.91 , pp. 797-802
    • Ogawa, K.1
  • 25
    • 33750033153 scopus 로고    scopus 로고
    • Immortalization of Epstein-Barr virus-negative human B lymphocytes with minimal chromosomal instability
    • Yamashita, Y. et al. (2006) Immortalization of Epstein-Barr virus-negative human B lymphocytes with minimal chromosomal instability. Pathol. Int., 56, 659-667.
    • (2006) Pathol. Int. , vol.56 , pp. 659-667
    • Yamashita, Y.1
  • 26
    • 84863502669 scopus 로고    scopus 로고
    • Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
    • Tanaka, N. et al. (2012) Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology, 56, 118-129.
    • (2012) Hepatology , vol.56 , pp. 118-129
    • Tanaka, N.1
  • 27
    • 39549101454 scopus 로고    scopus 로고
    • Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis
    • Yamaguchi, K. et al. (2008) Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Hepatology, 47, 625-635.
    • (2008) Hepatology , vol.47 , pp. 625-635
    • Yamaguchi, K.1
  • 28
    • 0031240077 scopus 로고    scopus 로고
    • High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32
    • Temme, A. et al. (1997) High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr. Biol., 7, 713-716.
    • (1997) Curr. Biol. , vol.7 , pp. 713-716
    • Temme, A.1
  • 29
    • 34248224743 scopus 로고    scopus 로고
    • The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1
    • Duffy, H.S. et al. (2007) The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J. Biol. Chem., 282, 9789-9796.
    • (2007) J. Biol. Chem. , vol.282 , pp. 9789-9796
    • Duffy, H.S.1
  • 30
    • 84856222495 scopus 로고    scopus 로고
    • Connexin 32 is involved in mitosis
    • Mones, S. et al. (2012) Connexin 32 is involved in mitosis. Glia, 60, 457-464.
    • (2012) Glia , vol.60 , pp. 457-464
    • Mones, S.1
  • 31
    • 77952539714 scopus 로고    scopus 로고
    • Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat
    • Naiki-Ito, A. et al. (2010) Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat. Toxicol. Pathol., 38, 280-286.
    • (2010) Toxicol. Pathol. , vol.38 , pp. 280-286
    • Naiki-Ito, A.1
  • 32
    • 70350508190 scopus 로고    scopus 로고
    • Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor
    • Tang, M. et al. (2009) Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor. Pathol. Int., 59, 790-796.
    • (2009) Pathol. Int. , vol.59 , pp. 790-796
    • Tang, M.1
  • 33
    • 84949858527 scopus 로고    scopus 로고
    • Molecular targets of luteolin in cancer
    • Tuorkey, M.J. (2015) Molecular targets of luteolin in cancer. Eur. J. Cancer Prev.
    • (2015) Eur. J. Cancer Prev.
    • Tuorkey, M.J.1
  • 34
    • 84924553458 scopus 로고    scopus 로고
    • Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFß/Smad signalling pathways
    • Li, J. et al. (2015) Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFß/Smad signalling pathways. Liver Int., 35, 1222-1233.
    • (2015) Liver Int. , vol.35 , pp. 1222-1233
    • Li, J.1
  • 35
    • 70350608144 scopus 로고    scopus 로고
    • Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin
    • Domitrovic, R. et al. (2009) Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin. Toxicol. Appl. Pharmacol., 241, 311-321.
    • (2009) Toxicol. Appl. Pharmacol. , vol.241 , pp. 311-321
    • Domitrovic, R.1
  • 36
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia, J. et al. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 482, 179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1
  • 37
    • 2542457495 scopus 로고    scopus 로고
    • Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases
    • Martinon, F. et al. (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell, 117, 561-574.
    • (2004) Cell , vol.117 , pp. 561-574
    • Martinon, F.1
  • 38
    • 50849119416 scopus 로고    scopus 로고
    • The caspase-1 inflammasome: a pilot of innate immune responses
    • Yu, H.B. et al. (2008) The caspase-1 inflammasome: a pilot of innate immune responses. Cell Host Microbe, 4, 198-208.
    • (2008) Cell Host Microbe , vol.4 , pp. 198-208
    • Yu, H.B.1
  • 39
    • 67349085771 scopus 로고    scopus 로고
    • Liver NF-kappaB and AP-1 DNA binding in obese patients
    • Obesity (Silver Spring)
    • Videla, L.A. et al. (2009) Liver NF-kappaB and AP-1 DNA binding in obese patients. Obesity (Silver Spring), 17, 973-979.
    • (2009) , vol.17 , pp. 973-979
    • Videla, L.A.1
  • 40
    • 27744458510 scopus 로고    scopus 로고
    • NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • Dela Peña, A. et al. (2005) NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology, 129, 1663-1674.
    • (2005) Gastroenterology , vol.129 , pp. 1663-1674
    • Dela Peña, A.1
  • 41
    • 84862956270 scopus 로고    scopus 로고
    • Green tea extract suppresses NF?B activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis
    • Park, H.J. et al. (2012) Green tea extract suppresses NF?B activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis. J. Nutr., 142, 57-63.
    • (2012) J. Nutr. , vol.142 , pp. 57-63
    • Park, H.J.1
  • 42
    • 0036102128 scopus 로고    scopus 로고
    • Cloning and expression pattern of a spermatogenesis- related gene, BEX1, mapped to chromosome Xq22
    • Yang, Q.S. et al. (2002) Cloning and expression pattern of a spermatogenesis- related gene, BEX1, mapped to chromosome Xq22. Biochem. Genet., 40, 1-12.
    • (2002) Biochem. Genet. , vol.40 , pp. 1-12
    • Yang, Q.S.1
  • 43
    • 33746163546 scopus 로고    scopus 로고
    • Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma
    • Foltz, G. et al. (2006) Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Cancer Res., 66, 6665-6674.
    • (2006) Cancer Res. , vol.66 , pp. 6665-6674
    • Foltz, G.1
  • 44
    • 84878771970 scopus 로고    scopus 로고
    • Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma
    • Lee, C.H. et al. (2013) Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma. J. Pathol., 230, 298-309.
    • (2013) J. Pathol. , vol.230 , pp. 298-309
    • Lee, C.H.1
  • 45
    • 76249087046 scopus 로고    scopus 로고
    • Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
    • Inokuchi, S. et al. (2010) Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc. Natl Acad. Sci. USA, 107, 844-849.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 844-849
    • Inokuchi, S.1
  • 46
    • 84876471980 scopus 로고    scopus 로고
    • Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis
    • Uehara, T. et al. (2013) Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicol. Sci., 132, 53-63.
    • (2013) Toxicol. Sci. , vol.132 , pp. 53-63
    • Uehara, T.1
  • 47
    • 84888433791 scopus 로고    scopus 로고
    • An X-chromosomal association study identifies a susceptibility locus at Xq22.1 for hepatitis B virus-related hepatocellular carcinoma
    • Jiang, J.H. et al. (2013) An X-chromosomal association study identifies a susceptibility locus at Xq22.1 for hepatitis B virus-related hepatocellular carcinoma. Clin. Res. Hepatol. Gastroenterol., 37, 586-595.
    • (2013) Clin. Res. Hepatol. Gastroenterol. , vol.37 , pp. 586-595
    • Jiang, J.H.1
  • 48
    • 78650676828 scopus 로고    scopus 로고
    • Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells
    • Attoub, S. et al. (2011) Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells. Eur. J. Pharmacol., 651, 18-25.
    • (2011) Eur. J. Pharmacol. , vol.651 , pp. 18-25
    • Attoub, S.1
  • 49
    • 33645278637 scopus 로고    scopus 로고
    • Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle
    • Vilar, M. et al. (2006) Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J., 25, 1219-1230.
    • (2006) EMBO J. , vol.25 , pp. 1219-1230
    • Vilar, M.1
  • 50
    • 58949085535 scopus 로고    scopus 로고
    • Inhibition of apoptosis by downregulation of hBex1, a novel mechanism, contributes to the chemoresistance of Bcr/ Abl+ leukemic cells
    • Ding, K. et al. (2009) Inhibition of apoptosis by downregulation of hBex1, a novel mechanism, contributes to the chemoresistance of Bcr/ Abl+ leukemic cells. Carcinogenesis, 30, 35-42.
    • (2009) Carcinogenesis , vol.30 , pp. 35-42
    • Ding, K.1


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