Age-Dependent Carcinogenic Susceptibility in Rat Liver Is Related to Potential of Gap Junctional Intercellular Communication

Toxicologic Pathology

Volumn 40, Issue 5, 2012, Pages 715-721

  Naiki Ito, Aya ^a   Kato, Hiroyuki ^a   Asamoto, Makoto ^a   Naiki, Taku ^a   Shirai, Tomoyuki ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

aging; animal models; carcinogenesis; gap junction; liver

Indexed keywords

DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; MESSENGER RNA;

AGE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER SUSCEPTIBILITY; CELL COMMUNICATION; CONTROLLED STUDY; EVALUATION; GAP JUNCTION; GAP JUNCTIONAL INTERCELLULAR COMMUNICATION; GENE EXPRESSION; LIVER CARCINOGENESIS; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSGENIC RAT;

ANIMALS; CARCINOGENS; CELL COMMUNICATION; CONNEXINS; DIETHYLNITROSAMINE; DISEASE SUSCEPTIBILITY; GAP JUNCTIONS; GLUTATHIONE TRANSFERASE; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC;

EID: 84862736476     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312441402     Document Type: Article

References (30)

1. Asamoto M. Hokaiwado N. Murasaki T. Shirai T. (2004). Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. Hepatology 40, 205–10.
2. Balducci L. Ershler W. B. (2005). Cancer and ageing: A nexus at several levels. Nat Rev Cancer 5, 655–62.
3. Bennett M. V. Barrio L. C. Bargiello T. A. Spray D. C. Hertzberg E. Saez J. C. (1991). Gap junctions: New tools, new answers, new questions. Neuron 6, 305–20.
4. Cotrina M. L. Gao Q. Lin J. H. Nedergaard M. (2001). Expression and function of astrocytic gap junctions in aging. Brain Res 901, 55–61.
5. DePinho R. A. (2000). The age of cancer. Nature 408, 248–54.
6. Evans W. H. Martin P. E. (2002). Gap junctions: Structure and function (Review). Mol Membr Biol 19, 121–36.
7. Fukushima S. Shibata M. Tamano S. Ito N. Suzuki E. Okada M. (1987). Aging and urinary bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Natl Cancer Inst 79, 263–7.
8. Gilula N. B. Reeves O. R. Steinbach A. (1972). Metabolic coupling, ionic coupling and cell contacts. Nature 235, 262–5.
9. Gloeckler Ries L. A. Reichman M. E. Lewis D. R. Hankey B. F. Edwards B. K. (2003). Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program. Oncologist 8, 541–52.
10. Hasegawa R. Takahashi S. Imaida K. Yamaguchi S. Shirai T. Ito N. (1991). Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine. Jpn J Cancer Res 82, 293–7.
11. Hokaiwado N. Asamoto M. Futakuchi M. Ogawa K. Takahashi S. Shirai T. (2007). Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication. J Membr Biol 218, 101–6.
12. Hokaiwado N. Asamoto M. Ogawa K. Shirai T. (2005). Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat. Toxicol Pathol 33, 695–701.
13. Huang T. Y. Hanani M. Ledda M. De Palo S. Pannese E. (2006). Aging is associated with an increase in dye coupling and in gap junction number in satellite glial cells of murine dorsal root ganglia. Neuroscience 137, 1185–92.
14. Jee H. Nam K. T. Kwon H. J. Han S. U. Kim D. Y. (2011). Altered expression and localization of connexin32 in human and murine gastric carcinogenesis. Dig Dis Sci 56, 1323–32.
15. Krutovskikh V. A. Mesnil M. Mazzoleni G. Yamasaki H. (1995). Inhibition of rat liver gap junction intercellular communication by tumor-promoting agents in vivo. Association with aberrant localization of connexin proteins. Lab Invest 72, 571–7.
16. Krutovskikh V. A. Oyamada M. Yamasaki H. (1991). Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: direct measurement of communication in vivo. Carcinogenesis 12, 1701–6.
17. Loewenstein W. R. (1981). Junctional intercellular communication: The cell-to-cell membrane channel. Physiol Rev 61, 829–913.
18. Nakashima Y. Ono T. Yamanoi A. El-Assal O. N. Kohno H. Nagasue N. (2004). Expression of gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. J Gastroenterol 39, 763–8.
19. Nicholson B. Dermietzel R. Teplow D. Traub O. Willecke K. Revel J. P. (1987). Two homologous protein components of hepatic gap junctions. Nature 329, 732–4.
20. Pasciu D. Montisci S. Greco M. Doratiotto S. Pitzalis S. Pani P. Laconi S. Laconi E. (2006). Aging is associated with increased clonogenic potential in rat liver in vivo. Aging Cell 5, 373–7.
21. Paul D. L. (1986). Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol 103, 123–34.
22. Peto R. Roe F. J. Lee P. N. Levy L. Clack J. (1975). Cancer and ageing in mice and men. Br J Cancer 32, 411–26.
23. Plante I. Charbonneau M. Cyr D. G. (2002). Decreased gap junctional intercellular communication in hexachlorobenzene-induced gender-specific hepatic tumor formation in the rat. Carcinogenesis 23, 1243–9.
24. Plante I. Cyr D. G. Charbonneau M. (2007). Sexual dimorphism in the regulation of liver connexin32 transcription in hexachlorobenzene-treated rats. Toxicol Sci 96, 47–57.
25. Reuber M. D. (1976). Effect of age and sex on lesions of the esophagus in Buffalo strain rats ingesting diethylnitrosamine. Exp Cell Biol 44, 65–72.
26. Sai K. Kanno J. Hasegawa R. Trosko J. E. Inoue T. (2000). Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol. Carcinogenesis 21, 1671–6.
27. Sakamoto H. Oyamada M. Enomoto K. Mori M. (1992). Differential changes in expression of gap junction proteins connexin 26 and 32 during hepatocarcinogenesis in rats. Jpn J Cancer Res 83, 1210–5.
28. Sato H. Hagiwara H. Ohde Y. Senba H. Virgona N. Yano T. (2007). Regulation of renal cell carcinoma cell proliferation, invasion and metastasis by connexin 32 gene. J Membr Biol 216, 17–21.
29. Sato H. Hagiwara H. Senba H. Fukumoto K. Nagashima Y. Yamasaki H. Ueno K. Yano T. (2008). The inhibitory effect of connexin 32 gene on metastasis in renal cell carcinoma. Mol Carcinog 47, 403–9.
30. Vinken M. Henkens T. De Rop E. Fraczek J. Vanhaecke T. Rogiers V. (2008). Biology and pathobiology of gap junctional channels in hepatocytes. Hepatology 47, 1077–88.