-
1
-
-
84890909335
-
Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy
-
P.E. Czabotar, and et al. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy Nat. Rev. Mol. Cell Biol. 15 2014 49 63
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 49-63
-
-
Czabotar, P.E.1
-
2
-
-
84923370451
-
Small-molecule Bax agonists for cancer therapy
-
M. Xin, and et al. Small-molecule Bax agonists for cancer therapy Nat. Commun. 5 2014 4935
-
(2014)
Nat. Commun.
, vol.5
, pp. 4935
-
-
Xin, M.1
-
3
-
-
84958900764
-
Direct activation of Bax protein for cancer therapy
-
PMID: 26395559
-
Z. Liu, and et al. Direct activation of Bax protein for cancer therapy Med. Res. Rev. 2015 10.1002/med.21379 PMID: 26395559.
-
(2015)
Med. Res. Rev.
-
-
Liu, Z.1
-
4
-
-
77958508493
-
Docetaxel-based combination therapy for castration-resistant prostate cancer
-
M.D. Galsky, and N.J. Vogelzang Docetaxel-based combination therapy for castration-resistant prostate cancer Annal. Oncol. 21 2010 2135 2144
-
(2010)
Annal. Oncol.
, vol.21
, pp. 2135-2144
-
-
Galsky, M.D.1
Vogelzang, N.J.2
-
5
-
-
63149129655
-
Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy
-
M.H. Kang, and C.P. Reynolds Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy Clin. Cancer Res. 15 2009 1126 1132
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 1126-1132
-
-
Kang, M.H.1
Reynolds, C.P.2
-
6
-
-
52149113769
-
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
-
M. Kvansakul, and et al. Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands Cell Death Differ. 15 2008 1564 1571
-
(2008)
Cell Death Differ.
, vol.15
, pp. 1564-1571
-
-
Kvansakul, M.1
-
7
-
-
84931083023
-
New dimension in therapeutic targeting of BCL-2 family proteins
-
S. Besbes, and et al. New dimension in therapeutic targeting of BCL-2 family proteins Oncotarget 6 2015 12862 12871
-
(2015)
Oncotarget
, vol.6
, pp. 12862-12871
-
-
Besbes, S.1
-
8
-
-
84871202790
-
Targeting the Bcl-2 family for cancer therapy
-
S. Thomas, and et al. Targeting the Bcl-2 family for cancer therapy Expert Opin. Ther. Targets 17 2013 61 75
-
(2013)
Expert Opin. Ther. Targets
, vol.17
, pp. 61-75
-
-
Thomas, S.1
-
9
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
T. Oltersdorf, and et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature 435 2005 677 681
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
-
10
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
C. Tse, and et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor Cancer Res. 68 2008 3421 3428
-
(2008)
Cancer Res.
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
-
11
-
-
84873540049
-
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
-
A.J. Souers, and et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets Nat. Med. 19 2013 202 208
-
(2013)
Nat. Med.
, vol.19
, pp. 202-208
-
-
Souers, A.J.1
-
12
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase i study of navitoclax in patients with relapsed or refractory disease
-
A.W. Roberts, and et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease J. Clin. Oncol. 30 2012 488 496
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 488-496
-
-
Roberts, A.W.1
-
13
-
-
84859423230
-
Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer
-
G. Sonpavde, and et al. Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer Annal. Oncol. 23 2012 1803 1808
-
(2012)
Annal. Oncol.
, vol.23
, pp. 1803-1808
-
-
Sonpavde, G.1
-
14
-
-
84891783231
-
Obatoclax mesylate, a pan-bcl-2 inhibitor, in combination with docetaxel in a phase 1/2 trial in relapsed non-small-cell lung cancer
-
A. Chiappori, and et al. Obatoclax mesylate, a pan-bcl-2 inhibitor, in combination with docetaxel in a phase 1/2 trial in relapsed non-small-cell lung cancer J. Thorac. Oncol. 9 2014 121 125
-
(2014)
J. Thorac. Oncol.
, vol.9
, pp. 121-125
-
-
Chiappori, A.1
-
15
-
-
78649630259
-
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
-
W.H. Wilson, and et al. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity Lancet Oncol. 11 2010 1149 1159
-
(2010)
Lancet Oncol.
, vol.11
, pp. 1149-1159
-
-
Wilson, W.H.1
-
16
-
-
77951442337
-
Acquired resistance to ABT-737 in lymphoma cells that upregulate MCL-1 and BFL-1
-
D. Yecies, and et al. Acquired resistance to ABT-737 in lymphoma cells that upregulate MCL-1 and BFL-1 Blood 115 2010 3304 3313
-
(2010)
Blood
, vol.115
, pp. 3304-3313
-
-
Yecies, D.1
-
17
-
-
84927939215
-
Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression
-
S.M. Woo, and et al. Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression Cell Death Dis. 5 2014 e1514
-
(2014)
Cell Death Dis.
, vol.5
, pp. e1514
-
-
Woo, S.M.1
-
18
-
-
0032481346
-
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
-
D.C. Huang, and et al. The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4 EMBO J. 17 1998 1029 1039
-
(1998)
EMBO J.
, vol.17
, pp. 1029-1039
-
-
Huang, D.C.1
-
19
-
-
0031465443
-
Conversion of Bcl-2 to a Bax-like death effector by caspases
-
E.H. Cheng, and et al. Conversion of Bcl-2 to a Bax-like death effector by caspases Science 278 1997 1966 1968
-
(1997)
Science
, vol.278
, pp. 1966-1968
-
-
Cheng, E.H.1
-
20
-
-
84876680098
-
The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond
-
G. Monaco, and et al. The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond Cell Mol. Life Sci. 70 2013 1171 1183
-
(2013)
Cell Mol. Life Sci.
, vol.70
, pp. 1171-1183
-
-
Monaco, G.1
-
21
-
-
67349156098
-
Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor
-
Y.P. Rong, and et al. Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor Biochim. Biophys. Acta 1793 2009 971 978
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, pp. 971-978
-
-
Rong, Y.P.1
-
22
-
-
0021934042
-
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18
-
A. Bakhshi, and et al. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18 Cell 41 1985 899 906
-
(1985)
Cell
, vol.41
, pp. 899-906
-
-
Bakhshi, A.1
-
23
-
-
0035853130
-
Solution structure of the antiapoptotic protein bcl-2
-
A.M. Petros, and et al. Solution structure of the antiapoptotic protein bcl-2 Proc. Natl. Acad. Sci. U. S. A. 98 2001 3012 3017
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 3012-3017
-
-
Petros, A.M.1
-
24
-
-
0029032660
-
Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax
-
M. Hanada, and et al. Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax J. Biol. Chem. 270 1995 11962 11969
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11962-11969
-
-
Hanada, M.1
-
25
-
-
84874589230
-
Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth
-
D. Trisciuoglio, and et al. Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth Neoplasia 15 2013 315 327
-
(2013)
Neoplasia
, vol.15
, pp. 315-327
-
-
Trisciuoglio, D.1
-
26
-
-
84886995034
-
BH4 domain of bcl-2 protein is required for its proangiogenic function under hypoxic condition
-
C. Gabellini, and et al. BH4 domain of bcl-2 protein is required for its proangiogenic function under hypoxic condition Carcinogenesis 34 2013 2558 2567
-
(2013)
Carcinogenesis
, vol.34
, pp. 2558-2567
-
-
Gabellini, C.1
-
27
-
-
79955805684
-
Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells
-
D. Trisciuoglio, and et al. Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells Cell Death Differ. 18 2011 1024 1035
-
(2011)
Cell Death Differ.
, vol.18
, pp. 1024-1035
-
-
Trisciuoglio, D.1
-
28
-
-
84904983087
-
A dual role for the anti-apoptotic Bcl-2 protein in cancer: Mitochondria versus endoplasmic reticulum
-
H. Akl, and et al. A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum Biochim. Biophys. Acta 1843 2014 2240 2252
-
(2014)
Biochim. Biophys. Acta
, vol.1843
, pp. 2240-2252
-
-
Akl, H.1
-
29
-
-
0033575142
-
NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis
-
M. Hirotani, and et al. NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis J. Biol. Chem. 274 1999 20415 20420
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20415-20420
-
-
Hirotani, M.1
-
30
-
-
84924044826
-
Inhibition of pro-apoptotic BAX by a noncanonical interaction mechanism
-
L.A. Barclay, and et al. Inhibition of pro-apoptotic BAX by a noncanonical interaction mechanism Mol. Cell 57 2015 873 886
-
(2015)
Mol. Cell
, vol.57
, pp. 873-886
-
-
Barclay, L.A.1
-
31
-
-
42549144606
-
Bcl-2 protein family members: Versatile regulators of calcium signaling in cell survival and apoptosis
-
Y. Rong, and C.W. Distelhorst Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis Annu. Rev. Physiol. 70 2008 73 91
-
(2008)
Annu. Rev. Physiol.
, vol.70
, pp. 73-91
-
-
Rong, Y.1
Distelhorst, C.W.2
-
32
-
-
70149105706
-
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
-
Y.P. Rong, and et al. The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor Proc. Natl. Acad. Sci. U. S. A. 106 2009 14397 14402
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 14397-14402
-
-
Rong, Y.P.1
-
33
-
-
84904982394
-
Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: Potential new target for cancer treatment
-
E.F. Greenberg, and et al. Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment Biochim. Biophys. Acta 1843 2014 2205 2210
-
(2014)
Biochim. Biophys. Acta
, vol.1843
, pp. 2205-2210
-
-
Greenberg, E.F.1
-
34
-
-
0037069667
-
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand
-
I. Bosanac, and et al. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand Nature 420 2002 696 700
-
(2002)
Nature
, vol.420
, pp. 696-700
-
-
Bosanac, I.1
-
35
-
-
84920772190
-
Role of IP3 receptor signaling in cell functions and diseases
-
K. Mikoshiba Role of IP3 receptor signaling in cell functions and diseases Adv. Biol. Regul. 57 2015 217 227
-
(2015)
Adv. Biol. Regul.
, vol.57
, pp. 217-227
-
-
Mikoshiba, K.1
-
36
-
-
34248584090
-
2+ release channels
-
2+ release channels Physiol. Rev. 87 2007 593 658
-
(2007)
Physiol. Rev.
, vol.87
, pp. 593-658
-
-
Foskett, J.K.1
-
37
-
-
47349089719
-
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2s inhibition of apoptotic calcium signals
-
Y.P. Rong, and et al. Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2s inhibition of apoptotic calcium signals Mol. Cell 31 2008 255 265
-
(2008)
Mol. Cell
, vol.31
, pp. 255-265
-
-
Rong, Y.P.1
-
38
-
-
35248880092
-
TAT transduction: The molecular mechanism and therapeutic prospects
-
J.M. Gump, and S.F. Dowdy TAT transduction: the molecular mechanism and therapeutic prospects Trends Mol. Med. 13 2007 443 448
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 443-448
-
-
Gump, J.M.1
Dowdy, S.F.2
-
39
-
-
84855679389
-
Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl
-
G. Monaco, and et al. Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl Cell Death Differ. 19 2012 295 309
-
(2012)
Cell Death Differ.
, vol.19
, pp. 295-309
-
-
Monaco, G.1
-
40
-
-
84926443310
-
2+ signals to mitochondria
-
2+ signals to mitochondria J. Biol. Chem. 290 2015 9150 9161
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 9150-9161
-
-
Monaco, G.1
-
41
-
-
0345498292
-
Bcl-2 targets the protein kinase Raf-1 to mitochondria
-
H.G. Wang, and et al. Bcl-2 targets the protein kinase Raf-1 to mitochondria Cell 87 1996 629 638
-
(1996)
Cell
, vol.87
, pp. 629-638
-
-
Wang, H.G.1
-
42
-
-
0030901628
-
Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2
-
F. Shibasaki, and et al. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2 Nature 386 1997 728 731
-
(1997)
Nature
, vol.386
, pp. 728-731
-
-
Shibasaki, F.1
-
43
-
-
0029843941
-
Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation
-
G.P. Linette, and et al. Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation Proc. Natl. Acad. Sci. U. S. A. 93 1996 9545 9552
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 9545-9552
-
-
Linette, G.P.1
-
44
-
-
0037458565
-
Bcl-2, via its BH4 domain, blocks apoptotic signaling mediated by mitochondrial Ras
-
G.V. Denis, and et al. Bcl-2, via its BH4 domain, blocks apoptotic signaling mediated by mitochondrial Ras J. Biol. Chem. 278 2003 5775 5785
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 5775-5785
-
-
Denis, G.V.1
-
45
-
-
1642483463
-
Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching
-
C.M. Sorenson Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching J. Biol. Chem. 279 2004 11368 11374
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 11368-11374
-
-
Sorenson, C.M.1
-
46
-
-
33744907788
-
Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity
-
Z. Jin, and et al. Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity J. Biol. Chem. 281 2006 14446 14456
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14446-14456
-
-
Jin, Z.1
-
47
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
48
-
-
34548234344
-
Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway
-
W. Qu, and et al. Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway Environ. Health Perspect. 115 2007 1094 1100
-
(2007)
Environ. Health Perspect.
, vol.115
, pp. 1094-1100
-
-
Qu, W.1
-
49
-
-
79953119371
-
Induction of Ca(2) + -driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction
-
F. Zhong, and et al. Induction of Ca(2) + -driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction Blood 117 2011 2924 2934
-
(2011)
Blood
, vol.117
, pp. 2924-2934
-
-
Zhong, F.1
-
50
-
-
84930573524
-
Small-molecule Bcl2 BH4 antagonist for lung cancer therapy
-
B. Han, and et al. Small-molecule Bcl2 BH4 antagonist for lung cancer therapy Cancer Cell 27 2015 852 863
-
(2015)
Cancer Cell
, vol.27
, pp. 852-863
-
-
Han, B.1
-
51
-
-
3342984659
-
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
-
R. Chen, and et al. Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate J. Cell Biol. 166 2004 193 203
-
(2004)
J. Cell Biol.
, vol.166
, pp. 193-203
-
-
Chen, R.1
-
52
-
-
47349099011
-
Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content
-
C.J. Hanson, and et al. Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content Cell Calcium 44 2008 324 338
-
(2008)
Cell Calcium
, vol.44
, pp. 324-338
-
-
Hanson, C.J.1
-
53
-
-
84879354997
-
IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2
-
H. Akl, and et al. IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2 Cell Death Dis. 4 2013 e632
-
(2013)
Cell Death Dis.
, vol.4
, pp. e632
-
-
Akl, H.1
-
54
-
-
84944462891
-
A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2
-
A.R. Lavik, and et al. A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2 Oncotarget 6 2015 27388 27402
-
(2015)
Oncotarget
, vol.6
, pp. 27388-27402
-
-
Lavik, A.R.1
-
55
-
-
84947907997
-
HA14-1 potentiates apoptosis in B-cell cancer cells sensitive to a peptide disrupting IP receptor/Bcl-2 complexes
-
PMID: 26260683
-
H. Akl, and et al. HA14-1 potentiates apoptosis in B-cell cancer cells sensitive to a peptide disrupting IP receptor/Bcl-2 complexes Int. J. Dev. Biol. 2015 10.1387/ijdb.150213gb PMID: 26260683
-
(2015)
Int. J. Dev. Biol.
-
-
Akl, H.1
-
56
-
-
84875643331
-
HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines
-
H. Akl, and et al. HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines Haematologica 98 2013 e49 e51
-
(2013)
Haematologica
, vol.98
, pp. e49-e51
-
-
Akl, H.1
-
57
-
-
84893350516
-
Phase II study of everolimus-erlotinib in previously treated patients with advanced non-small-cell lung cancer
-
B. Besse, and et al. Phase II study of everolimus-erlotinib in previously treated patients with advanced non-small-cell lung cancer Annal. Oncol. 25 2014 409 415
-
(2014)
Annal. Oncol.
, vol.25
, pp. 409-415
-
-
Besse, B.1
-
58
-
-
84874027374
-
Phase II study of docetaxel in combination with everolimus for second- or third-line therapy of advanced non-small-cell lung cancer
-
S.S. Ramalingam, and et al. Phase II study of docetaxel in combination with everolimus for second- or third-line therapy of advanced non-small-cell lung cancer J. Thorac. Oncol. 8 2013 369 372
-
(2013)
J. Thorac. Oncol.
, vol.8
, pp. 369-372
-
-
Ramalingam, S.S.1
-
59
-
-
33847381100
-
A decade of fragment-based drug design: Strategic advances and lessons learned
-
P.J. Hajduk, and J. Greer A decade of fragment-based drug design: strategic advances and lessons learned Nat. Rev. Drug Discov. 6 2007 211 219
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 211-219
-
-
Hajduk, P.J.1
Greer, J.2
-
60
-
-
84873738776
-
Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy
-
H. Chen, and et al. Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy Eur. J. Med. Chem. 62 2013 498 507
-
(2013)
Eur. J. Med. Chem.
, vol.62
, pp. 498-507
-
-
Chen, H.1
-
61
-
-
84902175603
-
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)
-
H. Chen, and et al. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3) Eur. J. Med. Chem. 82 2014 195 203
-
(2014)
Eur. J. Med. Chem.
, vol.82
, pp. 195-203
-
-
Chen, H.1
-
62
-
-
84921533887
-
Evolutions in fragment-based drug design: The deconstruction-reconstruction approach
-
H. Chen, and et al. Evolutions in fragment-based drug design: the deconstruction-reconstruction approach Drug Discov. Today 20 2015 105 113
-
(2015)
Drug Discov. Today
, vol.20
, pp. 105-113
-
-
Chen, H.1
-
63
-
-
50449091105
-
Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2
-
C. Katz, and et al. Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2 Proc. Natl. Acad. Sci. U. S. A. 105 2008 12277 12282
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 12277-12282
-
-
Katz, C.1
-
64
-
-
77955606618
-
Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90
-
D. Trisciuoglio, and et al. Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90 PLoS One 5 2010 e11772
-
(2010)
PLoS One
, vol.5
, pp. e11772
-
-
Trisciuoglio, D.1
-
65
-
-
34247882128
-
Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex
-
Y. Hou, and et al. Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex J. Biol. Chem. 282 2007 9279 9287
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9279-9287
-
-
Hou, Y.1
-
66
-
-
84892705383
-
Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase
-
M. Xie, and et al. Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase Cancer Res. 74 2014 212 223
-
(2014)
Cancer Res.
, vol.74
, pp. 212-223
-
-
Xie, M.1
-
67
-
-
84902531937
-
Bcl-2 binds to and inhibits ryanodine receptors
-
T. Vervliet, and et al. Bcl-2 binds to and inhibits ryanodine receptors J. Cell Sci. 127 2014 2782 2792
-
(2014)
J. Cell Sci.
, vol.127
, pp. 2782-2792
-
-
Vervliet, T.1
-
68
-
-
0034724190
-
BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death
-
S. Shimizu, and et al. BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death Proc. Natl. Acad. Sci. U. S. A. 97 2000 3100 3105
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 3100-3105
-
-
Shimizu, S.1
|