HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines

Haematologica

Volumn 98, Issue 4, 2013, Pages

  Akl, Haidar ^a   Vandecaetsbeek, Ilse ^a   Monaco, Giovanni ^a   Kauskot, Alexandre ^b   Luyten, Tomas ^a   Welkenhuyzen, Kirsten ^a   Hoylaerts, Marc ^a   De Smedt, Humbert ^a   Parys, Jan B ^a   Bultynck, Geert ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

BH3 mimetic; Calcium; Molecular pharmacology; Platelets

Indexed keywords

2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL) PROPYLAMINO] 3 NITROBENZENESULFONYL] BENZAMIDE; CALCIUM; FURA 2; LIPOCORTIN 5; PROTEIN BCL 2; PROTEIN BCL XL; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THAPSIGARGIN; UNCLASSIFIED DRUG;

APOPTOSIS; CALCIUM HOMEOSTASIS; COLORIMETRY; CONTROLLED STUDY; DOSE RESPONSE; DYNAMICS; FLOW CYTOMETRY; FLUOROMETRY; HISTOGRAM; HUMAN; HUMAN CELL; LETTER; THROMBOCYTE; THROMBOCYTOPENIA; VENOUS BLOOD;

APOPTOSIS; BENZOPYRANS; BIPHENYL COMPOUNDS; BLOOD PLATELETS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; FLOW CYTOMETRY; HEK293 CELLS; HELA CELLS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; NITRILES; NITROPHENOLS; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SULFONAMIDES; THAPSIGARGIN;

EID: 84875643331     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2012.080598     Document Type: Letter

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