The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria

Journal of Biological Chemistry

Volumn 290, Issue 14, 2015, Pages 9150-9161

  Monaco, Giovanni ^a   Decrock, Elke ^b   Arbel, Nir ^c   Van Vliet, Alexander R ^a   La Rovere, Rita M ^a,d   De Smedt, Humbert ^a   Parys, Jan B ^a   Agostinis, Patrizia ^a   Leybaert, Luc ^b   Shoshan Barmatz, Varda ^c   Bultynck, Geert ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d Faculty of Pharmacy   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL MEMBRANES; MITOCHONDRIA; PEPTIDES; PLANTS (BOTANY);

APOPTOTIC CELL DEATH; APOPTOTIC FUNCTION; ENDOPLASMIC RETICULUM; N-TERMINAL DOMAINS; OUTER MITOCHONDRIAL MEMBRANES; SYNTHETIC PEPTIDE; TRANSPORT SYSTEMS; VOLTAGE-DEPENDENT ANION CHANNELS;

CALCIUM COMPOUNDS;

CALCIUM ION; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PROTEIN BCL 2; PROTEIN BCL XL; STAUROSPORINE; VOLTAGE DEPENDENT ANION CHANNEL 1; BCL2L1 PROTEIN, MOUSE; PROTEIN BCL X;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; BH4 DOMAIN; CALCIUM CONDUCTANCE; CALCIUM SIGNALING; CONTROLLED STUDY; ELECTROPORATION; EMBRYO; ENDOPLASMIC RETICULUM; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; CALCIUM SIGNALING; CELLS, CULTURED; MICE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 84926443310     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.622514     Document Type: Article

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