IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2

Cell Death and Disease

Volumn 4, Issue 5, 2013, Pages

  Akl, H ^a   Monaco, G ^a   La Rovere, R ^a,b   Welkenhuyzen, K ^a   Kiviluoto, S ^a   Vervliet, T ^a   Molgo J ^c   Distelhorst, C W ^d   Missiaen, L ^a   Mikoshiba, K ^e   Parys, J B ^a   De Smedt, H ^a   Bultynck, G ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY OF CHIETI   (Italy)

^c CNRS   (France)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Apoptosis; B cell lymphoma; Bcl 2; Ca2+ signaling; Cell death; IP3 receptors

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM ION; HYBRID PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR 2; POLYPEPTIDE; PROTEIN BCL 2; STABILIZED TAT INOSITOL 1,4,5 TRIPHOSPHATE RECEPTOR DERIVED PEPTIDE FUSION PROTEIN; UNCLASSIFIED DRUG; CALCIUM; ISOPROTEIN; PEPTIDE; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CANCER RESISTANCE; CELL ACTIVATION; CELL LEVEL; CELL SURVIVAL; CHEMOSENSITIVITY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; DRUG TARGETING; LARGE CELL LYMPHOMA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STRAIN DIFFERENCE; CHEMISTRY; CHRONIC LYMPHATIC LEUKEMIA; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RNA INTERFERENCE; TUMOR CELL LINE;

APOPTOSIS; CALCIUM; CELL LINE, TUMOR; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; PEPTIDES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84879354997     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.140     Document Type: Article

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