Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 195-203

  Chen, Haijun ^a,c   Yang, Zhengduo ^b   Ding, Chunyong ^a   Xiong, Ailian ^b   Wild, Christopher ^a   Wang, Lili ^b   Ye, Na ^a   Cai, Guoshuai ^b   Flores, Rudolfo M ^a   Ding, Ye ^a   Shen, Qiang ^b   Zhou, Jia ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c FUZHOU UNIVERSITY   (China)

Author keywords

Anticancer agents; Breast cancer; Oral bioavailability; Pancreatic cancer; STAT3 inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CYCLIN D1; HJC 0149; HJC0416; HYDROXYL GROUP; STAT3 PROTEIN; UNCLASSIFIED DRUG; (5-CHLORO-N-(1,1-DIOXO-1H-1LAMDA(6)-BENZO(B)THIOPHEN-6-YL)-2-HYDROXYBENZAMIDE; BENZAMIDE DERIVATIVE; MOLECULAR LIBRARY; STAT3 PROTEIN, HUMAN; THIOPHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER SIZE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DOWN REGULATION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRIPLE NEGATIVE BREAST CANCER; ADMINISTRATION AND DOSAGE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF 7 CELL LINE; METABOLISM; MOLECULAR LIBRARY; NUDE MOUSE; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHARMACOLOGY; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; MICE; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; STAT3 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84902175603     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.049     Document Type: Article

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