Optimization, physicochemical characterization and in vivo assessment of spray dried emulsion: A step toward bioavailability augmentation and gastric toxicity minimization

International Journal of Pharmaceutics

Volumn 496, Issue 2, 2015, Pages 766-779

  Mehanna, Mohammed M ^a,b   Alwattar, Jana K ^a   Elmaradny, Hoda A ^a  

^a BEIRUT ARAB UNIVERSITY   (Lebanon)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Bioavailability; Class II; Dissolution; Dry emulsion; Factorial design; Spray drying

Indexed keywords

INDOMETACIN; POLOXAMER; ACYLGLYCEROL; EMULSION; LABRASOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; EMULSION; FACTORIAL DESIGN; FEMALE; GASTROINTESTINAL TOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SPRAY DRIED EMULSION; SPRAY DRYING; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DRUG EFFECTS; SOLUBILITY; STOMACH MUCOSA;

ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; EMULSIONS; FEMALE; GASTRIC MUCOSA; GLYCERIDES; INDOMETHACIN; MICROSCOPY, ELECTRON, SCANNING; POLOXAMER; RATS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84949624297     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.11.009     Document Type: Article

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