The physicochemical characteristics and bioavailability of indomethacin from β-cyclodextrin, hydroxyethyl-β-cyclodextrin, and hydroxypropyl-β-cyclodextrin complexes

International Journal of Pharmaceutics

Volumn 270, Issue 1-2, 2004, Pages 149-166

  Jambhekar, Sunil ^a   Casella, R ^b   Maher, T ^a  

^a MA Coll of Pharm and Hlth Sci   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Bioavailability; Complex formation; Differential scanning calorimetry; Infrared; Nuclear magnetic resonance; Phase solubility; Powder X ray diffraction; Thermogravimetric analysis; Ultraviolet

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; BETA CYCLODEXTRIN; CYCLODEXTRIN DERIVATIVE; HYDROCHLORIC ACID; HYDROXYETHYL BETA CYCLODEXTRIN; INDOMETACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CAPSULE FILLING; COMPLEX FORMATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SOLUBILITY; INFRARED SPECTROMETRY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; POWDER DIFFRACTION; PREFORMULATION; PRIORITY JOURNAL; X RAY POWDER DIFFRACTION;

EID: 0347651904     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.10.012     Document Type: Article

References (23)

1. Borka L. The polymorphism of indomethacine. Acta. Pharm. Suecica. 11:1974;295-303.
2. Brooks M., Weinfeld R. A validation process for data from the analysis of drugs in biological fluids. Drug Dev. Ind. Pharm. 11:1985;1703-1728.
3. Casella R., Williams D., Jambhekar S. Solid-state β-cyclodextrin complexes containing indomethacin, ammonia, and water. I. Formation studies. Int. J. Pharm. 165:1998a;1-14.
4. Casella R., Williams D., Jambhekar S. Solid-state β-cyclodextrin complexes containing indomethacin, ammonia, and water. II. Solubility studies. Int. J. Pharm. 165:1998;15-22.
5. Chan K., Miller K. Nonlinear regression approach for determining whether absorption and elimination rate constants are equal in the one-compartment model with first-order processes. J. Pharm. Sci. 72:1983;574-576.
6. Chiba K., Takahashi M., Hayase N., Akutsu S., Inagaki S. Stability of indomethacin in aqueous solution (1): kinetic studies and effect of solvents on the hydrolysis of indomethacin. Jpn. J. Hosp. Pharm. 18:1992;43-51.
7. Eng L., Carrig C., Cordle C., Metz C. Delivery of substances to the rabbit gastrointestinal tract by oral dosing with gelatin capsules. Lab. Anim. Sci. 37:1987;239-241.
8. Frank D. Inclusion compounds. J. Pharm. Sci. 64:1975;1585-1604.
9. Gibaldi, M., Perrier, D., 1982. Pharmacokinetics. Second edition. Marcel Dekker, NY, pp. 30-45.
10. Iwaoku R., Arimori K., Nakano M., Uekama K. Enhanced absorption of phenobarbital from suppositories containing phenobarbital-β-cyclodextrin inclusion complex. Chem. Pharm. Bull. 30:1982;1416-1421.
11. Kuroda T., Yokoyama T., Umeda T., Matsuzawa A., Kuroda K., Asada S. Studies on sustained-release dosage forms II. Pharmacokinetics after rectal administration of indomethacin suppositories in rabbits. Chem. Pharm. Bull. 31:1983;3319-3325.
12. Nambu N., Shimoda M., Takahashi Y., Ueda H., Nagai T. Bioavailability of powdered inclusion compounds of non-steroidal anti-inflammatory drugs with β-cyclodextrin in rabbits and dogs. Chem. Pharm. Bull. 26:1978;2952-2956.
13. Ohnishi N., Yokoyama T., Umeda T., Kiyohara Y., Kuroda T., Kita Y., Kuroda K. Preparation of sustained-release suppositories of indomethacin using a solid dispersion system and evaluation of bioavailability in rabbits. Chem. Pharm. Bull. 34:1986;2999-3004.
14. Otagiri M., Imia T., Matsuo N., Uekama K. Improvement to some pharmaceutical properties of flurbiprofen by β- and γ-cyclodextrin complexations. Acta. Pharm. Suec. 20:1983;1-10.
15. Patel I. Concentration ratio method to determine the rate constant for the special case when Ka = ke. J. Pharm. Sci. 73:1984;859-861.
16. Pitha J., Harman S., Michel E. Hydrophilic cyclodextrin derivatives enable effective oral administration of steroidal hormones. J. Pharm. Sci. 75:1986;165-167.
17. Rowland, M., Tozer, T., 1989. Clinical Pharmacokinetics: Concepts and Applications. Second edition. Lea and Febiger, Philadelphia, PA, pp. 35-41.
18. Shen T., Winter C. Chemical and biological studies on indomethacin, sulindac and their analogs. Adv. Drug Res. 12:1972;165-169.
19. Seo H., Tsuruoka M., Hashimoto T., Fujinaga T., Otagiri M., Uekama K. Enhancement of the oral bioavailability of spironolacone by β- and γ-cyclodextrin complexations. Chem. Pharm. Bull. 31:1983;286-291.
20. Uekama K., Fujinaga T., Hirayama F., Otagiri M., Yamasaki M., Seo H., Hashimoto T., Tsuruoka M. Improvement of the oral bioavailability of digitalis glycosides by cyclodextrin complexation. J. Pharm. Sci. 72:1983a;1338-1341.
21. Uekama K., Narisawa S., Hirayama F., Otagiri M. Improvement of dissolution and absorption characteristics of benzodiazepines by cyclodextrin complexation. Int. J. Pharm. 16:1983;327-338.
22. l methyl ester by cyclodextrin complexation. J. Pharm. Sci. 68:1979;1059-1060.
23. Venho V., Eriksson H. The rabbit: an animal model for comparative bioavailability studies of drugs. Int. J. Pharm. 30:1986;91-94.