Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid

International Journal of Pharmaceutics

Volumn 287, Issue 1-2, 2004, Pages 55-66

  Hansen, Tue ^a,b   Holm, Per ^c   Schultz, Kirsten ^a  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c LifeCycle Pharma   (Denmark)

Author keywords

Compactibility; Compressibility; Dry emulsion; Lipid formulation; Poorly soluble drug; Spray drying

Indexed keywords

ATTAPULGITE; GELATIN; LIPID; MANNITOL; MEDIUM CHAIN TRIACYLGLYCEROL; SUGAR; TREHALOSE; WATER OIL CREAM;

ARTICLE; DRUG FORMULATION; DRUG SOLUBILITY; DRY POWDER; EMULSION; MICROENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL; SPRAY DRYING; TABLET COMPRESSION;

EMULSIONS; PARTICLE SIZE; POWDERS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TRIGLYCERIDES; WATER;

EID: 8444221211     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.08.014     Document Type: Article

References (27)

1. A. Burger, J.O. Henck, S. Hetz, J.M. Rollinger, A.A. Weissnicht, and H. Stöttner Energy/temperature diagram and compression behavior of the polymorphs of d-mannitol J. Pharm. Sci. 89 2000 457 468
2. W.N. Charman, C.J.H. Porter, S. Mithani, and J.B. Dressman Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH J. Pharm. Sci. 86 1997 269 282
3. K.L. Christensen, G.P. Pedersen, and H.G. Kristensen Preparation of redispersible dry emulsions by spray drying Int. J. Pharm. 212 2001 187 194
4. K.L. Christensen, G.P. Pedersen, and H.G. Kristensen Technical optimisation of redispersible dry emulsions Int. J. Pharm. 212 2001 195 202
5. K.L. Christensen, G.P. Pedersen, and H.G. Kristensen Physical stability of redispersible dry emulsions containing amorphous sucrose Eur. J. Pharm. Biopharm. 53 2002 147 153
6. S. Corveleyn, and J.P. Remon Stability of freeze-dried tablets at different relative humidities Drug Dev. Ind. Pharm. 25 1999 1005 1013
7. G. Dollo, P. Le Corre, A. Guérin, F. Chevanne, J.L. Burgot, and R. Leverge Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs Eur. J. Pharm. Sci. 19 2003 273 280
8. J.T. Fell, and J.M. Newton Determination of tablet strength by the diametral-compression test J. Pharm. Sci. 59 1970 688 691
9. A.J. Humberstone, and W.N. Charman Lipid-based vehicles for the oral delivery of poorly water soluble drugs Adv. Drug Deliv. Rev. 25 1997 103 128
10. J. Kristensen, T. Schaefer, and P. Kleinebudde Development of fast-disintegrating pellets in a rotary processor Drug Dev. Ind. Pharm. 28 2002 1201 1212
11. K. Masters Spray Drying in Practice 2002 SprayDryConsult International ApS Charlottenlund pp. 190-197
12. V. Naini, P.R. Byron, and E.M. Phillips Physicochemical stability of crystalline sugars and their spray-dried forms: dependence upon relative humidity and suitability for use in powder inhalers Drug Dev. Ind. Pharm. 24 1998 895 909
13. Y. Nakamoto, M. Hashida, S. Muranishi, and H. Sezaki Studies on pharmaceutical modification of anticancer agents. II. Enhanced delivery of bleomycin into lymph by emulsions and drying emulsions Chem. Pharm. Bull. 23 1975 3125 3131
14. J.M. Odeberg, P. Kaufmann, K.G. Kroon, and P. Höglund Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine Eur. J. Pharm. Sci. 20 2003 375 382
15. G.P. Pedersen, P. Faldt, B. Bergenstahl, and H.G. Kristensen Solid state characterisation of a dry emulsion: a potential drug delivery system Int. J. Pharm. 171 1998 257 270
16. S. Pedersen, and H.G. Kristensen Change in crystal density of acetylsalicylic acid during compaction STP Pharm. Sci. 4 1994 201 206
17. C.J.H. Porter, S.A. Charman, R.D. Williams, M.V. Bakalova, and W.N. Charman Evaluation of emulsifiable glasses for the oral administration of cyclosporin in beagle dogs Int. J. Pharm. 141 1996 227 237
18. A. Richter, and K. Steiger-Trippi Untersuchungen über die zerstäubungstrocknung von emulgierten Arzneizubereitungen Pharm. Acta Helv. 36 1961 322 337
19. J.M. Sonnergaard A critical evaluation of the Heckel equation Int. J. Pharm. 193 1999 63 71
20. H. Takeuchi, H. Sasaki, T. Niwa, T. Hino, Y. Kawashima, K. Uesugi, M. Kayano, and Y. Miyake Preparation of powdered redispersible vitamin E acetate emulsion by spray-drying technique Chem. Pharm. Bull. 39 1991 1528 1531
21. H. Takeuchi, H. Sasaki, T. Niwa, T. Hino, Y. Kawashima, K. Uesugi, and H. Ozawa Redispersible dry emulsion system as novel oral dosage form of oily drugs: in vivo studies in beagle dogs Chem. Pharm. Bull. 39 1991 3362 3364
22. H. Takeuchi, H. Sasaki, T. Niwa, T. Hino, Y. Kawashima, K. Uesugi, and H. Ozawa Design of redispersible dry emulsion as an advanced dosage form of oily drug (vitamin E nicotinate) by spray-drying technique Drug Dev. Ind. Pharm. 18 1992 919 937
23. H. Takeuchi, H. Sasaki, T. Niwa, T. Hino, Y. Kawashima, K. Uesugi, and H. Ozawa Improvement of photostability of ubidecarenone in the formulation of a novel powdered dosage form termed redispersible dry emulsion Int. J. Pharm. 86 1992 25 33
24. B.D. Tarr, and S.H. Yalkowsky Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size Pharm. Res. 6 1989 40 43
25. L.S. Taylor, and P. York Characterization of the phase transitions of trehalose dihydrate on heating and subsequent dehydration J. Pharm. Sci. 87 1998 347 355
26. E.E. Walker The properties of powders. VI. The compressibility of powders Trans. Faraday Soc. 19 1923 73 82
27. J. Zhang, and G. Zografi Water vapor absorption into amorphous sucrose-poly(vinyl pyrrolidone) and trehalose-poly(vinyl pyrrolidone) mixtures J. Pharm. Sci. 90 2001 1375 1385