Cerebro-cerebellar circuits in autism spectrum disorder

Frontiers in Neuroscience

Volumn 9, Issue NOV, 2015, Pages

  D'Mello, Anila M ^a   Stoodley, Catherine J ^a  

^a AMERICAN UNIVERSITY   (United States)

Author keywords

Autism spectrum disorder; Cerebellum; Cerebo cerebellar circuits; Diffusion tensor imaging; Functional connectivity; Neuroimaging; Resting state MRI; Voxel based morphometry

Indexed keywords

ARTICLE; AUTISM; BRAIN CORTEX; BRAIN MALFORMATION; CEREBELLUM; CONNECTOME; DISEASE ASSOCIATION; DISEASE SEVERITY; HUMAN; LANGUAGE ABILITY; MOTOR CONTROL; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NEUROMODULATION; NONHUMAN; SENSORIMOTOR CORTEX; SOCIAL COGNITION; SOCIAL INTERACTION; STEREOTYPY; TOPOGRAPHY;

EID: 84949549954     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2015.00408     Document Type: Article

References (185)

1. Adamaszek, M., Kirkby, K. C., D'Agata, F., Olbrich, S., Langner, S., Steele, C., et al. (2015). Neural correlates of impaired emotional face recognition in cerebellar lesions. Brain Res. 1613, 1-12. doi: 10.1016/j.brainres.2015.01.027.
2. Akshoomoff, N., Lord, C., Lincoln, A. J., Courchesne, R. Y., Carper, R. A., Townsend, J., et al. (2004). Outcome classification of preschool children with autism spectrum disorders using MRI brain measures. J. Am. Acad. Child Adolesc. Psychiatry 43, 349-357. doi: 10.1097/00004583-200403000-00018.
3. Allen, G., and Courchesne, E. (2003). Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: an fMRI study of Autism. Am. J. Psychiatry 160, 262-273. doi: 10.1176/appi.ajp.160.2.262.
4. Allen, G., Müller, R.-A., and Courchesne, E. (2004). Cerebellar function in autism: functional magnetic resonance image activation during a simple motor task. Biol. Psychiatry 56, 269-278. doi: 10.1016/j.biopsych.2004.06.005.
5. Allen, G. (2005). The cerebellum in autism. Clin. Neuropsychiatry 2, 321-337.
6. Balsters, J. H., Cussans, E., Diedrichsen, J., Phillips, K. A., Preuss, T. M., Rilling, J. K., et al. (2010). Evolution of the cerebellar cortex: the selective expansion of prefrontal-projecting cerebellar lobules. Neuroimage 49, 2045-2052. doi: 10.1016/j.neuroimage.2009.10.045.
7. Baron-Cohen, S. (2000). "Theory of mind and autism: A fifteen year review," in Understanding other Minds: Perspectives from Developmental Cognitive Neuroscience, 2nd Edn., eds. S. Baron-Cohen, H. Tager-Flusberg and D. J. Cohen (New York, NY,: Oxford University Press), 3-20.
8. Bauman, M. L., and Kemper, T. L. (2005). Neuroanatomic observations of the brain in autism: a review and future directions. Int. J. Dev. Neurosci. 23, 183-187. doi: 10.1016/j.ijdevneu.2004.09.006.
9. Beaulieu, C. (2002). The basis of anisotropic water diffusion in the nervous system-a technical review. NMR Biomed. 15, 435-455. doi: 10.1002/nbm.782.
10. Becker, E. B., and Stoodley, C. J. (2013). Autism spectrum disorder and the cerebellum. Int. Rev. Neurobiol. 113, 1-34. doi: 10.1016/B978-0-12-418700-9.00001-0.
11. Beebe, D. W., Ris, M. D., Armstrong, F. D., Fontanesi, J., Mulhern, R., Holmes, E., et al. (2005). Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891/POG 9130). J. Clin. Oncol. 23, 5198-5204. doi: 10.1200/JCO.2005.06.117.
12. Berl, M. M., Mayo, J., Parks, E. N., Rosenberger, L. R., VanMeter, J., Ratner, N. B., et al. (2014). Regional differences in the developmental trajectory of lateralization of the language network. Hum. Brain Mapp. 35, 270-284. doi: 10.1002/hbm.22179.
13. Biotteau, M., Chaix, Y., and Albaret, J.-M. (2015). Procedural learning and automatization process in children with developmental coordination disorder and/or developmental dyslexia. Hum. Mov. Sci. 43, 78-89. doi: 10.1016/j.humov.2015.07.005.
14. Bird, G., Silani, G., Brindley, R., White, S., Frith, U., and Singer, T. (2010). Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain 133, 1515-1525. doi: 10.1093/brain/awq060.
15. Bohlhalter, S., Goldfine, A., Matteson, S., Garraux, G., Hanakawa, T., Kansaku, K., et al. (2006). Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study. Brain 129, 2029-2037. doi: 10.1093/brain/awl050.
16. Bolduc, M.-E., and Limperopoulos, C. (2009). Neurodevelopmental outcomes in children with cerebellar malformations: a systematic review. Dev. Med. Child Neurol. 51, 256-267. doi: 10.1111/j.1469-8749.2008.03224.x.
17. Bolduc, M.-E., du Plessis, A. J., Sullivan, N., Guizard, N., Zhang, X., Robertson, R. L., et al. (2012). Regional cerebellar volumes predict functional outcome in children with cerebellar malformations. Cerebellum 11, 531-542. doi: 10.1007/s12311-011-0312-z.
18. Booth, J. R., Wood, L., Lu, D., Houk, J. C., and Bitan, T. (2007). The role of the basal ganglia and cerebellum in language processing. Brain Res. 1133, 136-144. doi: 10.1016/j.brainres.2006.11.074.
19. Bostan, A. C., and Strick, P. L. (2010). The cerebellum and basal ganglia are interconnected. Neuropsychol. Rev. 20, 261-270. doi: 10.1007/s11065-010-9143-9.
20. Brielmaier, J., Matteson, P. G., Silverman, J. L., Senerth, J. M., Kelly, S., Genestine, M., et al. (2012). Autism-relevant social abnormalities and cognitive deficits in Engrailed-2 knockout mice. PLoS ONE 7:e40914. doi: 10.1371/journal.pone.0040914.
21. Brito, A. R., Vasconcelos, M. M., Domingues, R. C., Hygino da Cruz, L. C. Jr., Rodrigues Lde, S., Calçada, C. A., et al. (2009). Diffusion Tensor Imaging findings in school-aged autistic children. J. Neuroimaging 19, 337-343. doi: 10.1111/j.1552-6569.2009.00366.x.
22. Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., and Yeo, B. T. T. (2011). The organization of the human cerebellum estimated by intrinsic functional connectivity. J. Neurophysiol. 106, 2322-2345. doi: 10.1152/jn.00339.2011.
23. Carper, R. A., and Courchesne, E. (2000). Inverse correlation between frontal lobe and cerebellum sizes in children with autism. Brain 123(Pt 4), 836-844. doi: 10.1093/brain/123.4.836.
24. Catani, M., Jones, D. K., Daly, E., Embiricos, N., Deeley, Q., Pugliese, L., et al. (2008). Altered cerebellar feedback projections in Asperger syndrome. Neuroimage 41, 1184-1191. doi: 10.1016/j.neuroimage.2008.03.041.
25. Cauda, F., Geda, E., Sacco, K., D'Agata, F., Duca, S., Geminiani, G., et al. (2011). Grey matter abnormality in autism spectrum disorder: an activation likelihood estimation meta-analysis study. J. Neurol. Neurosurg. Psychiatry 82, 1304-1313. doi: 10.1136/jnnp.2010.239111.
26. Chen, S. H. A., and Desmond, J. E. (2005a). Cerebrocerebellar networks during articulatory rehearsal and verbal working memory tasks. Neuroimage 24, 332-338. doi: 10.1016/j.neuroimage.2004.08.032.
27. Chen, S. H. A., and Desmond, J. E. (2005b). Temporal dynamics of cerebro-cerebellar network recruitment during a cognitive task. Neuropsychologia 43, 1227-1237. doi: 10.1016/j.neuropsychologia.2004.12.015.
28. Cheng, Y., Chou, K.-H., Chen, I.-Y., Fan, Y.-T., Decety, J., and Lin, C.-P. (2010). Atypical development of white matter microstructure in adolescents with autism spectrum disorders. Neuroimage 50, 873-882. doi: 10.1016/j.neuroimage.2010.01.011.
29. Cheung, C., Chua, S. E., Cheung, V., Khong, P. L., Tai, K. S., Wong, T. K. W., et al. (2009). White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism. J. Child Psychol. Psychiatry 50, 1102-1112. doi: 10.1111/j.1469-7610.2009.02086.x.
30. Chevallier, C., Kohls, G., Troiani, V., Brodkin, E. S., and Schultz, R. T. (2012). The social motivation theory of autism. Trends Cogn. Sci. 16, 231-239. doi: 10.1016/j.tics.2012.02.007.
31. Courchesne, E., Saitoh, O., Yeung-Courchesne, R., Press, G. A., Lincoln, A. J., Haas, R. H., et al. (1994a). Abnormality of cerebellar vermian lobules VI and VII in patients with infantile autism: identification of hypoplastic and hyperplastic subgroups with MR imaging. Am. J. Roentgenol. 162, 123-130. doi: 10.2214/ajr.162.1.8273650.
32. Courchesne, E., Townsend, J., and Saitoh, O. (1994b). The brain in infantile autism: posterior fossa structures are abnormal. Neurology 44, 214-223. doi: 10.1212/WNL.44.2.214.
33. Courchesne, E., Yeung-Courchesne, R., Press, G. A., Hesselink, J. R., and Jernigan, T. L. (1988). Hypoplasia of cerebellar vermal lobules VI and VII in autism. N. Engl. J. Med. 318, 1349-1354. doi: 10.1056/NEJM198805263182102.
34. Critchley, H. D., Daly, E. M., Bullmore, E. T., Williams, S. C. R., Van Amelsvoort, T., Robertson, D. M., et al. (2000). The functional neuroanatomy of social behaviour. Brain 123, 2203-2212. doi: 10.1093/brain/123.11.2203.
35. Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., et al. (2006). Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat. Neurosci. 9, 28-30. doi: 10.1038/nn1611.
36. Dawson, G., Warrenburg, S., and Fuller, P. (1982). Cerebral lateralization in individuals diagnosed as autistic in early childhood. Brain Lang. 15, 353-368. doi: 10.1016/0093-934X(82)90065-7.
37. Deeley, Q., Daly, E. M., Surguladze, S., Page, L., Toal, F., Robertson, D., et al. (2007). An event related functional magnetic resonance imaging study of facial emotion processing in Asperger Syndrome. Biol. Psychiatry 62, 207-217. doi: 10.1016/j.biopsych.2006.09.037.
38. Dell'Acqua, F., Bodi, I., Slater, D., Catani, M., and Modo, M. (2013). MR diffusion histology and micro-tractography reveal mesoscale features of the human cerebellum. Cerebellum 12, 923-931. doi: 10.1007/s12311-013-0503-x.
39. Deniz Can, D., Richards, T., and Kuhl, P. K. (2013). Early gray-matter and white-matter concentration in infancy predict later language skills: a whole brain voxel-based morphometry study. Brain Lang. 124, 34-44. doi: 10.1016/j.bandl.2012.10.007.
40. DeRamus, T. P., and Kana, R. K. (2015). Anatomical likelihood estimation meta-analysis of grey and white matter anomalies in autism spectrum disorders. Neuroimage Clin. 7, 525-536. doi: 10.1016/j.nicl.2014.11.004.
41. Desmond, J. E., Gabrieli, J. D., Wagner, A. D., Ginier, B. L., and Glover, G. H. (1997). Lobular patterns of cerebellar activation in verbal working-memory and finger-tapping tasks as revealed by functional MRI. J. Neurosci. 17, 9675-9685.
42. Diedrichsen, J., Balsters, J. H., Flavell, J., Cussans, E., and Ramnani, N. (2009). A probabilistic MR atlas of the human cerebellum. Neuroimage 46, 39-46. doi: 10.1016/j.neuroimage.2009.01.045.
43. Diedrichsen, J. (2006). A spatially unbiased atlas template of the human cerebellum. Neuroimage 33, 127-138. doi: 10.1016/j.neuroimage.2006.05.056.
44. D'Mello, A. M., Crocetti, D., Mostofsky, S. H., and Stoodley, C. J. (2014). "Cerebellar grey matter correlates with early language delay in autism," in Cerebellum and Autism Nanosymposium, Society for Neuroscience Annual Meeting (Washington, DC).
45. D'Mello, A. M., Crocetti, D., Mostofsky, S. H., and Stoodley, C. J. (2015). Cerebellar gray matter and lobular volumes correlate with core autism symptoms. Neuroimage Clin. 7, 631-639. doi: 10.1016/j.nicl.2015.02.007.
46. Doyon, J., Song, A. W., Karni, A., Lalonde, F., Adams, M. M., and Ungerleider, L. G. (2002). Experience-dependent changes in cerebellar contributions to motor sequence learning. Proc. Natl. Acad. Sci. U.S.A. 99, 1017-1022. doi: 10.1073/pnas.022615199.
47. Dum, R. P., and Strick, P. L. (2003). An unfolded map of the cerebellar dentate nucleus and its projections to the cerebral cortex. J. Neurophysiol. 89, 634-639. doi: 10.1152/jn.00626.2002.
48. Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J. N., Lin, L., Genestine, M., et al. (2015). Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol. Psychiatry 20, 118-125. doi: 10.1038/mp.2014.98.
49. Escalante-Mead, P. R., Minshew, N. J., and Sweeney, J. A. (2003). Abnormal brain lateralization in high-functioning Autism. J. Autism Dev. Disord. 33, 539-543. doi: 10.1023/A:1025887713788.
50. Eyler, L. T., Pierce, K., and Courchesne, E. (2012). A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism. Brain 135, 949-960. doi: 10.1093/brain/awr364.
51. Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., et al. (2012). Consensus paper: pathological role of the cerebellum in autism. Cerebellum 11, 777-807. doi: 10.1007/s12311-012-0355-9.
52. Fatemi, S. H., Halt, A. R., Realmuto, G., Earle, J., Kist, D. A., Thuras, P., et al. (2002). Purkinje cell size is reduced in cerebellum of patients with Autism. Cell. Mol. Neurobiol. 22, 171-175. doi: 10.1023/A:1019861721160.
53. Fitzgerald, J., Johnson, K., Kehoe, E., Bokde, A. L. W., Garavan, H., Gallagher, L., et al. (2015). Disrupted functional connectivity in dorsal and ventral attention networks during attention orienting in Autism spectrum disorders. Autism Res. 8, 136-152. doi: 10.1002/aur.1430.
54. Flagg, E. J., Cardy, J. E. O., Roberts, W., and Roberts, T. P. L. (2005). Language lateralization development in children with autism: insights from the late field magnetoencephalogram. Neurosci. Lett. 386, 82-87. doi: 10.1016/j.neulet.2005.05.037.
55. Fulbright, R. K., Jenner, A. R., Mencl, W. E., Pugh, K. R., Shaywitz, B. A., Shaywitz, S. E., et al. (1999). The cerebellum's role in reading: a functional MR imaging study. Am. J. Neuroradiol. 20, 1925-1930.
56. Galea, J. M., Vazquez, A., Pasricha, N., de Xivry, J.-J. O., and Celnik, P. (2011). Dissociating the roles of the cerebellum and motor cortex during adaptive learning: the motor cortex retains what the cerebellum learns. Cereb. Cortex 21, 1761-1770. doi: 10.1093/cercor/bhq246.
57. Grodd, W., Hülsmann, E., Lotze, M., Wildgruber, D., and Erb, M. (2001). Sensorimotor mapping of the human cerebellum: fMRI evidence of somatotopic organization. Hum. Brain Mapp. 13, 55-73. doi: 10.1002/hbm.1025.
58. Groen, W. B., Buitelaar, J. K., van der Gaag, R. J., and Zwiers, M. P. (2011). Pervasive microstructural abnormalities in autism: a DTI study. J. Psychiatry Neurosci. 36, 32-40. doi: 10.1503/jpn.090100.
59. Groen, W. B., Tesink, C., Petersson, K. M., Berkum, J., van der Gaag, R. J., Hagoort, P., et al. (2010). Semantic, factual, and social language comprehension in adolescents with Autism: an FMRI study. Cereb. Cortex 20, 1937-1945. doi: 10.1093/cercor/bhp264.
60. Groen, W. B., Zwiers, M. P., van der Gaag, R.-J., and Buitelaar, J. K. (2008). The phenotype and neural correlates of language in autism: an integrative review. Neurosci. Biobehav. Rev. 32, 1416-1425. doi: 10.1016/j.neubiorev.2008.05.008.
61. Grogan, A., Green, D. W., Ali, N., Crinion, J. T., and Price, C. J. (2009). Structural correlates of semantic and phonemic fluency ability in first and second languages. Cereb. Cortex 19, 2690-2698. doi: 10.1093/cercor/bhp023.
62. Habas, C., Kamdar, N., Nguyen, D., Prater, K., Beckmann, C. F., Menon, V., et al. (2009). Distinct cerebellar contributions to intrinsic connectivity networks. J. Neurosci. 29, 8586-8594. doi: 10.1523/JNEUROSCI.1868-09.2009.
63. Haber, S. N. (2011). "Neuroanatomy of reward: a view from the Ventral Striatum," in Neurobiology of Sensation and Reward. Frontiers in Neuroscience, ed J. Gottfried (Boca Raton, FL: CRC Press), 235.
64. Hanaie, R., Mohri, I., Kagitani-Shimono, K., Tachibana, M., Azuma, J., Matsuzaki, J., et al. (2013). Altered microstructural connectivity of the superior cerebellar peduncle is related to motor dysfunction in children with autistic spectrum disorders. Cerebellum 12, 645-656. doi: 10.1007/s12311-013-0475-x.
65. Harris, G. J., Chabris, C. F., Clark, J., Urban, T., Aharon, I., Steele, S., et al. (2006). Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging. Brain Cogn. 61, 54-68. doi: 10.1016/j.bandc.2005.12.015.
66. Heath, R. G., and Harper, J. W. (1974). Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: evoked potential and histological studies in monkeys and cats. Exp. Neurol. 45, 268-287. doi: 10.1016/0014-4886(74)90118-6.
67. Hervais-Adelman, A., Moser-Mercer, B., and Golestani, N. (2015). Brain functional plasticity associated with the emergence of expertise in extreme language control. Neuroimage 114, 264-274. doi: 10.1016/j.neuroimage.2015.03.072.
68. Hodge, S. M., Makris, N., Kennedy, D. N., Caviness, V. S. Jr., Howard, J., McGrath, L., et al. (2010). Cerebellum, language, and cognition in autism and specific language impairment. J. Autism Dev. Disord. 40, 300-316. doi: 10.1007/s10803-009-0872-7.
69. Hollander, E., Anagnostou, E., Chaplin, W., Esposito, K., Haznedar, M. M., Licalzi, E., et al. (2005). Striatal volume on magnetic resonance imaging and repetitive behaviors in Autism. Biol. Psychiatry 58, 226-232. doi: 10.1016/j.biopsych.2005.03.040.
70. Hou, J., Wu, W., Lin, Y., Wang, J., Zhou, D., Guo, J., et al. (2012). Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: a resting-state fMRI study. J. Affect. Disord. 138, 313-321. doi: 10.1016/j.jad.2012.01.022.
71. Ingram, J. L., Peckham, S. M., Tisdale, B., and Rodier, P. M. (2000). Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicol. Teratol. 22, 319-324. doi: 10.1016/S0892-0362(99)00083-5.
72. Itahashi, T., Yamada, T., Watanabe, H., Nakamura, M., Jimbo, D., Shioda, S., et al. (2014). Altered network topologies and hub organization in adults with Autism: a resting-state fMRI study. PLoS ONE 9:e94115. doi: 10.1371/journal.pone.0094115.
73. Itahashi, T., Yamada, T., Watanabe, H., Nakamura, M., Ohta, H., Kanai, C., et al. (2015). Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder. Mol. Autism 6, 30. doi: 10.1186/s13229-015-0026-z.
74. Ito, M. (2002). Historical review of the significance of the cerebellum and the role of Purkinje cells in motor learning. Ann. N. Y. Acad. Sci. 978, 273-288. doi: 10.1111/j.1749-6632.2002.tb07574.x.
75. Ito, M. (2006). Cerebellar circuitry as a neuronal machine. Prog. Neurobiol. 78, 272-303. doi: 10.1016/j.pneurobio.2006.02.006.
76. Ito, M. (2008). Control of mental activities by internal models in the cerebellum. Nat. Rev. Neurosci. 9, 304-313. doi: 10.1038/nrn2332.
77. Jack, A., Englander, Z. A., and Morris, J. P. (2011). Subcortical contributions to effective connectivity in brain networks supporting imitation. Neuropsychologia 49, 3689-3698. doi: 10.1016/j.neuropsychologia.2011.09.024.
78. Jack, A., and Morris, J. P. (2014). Neocerebellar contributions to social perception in adolescents with autism spectrum disorder. Dev. Cogn. Neurosci. 10, 77-92. doi: 10.1016/j.dcn.2014.08.001.
79. Jack, A., and Pelphrey, K. A. (2014). Neural correlates of animacy attribution include neocerebellum in healthy adults. Cereb. Cortex 25:bhu146. doi: 10.1093/cercor/bhu146.
80. Jeong, J. W., Chugani, D. C., Behen, M. E., Tiwari, V. N., and Chugani, H. T. (2012). Altered white matter structure of the dentatorubrothalamic pathway in children with autistic spectrum disorders. Cerebellum 11, 957-971. doi: 10.1007/s12311-012-0369-3.
81. Jeong, J. W., Tiwari, V. N., Behen, M. E., Chugani, H. T., and Chugani, D. C. (2014). In vivo detection of reduced Purkinje cell fibers with diffusion MRI tractography in children with autistic spectrum disorders. Front. Hum. Neurosci. 8:110. doi: 10.3389/fnhum.2014.00110.
82. Jissendi, P., Baudry, S., and Balériaux, D. (2008). Diffusion tensor imaging (DTI) and tractography of the cerebellar projections to prefrontal and posterior parietal cortices: a study at 3T. J. Neuroradiol. 35, 42-50. doi: 10.1016/j.neurad.2007.11.001.
83. Jones, T. B., Bandettini, P. A., Kenworthy, L., Case, L. K., Milleville, S. C., Martin, A., et al. (2010). Sources of group differences in functional connectivity: an investigation applied to autism spectrum disorder. Neuroimage 49, 401-414. doi: 10.1016/j.neuroimage.2009.07.051.
84. Joseph, R. M., Fricker, Z., Fenoglio, A., Lindgren, K. A., Knaus, T. A., and Tager-Flusberg, H. (2014). Structural asymmetries of language-related gray and white matter and their relationship to language function in young children with ASD. Brain Imaging Behav. 8, 60-72. doi: 10.1007/s11682-013-9245-0.
85. Jung, M., Kosaka, H., Saito, D. N., Ishitobi, M., Morita, T., Inohara, K., et al. (2014). Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits. Mol. Autism 5:35. doi: 10.1186/2040-2392-5-35.
86. Kates, W. R., Burnette, C. P., Eliez, S., Strunge, L. A., Kaplan, D., Landa, R., et al. (2004). Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism. Am. J. Psychiatry 161, 539-546. doi: 10.1176/appi.ajp.161.3.539.
87. Kellermann, T., Regenbogen, C., De Vos, M., Mößnang, C., Finkelmeyer, A., and Habel, U. (2012). Effective connectivity of the human cerebellum during visual attention. J. Neurosci. 32, 11453-11460. doi: 10.1523/JNEUROSCI.0678-12.2012.
88. Kelly, R. M., and Strick, P. L. (2003). Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J. Neurosci. 23, 8432-8444.
89. Khan, A. J., Nair, A., Keown, C. L., Datko, M. C., Lincoln, A. J., and Müller, R.-A. (2015). Cerebro-cerebellar resting state functional connectivity in children and adolescents with autism spectrum disorder. Biol. Psychiatry 28, 625-634. doi: 10.1016/j.biopsych.2015.03.024.
90. Kim, J.-J., Lee, M. C., Kim, J., Kim, I. Y., Kim, S. I., Han, M. H., et al. (2001). Grey matter abnormalities in obsessive-compulsive disorder. Br. J. Psychiatry 179, 330-334. doi: 10.1192/bjp.179.4.330.
91. Kleinhans, N. M., Schweinsburg, B. C., Cohen, D. N., Müller, R.-A., and Courchesne, E. (2007). N-acetyl aspartate in autism spectrum disorders: regional effects and relationship to fMRI activation. Brain Res. 1162, 85-97. doi: 10.1016/j.brainres.2007.04.081.
92. Klucharev, V., Hytönen, K., Rijpkema, M., Smidts, A., and Fernández, G. (2009). Reinforcement learning signal predicts social conformity. Neuron 61, 140-151. doi: 10.1016/j.neuron.2008.11.027.
93. Knaus, T. A., Silver, A. M., Kennedy, M., Lindgren, K. A., Dominick, K. C., Siegel, J., et al. (2010). Language laterality in autism spectrum disorder and typical controls: a functional, volumetric, and diffusion tensor MRI study. Brain Lang. 112, 113-120. doi: 10.1016/j.bandl.2009.11.005.
94. Koshino, H., Kana, R. K., Keller, T. A., Cherkassky, V. L., Minshew, N. J., and Just, M. A. (2008). fMRI investigation of working memory for faces in Autism: visual coding and underconnectivity with frontal areas. Cereb. Cortex 18, 289-300. doi: 10.1093/cercor/bhm054.
95. Küper, M., Dimitrova, A., Thürling, M., Maderwald, S., Roths, J., Elles, H. G., et al. (2011). Evidence for a motor and a non-motor domain in the human dentate nucleus-An fMRI study. Neuroimage 54, 2612-2622. doi: 10.1016/j.neuroimage.2010.11.028.
96. Lerner, A., Bagic, A., Boudreau, E. A., Hanakawa, T., Pagan, F., Mari, Z., et al. (2007). Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome. Neurology 68, 1979-1987. doi: 10.1212/01.wnl.0000264417.18604.12.
97. Leslie, K. R., Johnson-Frey, S. H., and Grafton, S. T. (2004). Functional imaging of face and hand imitation: towards a motor theory of empathy. Neuroimage 21, 601-607. doi: 10.1016/j.neuroimage.2003.09.038.
98. Levisohn, L., Cronin-Golomb, A., and Schmahmann, J. D. (2000). Neuropsychological consequences of cerebellar tumour resection in children: cerebellar cognitive affective syndrome in a paediatric population. Brain 123(Pt 5), 1041-1050. doi: 10.1093/brain/123.5.1041.
99. Limperopoulos, C., Bassan, H., Gauvreau, K., Robertson, R. L., Sullivan, N. R., Benson, C. B., et al. (2007). Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? Pediatrics 120, 584-593. doi: 10.1542/peds.2007-1041.
100. Limperopoulos, C., Chilingaryan, G., Guizard, N., Robertson, R. L., and Du Plessis, A. J. (2010). Cerebellar injury in the premature infant is associated with impaired growth of specific cerebral regions. Pediatr. Res. 68, 145-150. doi: 10.1203/PDR.0b013e3181e1d032.
101. Limperopoulos, C., Chilingaryan, G., Sullivan, N., Guizard, N., Robertson, R. L., and du Plessis, A. J. (2012). Injury to the premature cerebellum: outcome is related to remote cortical development. Cereb. Cortex 24, 728-736. doi: 10.1093/cercor/bhs354.
102. Lindell, A. K., and Hudry, K. (2013). Atypicalities in cortical structure, handedness, and functional lateralization for language in Autism spectrum disorders. Neuropsychol. Rev. 23, 257-270. doi: 10.1007/s11065-013-9234-5.
103. Lombardo, M. V., Chakrabarti, B., Bullmore, E. T., Sadek, S. A., Pasco, G., Wheelwright, S. J., et al. (2010). Atypical neural self-representation in autism. Brain 133, 611-624. doi: 10.1093/brain/awp306.
104. Mariën, P., Ackermann, H., Adamaszek, M., Barwood, C. H. S., Beaton, A., Desmond, J., et al. (2014). Consensus paper: language and the cerebellum: an ongoing enigma. Cerebellum 13, 386-410. doi: 10.1007/s12311-013-0540-5.
105. Mars, R. B., Sallet, J., Schüffelgen, U., Jbabdi, S., Toni, I., and Rushworth, M. F. S. (2012). Connectivity-based subdivisions of the human right "temporoparietal junction area": evidence for different areas participating in different cortical networks. Cereb. Cortex 22, 1894-1903. doi: 10.1093/cercor/bhr268.
106. Mathiak, K., Hertrich, I., Grodd, W., and Ackermann, H. (2002). Cerebellum and speech perception: a functional magnetic resonance imaging study. J. Cogn. Neurosci. 14, 902-912. doi: 10.1162/089892902760191126.
107. Mathiak, K., Hertrich, I., Grodd, W., and Ackermann, H. (2004). Discrimination of temporal information at the cerebellum: functional magnetic resonance imaging of nonverbal auditory memory. Neuroimage 21, 154-162. doi: 10.1016/j.neuroimage.2003.09.036.
108. McAlonan, G. M., Suckling, J., Wong, N., Cheung, V., Lienenkaemper, N., Cheung, C., et al. (2008). Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome. J. Child Psychol. Psychiatry 49, 1287-1295. doi: 10.1111/j.1469-7610.2008.01933.x.
109. Middleton, F. A., and Strick, P. L. (2000). Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res. Rev. 31, 236-250. doi: 10.1016/S0165-0173(99)00040-5.
110. Mosconi, M. W., Kay, M., D'Cruz, A.-M., Seidenfeld, A., Guter, S., Stanford, L. D., et al. (2009). Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders. Psychol. Med. 39, 1559-1566. doi: 10.1017/S0033291708004984.
111. Mostofsky, S. H., Dubey, P., Jerath, V. K., Jansiewicz, E. M., Goldberg, M. C., and Denckla, M. B. (2006). Developmental dyspraxia is not limited to imitation in children with autism spectrum disorders. J. Int. Neuropsychol. Soc. 12, 314-326. doi: 10.1017/s1355617706060437.
112. Mostofsky, S. H., Powell, S. K., Simmonds, D. J., Goldberg, M. C., Caffo, B., and Pekar, J. J. (2009). Decreased connectivity and cerebellar activity in autism during motor task performance. Brain 132, 2413-2425. doi: 10.1093/brain/awp088.
113. Müller, R.-A., Chugani, D. C., Behen, M. E., Rothermel, R. D., Muzik, O., Chakraborty, P. K., et al. (1998). Impairment of dentato-thalamo-cortical pathway in autistic men: language activation data from positron emission tomography. Neurosci. Lett. 245, 1-4. doi: 10.1016/S0304-3940(98)00151-7.
114. Müller, R.-A., Kleinhans, N., Kemmotsu, N., Pierce, K., and Courchesne, E. (2003). Abnormal variability and distribution of functional maps in autism: an FMRI study of visuomotor learning. Am. J. Psychiatry 160, 1847-1862. doi: 10.1176/appi.ajp.160.10.1847.
115. Müller, R.-A., Pierce, K., Ambrose, J. B., Allen, G., and Courchesne, E. (2001). Atypical patterns of cerebral motor activation in autism: a functional magnetic resonance study. Biol. Psychiatry 49, 665-676. doi: 10.1016/S0006-3223(00)01004-0.
116. Murphy, C. M., Christakou, A., Daly, E. M., Ecker, C., Giampietro, V., Brammer, M., et al. (2014). Abnormal functional activation and maturation of fronto-striato-temporal and cerebellar regions during sustained attention in Autism spectrum disorder. Am. J. Psychiatry 171, 1107-1116. doi: 10.1176/appi.ajp.2014.12030352.
117. Nabeyama, M., Nakagawa, A., Yoshiura, T., Nakao, T., Nakatani, E., Togao, O., et al. (2008). Functional MRI study of brain activation alterations in patients with obsessive-compulsive disorder after symptom improvement. Psychiatry Res. Neuroimaging 163, 236-247. doi: 10.1016/j.pscychresns.2007.11.001.
118. Nebel, M. B., Joel, S. E., Muschelli, J., Barber, A. D., Caffo, B. S., Pekar, J. J., et al. (2014). Disruption of functional organization within the primary motor cortex in children with autism: functional parcellation of the motor cortex. Hum. Brain Mapp. 35, 567-580. doi: 10.1002/hbm.22188.
119. Noonan, S. K., Haist, F., and Müller, R.-A. (2009). Aberrant functional connectivity in autism: evidence from low-frequency BOLD signal fluctuations. Brain Res. 1262, 48-63. doi: 10.1016/j.brainres.2008.12.076.
120. Paakki, J.-J., Rahko, J., Long, X., Moilanen, I., Tervonen, O., Nikkinen, J., et al. (2010). Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders. Brain Res. 1321, 169-179. doi: 10.1016/j.brainres.2009.12.081.
121. Padmanabhan, A., Lynn, A., Foran, W., Luna, B., and O'Hearn, K. (2013). Age related changes in striatal resting state functional connectivity in autism. Front. Hum. Neurosci. 7:814. doi: 10.3389/fnhum.2013.00814.
122. Pantelis, P. C., Byrge, L., Tyszka, J. M., Adolphs, R., and Kennedy, D. P. (2015). A specific hypoactivation of right temporo-parietal junction/posterior superior temporal sulcus in response to socially awkward situations in autism. Soc. Cogn. Affect. Neurosci. 10, 1348-1356. doi: 10.1093/scan/nsv021.
123. Papathanassiou, D., Etard, O., Mellet, E., Zago, L., Mazoyer, B., and Tzourio-Mazoyer, N. (2000). A common language network for comprehension and production: a contribution to the definition of language epicenters with PET. Neuroimage 11, 347-357. doi: 10.1006/nimg.2000.0546.
124. Petersen, S. E., Fox, P. T., Posner, M. I., Mintun, M., and Raichle, M. E. (1989). Positron emission tomographic studies of the processing of single words. J. Cogn. Neurosci. 1, 153-170. doi: 10.1162/jocn.1989.1.2.153.
125. Philip, R. C. M., Dauvermann, M. R., Whalley, H. C., Baynham, K., Lawrie, S. M., and Stanfield, A. C. (2012). A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders. Neurosci. Biobehav. Rev. 36, 901-942. doi: 10.1016/j.neubiorev.2011.10.008.
126. Pierce, K., and Courchesne, E. (2001). Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biol. Psychiatry 49, 655-664. doi: 10.1016/S0006-3223(00)01008-8.
127. Pierce, K., Haist, F., Sedaghat, F., and Courchesne, E. (2004). The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain 127, 2703-2716. doi: 10.1093/brain/awh289.
128. Pliatsikas, C., Johnstone, T., and Marinis, T. (2014a). fMRI evidence for the involvement of the procedural memory system in morphological processing of a second language. PLoS ONE 9:e97298. doi: 10.1371/journal.pone.0097298.
129. Pliatsikas, C., Johnstone, T., and Marinis, T. (2014b). Grey matter volume in the cerebellum is related to the processing of grammatical rules in a second language: a structural voxel-based morphometry study. Cerebellum 13, 55-63. doi: 10.1007/s12311-013-0515-6.
130. Redcay, E., and Courchesne, E. (2008). Deviant fMRI patterns of brain activity to speech in 2-3 year-old children with autism spectrum disorder. Biol. Psychiatry 64, 589-598. doi: 10.1016/j.biopsych.2008.05.020.
131. Redcay, E., Haist, F., and Courchesne, E. (2008). Functional neuroimaging of speech perception during a pivotal period in language acquisition. Dev. Sci. 11, 237-252. doi: 10.1111/j.1467-7687.2008.00674.x.
132. Riva, D., Annunziata, S., Contarino, V., Erbetta, A., Aquino, D., and Bulgheroni, S. (2013). Gray matter reduction in the vermis and CRUS-II is associated with social and interaction deficits in low-functioning children with Autistic Spectrum Disorders: a VBM-DARTEL study. Cerebellum 12, 676-685. doi: 10.1007/s12311-013-0469-8.
133. Riva, D., and Giorgi, C. (2000). The cerebellum contributes to higher functions during development: evidence from a series of children surgically treated for posterior fossa tumours. Brain 123(Pt 5), 1051-1061. doi: 10.1093/brain/123.5.1051.
134. Rogers, S. J., and Pennington, B. F. (1991). A theoretical approach to the deficits in infantile autism. Dev. Psychopathol. 3, 137-162. doi: 10.1017/S0954579400000043.
135. Rogers, T. D., McKimm, E., Dickson, P. E., Goldowitz, D., Blaha, C. D., and Mittleman, G. (2013). Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research. Front. Syst. Neurosci. 7:15. doi: 10.3389/fnsys.2013.00015.
136. Rojas, D. C., Peterson, E., Winterrowd, E., Reite, M. L., Rogers, S. J., and Tregellas, J. R. (2006). Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms. BMC Psychiatry 6:56. doi: 10.1186/1471-244X-6-56.
137. Sahyoun, C. P., Belliveau, J. W., and Mody, M. (2010). White matter integrity and pictorial reasoning in high-functioning children with autism. Brain Cogn. 73, 180-188. doi: 10.1016/j.bandc.2010.05.002.
138. Schmahmann, J. D., Macmore, J., and Vangel, M. (2009). Cerebellar stroke without motor deficit: clinical evidence for motor and non-motor domains within the human cerebellum. Neuroscience 162, 852-861. doi: 10.1016/j.neuroscience.2009.06.023.
139. Schmahmann, J. D., and Pandya, D. N. (1997). Anatomic organization of the basilar pontine projections from prefrontal cortices in rhesus monkey. J. Neurosci. 17, 438-458.
140. Schmahmann, J. D., and Sherman, J. C. (1998). The cerebellar cognitive affective syndrome. Brain 121(Pt 4), 561-579. doi: 10.1093/brain/121.4.561.
141. Schmahmann, J. D., Weilburg, J. B., and Sherman, J. C. (2007). The neuropsychiatry of the cerebellum-insights from the clinic. Cerebellum 6, 254-267. doi: 10.1080/14734220701490995.
142. Schmahmann, J. D. (1991). An emerging concept: the cerebellar contribution to higher function. Arch. Neurol. 48, 1178-1187. doi: 10.1001/archneur.1991.00530230086029.
143. Schutter, D. J. L. G., Enter, D., and Hoppenbrouwers, S. S. (2009). High-frequency repetitive transcranial magnetic stimulation to the cerebellum and implicit processing of happy facial expressions. J. Psychiatry Neurosci. 34, 60-65.
144. Schutter, D. J. L. G., and van Honk, J. (2005). The cerebellum on the rise in human emotion. Cerebellum 4, 290-294. doi: 10.1080/14734220500348584.
145. Scott, R. B., Stoodley, C. J., Anslow, P., Paul, C., Stein, J. F., Sugden, E. M., et al. (2001). Lateralized cognitive deficits in children following cerebellar lesions. Dev. Med. Child Neurol. 43, 685-691. doi: 10.1017/S0012162201001232.
146. Seery, A. M., Vogel-Farley, V., Tager-Flusberg, H., and Nelson, C. A. (2013). Atypical lateralization of ERP response to native and non-native speech in infants at risk for autism spectrum disorder. Dev. Cogn. Neurosci. 5, 10-24. doi: 10.1016/j.dcn.2012.11.007.
147. Sens, P. M., de Almeida, C. I. R., de Souza, M. M. N., Gonçalves, J. B. A., and do Carmo, L. C. (2011). The role of the cerebellum in auditory processing using the SSI test. Braz. J. Otorhinolaryngol. 77, 584-588.
148. Shukla, D. K., Keehn, B., Lincoln, A. J., and Müller, R.-A. (2010). White matter compromise of callosal and subcortical fiber tracts in children with Autism spectrum disorder: a diffusion tensor imaging study. J. Am. Acad. Child Adolesc. Psychiatry 49, 1269-1278.e2. doi: 10.1016/j.jaac.2010.08.018.
149. Sivaswamy, L., Kumar, A., Rajan, D., Behen, M., Muzik, O., Chugani, D., et al. (2010). A diffusion tensor imaging study of the cerebellar pathways in children with Autism spectrum disorder. J. Child Neurol. 25, 1223-1231. doi: 10.1177/0883073809358765.
150. Snider, R., and Eldred, E. (1951). Electro-anatomical studies on cerebro-cerebellar connections in the cat. J. Comp. Neurol. 95, 1-16. doi: 10.1002/cne.900950102.
151. Snider, R. S. (1950). Recent contributions to the anatomy and physiology of the cerebellum. Arch. Neurol. Psychiatry 64, 196-219. doi: 10.1001/archneurpsyc.1950.02310260034002.
152. Snider, R. S., and Maiti, A. (1976). Cerebellar contributions to the Papez circuit. J. Neurosci. Res. 2, 133-146. doi: 10.1002/jnr.490020204.
153. Snider, R. S., and Stowell, A. (1944). Receiving areas of the tactile, auditory, and visual systems in the cerebellum. J. Neurophysiol. 7, 331-357.
154. Sokolov, A. A., Erb, M., Grodd, W., and Pavlova, M. A. (2012). Structural loop between the cerebellum and the superior temporal sulcus: evidence from diffusion tensor imaging. Cereb. Cortex 24, 626-632. doi: 10.1093/cercor/bhs346.
155. Spanagel, R., and Weiss, F. (1999). The dopamine hypothesis of reward: past and current status. Trends Neurosci. 22, 521-527. doi: 10.1016/S0166-2236(99)01447-2.
156. Stanfield, A. C., McIntosh, A. M., Spencer, M. D., Philip, R., Gaur, S., and Lawrie, S. M. (2008). Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies. Eur. Psychiatry 23, 289-299. doi: 10.1016/j.eurpsy.2007.05.006.
157. Stern, E., Silbersweig, D. A., Chee, K. Y., Holmes, A., Robertson, M. M., Trimble, M., et al. (2000). A functional neuroanatomy of tics in Tourette syndrome. Arch. Gen. Psychiatry 57, 741-748. doi: 10.1001/archpsyc.57.8.741.
158. Stoodley, C. J., and Schmahmann, J. D. (2009). Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 44, 489-501. doi: 10.1016/j.neuroimage.2008.08.039.
159. Stoodley, C. J., and Schmahmann, J. D. (2010). Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 46, 831-844. doi: 10.1016/j.cortex.2009.11.008.
160. Stoodley, C. J., and Schmahmann, J. D. (2015). "Functional linguistic topography of the cerebellum," in The Linguistic Cerebellum, eds P. Marien and M. Manto (Waltham, MA: Academic Press), 315-335.
161. Stoodley, C. J., Valera, E. M., and Schmahmann, J. D. (2010). An fMRI study of intra-individual functional topography in the human cerebellum. Behav. Neurol. 23, 65-79. doi: 10.1155/2010/840942.
162. Stoodley, C. J., Valera, E. M., and Schmahmann, J. D. (2012). Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study. Neuroimage 59, 1560-1570. doi: 10.1016/j.neuroimage.2011.08.065.
163. Stoodley, C. J. (2014). Distinct regions of the cerebellum show gray matter decreases in autism, ADHD, and developmental dyslexia. Front. Syst. Neurosci. 8:92. doi: 10.3389/fnsys.2014.00092.
164. Stoodley, C. J. (2015). The cerebellum and neurodevelopmental disorders. Cerebellum 8:92. doi: 10.33389/fnsys.2014.00092.
165. Strick, P. L., Dum, R. P., and Fiez, J. A. (2009). Cerebellum and nonmotor function. Annu. Rev. Neurosci. 32, 413-434. doi: 10.1146/annurev.neuro.31.060407.125606.
166. Takeuchi, M., Harada, M., Matsuzaki, K., Nishitani, H., and Mori, K. (2004). Difference of signal change by a language task on autistic patients using functional MRI. J. Med. Invest. 51, 59-62. doi: 10.2152/jmi.51.59.
167. Tavano, A., Grasso, R., Gagliardi, C., Triulzi, F., Bresolin, N., Fabbro, F., et al. (2007). Disorders of cognitive and affective development in cerebellar malformations. Brain 130, 2646-2660. doi: 10.1093/brain/awm201.
168. Tesink, C. M. J. Y., Petersson, K. M., van Berkum, J. J. A., van den Brink, D., Buitelaar, J. K., and Hagoort, P. (2009). Unification of speaker and meaning in language comprehension: an FMRI study. J. Cogn. Neurosci. 21, 2085-2099. doi: 10.1162/jocn.2008.21161.
169. Tiemeier, H., Lenroot, R. K., Greenstein, D. K., Tran, L., Pierson, R., and Giedd, J. N. (2010). Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study. Neuroimage 49, 63-70. doi: 10.1016/j.neuroimage.2009.08.016.
170. Tobe, R. H., Bansal, R., Xu, D., Hao, X., Liu, J., Sanchez, J., et al. (2010). Cerebellar morphology in Tourette Syndrome and Obsessive-compulsive disorder. Ann. Neurol. 67, 479-487. doi: 10.1002/ana.21918.
171. Travers, B. G., Adluru, N., Ennis, C., Trompdo, P. M., Destiche, D., Doran, S., et al. (2012). Diffusion tensor imaging in Autism spectrum disorder: a Review. Autism Res. 5, 289-313. doi: 10.1002/aur.1243.
172. Tsai, P. T., Hull, C., Chu, Y., Greene-Colozzi, E., Sadowski, A. R., Leech, J. M., et al. (2012). Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature 488, 647-651. doi: 10.1038/nature11310.
173. Ullman, M. T., and Pullman, M. Y. (2015). A compensatory role for declarative memory in neurodevelopmental disorders. Neurosci. Biobehav. Rev. 51, 205-222. doi: 10.1016/j.neubiorev.2015.01.008.
174. Van Overwalle, F., Baetens, K., Mariën, P., and Vandekerckhove, M. (2014). Social cognition and the cerebellum: a meta-analysis of over 350 fMRI studies. Neuroimage 86, 554-572. doi: 10.1016/j.neuroimage.2013.09.033.
175. Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., and Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57, 67-81. doi: 10.1002/ana.20315.
176. Verly, M., Verhoeven, J., Zink, I., Mantini, D., Peeters, R., Deprez, S., et al. (2014). Altered functional connectivity of the language network in ASD: role of classical language areas and cerebellum. NeuroImage Clin. 4, 374-382. doi: 10.1016/j.nicl.2014.01.008.
177. Via, E., Radua, J., Cardoner, N., Happé, F., and Mataix-Cols, D. (2011). Meta-analysis of gray matter abnormalities in autism spectrum disorder: should Asperger disorder be subsumed under a broader umbrella of autistic spectrum disorder? Arch. Gen. Psychiatry 68, 409-418. doi: 10.1001/archgenpsychiatry.2011.27.
178. Volpe, J. J. (2009). Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important. J. Child Neurol. 24, 1085-1104. doi: 10.1177/0883073809338067.
179. Walker, L., Gozzi, M., Lenroot, R., Thurm, A., Behseta, B., Swedo, S., et al. (2012). Diffusion Tensor Imaging in young children with Autism: biological effects and potential confounds. Biol. Psychiatry 72, 1043-1051. doi: 10.1016/j.biopsych.2012.08.001.
180. Wang, A. T., Lee, S. S., Sigman, M., and Dapretto, M. (2007). Reading affect in the face and voice. Arch. Gen. Psychiatry 64, 698-708. doi: 10.1001/archpsyc.64.6.698.
181. Wang, S. S.-H., Kloth, A. D., and Badura, A. (2014). The cerebellum, sensitive periods, and autism. Neuron 83, 518-532. doi: 10.1016/j.neuron.2014.07.016.
182. Weber, A. M., Egelhoff, J. C., McKellop, J. M., and Franz, D. N. (2000). Autism and the cerebellum: evidence from Tuberous Sclerosis. J. Autism Dev. Disord. 30, 511-517. doi: 10.1023/A:1005679108529.
183. Yeo, B. T. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., et al. (2011). The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J. Neurophysiol. 106, 1125-1165. doi: 10.1152/jn.00338.2011.
184. Yu, K. K., Cheung, C., Chua, S. E., and McAlonan, G. M. (2011). Can Asperger syndrome be distinguished from autism? An anatomic likelihood meta-analysis of MRI studies. J. Psychiatry Neurosci. 36, 412-421. doi: 10.1503/jpn.100138.
185. Zwicker, J. G., Missiuna, C., Harris, S. R., and Boyd, L. A. (2011). Brain activation associated with motor skill practice in children with developmental coordination disorder: an fMRI study. Int. J. Dev. Neurosci. 29, 145-152. doi: 10.1016/j.ijdevneu.2010.12.002.