A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway

British Journal of Pharmacology

Volumn 172, Issue 23, 2015, Pages 5573-5585

  Zheng, Xiaopu ^b   Yin, Qian ^a,b   Lu, Haiyan ^a,c   Bai, Yajun ^c   Tian, Aiju ^a   Yang, Qiuxiang ^a,c   Wu, Jimin ^a   Yang, Chengzhi ^a   Fan, Tai Ping ^d   Zhang, Youyi ^a   Zheng, Xiaohui ^c   Li, Zijian ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^c NORTHWEST UNIVERSITY   (China)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBROTIC AGENT; BETA ADRENERGIC RECEPTOR; COLLAGEN TYPE 1; ISOPRENALINE; ISOPROPYL 3 (3,4 DIHYDROXYPHENYL) 2 HYDROXYLPROPANOATE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PLANT MEDICINAL PRODUCT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; CYBB PROTEIN, RAT; HERBACEOUS AGENT; ISOPROPYL 3-(3, 4-DIHYDROXYPHENYL)-2-HYDROXYPROPANOATE; MEMBRANE PROTEIN; PROPIONIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; HEART FIBROBLAST; HEART MUSCLE FIBROSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CELL PROLIFERATION; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FIBROBLAST; FIBROSIS; HEART; HEART FAILURE; METABOLISM; PHOSPHORYLATION; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANIMALS, NEWBORN; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FIBROBLASTS; FIBROSIS; HEART; HEART FAILURE; INJECTIONS, SUBCUTANEOUS; ISOPROTERENOL; MALE; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROPIONATES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84949539515     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13133     Document Type: Article

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