Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface

Biochemistry

Volumn 35, Issue 14, 1996, Pages 4287-4297

  Borgstahl, Gloria E O ^a   Parge, Hans E ^a,e   Hickey, Michael J ^a   Johnson, Michael J ^a   Boissinot, Maurice ^a,f   Hallewell, Robert A ^b   Lepock, James R ^c   Cabelli, Diane E ^d   Tainer, John A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF WATERLOO   (Canada)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

^e AGOURON PHARMACEUTICALS INC   (United States)

^f UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

SUPEROXIDE DISMUTASE;

ARTICLE; CELL SURVIVAL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME STABILITY; HUMAN; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL;

BINDING SITES; ELECTROCHEMISTRY; ENZYME STABILITY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; OXIDATIVE STRESS; PHENOTYPE; POINT MUTATION; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; SUPEROXIDE DISMUTASE; TEMPERATURE; VARIATION (GENETICS);

EID: 0029883978     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi951892w     Document Type: Article

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