Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons

Nature Communications

Volumn 6, Issue , 2015, Pages

  Jiang, Houbo ^a,b   Xu, Zhimin ^b,c   Zhong, Ping ^a,b   Ren, Yong ^b   Liang, Gaoyang ^d   Schilling, Haley A ^b   Hu, Zihua ^e   Zhang, Yi ^d   Wang, Xiaomin ^f   Chen, Shengdi ^c   Yan, Zhen ^a,b   Feng, Jian ^a,b,f  

^a VA WESTERN NEW YORK HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY AT BUFFALO   (United States)

^f BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; LMX1A PROTEIN; MICRORNA 124; NUCLEAR RECEPTOR RELATED FACTOR 1; PEPTIDES AND PROTEINS; PROTEIN P53; TET1 PROTEIN; TRANSCRIPTION FACTOR MASH1; UNCLASSIFIED DRUG; ASCL1 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; LIM HOMEODOMAIN PROTEIN; LMX1A PROTEIN, HUMAN; MICRORNA; MIRN124 MICRORNA, HUMAN; MIXED FUNCTION OXIDASE; NR4A2 PROTEIN, HUMAN; ONCOPROTEIN; TET1 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

CELLS AND CELL COMPONENTS; DISEASE; GENE EXPRESSION; GENETIC MARKER; MUSCLE; NEUROLOGY; PROTEIN;

ARTICLE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; FIBROBLAST; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MESENCEPHALON; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PROTEIN EXPRESSION; CELL CYCLE; CELL CYCLE CHECKPOINT; CELL LINE; CYTOLOGY; GENE SILENCING; GENETICS; METABOLISM; NUCLEAR REPROGRAMMING;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE; CELL TRANSDIFFERENTIATION; CELLULAR REPROGRAMMING; DNA-BINDING PROTEINS; DOPAMINERGIC NEURONS; FIBROBLASTS; G1 PHASE CELL CYCLE CHECKPOINTS; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIM-HOMEODOMAIN PROTEINS; MESENCEPHALON; MICRORNAS; MIXED FUNCTION OXYGENASES; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84949527122     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10100     Document Type: Article

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