JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice

Diabetologia

Volumn 59, Issue 1, 2016, Pages 187-196

  Shi, Sally Yu ^a,b   Zhang, Wei ^a,c   Luk, Cynthia T ^a,b   Sivasubramaniyam, Tharini ^a,b   Brunt, Jara J ^a,b   Schroer, Stephanie A ^a   Desai, Harsh R ^a,b   Majerski, Alexandra ^a   Woo, Minna ^a,b,d  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SHANDONG UNIVERSITY   (China)

^d TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Adaptive thermogenesis; Brown adipose tissue; Diabetes; Glucose homeostasis; Janus kinase 2 (JAK2); Obesity; Uncoupling protein 1 (UCP1)

Indexed keywords

JANUS KINASE 2; MESSENGER RNA; UNCOUPLING PROTEIN 1; INSULIN; ION CHANNEL; JAK2 PROTEIN, MOUSE; JANUS KINASE 1; MITOCHONDRIAL PROTEIN; STAT1 PROTEIN; STAT1 PROTEIN, MOUSE; UCP1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; FEMALE; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS FAT; THERMOGENESIS; UPREGULATION; WEIGHT GAIN; WHITE ADIPOSE TISSUE; ADIPOCYTE; ADIPOGENESIS; ANIMAL; CYTOLOGY; KNOCKOUT MOUSE; METABOLISM; OBESITY; PHYSIOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION;

ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ADIPOSITY; ANIMALS; DIET, HIGH-FAT; FEMALE; INSULIN; ION CHANNELS; JANUS KINASE 1; JANUS KINASE 2; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; THERMOGENESIS; UNCOUPLING PROTEIN 1; UP-REGULATION;

EID: 84949323641     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3786-2     Document Type: Article

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