Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax

Oncogene

Volumn 35, Issue 30, 2016, Pages 3955-3964

  Bajpai, R ^a   Matulis, S M ^a   Wei, C ^a   Nooka, A K ^a   Von Hollen, H E ^a   Lonial, S ^a   Boise, L H ^a   Shanmugam, M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 6 DIAZO 5 OXONORLEUCINE; BIM PROTEIN; GLUCOSE; GLUCOSE TRANSPORTER 4; GLUTAMINE; MYELOID CELL LEUKEMIC FACTOR 1; PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PUMA PROTEIN; RITONAVIR; UNCLASSIFIED DRUG; VENETOCLAX; ANTINEOPLASTIC AGENT; FUSED HETEROCYCLIC RINGS; SULFONAMIDE;

ADULT; AGED; AMINO ACID METABOLISM; APOPTOSIS; ARTICLE; CELL SURVIVAL; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG TARGETING; FEMALE; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MALE; MIDDLE AGED; MULTIPLE MYELOMA; MULTIPLE MYELOMA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; VERY ELDERLY; ANTAGONISTS AND INHIBITORS; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BCL-2-LIKE PROTEIN 11; BRIDGED BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TUMOR; GLUCOSE TRANSPORTER TYPE 4; GLUTAMINE; HUMANS; MULTIPLE MYELOMA; PROTO-ONCOGENE PROTEINS C-BCL-2; RITONAVIR; SULFONAMIDES;

EID: 84949267062     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.464     Document Type: Article

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