Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism

Behavioural Brain Research

Volumn 251, Issue , 2013, Pages 41-49

  El Kordi, Ahmed ^a,b   Winkler, Daniela ^a   Hammerschmidt, Kurt ^c   Kästner, Anne ^a   Krueger, Dilja ^a   Ronnenberg, Anja ^a   Ritter, Caroline ^a   Jatho, Jasmin ^a   Radyushkin, Konstantin ^a,b   Bourgeron, Thomas ^d,e,f   Fischer, Julia ^c   Brose, Nils ^a,b   Ehrenreich, Hannelore ^a,b  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b Deutsche Forschungsgemeinschaft   (Germany)

^c GERMAN PRIMATE CENTER   (Germany)

^d Institut Pasteur ^*

^e INSTITUT PASTEUR   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

ASD; Gender differences; Grooming; Nest building; Repetitive behaviors; Social interaction; Stereotypies; Ultra sound vocalization

Indexed keywords

NEUROLIGIN; NEUROLIGIN 4; UNCLASSIFIED DRUG;

AGGRESSION; ANIMAL BEHAVIOR; ANIMAL COMMUNICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTISM; COMPULSION; CONSTRUCT VALIDITY; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; EXPLORATORY BEHAVIOR; FACE VALIDITY; FEEDING BEHAVIOR; FEMALE; GENE MUTATION; GENOTYPE; GROOMING; HERITABILITY; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NESTING; NLGN4X GENE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; SOCIAL INTERACTION; STEREOTYPY; SYNAPTIC TRANSMISSION;

ASD; GENDER DIFFERENCES; GROOMING; NEST BUILDING; REPETITIVE BEHAVIORS; SOCIAL INTERACTION; STEREOTYPIES; ULTRA-SOUND VOCALIZATION;

ANIMALS; AUTISTIC DISORDER; BEHAVIOR, ANIMAL; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GROOMING; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PHENOTYPE; SEVERITY OF ILLNESS INDEX; SEX CHARACTERISTICS; SOCIAL BEHAVIOR; STEREOTYPED BEHAVIOR; VOCALIZATION, ANIMAL;

EID: 84878665879     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.11.016     Document Type: Article

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