D-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling

Brain Research Bulletin

Volumn 96, Issue , 2013, Pages 62-70

  Burket, Jessica A ^a   Benson, Andrew D ^a   Tang, Amy H ^a   Deutsch, Stephen I ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

BTBR mice; D Cycloserine; NMDA receptor; Sociability; Stereotypies

Indexed keywords

CYCLOSERINE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RAF PROTEIN; RAS PROTEIN;

ACCLIMATIZATION; ANIMAL EXPERIMENT; ARTICLE; AUTISM; DRUG EFFECT; DRUG EFFICACY; GROOMING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REARING; SIGNAL TRANSDUCTION; SOCIAL AVOIDANCE BEHAVIOR; SOCIAL BEHAVIOR; SOCIAL INTERACTION; STEREOTYPY;

BTBR MICE; D-CYCLOSERINE; NMDA RECEPTOR; SOCIABILITY; STEREOTYPIES;

ANIMALS; BEHAVIOR, ANIMAL; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CYCLOSERINE; DISEASE MODELS, ANIMAL; GROOMING; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; MICE, TRANSGENIC; SOCIAL BEHAVIOR; STEREOTYPED BEHAVIOR; TOR SERINE-THREONINE KINASES;

EID: 84878804982     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2013.05.003     Document Type: Article

References (44)

1. Brodkin E.S. BALB/c mice: low sociability and other phenotypes that may be relevant to autism. Behavioural Brain Research 2007, 176:53-65.
2. Burket J.A., Cannon W.R., Jacome L.F., Deutsch S.I. MK-801 a noncompetitive NMDA receptor antagonist, elicits circling behavior in the genetically inbred Balb/c mouse strain. Brain Research Bulletin 2010, 83:337-339.
3. Burket J.A., Herndon A.L., Deutsch S.I. Locomotor activity of the genetically inbred Balb/c mouse strain is suppressed by a socially salient stimulus. Brain Research Bulletin 2010, 83:255-256.
4. Campbell M., Locascio J.J., Choroco M.C., Spencer E.K., Malone R.P., Kafantaris V., Overall J.E. Stereotypies and tardive dyskinesia: abnormal movements in autistic children. Psychopharmacology Bulletin 1990, 26:260-266.
5. Cleary C., Linde J.A.S., Hiscock K.M., Hadas I., Belmaker R.H., Agam G., Flaisher-Grinberg S., Einat H. Antidepressive-like effects of rapamycin in animal models Implications for mTOR inhibition as a new target for treatment of affective disorders. Brain Research Bulletin 2008, 76:469-473.
6. Crawley J.N. Designing mouse behavioral tasks relevant to autistic-like behaviors. Mental Retardation and Developmental Disabilities Research Reviews 2004, 10:248-258.
7. Crawley J.N. Mouse behavioral assays relevant to the symptoms of autism. Brain Pathology 2007, 17:448-459.
8. Crino P.B. mTOR: A pathogenic signaling pathway in developmental brain malformations. Trends in Molecular Medicine 2011, 17:734-742.
9. Cuscó I., Medrano A., Gener B., Vilardell M., Gallastegui F., Villa O., González E., Rodríguez-Santiago B., Vilella E., Del Campo M., Pérez-Jurado L.A. Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder. Human Molecular Genetics 2009, 18:1795-1804.
10. Deutsch S.I., Burket J.A., Jacome L.F., Cannon W.R., Herndon A.L. d-Cycloserine improves the impaired sociability of the Balb/c mouse. Brain Research Bulletin 2011, 84:8-11.
11. Deutsch, S.I., Burket, J.A., Urbano, M.R., Herndon, A.L., Winebarger, E.E., 2011. Impaired Sociability of the Balb/c Mouse, an Animal Model of Autism Spectrum Disorders, is Attenuated by NMDA Receptor Agonist Interventions: Clinical Implications, in: Mohammad-Reza, M. (Ed.), A Comprehensive Book on Autism Spectrum Disorders. InTech.
12. Deutsch S.I., Mastropaolo J., Powell D.G., Rosse R.B., Bachus S.E. Inbred mouse strains differ in their sensitivity to an antiseizure effect of MK-801. Clinical Neuropharmacology 1998, 21:255-257.
13. Deutsch S.I., Pepe G.J., Burket J.A., Winebarger E.E., Herndon A.L., Benson A.D. D-cycloserine improves sociability and spontaneous stereotypic behaviors in 4-week old mice. Brain Research 2012, 1439:96-107.
14. Deutsch S.I., Rosse R.B., Paul S.M., Riggs R.L., Mastropaolo J. Inbred mouse strains differ in sensitivity to popping behavior elicited by MK-801. Pharmacology Biochemistry and Behavior 1997, 57:315-317.
15. Ehninger D., Silva A.J. Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends in Molecular Medicine 2011, 17:78-87.
16. Fitzpatrick C.J., Lombroso P.J. The role of striatal-enriched protein tyrosine phosphatase (STEP) in cognition. Frontiers in Neuroanatomy 2011, 5:47.
17. Goldman S., Wang C., Salgado M.W., Greene P.E., Kim M., Rapin I. Motor stereotypies in children with autism and other developmental disorders. Developmental Medicine and Child Neurology 2009, 51:30-38.
18. Halene T.B., Ehrlichman R.S., Liang Y., Christian E.P., Jonak G.J., Gur T.L., Blendy J.A., Dow H.C., Brodkin E.S., Schneider F., Gur R.C., Siegel S.J. Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia. Genes, Brain and Behavior 2009, 8:661-675.
19. Haller J., Nagy R., Toth M., Pelczer K.G., Mikics E. NR2B subunit-specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear: a comparison with the NMDA antagonist MK-801 and fluoxetine. Behavioural Pharmacology 2011, 22:113-121.
20. Huang Y., Kang B.N., Tian J., Liu Y., Luo H.R., Hester L., Snyder S.H. The Cationic Amino Acid Transporters CAT1 and CAT3 Mediate NMDA Receptor Activation-Dependent Changes in Elaboration of Neuronal Processes via the Mammalian Target of Rapamycin mTOR Pathway. Journal of Neuroscience 2007, 27:449-458.
21. Jacome L.F., Burket J.A., Herndon A.L., Cannon W.R., Deutsch S.I. D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain. Brain Research Bulletin 2011, 84:12-16.
22. Jacome L.F., Burket J.A., Herndon A.L., Deutsch S.I. D-Cycloserine enhances social exploration in the Balb/c mouse. Brain Research Bulletin 2011, 85:141-144.
23. Jacome L.F., Burket J.A., Herndon A.L., Deutsch S.I. Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders. Autism Research 2011, 4:393-400.
24. Labrie V., Lipina T., Roder J.C. Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia. Psychopharmacology (Berlin) 2008, 200:217-230.
25. Langton J.M., Richardson R. The effect of d-cycloserine on immediate vs delayed extinction of learned fear. Learning & Memory 2010, 17:547-551.
26. McFarlane H.G., Kusek G.K., Yang M., Phoenix J.L., Bolivar V.J., Crawley J.N. Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes, Brain and Behavior 2008, 7:152-163.
27. Papouin T., Ladépêche L., Ruel J., Sacchi S., Labasque M., Hanini M., Groc L., Pollegioni L., Mothet J.-P., Oliet S.H.R. Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell 2012, 150:633-646.
28. Paul S., Connor J.A. NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling. Journal of Neurochemistry 2010, 114:1107-1118.
29. Paul S., Nairn A.C., Wang P., Lombroso P.J. NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nature Neuroscience 2003, 6:34-42.
30. Sahin M. Targeted treatment trials for tuberous sclerosis and autism: no longer a dream. Current Opinion in Neurobiology 2012, 22:895-901.
31. Sankoorikal G.M.V., Kaercher K.A., Boon C.J., Lee J.K., Brodkin E.S. A mouse model system for genetic analysis of sociability: C57BL/6J versus BALB/cJ inbred mouse strains. Biological Psychiatry 2006, 59:415-423.
32. Scattoni M.L., Gandhy S.U., Ricceri L., Crawley J.N. Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism. PLoS One 2008, 3:e3067.
33. Scattoni M.L., Ricceri L., Crawley J.N. Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters. Genes, Brain and Behavior 2011, 10:44-56.
34. Sharma A., Hoeffer C.A., Takayasu Y., Miyawaki T., McBride S.M., Klann E., Zukin R.S. Dysregulation of mTOR signaling in fragile X syndrome. Journal of Neuroscience 2010, 30:694-702.
35. Silverman J.L., Tolu S.S., Barkan C.L., Crawley J.N. Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Neuropsychopharmacology 2010, 35:976-989.
36. Talos D.M., Sun H., Zhou X., Fitzgerald E.C., Jackson M.C., Klein P.M., Lan V.J., Joseph A., Jensen F.E. The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway. PLoS One 2012, 7:e35885.
37. Tsai P.T., Hull C., Chu Y., Greene-Colozzi E., Sadowski A.R., Leech J.M., Steinberg J., Crawley J.N., Regehr W.G., Sahin M. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature 2012, 488:647-651.
38. Vizi E.S., Kisfali M., Lo{doubleacute}rincz T. Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects. Brain Research Bulletin 2013, 93:32-38.
39. Wlaź P., Baran H., Löscher W. Effect of the glycine/NMDA receptor partial agonist d-cycloserine, on seizure threshold and some pharmacodynamic effects of MK-801 in mice. European Journal of Pharmacology 1994, 257:217-225.
40. Wöhr M., Roullet F.I., Crawley J.N. Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism. Genes, Brain and Behavior 2011, 10:35-43.
41. Yang K., Sheikh A.M., Malik M., Wen G., Zou H., Brown W.T., Li X. Upregulation of Ras/Raf/ERK1/2 signaling and ERK5 in the brain of autistic subjects. Genes, Brain and Behavior 2011, 10:834-843.
42. Yang M., Zhodzishsky V., Crawley J.N. Social deficits in BTBR T+tf/J mice are unchanged by cross-fostering with C57BL/6 J mothers. International Journal of Developmental Neuroscience 2007, 25:515-521.
43. Zhou J., Blundell J., Ogawa S., Kwon C.-H., Zhang W., Sinton C., Powell C.M., Parada L.F. Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. Journal of Neuroscience 2009, 29:1773-1783.
44. Zou H., Yu Y., Sheikh A.M., Malik M., Yang K., Wen G., Chadman K.K., Brown W.T., Li X. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes, Brain and Behavior 2011, 10:615-624.