Autistic-like behaviour in Scn1a +- mice and rescue by enhanced GABA-mediated neurotransmission

Nature

Volumn 489, Issue 7416, 2012, Pages 385-390

  Han, Sung ^a,b   Tai, Chao ^b   Westenbroek, Ruth E ^b   Yu, Frank H ^b,d   Cheah, Christine S ^b   Potter, Gregory B ^c   Rubenstein, John L ^c   Scheuer, Todd ^b   De La Iglesia, Horacio O ^a   Catterall, William A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CLONAZEPAM; SODIUM CHANNEL NAV1.1;

AMINO ACID; COGNITION; DISEASE TREATMENT; GENE EXPRESSION; MEMORY; MENTAL HEALTH; NERVOUS SYSTEM DISORDER; NEUROLOGY; RODENT; STEREOTYPIC BEHAVIOR;

ARTICLE; AUTISM; CONTROLLED STUDY; FOREBRAIN; GABAERGIC TRANSMISSION; HAPLOINSUFFICIENCY; HYPERACTIVITY; LOW DRUG DOSE; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; OLFACTORY SYSTEM; PRIORITY JOURNAL; RECURRENT DISEASE; SEIZURE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SOCIAL INTERACTION; SOCIOPATHY; SPATIAL MEMORY; STEREOTYPY;

ANIMALS; ANXIETY; AUTISTIC DISORDER; CLONAZEPAM; EPILEPSIES, MYOCLONIC; GABA MODULATORS; GABAERGIC NEURONS; GAMMA-AMINOBUTYRIC ACID; HAPLOINSUFFICIENCY; HETEROZYGOTE; HIPPOCAMPUS; HOMEODOMAIN PROTEINS; HYPERKINESIS; INTERNEURONS; MALE; MEMORY; MICE; NERVE TISSUE PROTEINS; SOCIAL BEHAVIOR; SODIUM CHANNELS; SPACE PERCEPTION; STEREOTYPIC MOVEMENT DISORDER; SYNAPTIC TRANSMISSION; SYNDROME; TRANSCRIPTION FACTORS;

MUS;

EID: 84866500624     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11356     Document Type: Article

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