Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase

Structure

Volumn 23, Issue 12, 2015, Pages 2213-2223

  Khare, Dheeraj ^a   Hale, Wendi A ^a,c   Tripathi, Ashootosh ^a   Gu, Liangcai ^a,d   Sherman, David H ^a   Gerwick, William H ^b   Håkansson, Kristina ^a   Smith, Janet L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; COENZYME A; CROTONYL COENZYME A; CURACIN A; CURACIN CYCLOPROPANASE; CURACIN ENOYL REDUCTASE; CYCLOPROPANE; ENOYL ACYL CARRIER PROTEIN REDUCTASE; ENOYL REDUCTASE JAMJ; HYDROLASE; JAMAICAMIDE; MEDIUM CHAIN DEHYDROGENASE REDUCTASE; NATURAL PRODUCT; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CYCLOPROPANE DERIVATIVE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); THIAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; CATALYSIS; CHIMERA; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOPROPANATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME SYNTHESIS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; AMINO ACID SEQUENCE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CYCLOPROPANES; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); MOLECULAR SEQUENCE DATA; THIAZOLES;

EID: 84949201589     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.09.013     Document Type: Article

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